Almonertinib (hydrochloride)_BT-474 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Almonertinib (hydrochloride) perturbation in BT-474 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Almonertinib (hydrochloride)_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPL23 ribosomal protein L23 0.0967367
PTMA prothymosin, alpha 0.0879022
RPL35A ribosomal protein L35a 0.0687672
RPS3 ribosomal protein S3 0.0652305
NDRG1 N-myc downstream regulated 1 0.0552709
FTH1 ferritin, heavy polypeptide 1 0.0487033
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0483977
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0431159
RPL9 ribosomal protein L9 0.0420349
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0397712
RPS12 ribosomal protein S12 0.039722
FTL ferritin, light polypeptide 0.0397143
TPT1 tumor protein, translationally-controlled 1 0.039712
RPL37A ribosomal protein L37a 0.0382607
RPL31 ribosomal protein L31 0.0376926
RPS8 ribosomal protein S8 0.0373584
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0357265
RPL12 ribosomal protein L12 0.0336715
RPS19 ribosomal protein S19 0.0325142
RPS13 ribosomal protein S13 0.0306046
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0298244
RPL26 ribosomal protein L26 0.0293638
RPS2 ribosomal protein S2 0.0292163
RPL27A ribosomal protein L27a 0.0287033
MCL1 myeloid cell leukemia 1 0.0286331
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0277833
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0267566
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0266885
EGR1 early growth response 1 0.0265485
MT2A metallothionein 2A 0.026167
RPL11 ribosomal protein L11 0.0252351
HILPDA hypoxia inducible lipid droplet-associated 0.0249584
RPLP1 ribosomal protein, large, P1 0.0248687
IFI6 interferon, alpha-inducible protein 6 0.0247205
RPS17 ribosomal protein S17 0.0246861
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0246371
AKAP12 A kinase (PRKA) anchor protein 12 0.024418
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0238414
TMSB10 thymosin beta 10 0.0233771
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0229682
ENO2 enolase 2 (gamma, neuronal) 0.0225579
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0218921
VIM vimentin 0.0210495
EIF1 eukaryotic translation initiation factor 1 0.0207287
RPLP0 ribosomal protein, large, P0 0.0202827
RPL30 ribosomal protein L30 0.020261
RPL37 ribosomal protein L37 0.020212
RPL34 ribosomal protein L34 0.0198108
B2M beta-2-microglobulin 0.0195157
PPME1 protein phosphatase methylesterase 1 0.019437
RPS6 ribosomal protein S6 0.0193062
WSB1 WD repeat and SOCS box containing 1 0.0191428
RPS24 ribosomal protein S24 0.0190497
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0188285
RPL36 ribosomal protein L36 0.0187326
CENPF centromere protein F, 350/400kDa 0.0186706
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) 0.0186131
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0182343
RPL13A ribosomal protein L13a 0.0181788
RPL5 ribosomal protein L5 0.0180957
RBM25 RNA binding motif protein 25 0.0180149
RPS29 ribosomal protein S29 0.0179668
RPLP2 ribosomal protein, large, P2 0.0179225
LDHA lactate dehydrogenase A 0.0178096
COX6C cytochrome c oxidase subunit VIc 0.0175617
INTS6 integrator complex subunit 6 0.0170913
NDUFA4 NDUFA4, mitochondrial complex associated 0.0170787
ENO1 enolase 1, (alpha) 0.0170205
RPS27A ribosomal protein S27a 0.0165145
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.016478
RPL7A ribosomal protein L7a 0.0163777
CCNL1 cyclin L1 0.0163517
AURKA aurora kinase A 0.016287
PRR11 proline rich 11 0.0157945
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0156125
RPS25 ribosomal protein S25 0.0154393
MKNK2 MAP kinase interacting serine/threonine kinase 2 0.0152418
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0151507
RPL36A ribosomal protein L36a 0.0150925
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0148529
TUBA1C tubulin, alpha 1c 0.0147874
ATF4 activating transcription factor 4 0.0146636
TUBA1B tubulin, alpha 1b 0.0146251
MIEN1 migration and invasion enhancer 1 0.0145833
PABPN1 poly(A) binding protein, nuclear 1 0.014491
VCL vinculin 0.0141654
CUL3 cullin 3 0.0140164
RPS16 ribosomal protein S16 0.0138688
RPL36AL ribosomal protein L36a-like 0.0138093
RPL15 ribosomal protein L15 0.0137841
NAP1L1 nucleosome assembly protein 1-like 1 0.0137736
FAM162A family with sequence similarity 162, member A 0.013708
KMT2E lysine (K)-specific methyltransferase 2E 0.013699
NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa 0.0136888
RPS4X ribosomal protein S4, X-linked 0.0136878
GCC2 GRIP and coiled-coil domain containing 2 0.0136702
RPS27 ribosomal protein S27 0.0134823
RSRC2 arginine/serine-rich coiled-coil 2 0.0134536
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0131303
IGF2 insulin-like growth factor 2 0.0128992

decreased expression

Symbol Name Standardized Value
ZMYND8 zinc finger, MYND-type containing 8 -0.289351
ACACA acetyl-CoA carboxylase alpha -0.11937
CDK12 cyclin-dependent kinase 12 -0.117862
