| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Almonertinib (hydrochloride) perturbation in H4 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Almonertinib (hydrochloride)_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.189437 |
| MT2A | metallothionein 2A | 0.152751 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0787102 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0717601 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0685564 |
| MYO10 | myosin X | 0.0659595 |
| STC1 | stanniocalcin 1 | 0.0590179 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0580528 |
| EGFR | epidermal growth factor receptor | 0.0567246 |
| SMAD3 | SMAD family member 3 | 0.0564622 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0537671 |
| NDRG1 | N-myc downstream regulated 1 | 0.053759 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0517632 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0480015 |
| INHBA | inhibin, beta A | 0.0477343 |
| TPM3 | tropomyosin 3 | 0.0425351 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0422311 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0415392 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0413449 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0402155 |
| RPL35A | ribosomal protein L35a | 0.0386335 |
| RPS8 | ribosomal protein S8 | 0.0383535 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0382611 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.037891 |
| RPL37A | ribosomal protein L37a | 0.0373816 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.0373215 |
| CD44 | CD44 molecule (Indian blood group) | 0.037143 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0370335 |
| ANTXR2 | anthrax toxin receptor 2 | 0.0368626 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0366757 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0353097 |
| MEF2A | myocyte enhancer factor 2A | 0.0350784 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0349866 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0327857 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0327739 |
| MSN | moesin | 0.0317753 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0313687 |
| RPS19 | ribosomal protein S19 | 0.0312436 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0312407 |
| ATP13A3 | ATPase type 13A3 | 0.0304612 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0304588 |
| RPS2 | ribosomal protein S2 | 0.030458 |
| YBX3 | Y box binding protein 3 | 0.0304184 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0302894 |
| COA1 | cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) | 0.0297875 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.029586 |
| RPS12 | ribosomal protein S12 | 0.0285283 |
| FLNB | filamin B, beta | 0.0284582 |
| FAT1 | FAT atypical cadherin 1 | 0.0283289 |
| RPL9 | ribosomal protein L9 | 0.0280063 |
| SKIL | SKI-like proto-oncogene | 0.0278365 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | 0.0277088 |
| PRKCE | protein kinase C, epsilon | 0.0273157 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0273033 |
| GRAMD1B | GRAM domain containing 1B | 0.0272299 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.026914 |
| HMGA2 | high mobility group AT-hook 2 | 0.0267247 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0261303 |
| RPS6 | ribosomal protein S6 | 0.0256893 |
| NAV3 | neuron navigator 3 | 0.0256384 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0255152 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.025486 |
| RACK1 | receptor for activated C kinase 1 | 0.0248967 |
| ZNF652 | zinc finger protein 652 | 0.0248661 |
| ATF4 | activating transcription factor 4 | 0.0247664 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0244706 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | 0.0241916 |
| SEC61G | Sec61 gamma subunit | 0.0236826 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0235216 |
| SET | SET nuclear proto-oncogene | 0.023453 |
| COPA | coatomer protein complex, subunit alpha | 0.0233586 |
| TLN1 | talin 1 | 0.0233449 |
| ZNF841 | zinc finger protein 841 | 0.023204 |
| FOXJ3 | forkhead box J3 | 0.0231444 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0229538 |
| KDELR1 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 | 0.0229353 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0228885 |
| PA2G4 | proliferation-associated 2G4, 38kDa | 0.0228691 |
| MAP4 | microtubule-associated protein 4 | 0.0228209 |
| HIPK3 | homeodomain interacting protein kinase 3 | 0.0227737 |
| NUCB2 | nucleobindin 2 | 0.0227101 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.02271 |
| ARFGEF1 | ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) | 0.0225307 |
| RPL7 | ribosomal protein L7 | 0.0221971 |
| LRRC49 | leucine rich repeat containing 49 | 0.0218353 |
| TOP1 | topoisomerase (DNA) I | 0.0218102 |
| CAPN2 | calpain 2, (m/II) large subunit | 0.0218024 |
| AVL9 | AVL9 homolog (S. cerevisiase) | 0.0217161 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0216649 |
| ETNK1 | ethanolamine kinase 1 | 0.0215616 |
| RPL36 | ribosomal protein L36 | 0.0215536 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0214752 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0211656 |
| ITSN2 | intersectin 2 | 0.0211461 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0207224 |
| NAA35 | N(alpha)-acetyltransferase 35, NatC auxiliary subunit | 0.0207059 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0206972 |
