| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Almonertinib (hydrochloride) perturbation in CHP-212 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Almonertinib (hydrochloride)_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0773386 |
| RPL35A | ribosomal protein L35a | 0.0716558 |
| ASPH | aspartate beta-hydroxylase | 0.0663043 |
| RPS12 | ribosomal protein S12 | 0.0611439 |
| NDRG1 | N-myc downstream regulated 1 | 0.0593125 |
| IGF2 | insulin-like growth factor 2 | 0.0586655 |
| VCL | vinculin | 0.054656 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0524994 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0507423 |
| RPL37A | ribosomal protein L37a | 0.0506421 |
| MEF2A | myocyte enhancer factor 2A | 0.046826 |
| SLITRK6 | SLIT and NTRK-like family, member 6 | 0.0467224 |
| VEGFA | vascular endothelial growth factor A | 0.0455025 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0450773 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0447454 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0440768 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0424413 |
| RPL23 | ribosomal protein L23 | 0.0408105 |
| CENPF | centromere protein F, 350/400kDa | 0.0404474 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0395683 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0389373 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0385121 |
| RPS6 | ribosomal protein S6 | 0.0378865 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0375599 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0370067 |
| RPS3 | ribosomal protein S3 | 0.0366265 |
| ZNF148 | zinc finger protein 148 | 0.0361779 |
| B2M | beta-2-microglobulin | 0.0360975 |
| FAM13A | family with sequence similarity 13, member A | 0.0359352 |
| MT2A | metallothionein 2A | 0.0352962 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | 0.0351137 |
| CRH | corticotropin releasing hormone | 0.034084 |
| CXXC5 | CXXC finger protein 5 | 0.0339678 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0338587 |
| RPLP1 | ribosomal protein, large, P1 | 0.0337586 |
| RPL9 | ribosomal protein L9 | 0.0332923 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0326569 |
| HLA-A | major histocompatibility complex, class I, A | 0.0322302 |
| ATXN1 | ataxin 1 | 0.0320406 |
| MCL1 | myeloid cell leukemia 1 | 0.0316951 |
| EGR1 | early growth response 1 | 0.0309893 |
| RPL36 | ribosomal protein L36 | 0.0306607 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0290912 |
| RPS8 | ribosomal protein S8 | 0.0290614 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.0290069 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0289978 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0287118 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0283668 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0283404 |
| RPL27 | ribosomal protein L27 | 0.0278084 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0277082 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.027661 |
| FAM162A | family with sequence similarity 162, member A | 0.0274848 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0271876 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0271336 |
| ST6GALNAC3 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 | 0.0271237 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | 0.0267844 |
| ENO1 | enolase 1, (alpha) | 0.0267765 |
| FN1 | fibronectin 1 | 0.0267705 |
| CCDC88A | coiled-coil domain containing 88A | 0.0266606 |
| RPL7A | ribosomal protein L7a | 0.0263923 |
| RPL37 | ribosomal protein L37 | 0.0262825 |
| SMYD3 | SET and MYND domain containing 3 | 0.026247 |
| RPL11 | ribosomal protein L11 | 0.026178 |
| LAMA5 | laminin, alpha 5 | 0.0260676 |
| RPS17 | ribosomal protein S17 | 0.0253742 |
| PCBP2 | poly(rC) binding protein 2 | 0.0250806 |
| ZFP36 | ZFP36 ring finger protein | 0.0249933 |
| RBFOX2 | RNA binding protein, fox-1 homolog (C. elegans) 2 | 0.0249751 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | 0.0245633 |
| POTEF | POTE ankyrin domain family, member F | 0.0245408 |
| DTNA | dystrobrevin, alpha | 0.0243712 |
| RPL21 | ribosomal protein L21 | 0.0243699 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0241179 |
| TOX | thymocyte selection-associated high mobility group box | 0.0240513 |
| RPL34 | ribosomal protein L34 | 0.0238799 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0238534 |
| RPS13 | ribosomal protein S13 | 0.0234404 |
| RPS10 | ribosomal protein S10 | 0.0234318 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0233861 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0233155 |
| FTL | ferritin, light polypeptide | 0.0231577 |
| RPS14 | ribosomal protein S14 | 0.0229012 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.022812 |
| RPLP2 | ribosomal protein, large, P2 | 0.0227067 |
| HLA-B | major histocompatibility complex, class I, B | 0.0226791 |
| PPIG | peptidylprolyl isomerase G (cyclophilin G) | 0.0224853 |
| RPS25 | ribosomal protein S25 | 0.0223085 |
| RPL31 | ribosomal protein L31 | 0.0221605 |
| PCDH10 | protocadherin 10 | 0.0220588 |
| RPL28 | ribosomal protein L28 | 0.0220574 |
| VDAC1 | voltage-dependent anion channel 1 | 0.0220355 |
| RYBP | RING1 and YY1 binding protein | 0.0217734 |
| HMGA2 | high mobility group AT-hook 2 | 0.0217339 |
| SCFD1 | sec1 family domain containing 1 | 0.0216097 |
| RPL12 | ribosomal protein L12 | 0.0215317 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0215124 |
| DARS1 | aspartyl-tRNA synthetase 1 | 0.0214485 |
| PFN1 | profilin 1 | 0.0212866 |
| SPOP | speckle-type POZ protein | 0.0210169 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SYT1 | synaptotagmin I | -0.0820818 |
