| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Almonertinib (hydrochloride) perturbation in C-33 A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Almonertinib (hydrochloride)_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.16243 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.137158 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | 0.0999407 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.093136 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | 0.0835024 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0757764 |
| SOX5 | SRY (sex determining region Y)-box 5 | 0.0745591 |
| RPS12 | ribosomal protein S12 | 0.0662278 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0598193 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.0581063 |
| CENPF | centromere protein F, 350/400kDa | 0.0561968 |
| CDH18 | cadherin 18, type 2 | 0.0515627 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0499833 |
| COL5A2 | collagen, type V, alpha 2 | 0.0489112 |
| POTEF | POTE ankyrin domain family, member F | 0.0422615 |
| ENO1 | enolase 1, (alpha) | 0.0402975 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0393547 |
| LDHA | lactate dehydrogenase A | 0.0382802 |
| ARHGAP32 | Rho GTPase activating protein 32 | 0.0381424 |
| RACK1 | receptor for activated C kinase 1 | 0.0364867 |
| VIM | vimentin | 0.0361599 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | 0.0361578 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.035939 |
| RPS2 | ribosomal protein S2 | 0.0357911 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0354883 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0354463 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.0339078 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0336452 |
| NRG1 | neuregulin 1 | 0.0330476 |
| SUPT16H | suppressor of Ty 16 homolog (S. cerevisiae) | 0.0327748 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0305535 |
| NEBL | nebulette | 0.0305083 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0304375 |
| SET | SET nuclear proto-oncogene | 0.0297952 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0296711 |
| RAD51B | RAD51 paralog B | 0.0295995 |
| PCBP2 | poly(rC) binding protein 2 | 0.0293734 |
| RCC1 | regulator of chromosome condensation 1 | 0.0292217 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0289683 |
| RPS17 | ribosomal protein S17 | 0.0285196 |
| TOX | thymocyte selection-associated high mobility group box | 0.0283832 |
| TENM3 | teneurin transmembrane protein 3 | 0.026417 |
| RPS8 | ribosomal protein S8 | 0.0263646 |
| SIK3 | SIK family kinase 3 | 0.0261993 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | 0.0261534 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0261509 |
| HMGA1 | high mobility group AT-hook 1 | 0.0254572 |
| RPS21 | ribosomal protein S21 | 0.0252669 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | 0.0250162 |
| RPS3 | ribosomal protein S3 | 0.0247937 |
| CALR | calreticulin | 0.0243873 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0243484 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0242778 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0242188 |
| R3HDM2 | R3H domain containing 2 | 0.0240791 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 0.0237612 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0234673 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0234611 |
| PA2G4 | proliferation-associated 2G4, 38kDa | 0.0233223 |
| CELF2 | CUGBP, Elav-like family member 2 | 0.0229687 |
| RPLP0 | ribosomal protein, large, P0 | 0.0227785 |
| TMSB10 | thymosin beta 10 | 0.0226106 |
| PTMA | prothymosin, alpha | 0.0224328 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0224205 |
| RANBP17 | RAN binding protein 17 | 0.0224092 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.022325 |
| ZRANB3 | zinc finger, RAN-binding domain containing 3 | 0.0219348 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0218381 |
| RRM2 | ribonucleotide reductase M2 | 0.0217553 |
| SLK | STE20-like kinase | 0.0214554 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0213759 |
| GOLGB1 | golgin B1 | 0.0212427 |
| FN1 | fibronectin 1 | 0.0212306 |
| RFC3 | replication factor C (activator 1) 3, 38kDa | 0.0211412 |
| MKI67 | marker of proliferation Ki-67 | 0.0211175 |
| CSNK1G1 | casein kinase 1, gamma 1 | 0.0209571 |
| ZNF146 | zinc finger protein 146 | 0.0208895 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0208184 |
| FMNL2 | formin-like 2 | 0.0206777 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0206323 |
| SMC3 | structural maintenance of chromosomes 3 | 0.0204878 |
| BPTF | bromodomain PHD finger transcription factor | 0.0203216 |
| PRICKLE1 | prickle homolog 1 (Drosophila) | 0.020281 |
| CBX5 | chromobox homolog 5 | 0.020179 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0201321 |
| ATF4 | activating transcription factor 4 | 0.0200365 |
| SMC1A | structural maintenance of chromosomes 1A | 0.0200161 |
| RPL35A | ribosomal protein L35a | 0.0200014 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.0199753 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0199471 |
| PPIG | peptidylprolyl isomerase G (cyclophilin G) | 0.0197557 |
| APOLD1 | apolipoprotein L domain containing 1 | 0.0197342 |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | 0.0194889 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | 0.0194583 |
| RPS13 | ribosomal protein S13 | 0.0194577 |
| ASPH | aspartate beta-hydroxylase | 0.0193722 |
| RPS10 | ribosomal protein S10 | 0.0192186 |
| UBE3A | ubiquitin protein ligase E3A | 0.0189811 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0189765 |
