| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Almonertinib (hydrochloride) perturbation in A498 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Almonertinib (hydrochloride)_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.248508 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.136155 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.122662 |
| B2M | beta-2-microglobulin | 0.118595 |
| APOL1 | apolipoprotein L, 1 | 0.082109 |
| CALR | calreticulin | 0.0742728 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0705787 |
| NDRG1 | N-myc downstream regulated 1 | 0.0703646 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0651596 |
| CCL2 | chemokine (C-C motif) ligand 2 | 0.0648576 |
| ASPH | aspartate beta-hydroxylase | 0.0607619 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0607104 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.058931 |
| CTSD | cathepsin D | 0.0583179 |
| PFN1 | profilin 1 | 0.0505161 |
| POTEF | POTE ankyrin domain family, member F | 0.0492922 |
| HLA-A | major histocompatibility complex, class I, A | 0.0479285 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.047444 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0469477 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0465082 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0451644 |
| ADM | adrenomedullin | 0.0450783 |
| RPL35A | ribosomal protein L35a | 0.0441514 |
| RPS2 | ribosomal protein S2 | 0.0413627 |
| IFI44L | interferon-induced protein 44-like | 0.0391885 |
| MYADM | myeloid-associated differentiation marker | 0.0391375 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0373223 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0371304 |
| RND3 | Rho family GTPase 3 | 0.0362759 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 | 0.0359689 |
| NUCB2 | nucleobindin 2 | 0.0356274 |
| ANXA5 | annexin A5 | 0.0355508 |
| MSN | moesin | 0.035143 |
| CBX3 | chromobox homolog 3 | 0.0334036 |
| RNASET2 | ribonuclease T2 | 0.03284 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.032509 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0322544 |
| CD63 | CD63 molecule | 0.0321101 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0317841 |
| CKAP4 | cytoskeleton-associated protein 4 | 0.0311432 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0310837 |
| JUN | jun proto-oncogene | 0.0305553 |
| MMP14 | matrix metallopeptidase 14 (membrane-inserted) | 0.0303753 |
| KDELR1 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 | 0.0297875 |
| FRMD4A | FERM domain containing 4A | 0.0296343 |
| CADM1 | cell adhesion molecule 1 | 0.0289302 |
| INTS6 | integrator complex subunit 6 | 0.0284151 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0283068 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0282866 |
| FAM120A | family with sequence similarity 120A | 0.0282419 |
| CD82 | CD82 molecule | 0.0281165 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0278015 |
| SERPINH1 | serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) | 0.0275087 |
| LGALS3BP | lectin, galactoside-binding, soluble, 3 binding protein | 0.0274432 |
| CYBA | cytochrome b-245, alpha polypeptide | 0.0274311 |
| PUM3 | pumilio RNA binding family member 3 | 0.027398 |
| LMNA | lamin A/C | 0.0272314 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0269268 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.026674 |
| HMGA1 | high mobility group AT-hook 1 | 0.0266526 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0265947 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0264594 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0264509 |
| TAGLN2 | transgelin 2 | 0.0263592 |
| DEGS1 | delta(4)-desaturase, sphingolipid 1 | 0.0257799 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.025655 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0256332 |
| ARPC1B | actin related protein 2/3 complex, subunit 1B, 41kDa | 0.0255953 |
| MAP1B | microtubule-associated protein 1B | 0.0254431 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0252204 |
| TPM3 | tropomyosin 3 | 0.0250847 |
| GDF15 | growth differentiation factor 15 | 0.0249692 |
| NOP58 | NOP58 ribonucleoprotein | 0.0249555 |
| PGM3 | phosphoglucomutase 3 | 0.0247573 |
| COPA | coatomer protein complex, subunit alpha | 0.0246156 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.024551 |
| AHCYL1 | adenosylhomocysteinase-like 1 | 0.0243949 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 0.0243811 |
| TUBA1B | tubulin, alpha 1b | 0.0241181 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0240258 |
| LAMB3 | laminin, beta 3 | 0.0238555 |
| SFTPA2 | surfactant protein A2 | 0.0237358 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.0235154 |
| DCAF13 | DDB1 and CUL4 associated factor 13 | 0.0232509 |
| VEGFA | vascular endothelial growth factor A | 0.0232075 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0231276 |
| EIF5AL1 | eukaryotic translation initiation factor 5A-like 1 | 0.0229247 |
| COL4A1 | collagen, type IV, alpha 1 | 0.0227449 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0224041 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.0220331 |
| COG6 | component of oligomeric golgi complex 6 | 0.0219975 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0219463 |
| HLA-C | major histocompatibility complex, class I, C | 0.0219127 |
| RPS7 | ribosomal protein S7 | 0.0217478 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0213316 |
| RHEB | Ras homolog enriched in brain | 0.0212418 |
| MTDH | metadherin | 0.021138 |
| HBP1 | HMG-box transcription factor 1 | 0.021076 |
