Almonertinib (hydrochloride)_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Almonertinib (hydrochloride) perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Almonertinib (hydrochloride)_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AREG amphiregulin 0.106519
B2M beta-2-microglobulin 0.0985118
EGR1 early growth response 1 0.078976
ANXA2 annexin A2 0.0787083
INTS6 integrator complex subunit 6 0.0760306
LCN2 lipocalin 2 0.0725444
C6ORF132 chromosome 6 open reading frame 132 0.0695651
TPT1 tumor protein, translationally-controlled 1 0.0685792
MT2A metallothionein 2A 0.0671356
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0649465
AKAP13 A kinase (PRKA) anchor protein 13 0.0644755
VCL vinculin 0.0631433
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0605243
LMO7 LIM domain 7 0.0604627
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0595403
FTL ferritin, light polypeptide 0.0581609
RPL35A ribosomal protein L35a 0.055062
STS steroid sulfatase (microsomal), isozyme S 0.0538613
MCL1 myeloid cell leukemia 1 0.0516305
ASPH aspartate beta-hydroxylase 0.0501755
IFI6 interferon, alpha-inducible protein 6 0.0501595
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.0480032
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0475481
CLDN4 claudin 4 0.0457171
ZSWIM6 zinc finger, SWIM-type containing 6 0.0453006
TMSB10 thymosin beta 10 0.0438985
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0434117
PLSCR2 phospholipid scramblase 2 0.0409538
VMP1 vacuole membrane protein 1 0.0400502
LPP LIM domain containing preferred translocation partner in lipoma 0.0400381
SMAD3 SMAD family member 3 0.0397549
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0385239
TM4SF19 transmembrane 4 L six family member 19 0.0385195
EFNB2 ephrin-B2 0.0382075
POTEF POTE ankyrin domain family, member F 0.0367629
RPL37A ribosomal protein L37a 0.0363065
ZNF292 zinc finger protein 292 0.0361853
TM4SF1 transmembrane 4 L six family member 1 0.0351562
MACC1 metastasis associated in colon cancer 1 0.0350261
TJP1 tight junction protein 1 0.0349621
PKM pyruvate kinase, muscle 0.0338583
BCL2L1 BCL2-like 1 0.033566
MYO1E myosin IE 0.0334817
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0330693
IGFBP3 insulin-like growth factor binding protein 3 0.0324716
RPS12 ribosomal protein S12 0.032082
RPL23 ribosomal protein L23 0.0316343
RPS3 ribosomal protein S3 0.031202
SEPTIN9 septin 9 0.0306635
AKAP12 A kinase (PRKA) anchor protein 12 0.0296631
RPS8 ribosomal protein S8 0.0296563
ENO1 enolase 1, (alpha) 0.0290766
RPS19 ribosomal protein S19 0.028571
RSAD2 radical S-adenosyl methionine domain containing 2 0.0282828
RPLP0 ribosomal protein, large, P0 0.0279799
ADAM10 ADAM metallopeptidase domain 10 0.027727
RPL9 ribosomal protein L9 0.0275803
S100P S100 calcium binding protein P 0.0274936
VIM vimentin 0.0273713
ACTG1 actin gamma 1 0.0273304
CEMIP cell migration inducing protein, hyaluronan binding 0.0272072
PLAUR plasminogen activator, urokinase receptor 0.0271679
EZR ezrin 0.027083
RAB7A RAB7A, member RAS oncogene family 0.0267764
TSC22D1 TSC22 domain family, member 1 0.0266578
RPS17 ribosomal protein S17 0.0260268
HLA-A major histocompatibility complex, class I, A 0.0259323
TMC5 transmembrane channel-like 5 0.025868
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0258112
NCEH1 neutral cholesterol ester hydrolase 1 0.0257965
POU2F2 POU class 2 homeobox 2 0.0257025
TACSTD2 tumor-associated calcium signal transducer 2 0.0254271
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0253953
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0251895
UGCG UDP-glucose ceramide glucosyltransferase 0.0251032
ZFP36L1 ZFP36 ring finger protein-like 1 0.024994
PGK1 phosphoglycerate kinase 1 0.0246192
RPL18 ribosomal protein L18 0.0245233
DIAPH1 diaphanous-related formin 1 0.0237444
MX2 MX dynamin-like GTPase 2 0.0235478
LIMA1 LIM domain and actin binding 1 0.0234767
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.022888
POMP proteasome maturation protein 0.0228802
FHL2 four and a half LIM domains 2 0.0226082
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0225476
ERBIN erbb2 interacting protein 0.0223216
RPLP1 ribosomal protein, large, P1 0.0221729
RPL31 ribosomal protein L31 0.0221538
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0213786
SLC38A2 solute carrier family 38, member 2 0.0213434
ETV6 ets variant 6 0.0211824
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0208281
RPS27 ribosomal protein S27 0.0208
RNF213 ring finger protein 213 0.0206947
MYH14 myosin, heavy chain 14, non-muscle 0.020423
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0201018
FTH1 ferritin, heavy polypeptide 1 0.0200712
RPLP2 ribosomal protein, large, P2 0.0198516
PADI1 peptidyl arginine deiminase, type I 0.0197863
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.019773

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.146223
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.109279
RUNX1 runt-related transcription factor 1 -0.0805528
