| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Almonertinib (hydrochloride) perturbation in AsPC-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Almonertinib (hydrochloride)_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DHRS9 | dehydrogenase/reductase (SDR family) member 9 | 0.11414 |
| LAMB3 | laminin, beta 3 | 0.104922 |
| TMSB10 | thymosin beta 10 | 0.0966735 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0894759 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | 0.0575853 |
| PTMA | prothymosin, alpha | 0.0562186 |
| ARPC1A | actin related protein 2/3 complex, subunit 1A, 41kDa | 0.0536385 |
| MXD1 | MAX dimerization protein 1 | 0.0495783 |
| KLK10 | kallikrein-related peptidase 10 | 0.0486385 |
| RPL35A | ribosomal protein L35a | 0.0462956 |
| FTL | ferritin, light polypeptide | 0.045325 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0444784 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.043767 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0427255 |
| SACK1A | scaffolding CK1 anchoring protein A | 0.0397192 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0370522 |
| ARPC1B | actin related protein 2/3 complex, subunit 1B, 41kDa | 0.0359998 |
| TXNIP | thioredoxin interacting protein | 0.0340109 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0316897 |
| VIM | vimentin | 0.0315148 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0312483 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0307834 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0303114 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0301928 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0289107 |
| CLMP | CXADR-like membrane protein | 0.0288688 |
| FERMT1 | fermitin family member 1 | 0.0282108 |
| HMGA1 | high mobility group AT-hook 1 | 0.0279648 |
| S100A6 | S100 calcium binding protein A6 | 0.0274901 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0268921 |
| FAM13A | family with sequence similarity 13, member A | 0.0267419 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.0254019 |
| S100A10 | S100 calcium binding protein A10 | 0.0253347 |
| S100A11 | S100 calcium binding protein A11 | 0.0252705 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0245699 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0242833 |
| ANXA1 | annexin A1 | 0.0233189 |
| BLZF1 | basic leucine zipper nuclear factor 1 | 0.0228823 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | 0.0225269 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | 0.0224526 |
| PGK1 | phosphoglycerate kinase 1 | 0.0218117 |
| TMBIM1 | transmembrane BAX inhibitor motif containing 1 | 0.0217548 |
| SMC3 | structural maintenance of chromosomes 3 | 0.0216991 |
| FN1 | fibronectin 1 | 0.0207018 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | 0.0202218 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.0200836 |
| NUDT4 | nudix (nucleoside diphosphate linked moiety X)-type motif 4 | 0.0199674 |
| IER3 | immediate early response 3 | 0.0193184 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | 0.0186745 |
| CSTB | cystatin B (stefin B) | 0.0183255 |
| RPS24 | ribosomal protein S24 | 0.0183026 |
| AK1 | adenylate kinase 1 | 0.0180781 |
| SREK1IP1 | SREK1-interacting protein 1 | 0.0179858 |
| ARF4 | ADP-ribosylation factor 4 | 0.0179608 |
| RPLP1 | ribosomal protein, large, P1 | 0.017728 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0177076 |
| ARF1 | ADP-ribosylation factor 1 | 0.017602 |
| EGR1 | early growth response 1 | 0.017601 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0173998 |
| RPL31 | ribosomal protein L31 | 0.0168478 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | 0.016753 |
| RPS21 | ribosomal protein S21 | 0.0164163 |
| ARPC5 | actin related protein 2/3 complex, subunit 5, 16kDa | 0.0163685 |
| NPSR1 | neuropeptide S receptor 1 | 0.0161269 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0161068 |
| FAM107B | family with sequence similarity 107, member B | 0.0161063 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0159888 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0155609 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0155157 |
| SH3BGRL3 | SH3 domain binding glutamate-rich protein like 3 | 0.0154923 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | 0.0153745 |
| S100A4 | S100 calcium binding protein A4 | 0.0151444 |
| STC1 | stanniocalcin 1 | 0.0148638 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0145418 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | 0.0144725 |
| EXOC1 | exocyst complex component 1 | 0.014426 |
| ERGIC1 | endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 | 0.0144096 |
| KLF6 | Kruppel-like factor 6 | 0.0143633 |
| CD63 | CD63 molecule | 0.0143073 |
| ZHX2 | zinc fingers and homeoboxes 2 | 0.0143004 |
| MMP7 | matrix metallopeptidase 7 | 0.014271 |
| COG6 | component of oligomeric golgi complex 6 | 0.0140396 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | 0.0140229 |
| GORASP2 | golgi reassembly stacking protein 2, 55kDa | 0.0139923 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.013871 |
| VDAC1 | voltage-dependent anion channel 1 | 0.0135574 |
| RPLP0 | ribosomal protein, large, P0 | 0.0135034 |
| NT5C2 | 5'-nucleotidase, cytosolic II | 0.0134955 |
| MACO1 | macoilin 1 | 0.0133997 |
| MT2A | metallothionein 2A | 0.0133425 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0132815 |
| RPL37 | ribosomal protein L37 | 0.0131491 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0130891 |
| TPI1 | triosephosphate isomerase 1 | 0.0129484 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0129145 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | 0.0129039 |