| SERF2 | small EDRK-rich factor 2 | 0.0210674 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0209753 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NAMPT | nicotinamide phosphoribosyltransferase | -0.110698 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.106593 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.102075 |
| EXT1 | exostosin glycosyltransferase 1 | -0.10062 |
| TXNRD1 | thioredoxin reductase 1 | -0.0975346 |
| GPC6 | glypican 6 | -0.0950963 |
| FNDC3B | fibronectin type III domain containing 3B | -0.068017 |
| NRP2 | neuropilin 2 | -0.0631843 |
| RPS6 | ribosomal protein S6 | -0.0631402 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0626166 |
| RPLP1 | ribosomal protein, large, P1 | -0.0580704 |
| RUNX1 | runt-related transcription factor 1 | -0.0551025 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0503033 |
| VCL | vinculin | -0.048811 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.04502 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0442356 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0430154 |
| SBF2 | SET binding factor 2 | -0.0423928 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0392382 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0373973 |
| LITAF | lipopolysaccharide-induced TNF factor | -0.0365354 |
| SP3 | Sp3 transcription factor | -0.0365331 |
| RPL19 | ribosomal protein L19 | -0.0359664 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0351803 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.035034 |
| GNA12 | guanine nucleotide binding protein (G protein) alpha 12 | -0.0335992 |
| RPS23 | ribosomal protein S23 | -0.0331113 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0324782 |
| GLIS3 | GLIS family zinc finger 3 | -0.0324361 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0323086 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0322783 |
| RNF216 | ring finger protein 216 | -0.0320118 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0319773 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.031962 |
| GGNBP2 | gametogenetin binding protein 2 | -0.0311561 |
| RIPK2 | receptor-interacting serine-threonine kinase 2 | -0.0309839 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0308492 |
| SKAP2 | src kinase associated phosphoprotein 2 | -0.0306688 |
| AVL9 | AVL9 homolog (S. cerevisiase) | -0.0303782 |
| ANAPC5 | anaphase promoting complex subunit 5 | -0.0300053 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0294364 |
| LPGAT1 | lysophosphatidylglycerol acyltransferase 1 | -0.029335 |
| NRP1 | neuropilin 1 | -0.0292669 |
| RPL8 | ribosomal protein L8 | -0.0290596 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0289884 |
| G0S2 | G0/G1 switch 2 | -0.0287039 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0286877 |
| MATR3 | matrin 3 | -0.0286043 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0284077 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0283763 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0282845 |
| OSBPL3 | oxysterol binding protein-like 3 | -0.0282491 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0281233 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | -0.028077 |
| MAP4 | microtubule-associated protein 4 | -0.0280388 |
| CALD1 | caldesmon 1 | -0.0280188 |
| RRBP1 | ribosome binding protein 1 | -0.0280159 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | -0.0274438 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0274005 |
| TMEM263 | transmembrane protein 263 | -0.0273849 |
| TUSC3 | tumor suppressor candidate 3 | -0.0271402 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0268574 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | -0.0267227 |
| HIBADH | 3-hydroxyisobutyrate dehydrogenase | -0.0266684 |
| STK24 | serine/threonine kinase 24 | -0.0266357 |
| RPS20 | ribosomal protein S20 | -0.0264703 |
| ETV6 | ets variant 6 | -0.0263401 |
| PTMA | prothymosin, alpha | -0.0262082 |
| NSMCE2 | non-SMC element 2, MMS21 homolog (S. cerevisiae) | -0.0260191 |
| SAA2 | serum amyloid A2 | -0.0260144 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0257612 |
| EIF2AK1 | eukaryotic translation initiation factor 2-alpha kinase 1 | -0.0253123 |
| DENND2B | DENN domain containing 2B | -0.025183 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0249709 |
| PALLD | palladin, cytoskeletal associated protein | -0.0248106 |
| PAX8 | paired box 8 | -0.0246167 |
| RPL7 | ribosomal protein L7 | -0.024557 |
| NFIA | nuclear factor I/A | -0.0244165 |
| UBB | ubiquitin B | -0.024362 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0243504 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.024169 |
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | -0.0239603 |
| NIBAN1 | niban apoptosis regulator 1 | -0.0239433 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.023892 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0238405 |
| ANXA4 | annexin A4 | -0.0238141 |
| PLSCR1 | phospholipid scramblase 1 | -0.0237907 |
| LRRC49 | leucine rich repeat containing 49 | -0.0237891 |
| GNAQ | guanine nucleotide binding protein (G protein), q polypeptide | -0.0237279 |
| RPL31 | ribosomal protein L31 | -0.0237253 |
| EXOC6B | exocyst complex component 6B | -0.0236882 |
| SPECC1 | sperm antigen with calponin homology and coiled-coil domains 1 | -0.0235038 |
| LOXL2 | lysyl oxidase-like 2 | -0.0234483 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | -0.0234291 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.023039 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0227511 |
| NF1 | neurofibromin 1 | -0.0224845 |
| RPLP2 | ribosomal protein, large, P2 | -0.0224816 |
| AKAP10 | A kinase (PRKA) anchor protein 10 | -0.0223537 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0223086 |