MBNL2 muscleblind-like splicing regulator 2 -0.0790845
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0675571
BTBD9 BTB (POZ) domain containing 9 -0.0622409
PDIA3 protein disulfide isomerase family A, member 3 -0.0602966
EPSTI1 epithelial stromal interaction 1 (breast) -0.058849
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0587662
RRBP1 ribosome binding protein 1 -0.057943
FNDC3A fibronectin type III domain containing 3A -0.0578879
H1-0 H1.0 linker histone -0.0565417
ZMYND8 zinc finger, MYND-type containing 8 -0.0553628
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0506779
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0495987
CANX calnexin -0.0495833
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0495691
RNF43 ring finger protein 43 -0.0486487
RHOBTB3 Rho-related BTB domain containing 3 -0.047695
PHF3 PHD finger protein 3 -0.0472719
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0423639
AHI1 Abelson helper integration site 1 -0.0416561
GOLGB1 golgin B1 -0.040282
SPATA13 spermatogenesis associated 13 -0.0398989
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0384507
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0377741
HDLBP high density lipoprotein binding protein -0.0374003
ARHGAP26 Rho GTPase activating protein 26 -0.0372786
UBAC2 UBA domain containing 2 -0.0355443
SQSTM1 sequestosome 1 -0.0345583
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.0344674
EHF ets homologous factor -0.0339965
TRIM2 tripartite motif containing 2 -0.0338769
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0337474
XAF1 XIAP associated factor 1 -0.0337296
SREBF2 sterol regulatory element binding transcription factor 2 -0.0332713
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0330452
AHNAK AHNAK nucleoprotein -0.032904
EPHB2 EPH receptor B2 -0.0328583
RABGAP1L RAB GTPase activating protein 1-like -0.0325572
UBR2 ubiquitin protein ligase E3 component n-recognin 2 -0.0312772
RBM39 RNA binding motif protein 39 -0.0305134
SEC24D SEC24 family member D -0.0303323
PATJ PATJ crumbs cell polarity complex component -0.0301384
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0299511
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0299415
NCOR1 nuclear receptor corepressor 1 -0.0289709
AOPEP aminopeptidase O (putative) -0.028015
MCTP2 multiple C2 domains, transmembrane 2 -0.0278546
TTC3 tetratricopeptide repeat domain 3 -0.0275905
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0274979
MECOM MDS1 and EVI1 complex locus -0.0273989
ZBTB20 zinc finger and BTB domain containing 20 -0.0273722
ZNRF3 zinc and ring finger 3 -0.0272431
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.025889
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 -0.0254046
CD2AP CD2-associated protein -0.0250301
SEC31A SEC31 homolog A (S. cerevisiae) -0.0248826
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha -0.024813
ABLIM1 actin binding LIM protein 1 -0.0247678
AGR2 anterior gradient 2 -0.0247055
CALR calreticulin -0.0246298
HDAC4 histone deacetylase 4 -0.0243323
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0241402
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0240343
GCLC glutamate-cysteine ligase, catalytic subunit -0.0240152
NKD1 naked cuticle homolog 1 (Drosophila) -0.0235043
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0234643
APP amyloid beta (A4) precursor protein -0.0233188
PIBF1 progesterone immunomodulatory binding factor 1 -0.0232973
UBL3 ubiquitin-like 3 -0.0226977
ADD3 adducin 3 (gamma) -0.0225441
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) -0.0224708
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0224142
ZMYM2 zinc finger, MYM-type 2 -0.021961
KIAA1217 KIAA1217 -0.0218194
BRCA2 breast cancer 2, early onset -0.0217714
GRAMD2B GRAM domain containing 2B -0.0216894
ETNK1 ethanolamine kinase 1 -0.0216512
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0214588
PCCA propionyl CoA carboxylase, alpha polypeptide -0.021439
XRN1 5'-3' exoribonuclease 1 -0.0213872
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0213609
PRELID2 PRELI domain containing 2 -0.0212697
LMAN1 lectin, mannose-binding, 1 -0.0212639
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0212002
LCORL ligand dependent nuclear receptor corepressor-like -0.0211105
MEIS2 Meis homeobox 2 -0.0210371
DIAPH3 diaphanous-related formin 3 -0.0207782
DSPP dentin sialophosphoprotein -0.0207564
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -0.0206997
NCOA7 nuclear receptor coactivator 7 -0.0204383
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 -0.0203174
SUCO SUN domain containing ossification factor -0.0201679
CHD9 chromodomain helicase DNA binding protein 9 -0.0201516
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0199975
EPB41 erythrocyte membrane protein band 4.1 -0.019914
USP3 ubiquitin specific peptidase 3 -0.0196775
ESRP1 epithelial splicing regulatory protein 1 -0.0196455
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.019571