| GCC2 | GRIP and coiled-coil domain containing 2 | 0.0128451 |
| UBE2B | ubiquitin-conjugating enzyme E2B | 0.01259 |
| FAM3C | family with sequence similarity 3, member C | 0.012527 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0124621 |
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.15747 |
| NDRG1 | N-myc downstream regulated 1 | -0.112235 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0999555 |
| SMAD3 | SMAD family member 3 | -0.0970351 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0923382 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0916715 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0904938 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0883686 |
| FLNB | filamin B, beta | -0.0844807 |
| LMTK2 | lemur tyrosine kinase 2 | -0.0830101 |
| ITGA6 | integrin, alpha 6 | -0.0798155 |
| EFNA5 | ephrin-A5 | -0.0796247 |
| UBC | ubiquitin C | -0.0780102 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.076444 |
| PLEC | plectin | -0.0750154 |
| RPS2 | ribosomal protein S2 | -0.0738465 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0701476 |
| ASPH | aspartate beta-hydroxylase | -0.0697768 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | -0.0689625 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0672631 |
| MYOF | myoferlin | -0.0650367 |
| EZR | ezrin | -0.064153 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0641012 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0611588 |
| JMJD1C | jumonji domain containing 1C | -0.0597988 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.0551474 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0550321 |
| RTN4 | reticulon 4 | -0.0541889 |
| VCL | vinculin | -0.0530423 |
| CORO1C | coronin, actin binding protein, 1C | -0.0526664 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0526268 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0504616 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0501863 |
| ARHGAP42 | Rho GTPase activating protein 42 | -0.049324 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0471779 |
| CAB39 | calcium binding protein 39 | -0.0464789 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | -0.0460802 |
| MED13L | mediator complex subunit 13-like | -0.0450508 |
| POTEF | POTE ankyrin domain family, member F | -0.0444817 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.0443796 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0440467 |
| DSG2 | desmoglein 2 | -0.0433872 |
| TUFT1 | tuftelin 1 | -0.042282 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | -0.0422073 |
| EGFR | epidermal growth factor receptor | -0.0420431 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0419814 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | -0.0418713 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0413519 |
| ANO6 | anoctamin 6 | -0.0409413 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.0407057 |
| SQSTM1 | sequestosome 1 | -0.0399077 |
| NEK7 | NIMA-related kinase 7 | -0.0396992 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0393369 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0388994 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0384925 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0383401 |
| PCBP2 | poly(rC) binding protein 2 | -0.0380665 |
| TPM3 | tropomyosin 3 | -0.0377429 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0376296 |
| CHD1 | chromodomain helicase DNA binding protein 1 | -0.0374271 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.037365 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0368929 |
| AHNAK | AHNAK nucleoprotein | -0.0364723 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0364035 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.035988 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | -0.0359426 |
| FOXO1 | forkhead box O1 | -0.0357639 |
| LAMC2 | laminin, gamma 2 | -0.03575 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0356446 |
| MPRIP | myosin phosphatase Rho interacting protein | -0.0356411 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.035498 |
| FOSL1 | FOS-like antigen 1 | -0.0354615 |
| WWC1 | WW and C2 domain containing 1 | -0.0353802 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0352406 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0345063 |
| IPO7 | importin 7 | -0.0344958 |
| CDCP1 | CUB domain containing protein 1 | -0.0342626 |
| NOS1AP | nitric oxide synthase 1 (neuronal) adaptor protein | -0.0342477 |
| ACTG1 | actin gamma 1 | -0.0341756 |
| BCL2L1 | BCL2-like 1 | -0.0337656 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0337515 |
| SEPTIN9 | septin 9 | -0.0335337 |
| ERBIN | erbb2 interacting protein | -0.0333021 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0330589 |
| FGD6 | FYVE, RhoGEF and PH domain containing 6 | -0.0329491 |
| AP3S1 | adaptor-related protein complex 3, sigma 1 subunit | -0.0327653 |
| RIOK3 | RIO kinase 3 | -0.0325124 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -0.032459 |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 | -0.0319733 |
| MYO1E | myosin IE | -0.0317475 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | -0.0316358 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0311777 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0308164 |
| MCL1 | myeloid cell leukemia 1 | -0.0307285 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0306591 |
| FGD4 | FYVE, RhoGEF and PH domain containing 4 | -0.0305542 |
| SERTAD2 | SERTA domain containing 2 | -0.0304053 |
| CDH17 | cadherin 17, LI cadherin (liver-intestine) | -0.0303057 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0301498 |
| RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) | -0.0299901 |
