| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Almonertinib (hydrochloride) perturbation in AN3 CA cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Almonertinib (hydrochloride)_AN3 CA drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MEST | mesoderm specific transcript | 0.14212 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.128949 |
| MT2A | metallothionein 2A | 0.105503 |
| RPS12 | ribosomal protein S12 | 0.0857393 |
| RPS2 | ribosomal protein S2 | 0.0660567 |
| RPS3 | ribosomal protein S3 | 0.0589091 |
| TXNRD1 | thioredoxin reductase 1 | 0.0548452 |
| ASPH | aspartate beta-hydroxylase | 0.0512785 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.050054 |
| FTL | ferritin, light polypeptide | 0.0489249 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0457847 |
| SET | SET nuclear proto-oncogene | 0.0446579 |
| SLK | STE20-like kinase | 0.0425957 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0387418 |
| ZNF292 | zinc finger protein 292 | 0.0379846 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0343489 |
| PRKD1 | protein kinase D1 | 0.0337898 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0332923 |
| NDRG1 | N-myc downstream regulated 1 | 0.032179 |
| RPL3 | ribosomal protein L3 | 0.0313677 |
| PDE10A | phosphodiesterase 10A | 0.0313111 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0296633 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0296042 |
| VEGFA | vascular endothelial growth factor A | 0.0293704 |
| MEOX2 | mesenchyme homeobox 2 | 0.0287791 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.0287699 |
| RPL12 | ribosomal protein L12 | 0.0284329 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0280324 |
| ITGAV | integrin, alpha V | 0.0276307 |
| RPS27 | ribosomal protein S27 | 0.0272 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0270002 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0266082 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0263844 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0263577 |
| RPL35A | ribosomal protein L35a | 0.0262062 |
| PCBP2 | poly(rC) binding protein 2 | 0.0260416 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.0259827 |
| SARNP | SAP domain containing ribonucleoprotein | 0.025474 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0254361 |
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 0.0252318 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0252098 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0249041 |
| ICE1 | interactor of little elongation complex ELL subunit 1 | 0.024473 |
| PFN1 | profilin 1 | 0.0242469 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.0241171 |
| RPS16 | ribosomal protein S16 | 0.0237878 |
| QKI | QKI, KH domain containing, RNA binding | 0.0233525 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0227498 |
| RACK1 | receptor for activated C kinase 1 | 0.0227173 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | 0.0225935 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.0220358 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0216829 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0215454 |
| FN1 | fibronectin 1 | 0.0215157 |
| PAPOLA | poly(A) polymerase alpha | 0.0214035 |
| IGF2 | insulin-like growth factor 2 | 0.0213628 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.021348 |
| CHD3 | chromodomain helicase DNA binding protein 3 | 0.0213022 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0212992 |
| VPS26A | vacuolar protein sorting 26 homolog A (S. pombe) | 0.02119 |
| RAD51B | RAD51 paralog B | 0.021189 |
| ZNF608 | zinc finger protein 608 | 0.0211525 |
| SSR1 | signal sequence receptor, alpha | 0.0210935 |
| PARD3 | par-3 family cell polarity regulator | 0.0210443 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.0209208 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0208578 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0208308 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0207285 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0205654 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0204633 |
| PCDH7 | protocadherin 7 | 0.0204466 |
| LAMB3 | laminin, beta 3 | 0.020239 |
| NAA50 | N(alpha)-acetyltransferase 50, NatE catalytic subunit | 0.020181 |
| TMEM41B | transmembrane protein 41B | 0.0200708 |
| EGFR | epidermal growth factor receptor | 0.0198845 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 0.0197916 |
| COL4A5 | collagen, type IV, alpha 5 | 0.0197636 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0197448 |
| RPL5 | ribosomal protein L5 | 0.0196951 |
| YBX1 | Y box binding protein 1 | 0.0194607 |
| RPL21 | ribosomal protein L21 | 0.0194584 |
| SRSF3 | serine/arginine-rich splicing factor 3 | 0.0194069 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0191692 |
| THRAP3 | thyroid hormone receptor associated protein 3 | 0.0191133 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0188514 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0188326 |
| OGA | O-GlcNAcase | 0.0187783 |
| PRELID2 | PRELI domain containing 2 | 0.01861 |
| CCDC14 | coiled-coil domain containing 14 | 0.0185874 |
| GGNBP2 | gametogenetin binding protein 2 | 0.0185075 |
| PLD3 | phospholipase D family, member 3 | 0.0185065 |
| ARGLU1 | arginine and glutamate rich 1 | 0.018461 |
| SCAF11 | SR-related CTD-associated factor 11 | 0.0184361 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.018429 |
| HYOU1 | hypoxia up-regulated 1 | 0.018402 |
| RPS7 | ribosomal protein S7 | 0.0182451 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0182399 |
