Almonertinib (hydrochloride)_A549 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Almonertinib (hydrochloride) perturbation in A549 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Almonertinib (hydrochloride)_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 0.157921
RPS19 ribosomal protein S19 0.0912323
ZSWIM6 zinc finger, SWIM-type containing 6 0.086067
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0762193
TMSB10 thymosin beta 10 0.0725014
EFNA5 ephrin-A5 0.0682343
RPS6 ribosomal protein S6 0.0587384
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0572824
EGR1 early growth response 1 0.0562035
RPL35A ribosomal protein L35a 0.0557106
MT2A metallothionein 2A 0.0546264
ALCAM activated leukocyte cell adhesion molecule 0.0545757
INTS6 integrator complex subunit 6 0.0523589
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0522894
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0518008
FTH1 ferritin, heavy polypeptide 1 0.0453414
HMGA1 high mobility group AT-hook 1 0.0441373
TPT1 tumor protein, translationally-controlled 1 0.0428904
ST6GAL2 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 0.0408509
CCDC88A coiled-coil domain containing 88A 0.0405371
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.039389
LMNA lamin A/C 0.0390896
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0387877
CEMIP cell migration inducing protein, hyaluronan binding 0.0385525
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0383426
VIM vimentin 0.0383024
PFN1 profilin 1 0.0373673
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0372765
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.037055
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0368559
HMGA2 high mobility group AT-hook 2 0.0368557
LMO7 LIM domain 7 0.0361135
BASP1 brain abundant, membrane attached signal protein 1 0.0361063
PDE4D phosphodiesterase 4D, cAMP-specific 0.0354989
AADAC arylacetamide deacetylase 0.0350104
MCL1 myeloid cell leukemia 1 0.0343288
DOCK5 dedicator of cytokinesis 5 0.0343112
EPAS1 endothelial PAS domain protein 1 0.0336266
RND3 Rho family GTPase 3 0.0329676
IGFBP1 insulin-like growth factor binding protein 1 0.0323511
RPL37A ribosomal protein L37a 0.0322547
MT1X metallothionein 1X 0.0320146
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0314817
RPL9 ribosomal protein L9 0.0310503
ZFP36L1 ZFP36 ring finger protein-like 1 0.0303077
RHCG Rh family, C glycoprotein 0.02961
LDHA lactate dehydrogenase A 0.029201
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0291101
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0286044
RPS17 ribosomal protein S17 0.0284132
DUSP5 dual specificity phosphatase 5 0.0281735
RPL18 ribosomal protein L18 0.0279692
MAML3 mastermind-like 3 (Drosophila) 0.0279582
FRMD6 FERM domain containing 6 0.0278502
S100A6 S100 calcium binding protein A6 0.0273611
PRKCA protein kinase C, alpha 0.0270898
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0267455
RPS12 ribosomal protein S12 0.0258171
RPS8 ribosomal protein S8 0.025631
CTBP2 C-terminal binding protein 2 0.0254685
POTEF POTE ankyrin domain family, member F 0.0251853
ASTN2 astrotactin 2 0.0248641
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0248062
OFD1 oral-facial-digital syndrome 1 0.0243367
RPL28 ribosomal protein L28 0.0234984
IGFBP4 insulin-like growth factor binding protein 4 0.0233241
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0227991
MYADM myeloid-associated differentiation marker 0.0224321
FERMT2 fermitin family member 2 0.0224274
ZC3H12C zinc finger CCCH-type containing 12C 0.0222564
KLF6 Kruppel-like factor 6 0.0222193
RPS4X ribosomal protein S4, X-linked 0.021366
RPS3 ribosomal protein S3 0.0207775
RPS13 ribosomal protein S13 0.0207126
RPLP2 ribosomal protein, large, P2 0.0205821
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0205297
RPL11 ribosomal protein L11 0.0202914
KANK1 KN motif and ankyrin repeat domains 1 0.0197435
ANKRD12 ankyrin repeat domain 12 0.0197095
EIF5B eukaryotic translation initiation factor 5B 0.0196591
ATF4 activating transcription factor 4 0.0195778
IGFBP3 insulin-like growth factor binding protein 3 0.0194348
RPS2 ribosomal protein S2 0.0193957
ZFP36 ZFP36 ring finger protein 0.0191458
KLF5 Kruppel-like factor 5 (intestinal) 0.0189067
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0188654
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0188396
USP47 ubiquitin specific peptidase 47 0.0187834
RPL36 ribosomal protein L36 0.0187349
RPS21 ribosomal protein S21 0.0185973
PMEPA1 prostate transmembrane protein, androgen induced 1 0.018163
HILPDA hypoxia inducible lipid droplet-associated 0.0180744
RAB7A RAB7A, member RAS oncogene family 0.0177325
SMC4 structural maintenance of chromosomes 4 0.017586
RPL12 ribosomal protein L12 0.017571
MAP7 microtubule-associated protein 7 0.0175438
TGFB1 transforming growth factor, beta 1 0.0175279
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0174662
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough 0.0173311
RPL26 ribosomal protein L26 0.0173247

decreased expression