THSD4 thrombospondin, type I, domain containing 4 -0.10639
CATSPERB catsper channel auxiliary subunit beta -0.104837
TRPS1 trichorhinophalangeal syndrome I -0.103496
ERBB2 erb-b2 receptor tyrosine kinase 2 -0.0811244
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 -0.0771084
LASP1 LIM and SH3 protein 1 -0.0687409
LPP LIM domain containing preferred translocation partner in lipoma -0.0642206
ASPH aspartate beta-hydroxylase -0.0638883
PBX1 pre-B-cell leukemia homeobox 1 -0.0633258
PTPRK protein tyrosine phosphatase, receptor type, K -0.0610492
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0610286
TENM2 teneurin transmembrane protein 2 -0.0602911
CCND1 cyclin D1 -0.0570673
VMP1 vacuole membrane protein 1 -0.0562721
ITCH itchy E3 ubiquitin protein ligase -0.0561271
TRIO trio Rho guanine nucleotide exchange factor -0.0548973
AHNAK AHNAK nucleoprotein -0.0534159
PRRC2B proline-rich coiled-coil 2B -0.0531409
DNAH14 dynein, axonemal, heavy chain 14 -0.0525919
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0525879
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0525042
CEP250 centrosomal protein 250kDa -0.0522162
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.0510029
KIAA1217 KIAA1217 -0.0496185
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0485182
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.048119
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0477017
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0475885
CLTC clathrin, heavy chain (Hc) -0.0470607
ZFAND3 zinc finger, AN1-type domain 3 -0.0457452
PTK2 protein tyrosine kinase 2 -0.0455058
EHMT1 euchromatic histone-lysine N-methyltransferase 1 -0.0441666
PAWR PRKC, apoptosis, WT1, regulator -0.0428496
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0422908
TC2N tandem C2 domains, nuclear -0.0419846
DENND1A DENN/MADD domain containing 1A -0.0411554
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0411196
SMYD3 SET and MYND domain containing 3 -0.0409653
GSK3B glycogen synthase kinase 3 beta -0.0407329
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0400171
JMJD1C jumonji domain containing 1C -0.0396317
LIMCH1 LIM and calponin homology domains 1 -0.0395269
CEMIP cell migration inducing protein, hyaluronan binding -0.0394149
GMDS GDP-mannose 4,6-dehydratase -0.0391337
RIMS2 regulating synaptic membrane exocytosis 2 -0.0387365
PATJ PATJ crumbs cell polarity complex component -0.0378781
FBXL20 F-box and leucine-rich repeat protein 20 -0.0375721
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0373195
IL1RAPL2 interleukin 1 receptor accessory protein-like 2 -0.0368087
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0365919
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0363326
ZC3H11A zinc finger CCCH-type containing 11A -0.0361351
EXOC4 exocyst complex component 4 -0.0357653
DSPP dentin sialophosphoprotein -0.035666
BCAS3 breast carcinoma amplified sequence 3 -0.0356143
SAMD12 sterile alpha motif domain containing 12 -0.0355309
MSI2 musashi RNA-binding protein 2 -0.0351617
NFIA nuclear factor I/A -0.0344721
ARID5B AT rich interactive domain 5B (MRF1-like) -0.0341954
MLLT6 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 -0.0341407
TMEM123 transmembrane protein 123 -0.0338031
LGALS12 lectin, galactoside-binding, soluble, 12 -0.0337801
CUX1 cut-like homeobox 1 -0.0337694
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0336868
NF1 neurofibromin 1 -0.033469
CD164 CD164 molecule, sialomucin -0.0334667
APP amyloid beta (A4) precursor protein -0.0333765
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0331546
STAU1 staufen double-stranded RNA binding protein 1 -0.0329973
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0329439
NRIP1 nuclear receptor interacting protein 1 -0.0328788
TMSB4X thymosin beta 4, X-linked -0.032596
FOXP1 forkhead box P1 -0.0322354
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0320294
DTNA dystrobrevin, alpha -0.0317012
NCOA6 nuclear receptor coactivator 6 -0.0314757
TOM1L1 target of myb1 (chicken)-like 1 -0.0313306
ZNF217 zinc finger protein 217 -0.0307405
IGFBP5 insulin-like growth factor binding protein 5 -0.0305485
PRKCA protein kinase C, alpha -0.0303068
MBD4 methyl-CpG binding domain protein 4 -0.0303031
TMC5 transmembrane channel-like 5 -0.0301648
DUSP16 dual specificity phosphatase 16 -0.0300508
ACSS2 acyl-CoA synthetase short-chain family member 2 -0.0294174
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0294057
BCAS1 breast carcinoma amplified sequence 1 -0.0293837
EFNA5 ephrin-A5 -0.0289374
ARHGAP32 Rho GTPase activating protein 32 -0.0289127
MIPOL1 mirror-image polydactyly 1 -0.0287858
ANKRD36C ankyrin repeat domain 36C -0.0287569
UBE2H ubiquitin-conjugating enzyme E2H -0.0287349
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0283824
PRLR prolactin receptor -0.0283083
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0283028
TRAPPC9 trafficking protein particle complex 9 -0.028189
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0280042
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0278927