| SPAG9 | sperm associated antigen 9 | -0.0806936 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0691764 |
| COL3A1 | collagen, type III, alpha 1 | -0.0677999 |
| TPST1 | tyrosylprotein sulfotransferase 1 | -0.0660919 |
| NRG1 | neuregulin 1 | -0.0652786 |
| MEIS2 | Meis homeobox 2 | -0.0646678 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0636377 |
| LPIN1 | lipin 1 | -0.0633559 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.0592429 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0584943 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0579364 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0573382 |
| AHNAK | AHNAK nucleoprotein | -0.0538488 |
| DST | dystonin | -0.0533297 |
| COL1A1 | collagen, type I, alpha 1 | -0.051854 |
| AOPEP | aminopeptidase O (putative) | -0.0509086 |
| NF1 | neurofibromin 1 | -0.046479 |
| LRFN5 | leucine rich repeat and fibronectin type III domain containing 5 | -0.0454515 |
| CLTC | clathrin, heavy chain (Hc) | -0.0421283 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0419379 |
| COL4A5 | collagen, type IV, alpha 5 | -0.041737 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0407462 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0406708 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0385291 |
| HMGB2 | high mobility group box 2 | -0.0381879 |
| KLHL13 | kelch-like family member 13 | -0.0380274 |
| ANTXR1 | anthrax toxin receptor 1 | -0.0379404 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0366125 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0364068 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0362938 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0356944 |
| TANC1 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 | -0.0354609 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0350067 |
| NEK7 | NIMA-related kinase 7 | -0.0346822 |
| MSI2 | musashi RNA-binding protein 2 | -0.0346789 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | -0.0345335 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0343796 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | -0.0342675 |
| FMN1 | formin 1 | -0.0341102 |
| RPTOR | regulatory associated protein of MTOR, complex 1 | -0.033501 |
| PRPF3 | pre-mRNA processing factor 3 | -0.0332527 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0324829 |
| NCAM2 | neural cell adhesion molecule 2 | -0.0323869 |
| PSMD12 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 | -0.032276 |
| MYO6 | myosin VI | -0.0322063 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0320401 |
| RNF213 | ring finger protein 213 | -0.0317801 |
| CEP95 | centrosomal protein 95kDa | -0.0315952 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | -0.0311217 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | -0.030733 |
| MATR3 | matrin 3 | -0.0304225 |
| PCNX1 | pecanex 1 | -0.0303689 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0301087 |
| MAP1B | microtubule-associated protein 1B | -0.0300474 |
| CDC27 | cell division cycle 27 | -0.0294129 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0291606 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0290667 |
| TPR | translocated promoter region, nuclear basket protein | -0.0290076 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0288995 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0288899 |
| AHR | aryl hydrocarbon receptor | -0.0288202 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0284084 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0283876 |
| CCND1 | cyclin D1 | -0.0282963 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | -0.0282021 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0280502 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0279802 |
| HDLBP | high density lipoprotein binding protein | -0.0278702 |
| FRMD4A | FERM domain containing 4A | -0.027748 |
| RIGI | RNA sensor RIG-I | -0.0274876 |
| PDZRN3 | PDZ domain containing ring finger 3 | -0.0274243 |
| FNBP4 | formin binding protein 4 | -0.0273777 |
| RBM20 | RNA binding motif protein 20 | -0.0272788 |
| CADM1 | cell adhesion molecule 1 | -0.0267419 |
| CFDP1 | craniofacial development protein 1 | -0.0265745 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.026545 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | -0.0262959 |
| NUP160 | nucleoporin 160kDa | -0.0262091 |
| ITPRID2 | ITPR interacting domain containing 2 | -0.0260791 |
| OGA | O-GlcNAcase | -0.0258996 |
| H3-3B | H3.3 histone B | -0.0258542 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | -0.0257388 |
| VIM | vimentin | -0.0255803 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | -0.025383 |
| GPR107 | G protein-coupled receptor 107 | -0.0250156 |
| DDX42 | DEAD (Asp-Glu-Ala-Asp) box helicase 42 | -0.0247319 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0246717 |
| ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | -0.0246486 |
| DYNC1LI2 | dynein, cytoplasmic 1, light intermediate chain 2 | -0.024396 |
| IGF2R | insulin-like growth factor 2 receptor | -0.0242388 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | -0.0240206 |
| DNM3 | dynamin 3 | -0.0237756 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0236752 |
| CAMKMT | calmodulin-lysine N-methyltransferase | -0.0236369 |
| HELZ | helicase with zinc finger | -0.0232752 |
| H1-0 | H1.0 linker histone | -0.0232289 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0231972 |
| ABCC1 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | -0.023013 |
| APP | amyloid beta (A4) precursor protein | -0.0230057 |