Symbol Name Standardized Value
SMAD3 SMAD family member 3 -0.134812
UBC ubiquitin C -0.13437
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.124542
PDE10A phosphodiesterase 10A -0.113363
AKAP12 A kinase (PRKA) anchor protein 12 -0.103872
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.100332
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0989929
AHNAK AHNAK nucleoprotein -0.0989477
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0911518
TXNRD1 thioredoxin reductase 1 -0.088542
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0865932
FNDC3B fibronectin type III domain containing 3B -0.0806907
ARHGAP26 Rho GTPase activating protein 26 -0.074101
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0667588
SOD2 superoxide dismutase 2, mitochondrial -0.065124
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0608253
FGD6 FYVE, RhoGEF and PH domain containing 6 -0.059117
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0590922
TNIP1 TNFAIP3 interacting protein 1 -0.0577195
SBF2 SET binding factor 2 -0.0561507
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0560549
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0554821
MYH9 myosin, heavy chain 9, non-muscle -0.0554649
TRIO trio Rho guanine nucleotide exchange factor -0.055437
NCOA7 nuclear receptor coactivator 7 -0.0552187
ANXA2 annexin A2 -0.0550196
RTN4 reticulon 4 -0.0549555
RPL4 ribosomal protein L4 -0.0547297
OSMR oncostatin M receptor -0.0541216
RPS27A ribosomal protein S27a -0.0538257
DGKD diacylglycerol kinase, delta 130kDa -0.0537788
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0529161
FLNB filamin B, beta -0.0527117
NAMPT nicotinamide phosphoribosyltransferase -0.0520736
NRIP1 nuclear receptor interacting protein 1 -0.0496498
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0478448
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0471669
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0467339
ENO1 enolase 1, (alpha) -0.0461715
APP amyloid beta (A4) precursor protein -0.0459082
CMIP c-Maf inducing protein -0.0451453
EEF2 eukaryotic translation elongation factor 2 -0.0450566
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0446488
CANX calnexin -0.0435268
BIRC6 baculoviral IAP repeat containing 6 -0.0430151
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0425421
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0422923
NAV2 neuron navigator 2 -0.0421552
VEZT vezatin, adherens junctions transmembrane protein -0.0403432
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0402002
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0392428
BMAL2 basic helix-loop-helix ARNT like 2 -0.0390263
RASA2 RAS p21 protein activator 2 -0.0384319
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0373973
ASPH aspartate beta-hydroxylase -0.0371402
C15ORF48 chromosome 15 open reading frame 48 -0.0365933
CA8 carbonic anhydrase VIII -0.0363701
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0363627
OGA O-GlcNAcase -0.0360589
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0341016
FAM107B family with sequence similarity 107, member B -0.0339624
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0339046
ACTN4 actinin, alpha 4 -0.0336951
RIGI RNA sensor RIG-I -0.0336123
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.033242
DENND4C DENN/MADD domain containing 4C -0.0327702
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0323937
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0323343
PGK1 phosphoglycerate kinase 1 -0.0323128
IPO7 importin 7 -0.0321934
RRBP1 ribosome binding protein 1 -0.0313954
NPC1 Niemann-Pick disease, type C1 -0.0313008
SMYD3 SET and MYND domain containing 3 -0.0306188
BHLHE40 basic helix-loop-helix family, member e40 -0.0305316
AOPEP aminopeptidase O (putative) -0.030183
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0296749
RNF213 ring finger protein 213 -0.0295155
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.029337
TOP2A topoisomerase (DNA) II alpha 170kDa -0.029245
AGFG1 ArfGAP with FG repeats 1 -0.0290016
TRPM7 transient receptor potential cation channel, subfamily M, member 7 -0.0289545
AKR1C2 aldo-keto reductase family 1, member C2 -0.028883
KIAA1217 KIAA1217 -0.0288684
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0285975
TM4SF1 transmembrane 4 L six family member 1 -0.0285674
USP9X ubiquitin specific peptidase 9, X-linked -0.0284924
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0284616
CALU calumenin -0.0283296
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0283211
GPRIN3 GPRIN family member 3 -0.0280743
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0280276
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0280213
PLSCR1 phospholipid scramblase 1 -0.0277147
KRT7 keratin 7, type II -0.0272442
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0271307
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0269991
TKT transketolase -0.0268932
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0266157
CFLAR CASP8 and FADD-like apoptosis regulator -0.0262235
TNS3 tensin 3 -0.0261754