| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Almonertinib (hydrochloride) perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Almonertinib (hydrochloride)_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | 0.212255 |
| TMSB10 | thymosin beta 10 | 0.13892 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.110801 |
| NDRG1 | N-myc downstream regulated 1 | 0.0925155 |
| PLAT | plasminogen activator, tissue | 0.0777115 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.065583 |
| COL5A1 | collagen, type V, alpha 1 | 0.0547094 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0536048 |
| CD44 | CD44 molecule (Indian blood group) | 0.0512375 |
| PTMA | prothymosin, alpha | 0.0511661 |
| LMNA | lamin A/C | 0.0498271 |
| PODXL | podocalyxin-like | 0.0494473 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0440093 |
| CALR | calreticulin | 0.0431572 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0427514 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | 0.0412699 |
| ASPH | aspartate beta-hydroxylase | 0.041269 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0390502 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0389601 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0375058 |
| RPL35A | ribosomal protein L35a | 0.0365475 |
| RPL23 | ribosomal protein L23 | 0.0359723 |
| RPS19 | ribosomal protein S19 | 0.0355064 |
| SEC61G | Sec61 gamma subunit | 0.0348323 |
| CAVIN1 | caveolae associated protein 1 | 0.0318095 |
| RPS24 | ribosomal protein S24 | 0.0296934 |
| RPL34 | ribosomal protein L34 | 0.0290787 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0281913 |
| RPL36 | ribosomal protein L36 | 0.028099 |
| FTL | ferritin, light polypeptide | 0.0274231 |
| EFNA5 | ephrin-A5 | 0.0270745 |
| PFN1 | profilin 1 | 0.0270129 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.0268004 |
| HLA-B | major histocompatibility complex, class I, B | 0.0267412 |
| RPL26 | ribosomal protein L26 | 0.0258689 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0258285 |
| RPS3 | ribosomal protein S3 | 0.025762 |
| SP100 | SP100 nuclear antigen | 0.0255987 |
| KLF6 | Kruppel-like factor 6 | 0.0255374 |
| MT1X | metallothionein 1X | 0.0254432 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0251884 |
| RPS12 | ribosomal protein S12 | 0.0248127 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0246878 |
| RPS6 | ribosomal protein S6 | 0.0246061 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0245168 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0244046 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | 0.024223 |
| RPL28 | ribosomal protein L28 | 0.0241341 |
| RPL31 | ribosomal protein L31 | 0.0239039 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0237844 |
| SQSTM1 | sequestosome 1 | 0.0237257 |
| RPL37A | ribosomal protein L37a | 0.0233959 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0226034 |
| RPS8 | ribosomal protein S8 | 0.0224128 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0223625 |
| POTEF | POTE ankyrin domain family, member F | 0.022239 |
| RPS17 | ribosomal protein S17 | 0.0221567 |
| ARPC1B | actin related protein 2/3 complex, subunit 1B, 41kDa | 0.0220887 |
| MYL12B | myosin, light chain 12B, regulatory | 0.0220506 |
| STC1 | stanniocalcin 1 | 0.0219512 |
| PRELID2 | PRELI domain containing 2 | 0.0219259 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0217826 |
| RPLP2 | ribosomal protein, large, P2 | 0.021634 |
| B2M | beta-2-microglobulin | 0.0214221 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0214113 |
| RPL12 | ribosomal protein L12 | 0.0213522 |
| NUCB2 | nucleobindin 2 | 0.0211392 |
| ACTG1 | actin gamma 1 | 0.0210914 |
| GLIS3 | GLIS family zinc finger 3 | 0.0208444 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0203681 |
| RUNX1 | runt-related transcription factor 1 | 0.0202784 |
| SON | SON DNA binding protein | 0.020081 |
| PGK1 | phosphoglycerate kinase 1 | 0.0200739 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0198381 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0196029 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0196021 |
| VCL | vinculin | 0.019366 |
| ATP5F1E | ATP synthase F1 subunit epsilon | 0.0193322 |
| SMAD3 | SMAD family member 3 | 0.0193316 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0192542 |
| PRSS23 | protease, serine, 23 | 0.0191726 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0191602 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0191311 |
| SMYD3 | SET and MYND domain containing 3 | 0.019069 |
| RPS21 | ribosomal protein S21 | 0.0187648 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0187632 |
| DSCAM | Down syndrome cell adhesion molecule | 0.018604 |
| NT5E | 5'-nucleotidase, ecto (CD73) | 0.018525 |
| TUBB4B | tubulin, beta 4B class IVb | 0.0184841 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.018406 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | 0.0180546 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0179012 |
| COL3A1 | collagen, type III, alpha 1 | 0.0178942 |
| FAM162A | family with sequence similarity 162, member A | 0.0178846 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | 0.017827 |
| INTS6 | integrator complex subunit 6 | 0.0176688 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0176508 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0175662 |
| DGKG | diacylglycerol kinase, gamma 90kDa | 0.0174567 |
