| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Almonertinib (hydrochloride) perturbation in C32 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Almonertinib (hydrochloride)_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.143316 |
| NDRG1 | N-myc downstream regulated 1 | 0.141228 |
| VIM | vimentin | 0.139011 |
| MT2A | metallothionein 2A | 0.126943 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.108865 |
| TMSB10 | thymosin beta 10 | 0.0994758 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0990771 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0913536 |
| CENPF | centromere protein F, 350/400kDa | 0.0848636 |
| VGF | VGF nerve growth factor inducible | 0.0841605 |
| NLGN1 | neuroligin 1 | 0.0823238 |
| PTMA | prothymosin, alpha | 0.0771438 |
| ASPH | aspartate beta-hydroxylase | 0.0748622 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0739834 |
| HLA-B | major histocompatibility complex, class I, B | 0.0726661 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0717863 |
| S100A6 | S100 calcium binding protein A6 | 0.0684619 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0668987 |
| TAGLN2 | transgelin 2 | 0.0601864 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0583926 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0558067 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0555358 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0542043 |
| B2M | beta-2-microglobulin | 0.0533826 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0531745 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0525912 |
| FTL | ferritin, light polypeptide | 0.0521903 |
| ENO1 | enolase 1, (alpha) | 0.0511463 |
| RPL37A | ribosomal protein L37a | 0.050446 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0489523 |
| PTK2 | protein tyrosine kinase 2 | 0.0488711 |
| CALR | calreticulin | 0.0473223 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0467106 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0459677 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0452174 |
| RPS19 | ribosomal protein S19 | 0.0447342 |
| LMNA | lamin A/C | 0.044037 |
| RPS12 | ribosomal protein S12 | 0.0438972 |
| RPL35A | ribosomal protein L35a | 0.0435499 |
| MT1X | metallothionein 1X | 0.0434974 |
| FYN | FYN proto-oncogene, Src family tyrosine kinase | 0.0427678 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0424719 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0401191 |
| RPS8 | ribosomal protein S8 | 0.0388038 |
| FMNL2 | formin-like 2 | 0.0386711 |
| ADM | adrenomedullin | 0.0381577 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0374011 |
| HLA-A | major histocompatibility complex, class I, A | 0.0368938 |
| TAC4 | tachykinin 4 (hemokinin) | 0.0364076 |
| GPC6 | glypican 6 | 0.0360747 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0354272 |
| ZNF292 | zinc finger protein 292 | 0.0348557 |
| POTEF | POTE ankyrin domain family, member F | 0.0343134 |
| TPR | translocated promoter region, nuclear basket protein | 0.0336698 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0335963 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa | 0.0332909 |
| PCDH7 | protocadherin 7 | 0.0331635 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0331279 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.0331247 |
| GOLGA4 | golgin A4 | 0.0330831 |
| LDHA | lactate dehydrogenase A | 0.0328772 |
| PKM | pyruvate kinase, muscle | 0.0326734 |
| CABIN1 | calcineurin binding protein 1 | 0.0324466 |
| PFN1 | profilin 1 | 0.0322033 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0319095 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | 0.0317131 |
| MEF2A | myocyte enhancer factor 2A | 0.0314983 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0309819 |
| ATXN1 | ataxin 1 | 0.0307271 |
| PTMS | parathymosin | 0.0305522 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0303507 |
| S100A9 | S100 calcium binding protein A9 | 0.0303398 |
| RPL34 | ribosomal protein L34 | 0.0302359 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0298344 |
| RPLP2 | ribosomal protein, large, P2 | 0.0297594 |
| ARPC1B | actin related protein 2/3 complex, subunit 1B, 41kDa | 0.0294795 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.029274 |
| TBC1D22A | TBC1 domain family, member 22A | 0.028867 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | 0.0287784 |
| KIRREL1 | kirre like nephrin family adhesion molecule 1 | 0.02867 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0284437 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0280562 |
| RPS3 | ribosomal protein S3 | 0.027893 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0277145 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.027684 |
| PGK1 | phosphoglycerate kinase 1 | 0.0271429 |
| ZNF638 | zinc finger protein 638 | 0.0270683 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0268748 |
| RPS6 | ribosomal protein S6 | 0.0268555 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.026838 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.0267436 |
| RPL23 | ribosomal protein L23 | 0.0263927 |
| CD63 | CD63 molecule | 0.0262268 |
| COPA | coatomer protein complex, subunit alpha | 0.0261901 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | 0.0261626 |
| RPLP1 | ribosomal protein, large, P1 | 0.026087 |
| RPL26 | ribosomal protein L26 | 0.0260212 |
| CD109 | CD109 molecule | 0.0258942 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | 0.0257391 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0257349 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.351691 |
