Allopurinol_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Allopurinol perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Allopurinol_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0948486
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0922299
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0760505
EEF2 eukaryotic translation elongation factor 2 0.0685728
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0621457
RBM39 RNA binding motif protein 39 0.0594149
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0569697
TPX2 TPX2, microtubule-associated 0.0559894
ANXA1 annexin A1 0.0548453
GOLGA4 golgin A4 0.0543911
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0482113
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0478371
NAMPT nicotinamide phosphoribosyltransferase 0.0472096
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0456729
TXNRD1 thioredoxin reductase 1 0.0452058
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.044365
SPAG9 sperm associated antigen 9 0.0430412
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0419619
MATR3 matrin 3 0.0410961
RSRC2 arginine/serine-rich coiled-coil 2 0.0404756
WAC WW domain containing adaptor with coiled-coil 0.0399706
ANLN anillin, actin binding protein 0.0399458
NUP58 nucleoporin 58 0.0399249
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0383055
PCBP2 poly(rC) binding protein 2 0.0379304
MYH9 myosin, heavy chain 9, non-muscle 0.0369891
CALR calreticulin 0.0368928
KIF5B kinesin family member 5B 0.0366519
ANXA2 annexin A2 0.0358045
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0349115
ZNF292 zinc finger protein 292 0.034543
LCORL ligand dependent nuclear receptor corepressor-like 0.0345215
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0337592
CANX calnexin 0.0336437
HELZ helicase with zinc finger 0.03331
HILPDA hypoxia inducible lipid droplet-associated 0.0331064
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0328635
ANKRD28 ankyrin repeat domain 28 0.0324742
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0324706
DIAPH3 diaphanous-related formin 3 0.0323428
CHD1 chromodomain helicase DNA binding protein 1 0.0314991
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0314449
SQSTM1 sequestosome 1 0.0313287
AHCTF1 AT hook containing transcription factor 1 0.0309907
CALU calumenin 0.0301796
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 0.0300866
MIS18BP1 MIS18 binding protein 1 0.0300381
BSG basigin (Ok blood group) 0.0296928
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0292126
ECT2 epithelial cell transforming 2 0.0292042
WDR43 WD repeat domain 43 0.0288503
GLS2 glutaminase 2 (liver, mitochondrial) 0.0286454
CENPF centromere protein F, 350/400kDa 0.0285264
SEC24A SEC24 family member A 0.0283917
HSPA8 heat shock 70kDa protein 8 0.0283621
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0283601
FUS FUS RNA binding protein 0.0280088
SET SET nuclear proto-oncogene 0.0279949
NUP153 nucleoporin 153kDa 0.027747
ADM adrenomedullin 0.0277191
DSCAM Down syndrome cell adhesion molecule 0.0272871
EIF1 eukaryotic translation initiation factor 1 0.0271461
SMC4 structural maintenance of chromosomes 4 0.0270404
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0268877
TTK TTK protein kinase 0.0268198
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0264785
FANCI Fanconi anemia, complementation group I 0.0260499
NAP1L1 nucleosome assembly protein 1-like 1 0.0255455
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0254972
QKI QKI, KH domain containing, RNA binding 0.0253231
SRRM2 serine/arginine repetitive matrix 2 0.0250189
TOP2B topoisomerase (DNA) II beta 180kDa 0.0249714
COPB1 coatomer protein complex, subunit beta 1 0.0246547
MORF4L2 mortality factor 4 like 2 0.0246536
YBX3 Y box binding protein 3 0.0244734
EZR ezrin 0.0243445
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0242665
APLP2 amyloid beta (A4) precursor-like protein 2 0.0242127
COG5 component of oligomeric golgi complex 5 0.024173
CKAP2 cytoskeleton associated protein 2 0.024169
SBNO1 strawberry notch homolog 1 (Drosophila) 0.0240479
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0238846
CKAP5 cytoskeleton associated protein 5 0.0234963
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0232666
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0230206
BRD2 bromodomain containing 2 0.0229469
RAB1A RAB1A, member RAS oncogene family 0.0227947
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.022569
XPO1 exportin 1 0.0223936
SGO2 shugoshin 2 0.0223603
IARS1 isoleucyl-tRNA synthetase 1 0.0222518
TJP2 tight junction protein 2 0.0221468
TNPO1 transportin 1 0.0219091
CEP250 centrosomal protein 250kDa 0.0216856
CRY1 cryptochrome circadian clock 1 0.0212339
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.02121
TSC22D2 TSC22 domain family, member 2 0.0211783
TPR translocated promoter region, nuclear basket protein 0.0211716
UBQLN1 ubiquilin 1 0.0211414
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0210806