| DUSP6 | dual specificity phosphatase 6 | 0.0172552 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.157252 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0819978 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0634606 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0547768 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.051321 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0458784 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.04341 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0387917 |
| SPAG9 | sperm associated antigen 9 | -0.0377695 |
| MAP1B | microtubule-associated protein 1B | -0.0376211 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0371969 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0336986 |
| FN1 | fibronectin 1 | -0.0310752 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0301354 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0281146 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.0280602 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0276635 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0268288 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0265938 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0260508 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0257392 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0251536 |
| ZNF148 | zinc finger protein 148 | -0.0242658 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0236292 |
| SRPK2 | SRSF protein kinase 2 | -0.0231045 |
| SUCNR1 | succinate receptor 1 | -0.023081 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0226781 |
| FLT1 | fms-related tyrosine kinase 1 | -0.0221985 |
| SBF2 | SET binding factor 2 | -0.0216005 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0214373 |
| UBC | ubiquitin C | -0.0210854 |
| MX2 | MX dynamin-like GTPase 2 | -0.0199943 |
| RNF168 | ring finger protein 168, E3 ubiquitin protein ligase | -0.0199002 |
| CD109 | CD109 molecule | -0.0198305 |
| MSI2 | musashi RNA-binding protein 2 | -0.0195271 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0193748 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.0190899 |
| ANXA2 | annexin A2 | -0.0190616 |
| SPIRE1 | spire-type actin nucleation factor 1 | -0.0176348 |
| RIPK1 | receptor (TNFRSF)-interacting serine-threonine kinase 1 | -0.0173668 |
| COPA | coatomer protein complex, subunit alpha | -0.0164008 |
| MEIS2 | Meis homeobox 2 | -0.0159565 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | -0.0158868 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | -0.0157562 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0155013 |
| IL7R | interleukin 7 receptor | -0.0153188 |
| S100A10 | S100 calcium binding protein A10 | -0.0153077 |
| AHNAK | AHNAK nucleoprotein | -0.0151975 |
| SAMD9L | sterile alpha motif domain containing 9-like | -0.0150953 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | -0.0150389 |
| RIGI | RNA sensor RIG-I | -0.0146231 |
| JAZF1 | JAZF zinc finger 1 | -0.014539 |
| NGLY1 | N-glycanase 1 | -0.0145213 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0141791 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0140393 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | -0.0140145 |
| FNBP1 | formin binding protein 1 | -0.0135308 |
| TPM4 | tropomyosin 4 | -0.0133768 |
| TFG | TRK-fused gene | -0.0132064 |
| POM121 | POM121 transmembrane nucleoporin | -0.0131721 |
| CDK12 | cyclin-dependent kinase 12 | -0.0128513 |
| TNS3 | tensin 3 | -0.0128448 |
| AAK1 | AP2 associated kinase 1 | -0.0126564 |
| MTCL1 | microtubule crosslinking factor 1 | -0.0125936 |
| RNF169 | ring finger protein 169 | -0.0124859 |
| FGF13 | fibroblast growth factor 13 | -0.0123747 |
| SP3 | Sp3 transcription factor | -0.0123276 |
| HLA-E | major histocompatibility complex, class I, E | -0.012255 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | -0.0120671 |
| INSIG1 | insulin induced gene 1 | -0.0119706 |
| ZBTB41 | zinc finger and BTB domain containing 41 | -0.0119313 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | -0.011921 |
| MPZL1 | myelin protein zero-like 1 | -0.0118597 |
| INVS | inversin | -0.0117842 |
| PLXNA2 | plexin A2 | -0.0116842 |
| TAOK1 | TAO kinase 1 | -0.0116758 |
| NAV2 | neuron navigator 2 | -0.0115939 |
| MICU3 | mitochondrial calcium uptake family, member 3 | -0.0115891 |
| RBM27 | RNA binding motif protein 27 | -0.0115371 |
| YEATS2 | YEATS domain containing 2 | -0.0115173 |
| GJA1 | gap junction protein, alpha 1, 43kDa | -0.011514 |
| CCSER2 | coiled-coil serine-rich protein 2 | -0.0114888 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0113893 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0113642 |
| FNBP4 | formin binding protein 4 | -0.011343 |
| CKAP5 | cytoskeleton associated protein 5 | -0.0112316 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0111091 |
| BLTP1 | bridge-like lipid transfer protein family member 1 | -0.0110696 |
| NCOA1 | nuclear receptor coactivator 1 | -0.0110444 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.010996 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0109949 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0109438 |
| MYOF | myoferlin | -0.0108782 |
| TNIP1 | TNFAIP3 interacting protein 1 | -0.0107672 |
| SEC24D | SEC24 family member D | -0.0107402 |
| RAB10 | RAB10, member RAS oncogene family | -0.0107025 |
| AFAP1 | actin filament associated protein 1 | -0.0105459 |
| MAP4 | microtubule-associated protein 4 | -0.0104063 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | -0.0103805 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.010328 |