| RASA2 | RAS p21 protein activator 2 | 0.0206771 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | 0.0206593 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | 0.0206138 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.267301 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.16623 |
| TMSB10 | thymosin beta 10 | -0.0949916 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0865069 |
| GRB10 | growth factor receptor-bound protein 10 | -0.080828 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0793786 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0788306 |
| FN1 | fibronectin 1 | -0.0753744 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0724362 |
| PRSS23 | protease, serine, 23 | -0.0706285 |
| CANX | calnexin | -0.0665648 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0621932 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0573917 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0564286 |
| VCL | vinculin | -0.0528598 |
| VIM | vimentin | -0.0525124 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0518377 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0512917 |
| HLA-B | major histocompatibility complex, class I, B | -0.0512471 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0494615 |
| ACTG1 | actin gamma 1 | -0.0483972 |
| SP100 | SP100 nuclear antigen | -0.047256 |
| GLCCI1 | glucocorticoid induced 1 | -0.0448415 |
| HDAC9 | histone deacetylase 9 | -0.0441801 |
| NLGN1 | neuroligin 1 | -0.0440112 |
| TMEM263 | transmembrane protein 263 | -0.0430987 |
| NAV2 | neuron navigator 2 | -0.0424355 |
| S100A10 | S100 calcium binding protein A10 | -0.0423214 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0404281 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0403688 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.0397709 |
| KYNU | kynureninase | -0.0393811 |
| DEK | DEK proto-oncogene | -0.0388593 |
| LOX | lysyl oxidase | -0.0377509 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0370047 |
| LDHA | lactate dehydrogenase A | -0.0367253 |
| AHNAK | AHNAK nucleoprotein | -0.0362951 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0359364 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0350175 |
| RPTOR | regulatory associated protein of MTOR, complex 1 | -0.0342971 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0340794 |
| RIGI | RNA sensor RIG-I | -0.0338125 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | -0.0334549 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.033402 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0329328 |
| ASPH | aspartate beta-hydroxylase | -0.0329184 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0322253 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0320796 |
| GLG1 | golgi glycoprotein 1 | -0.0316923 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0315587 |
| FNIP1 | folliculin interacting protein 1 | -0.0312821 |
| INTS6 | integrator complex subunit 6 | -0.0303794 |
| TAOK1 | TAO kinase 1 | -0.0302176 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0300648 |
| STXBP1 | syntaxin binding protein 1 | -0.03004 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 | -0.029836 |
| SQSTM1 | sequestosome 1 | -0.0290711 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0289537 |
| TMSB4X | thymosin beta 4, X-linked | -0.0288718 |
| CUL4B | cullin 4B | -0.0285166 |
| TPM4 | tropomyosin 4 | -0.0281119 |
| TUBA1B | tubulin, alpha 1b | -0.0280449 |
| RPS11 | ribosomal protein S11 | -0.028028 |
| LRRC23 | leucine rich repeat containing 23 | -0.0278895 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0278614 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0277555 |
| MT1X | metallothionein 1X | -0.0273348 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0272468 |
| RAPGEF6 | Rap guanine nucleotide exchange factor (GEF) 6 | -0.0271409 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.027097 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0270042 |
| HIP1 | huntingtin interacting protein 1 | -0.0267531 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0261751 |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | -0.0259528 |
| FUS | FUS RNA binding protein | -0.025921 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | -0.025889 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0258555 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0257883 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0256059 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0252725 |
| RPL11 | ribosomal protein L11 | -0.0251338 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0250721 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | -0.0249529 |
| SKP1 | S-phase kinase-associated protein 1 | -0.0248724 |
| TXNL1 | thioredoxin-like 1 | -0.0247931 |
| NPAS3 | neuronal PAS domain protein 3 | -0.0247752 |
| ITGB3BP | integrin beta 3 binding protein (beta3-endonexin) | -0.0245878 |
| AEBP2 | AE binding protein 2 | -0.0244799 |
| ATM | ATM serine/threonine kinase | -0.0244062 |
| CCL5 | chemokine (C-C motif) ligand 5 | -0.0242042 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0241906 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0240679 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.0239545 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0238362 |
| GPATCH2L | G patch domain containing 2-like | -0.0238277 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0237339 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0234557 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.0233361 |
| HS6ST3 | heparan sulfate 6-O-sulfotransferase 3 | -0.0233109 |
| LARP1B | La ribonucleoprotein domain family, member 1B | -0.0232246 |