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.142485
FNDC3B fibronectin type III domain containing 3B -0.0926518
TMSB10 thymosin beta 10 -0.0829535
HMGA2 high mobility group AT-hook 2 -0.0663855
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0652849
CD44 CD44 molecule (Indian blood group) -0.0625138
ZBTB20 zinc finger and BTB domain containing 20 -0.0618533
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0606011
DST dystonin -0.0522122
PRSS23 protease, serine, 23 -0.0514259
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0505274
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0503738
DPYD dihydropyrimidine dehydrogenase -0.0498261
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0488776
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.04835
TPT1 tumor protein, translationally-controlled 1 -0.0454055
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0440722
THSD4 thrombospondin, type I, domain containing 4 -0.0434504
SLC38A2 solute carrier family 38, member 2 -0.0434432
VIM vimentin -0.0428101
FMN1 formin 1 -0.0419199
ANGPTL4 angiopoietin-like 4 -0.0404506
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0402591
OSMR oncostatin M receptor -0.039478
NALCN sodium leak channel, non selective -0.0388489
NT5E 5'-nucleotidase, ecto (CD73) -0.0383844
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0381921
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0379453
RAI14 retinoic acid induced 14 -0.036429
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0362614
ZMYND8 zinc finger, MYND-type containing 8 -0.0355174
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.034253
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.034067
RIGI RNA sensor RIG-I -0.0337658
RAD51B RAD51 paralog B -0.0337633
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0329587
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0328511
ATXN1 ataxin 1 -0.0319362
FNDC3A fibronectin type III domain containing 3A -0.0316868
SH3KBP1 SH3-domain kinase binding protein 1 -0.0312299
RPL35A ribosomal protein L35a -0.0308032
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0304999
PRR16 proline rich 16 -0.0299224
MACF1 microtubule-actin crosslinking factor 1 -0.0298844
IGF2 insulin-like growth factor 2 -0.0296935
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0296577
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.029611
PCED1B PC-esterase domain containing 1B -0.0289093
SVIL supervillin -0.0280982
NPAS2 neuronal PAS domain protein 2 -0.0278158
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0275188
SDC4 syndecan 4 -0.0268521
SMYD3 SET and MYND domain containing 3 -0.0267983
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0264676
POTEF POTE ankyrin domain family, member F -0.0264447
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0264137
PRKCA protein kinase C, alpha -0.026326
EXOC4 exocyst complex component 4 -0.0262611
PRH1 proline-rich protein HaeIII subfamily 1 -0.0262059
FLNB filamin B, beta -0.0261489
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0261012
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0258604
BPTF bromodomain PHD finger transcription factor -0.0256802
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0256354
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0256135
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0253586
BICD1 bicaudal D homolog 1 (Drosophila) -0.0249613
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0244098
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0240915
AHNAK AHNAK nucleoprotein -0.0239366
SBF2 SET binding factor 2 -0.0238948
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0238759
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.023737
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0235942
ACTG1 actin gamma 1 -0.0235503
BASP1 brain abundant, membrane attached signal protein 1 -0.0234065
PODXL podocalyxin-like -0.0232287
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0232003
NAV3 neuron navigator 3 -0.0230513
PLEK2 pleckstrin 2 -0.0228911
FMNL2 formin-like 2 -0.0228312
PTPRG protein tyrosine phosphatase, receptor type, G -0.0227627
ATM ATM serine/threonine kinase -0.0227072
EGFR epidermal growth factor receptor -0.0226541
RNF213 ring finger protein 213 -0.0223865
TM4SF1 transmembrane 4 L six family member 1 -0.0223263
ARMH4 armadillo like helical domain containing 4 -0.0223132
B2M beta-2-microglobulin -0.0221544
BCAR3 breast cancer anti-estrogen resistance 3 -0.0221236
EXT1 exostosin glycosyltransferase 1 -0.021314
FBXL7 F-box and leucine-rich repeat protein 7 -0.0212909
SCAPER S-phase cyclin A-associated protein in the ER -0.0211271
WARS1 tryptophanyl-tRNA synthetase 1 -0.0211247
PTK2 protein tyrosine kinase 2 -0.0209273
RIN2 Ras and Rab interactor 2 -0.020901
RABGAP1L RAB GTPase activating protein 1-like -0.0208656
ATG7 autophagy related 7 -0.0207576
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0207508
AKAP12 A kinase (PRKA) anchor protein 12 -0.0205007
PARD3 par-3 family cell polarity regulator -0.0204861