| ZNF609 | zinc finger protein 609 | 0.0189481 |
| Symbol | Name | Standardized Value |
|---|---|---|
| KDM3A | lysine (K)-specific demethylase 3A | -0.073959 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | -0.0543018 |
| JMJD1C | jumonji domain containing 1C | -0.0487049 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0457825 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | -0.0447104 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0418958 |
| MAP3K14 | mitogen-activated protein kinase kinase kinase 14 | -0.041292 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0409181 |
| TPD52 | tumor protein D52 | -0.0375358 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | -0.0366405 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0353911 |
| WDR45B | WD repeat domain 45B | -0.0338226 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | -0.0335762 |
| EGR1 | early growth response 1 | -0.033212 |
| CABIN1 | calcineurin binding protein 1 | -0.0319973 |
| ZNF638 | zinc finger protein 638 | -0.0318069 |
| NFIA | nuclear factor I/A | -0.0316305 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.031444 |
| TET2 | tet methylcytosine dioxygenase 2 | -0.0314303 |
| FAM162A | family with sequence similarity 162, member A | -0.0313984 |
| RPL13A | ribosomal protein L13a | -0.031357 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0305597 |
| QKI | QKI, KH domain containing, RNA binding | -0.0299532 |
| SEPTIN7 | septin 7 | -0.0296525 |
| H1-0 | H1.0 linker histone | -0.0294197 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0292748 |
| EFNA5 | ephrin-A5 | -0.0289767 |
| OGA | O-GlcNAcase | -0.0289688 |
| GRID2 | glutamate receptor, ionotropic, delta 2 | -0.0287463 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0285808 |
| CCDC47 | coiled-coil domain containing 47 | -0.0283233 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0281092 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0280772 |
| FOXO3 | forkhead box O3 | -0.0280231 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0277684 |
| RNMT | RNA (guanine-7-) methyltransferase | -0.0277047 |
| ARL15 | ADP-ribosylation factor-like 15 | -0.0276887 |
| RRBP1 | ribosome binding protein 1 | -0.027511 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0275018 |
| KIAA1958 | KIAA1958 | -0.0274554 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0274037 |
| MIMS1 | mitochondrial inner membrane scaffold 1 | -0.0272638 |
| RPS24 | ribosomal protein S24 | -0.0268124 |
| ARFGEF3 | ARFGEF family member 3 | -0.0267044 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0266331 |
| CEP95 | centrosomal protein 95kDa | -0.0255123 |
| SMYD3 | SET and MYND domain containing 3 | -0.0253981 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | -0.02537 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0253423 |
| MAPK8 | mitogen-activated protein kinase 8 | -0.0251173 |
| TMEM41B | transmembrane protein 41B | -0.0251065 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0249701 |
| NGLY1 | N-glycanase 1 | -0.0248665 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0241215 |
| SHROOM3 | shroom family member 3 | -0.0241092 |
| FUS | FUS RNA binding protein | -0.0238544 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0236985 |
| NUP58 | nucleoporin 58 | -0.0236449 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0231283 |
| HELZ | helicase with zinc finger | -0.0228212 |
| MED14 | mediator complex subunit 14 | -0.0228064 |
| MIPOL1 | mirror-image polydactyly 1 | -0.022633 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.0222853 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0222628 |
| RBM33 | RNA binding motif protein 33 | -0.0221951 |
| CDC73 | cell division cycle 73 | -0.0218951 |
| PEG10 | paternally expressed 10 | -0.0218923 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0218465 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0218373 |
| RYBP | RING1 and YY1 binding protein | -0.0217296 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0215699 |
| USP9X | ubiquitin specific peptidase 9, X-linked | -0.0213584 |
| RNF130 | ring finger protein 130 | -0.0212483 |
| ATRN | attractin | -0.0212042 |
| CHSY1 | chondroitin sulfate synthase 1 | -0.0211338 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0211119 |
| RLF | rearranged L-myc fusion | -0.0210933 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.0209419 |
| KIF13A | kinesin family member 13A | -0.0208797 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0208333 |
| SEMA3D | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D | -0.0206923 |
| PTCH1 | patched 1 | -0.0206845 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0205703 |
| SMAP1 | small ArfGAP 1 | -0.0203715 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0203363 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0202429 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | -0.0202034 |
| RPL32 | ribosomal protein L32 | -0.0202003 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0201274 |
| ABI2 | abl-interactor 2 | -0.0200876 |
| DEK | DEK proto-oncogene | -0.0200634 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0200252 |
| ZNF544 | zinc finger protein 544 | -0.0198817 |
| SMC5 | structural maintenance of chromosomes 5 | -0.019871 |
| ZC3H12B | zinc finger CCCH-type containing 12B | -0.0197484 |
| XPO7 | exportin 7 | -0.0196821 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0196676 |
| FOXJ3 | forkhead box J3 | -0.0194578 |
| DCLK2 | doublecortin-like kinase 2 | -0.0194475 |
| PDGFA | platelet-derived growth factor alpha polypeptide | -0.0194412 |