| FMN1 | formin 1 | -0.0568322 |
| COL19A1 | collagen, type XIX, alpha 1 | -0.0494997 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0465672 |
| HMCN1 | hemicentin 1 | -0.0430659 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0372449 |
| TNNC1 | troponin C type 1 (slow) | -0.0338297 |
| AHNAK | AHNAK nucleoprotein | -0.0337366 |
| PDE10A | phosphodiesterase 10A | -0.032826 |
| A2M | alpha-2-macroglobulin | -0.0324545 |
| EHBP1 | EH domain binding protein 1 | -0.0322839 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | -0.0302402 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0295827 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0295128 |
| NAV3 | neuron navigator 3 | -0.0292187 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0291023 |
| PI15 | peptidase inhibitor 15 | -0.0271351 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | -0.0265489 |
| TNFRSF19 | tumor necrosis factor receptor superfamily, member 19 | -0.0255689 |
| NPC1 | Niemann-Pick disease, type C1 | -0.024732 |
| CPEB2 | cytoplasmic polyadenylation element binding protein 2 | -0.0247233 |
| MITF | microphthalmia-associated transcription factor | -0.0237616 |
| ANKRD28 | ankyrin repeat domain 28 | -0.022391 |
| FRMD4A | FERM domain containing 4A | -0.0217312 |
| UHMK1 | U2AF homology motif (UHM) kinase 1 | -0.0213954 |
| AHR | aryl hydrocarbon receptor | -0.0213327 |
| PRKD1 | protein kinase D1 | -0.0205926 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0203378 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0199 |
| C10ORF90 | chromosome 10 open reading frame 90 | -0.0198979 |
| FRMD5 | FERM domain containing 5 | -0.0196177 |
| RUNX1 | runt-related transcription factor 1 | -0.0192642 |
| ITGB8 | integrin, beta 8 | -0.0183951 |
| AOPEP | aminopeptidase O (putative) | -0.0182497 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0181055 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0178888 |
| ZSWIM5 | zinc finger, SWIM-type containing 5 | -0.0178389 |
| SOX6 | SRY (sex determining region Y)-box 6 | -0.0176244 |
| JAZF1 | JAZF zinc finger 1 | -0.0175353 |
| INPP5F | inositol polyphosphate-5-phosphatase F | -0.0173104 |
| OSMR | oncostatin M receptor | -0.0167126 |
| AHCYL2 | adenosylhomocysteinase-like 2 | -0.0165358 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0164517 |
| PARD3B | par-3 family cell polarity regulator beta | -0.0163159 |
| EXOC6B | exocyst complex component 6B | -0.0162807 |
| MACROD2 | MACRO domain containing 2 | -0.0160579 |
| CDH19 | cadherin 19, type 2 | -0.0159888 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | -0.0158623 |
| AKAP6 | A kinase (PRKA) anchor protein 6 | -0.0158251 |
| ST6GALNAC3 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 | -0.0156462 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0155181 |
| DSTYK | dual serine/threonine and tyrosine protein kinase | -0.0155022 |
| PRRC2B | proline-rich coiled-coil 2B | -0.0153221 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0152044 |
| ST3GAL6 | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 | -0.0151926 |
| HBP1 | HMG-box transcription factor 1 | -0.014556 |
| RBM33 | RNA binding motif protein 33 | -0.0144071 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0143433 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0142948 |
| CAPRIN1 | cell cycle associated protein 1 | -0.0142542 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.014225 |
| VMP1 | vacuole membrane protein 1 | -0.014003 |
| RHOJ | ras homolog family member J | -0.0139914 |
| RPL4 | ribosomal protein L4 | -0.0137682 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | -0.0137577 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0136854 |
| DST | dystonin | -0.0136241 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0135589 |
| CNOT4 | CCR4-NOT transcription complex, subunit 4 | -0.0132581 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0129866 |
| LYST | lysosomal trafficking regulator | -0.0129645 |
| VCL | vinculin | -0.0126109 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0125765 |
| SLC25A13 | solute carrier family 25 (aspartate/glutamate carrier), member 13 | -0.0125637 |
| IL6ST | interleukin 6 signal transducer | -0.012529 |
| NF1 | neurofibromin 1 | -0.0125248 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0124364 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | -0.0123975 |
| TMEM168 | transmembrane protein 168 | -0.0123119 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0121941 |
| HIPK2 | homeodomain interacting protein kinase 2 | -0.012162 |
| DMD | dystrophin | -0.0121567 |
| ZNF654 | zinc finger protein 654 | -0.0121059 |
| ARHGAP24 | Rho GTPase activating protein 24 | -0.0120977 |
| ZNF655 | zinc finger protein 655 | -0.0120245 |
| OPHN1 | oligophrenin 1 | -0.0120244 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | -0.0119599 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | -0.0119427 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0119075 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | -0.0119013 |
| TNRC6B | trinucleotide repeat containing 6B | -0.0117818 |
| MYSM1 | Myb-like, SWIRM and MPN domains 1 | -0.0117441 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.011636 |
| ETV6 | ets variant 6 | -0.0115508 |
| ZC3H11A | zinc finger CCCH-type containing 11A | -0.0114987 |
| FNIP1 | folliculin interacting protein 1 | -0.0114779 |
| TCF12 | transcription factor 12 | -0.0114584 |
| TRIM9 | tripartite motif containing 9 | -0.011411 |
| GNS | glucosamine (N-acetyl)-6-sulfatase | -0.0113977 |
| CEP350 | centrosomal protein 350kDa | -0.0113943 |
