| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Almonertinib (hydrochloride) perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Almonertinib (hydrochloride)_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.249175 |
| NLGN1 | neuroligin 1 | 0.19903 |
| TMSB10 | thymosin beta 10 | 0.123623 |
| YBX3 | Y box binding protein 3 | 0.114387 |
| MYL12B | myosin, light chain 12B, regulatory | 0.113344 |
| RPS12 | ribosomal protein S12 | 0.107836 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.101964 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0984193 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0911919 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0770626 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0710173 |
| TPI1 | triosephosphate isomerase 1 | 0.0705393 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0686148 |
| YAP1 | Yes-associated protein 1 | 0.0686084 |
| RPL9 | ribosomal protein L9 | 0.0647772 |
| PCDH7 | protocadherin 7 | 0.0634919 |
| RPS3 | ribosomal protein S3 | 0.0623419 |
| RPL35A | ribosomal protein L35a | 0.0605936 |
| RPL26 | ribosomal protein L26 | 0.0589003 |
| ASPH | aspartate beta-hydroxylase | 0.057526 |
| RRM2 | ribonucleotide reductase M2 | 0.0556415 |
| PFN1 | profilin 1 | 0.0534334 |
| JMJD1C | jumonji domain containing 1C | 0.0521851 |
| NHSL1 | NHS-like 1 | 0.0502535 |
| RACK1 | receptor for activated C kinase 1 | 0.0500174 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0470364 |
| TMEM41B | transmembrane protein 41B | 0.0469933 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | 0.0465099 |
| KIF18B | kinesin family member 18B | 0.0449982 |
| EHBP1 | EH domain binding protein 1 | 0.0446017 |
| RPS21 | ribosomal protein S21 | 0.0443292 |
| EGR1 | early growth response 1 | 0.044247 |
| RPS8 | ribosomal protein S8 | 0.0437191 |
| RPLP0 | ribosomal protein, large, P0 | 0.0430941 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | 0.0430377 |
| RCOR1 | REST corepressor 1 | 0.0410637 |
| ARPC1B | actin related protein 2/3 complex, subunit 1B, 41kDa | 0.0410483 |
| RPL12 | ribosomal protein L12 | 0.0404336 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0403062 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0396028 |
| PDGFC | platelet derived growth factor C | 0.0389077 |
| TUBA1B | tubulin, alpha 1b | 0.0385265 |
| CBX3 | chromobox homolog 3 | 0.038317 |
| CENPF | centromere protein F, 350/400kDa | 0.038159 |
| KLF6 | Kruppel-like factor 6 | 0.038066 |
| RASAL2 | RAS protein activator like 2 | 0.0374222 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0369827 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0368478 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.0366734 |
| TRA2B | transformer 2 beta homolog (Drosophila) | 0.0362809 |
| LDHA | lactate dehydrogenase A | 0.0362445 |
| ZNF804A | zinc finger protein 804A | 0.0357376 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0354635 |
| TUBA1C | tubulin, alpha 1c | 0.0353188 |
| MTAP | methylthioadenosine phosphorylase | 0.0341701 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0340171 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.033176 |
| SPATS2 | spermatogenesis associated, serine-rich 2 | 0.0327288 |
| HMGA2 | high mobility group AT-hook 2 | 0.0326624 |
| RPS4X | ribosomal protein S4, X-linked | 0.032603 |
| RPS7 | ribosomal protein S7 | 0.032533 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | 0.0323251 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.0321386 |
| RPS19 | ribosomal protein S19 | 0.0320093 |
| TENM3 | teneurin transmembrane protein 3 | 0.0316075 |
| RPS24 | ribosomal protein S24 | 0.0313371 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.031148 |
| PRDX1 | peroxiredoxin 1 | 0.0311417 |
| ERBIN | erbb2 interacting protein | 0.0308093 |
| DST | dystonin | 0.030528 |
| RPL27 | ribosomal protein L27 | 0.030111 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0300465 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0300177 |
| CALR | calreticulin | 0.0294004 |
| DOCK1 | dedicator of cytokinesis 1 | 0.0289897 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0289633 |
| KRR1 | KRR1, small subunit (SSU) processome component, homolog (yeast) | 0.0288807 |
| EDARADD | EDAR-associated death domain | 0.0288802 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | 0.0288146 |
| RPL23 | ribosomal protein L23 | 0.0283866 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0279981 |
| CENPE | centromere protein E, 312kDa | 0.0275326 |
| ETV6 | ets variant 6 | 0.0275213 |
| NDC80 | NDC80 kinetochore complex component | 0.027477 |
| RPL18 | ribosomal protein L18 | 0.026819 |
| DUSP6 | dual specificity phosphatase 6 | 0.0268028 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.0265691 |
| ATP5F1E | ATP synthase F1 subunit epsilon | 0.026412 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0262839 |
| ADIPOR2 | adiponectin receptor 2 | 0.0262043 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0258044 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0255077 |
| MSRB3 | methionine sulfoxide reductase B3 | 0.0251252 |
| PTMA | prothymosin, alpha | 0.025001 |
| CMIP | c-Maf inducing protein | 0.024933 |
| EXOC4 | exocyst complex component 4 | 0.0247728 |
| LMO7 | LIM domain 7 | 0.0247303 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | 0.0247208 |
| MIB1 | mindbomb E3 ubiquitin protein ligase 1 | 0.0246038 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.0245068 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.291986 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.102684 |