| RAB8B | RAB8B, member RAS oncogene family | 0.0182362 |
| TBL1X | transducin (beta)-like 1X-linked | 0.0182278 |
| DARS1 | aspartyl-tRNA synthetase 1 | 0.0179855 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.18805 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.140811 |
| ACTG1 | actin gamma 1 | -0.0891375 |
| PRKG1 | protein kinase, cGMP-dependent, type I | -0.0876641 |
| DEK | DEK proto-oncogene | -0.0870905 |
| CENPF | centromere protein F, 350/400kDa | -0.0803736 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0744952 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0722835 |
| TUBB | tubulin, beta class I | -0.0643372 |
| ZFHX3 | zinc finger homeobox 3 | -0.0630681 |
| HMGA2 | high mobility group AT-hook 2 | -0.0612622 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0610507 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.060517 |
| PEG10 | paternally expressed 10 | -0.0602533 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0589972 |
| CUX1 | cut-like homeobox 1 | -0.0587355 |
| MGP | matrix Gla protein | -0.0559246 |
| MKI67 | marker of proliferation Ki-67 | -0.0552987 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0546796 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0546248 |
| RPS23 | ribosomal protein S23 | -0.0527894 |
| RPS24 | ribosomal protein S24 | -0.0521799 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0506069 |
| SPPL3 | signal peptide peptidase like 3 | -0.0500251 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0494722 |
| CENPE | centromere protein E, 312kDa | -0.0487912 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0459182 |
| HMGA1 | high mobility group AT-hook 1 | -0.0457957 |
| IER3 | immediate early response 3 | -0.0442991 |
| SBF2 | SET binding factor 2 | -0.0437466 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0408463 |
| RPL34 | ribosomal protein L34 | -0.0405508 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0398791 |
| JMJD1C | jumonji domain containing 1C | -0.0396818 |
| RPS5 | ribosomal protein S5 | -0.0396773 |
| RANBP17 | RAN binding protein 17 | -0.0393315 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0392351 |
| SFTPA2 | surfactant protein A2 | -0.0389015 |
| FOXC1 | forkhead box C1 | -0.0386148 |
| TPX2 | TPX2, microtubule-associated | -0.0384195 |
| NBEA | neurobeachin | -0.038237 |
| ECT2 | epithelial cell transforming 2 | -0.0373653 |
| RAI1 | retinoic acid induced 1 | -0.0371288 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0369698 |
| RAD21 | RAD21 homolog (S. pombe) | -0.036914 |
| PCM1 | pericentriolar material 1 | -0.0368025 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.036419 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0364176 |
| PHIP | pleckstrin homology domain interacting protein | -0.036413 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | -0.0363432 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0358359 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0352774 |
| SEPTIN7 | septin 7 | -0.0351438 |
| PTMA | prothymosin, alpha | -0.0349387 |
| FGFR1 | fibroblast growth factor receptor 1 | -0.034846 |
| RPLP0 | ribosomal protein, large, P0 | -0.0346364 |
| RPS14 | ribosomal protein S14 | -0.0342206 |
| IGF2R | insulin-like growth factor 2 receptor | -0.0340442 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0340079 |
| SRPK2 | SRSF protein kinase 2 | -0.0337992 |
| CBX3 | chromobox homolog 3 | -0.0336683 |
| CDK1 | cyclin-dependent kinase 1 | -0.0336118 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0334873 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0332812 |
| AHNAK | AHNAK nucleoprotein | -0.0331827 |
| SOBP | sine oculis binding protein homolog (Drosophila) | -0.0330277 |
| KIF20B | kinesin family member 20B | -0.0328612 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0328185 |
| NFIB | nuclear factor I/B | -0.0326969 |
| MEIS2 | Meis homeobox 2 | -0.0323538 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0323237 |
| RPL32 | ribosomal protein L32 | -0.0322439 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0319926 |
| GNAQ | guanine nucleotide binding protein (G protein), q polypeptide | -0.0319066 |
| BCOR | BCL6 corepressor | -0.0318195 |
| RPL7A | ribosomal protein L7a | -0.0314571 |
| HMGB1 | high mobility group box 1 | -0.0313254 |
| KIF13A | kinesin family member 13A | -0.0312647 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0311402 |
| MED13L | mediator complex subunit 13-like | -0.0309245 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | -0.0307079 |
| TUT4 | terminal uridylyl transferase 4 | -0.0306855 |
| COTL1 | coactosin-like F-actin binding protein 1 | -0.0305611 |
| COL1A2 | collagen, type I, alpha 2 | -0.0300602 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0296176 |
| IPO7 | importin 7 | -0.0295853 |
| CANX | calnexin | -0.0295675 |
| RPAP2 | RNA polymerase II associated protein 2 | -0.0294024 |
| MRTFA | myocardin related transcription factor A | -0.0288139 |
| TMSB4X | thymosin beta 4, X-linked | -0.0287271 |
| ACAP2 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 | -0.0286207 |
| SPAG9 | sperm associated antigen 9 | -0.0282122 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0281924 |
| DBF4 | DBF4 zinc finger | -0.0281897 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0279915 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.0279063 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0278133 |
| RPS11 | ribosomal protein S11 | -0.0277916 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0272666 |
| DENND1A | DENN/MADD domain containing 1A | -0.0270825 |