| VIM | vimentin | -0.0990747 |
| AREG | amphiregulin | -0.0846941 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0839671 |
| MMP12 | matrix metallopeptidase 12 | -0.0647506 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0594195 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0573723 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0555786 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0529366 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.049962 |
| SETD5 | SET domain containing 5 | -0.0488223 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -0.0487162 |
| BCHE | butyrylcholinesterase | -0.0481191 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0431015 |
| CPOX | coproporphyrinogen oxidase | -0.0417143 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0401317 |
| RPS23 | ribosomal protein S23 | -0.0397051 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | -0.0393391 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0384022 |
| WNK1 | WNK lysine deficient protein kinase 1 | -0.038091 |
| TXNRD1 | thioredoxin reductase 1 | -0.0364665 |
| RPS29 | ribosomal protein S29 | -0.0356105 |
| PCM1 | pericentriolar material 1 | -0.0353804 |
| S100A10 | S100 calcium binding protein A10 | -0.0336569 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0333813 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0331328 |
| EIF2AK1 | eukaryotic translation initiation factor 2-alpha kinase 1 | -0.0324896 |
| WDR45B | WD repeat domain 45B | -0.0320194 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | -0.0319486 |
| FUS | FUS RNA binding protein | -0.0312329 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0309515 |
| AHNAK | AHNAK nucleoprotein | -0.0302267 |
| THOC1 | THO complex 1 | -0.0296106 |
| VMP1 | vacuole membrane protein 1 | -0.0295617 |
| USP9X | ubiquitin specific peptidase 9, X-linked | -0.0287732 |
| SQSTM1 | sequestosome 1 | -0.0284582 |
| GGNBP2 | gametogenetin binding protein 2 | -0.0283729 |
| RPL4 | ribosomal protein L4 | -0.0280539 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.0280102 |
| BPTF | bromodomain PHD finger transcription factor | -0.0280009 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0274554 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0274277 |
| USP34 | ubiquitin specific peptidase 34 | -0.0266092 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.0264564 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.025946 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0259405 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | -0.025886 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0258848 |
| RPL8 | ribosomal protein L8 | -0.0256899 |
| GOLGA4 | golgin A4 | -0.0254634 |
| SEPTIN7 | septin 7 | -0.0253573 |
| CLTC | clathrin, heavy chain (Hc) | -0.0251705 |
| UBC | ubiquitin C | -0.0244599 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0244365 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0242864 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0241803 |
| ARHGAP12 | Rho GTPase activating protein 12 | -0.023952 |
| ATP11A | ATPase, class VI, type 11A | -0.0239312 |
| TRMT112 | tRNA methyltransferase 11-2 homolog (S. cerevisiae) | -0.0238753 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0237965 |
| YEATS2 | YEATS domain containing 2 | -0.0237407 |
| PGK1 | phosphoglycerate kinase 1 | -0.0237149 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0236376 |
| KLHL24 | kelch-like family member 24 | -0.0233447 |
| ENO1 | enolase 1, (alpha) | -0.0227707 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0224058 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0223341 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | -0.0219207 |
| CLDND1 | claudin domain containing 1 | -0.0218577 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0218025 |
| ZNF207 | zinc finger protein 207 | -0.0216182 |
| SBF2 | SET binding factor 2 | -0.0213105 |
| NCKAP1 | NCK-associated protein 1 | -0.021084 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0209705 |
| RPL3 | ribosomal protein L3 | -0.0209605 |
| ZNF292 | zinc finger protein 292 | -0.0208592 |
| USP53 | ubiquitin specific peptidase 53 | -0.0207102 |
| OGA | O-GlcNAcase | -0.02071 |
| RPS15 | ribosomal protein S15 | -0.0206175 |
| BTG3 | BTG family, member 3 | -0.0205963 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0204058 |
| HDLBP | high density lipoprotein binding protein | -0.0203687 |
| TASOR2 | transcription activation suppressor family member 2 | -0.0202828 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | -0.0201078 |
| VPS41 | vacuolar protein sorting 41 homolog (S. cerevisiae) | -0.0197295 |
| ITGA6 | integrin, alpha 6 | -0.0196014 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0193888 |
| RPL38 | ribosomal protein L38 | -0.0193657 |
| FTL | ferritin, light polypeptide | -0.0192297 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0191705 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0190997 |
| MGAT4C | MGAT4 family, member C | -0.0189403 |
| TMEM123 | transmembrane protein 123 | -0.0188887 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0186887 |
| MATR3 | matrin 3 | -0.0186293 |
| PTEN | phosphatase and tensin homolog | -0.0185942 |
| HSPB1 | heat shock 27kDa protein 1 | -0.018562 |
| LPGAT1 | lysophosphatidylglycerol acyltransferase 1 | -0.0183377 |
| TRPM7 | transient receptor potential cation channel, subfamily M, member 7 | -0.018328 |
