Almonertinib (hydrochloride)_HCT15 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Almonertinib (hydrochloride) perturbation in HCT15 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Almonertinib (hydrochloride)_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 0.181111
RPL35A ribosomal protein L35a 0.123589
FTL ferritin, light polypeptide 0.0975016
RPS3 ribosomal protein S3 0.0902158
MT2A metallothionein 2A 0.0894457
RPS6 ribosomal protein S6 0.0849021
TMSB10 thymosin beta 10 0.0794646
RPS12 ribosomal protein S12 0.0753136
RPS19 ribosomal protein S19 0.0752704
RPS8 ribosomal protein S8 0.0679072
RPLP1 ribosomal protein, large, P1 0.0610178
RPL37A ribosomal protein L37a 0.0561611
S100A9 S100 calcium binding protein A9 0.0504495
RPLP2 ribosomal protein, large, P2 0.0490195
RPL36 ribosomal protein L36 0.0485851
RPL9 ribosomal protein L9 0.0473376
RPL26 ribosomal protein L26 0.0409167
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0395251
RPL23 ribosomal protein L23 0.0394888
RPL18 ribosomal protein L18 0.0391668
RPLP0 ribosomal protein, large, P0 0.0389354
MIDN midnolin 0.0378393
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0377253
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0370339
VIM vimentin 0.0368921
RPS2 ribosomal protein S2 0.0367745
RPS27 ribosomal protein S27 0.0357298
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0355411
RPS17 ribosomal protein S17 0.0353639
RPS14 ribosomal protein S14 0.0350992
RPL27 ribosomal protein L27 0.0344206
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0340758
B2M beta-2-microglobulin 0.0328658
EIF1 eukaryotic translation initiation factor 1 0.0323421
RPL5 ribosomal protein L5 0.0319954
POTEF POTE ankyrin domain family, member F 0.0319838
RPS16 ribosomal protein S16 0.031048
AKAP12 A kinase (PRKA) anchor protein 12 0.0308681
RPL12 ribosomal protein L12 0.0307706
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0305595
PLAUR plasminogen activator, urokinase receptor 0.0302982
RPL28 ribosomal protein L28 0.0296728
RPL35 ribosomal protein L35 0.0295842
LDHA lactate dehydrogenase A 0.0295138
ISG15 ISG15 ubiquitin-like modifier 0.0294552
RPS4X ribosomal protein S4, X-linked 0.0294009
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0293369
RPL27A ribosomal protein L27a 0.0292626
ASPH aspartate beta-hydroxylase 0.0289536
RPS29 ribosomal protein S29 0.0287511
LOC102724023 ES1 protein homolog, mitochondrial 0.0287418
PRDX2 peroxiredoxin 2 0.028157
RACK1 receptor for activated C kinase 1 0.0270353
RPL31 ribosomal protein L31 0.0268366
RPL38 ribosomal protein L38 0.0265229
RPS13 ribosomal protein S13 0.0263988
SQSTM1 sequestosome 1 0.0261392
SRSF11 serine/arginine-rich splicing factor 11 0.0259337
RPS25 ribosomal protein S25 0.0259109
RPS23 ribosomal protein S23 0.0252363
YBX3 Y box binding protein 3 0.0245287
EGR1 early growth response 1 0.0241758
HLA-B major histocompatibility complex, class I, B 0.0237308
PGK1 phosphoglycerate kinase 1 0.0229394
RPS20 ribosomal protein S20 0.0229112
RPL36A ribosomal protein L36a 0.0227594
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0225308
SEC61G Sec61 gamma subunit 0.0220752
RPS27A ribosomal protein S27a 0.0219009
RPS21 ribosomal protein S21 0.0214284
FN1 fibronectin 1 0.0211961
IFITM3 interferon induced transmembrane protein 3 0.0208462
RPS24 ribosomal protein S24 0.0207527
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0206769
RPL37 ribosomal protein L37 0.020079
RPL7 ribosomal protein L7 0.0199501
RPL34 ribosomal protein L34 0.019289
IGFBP3 insulin-like growth factor binding protein 3 0.0192221
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 0.0191622
RBM39 RNA binding motif protein 39 0.0189458
WSB1 WD repeat and SOCS box containing 1 0.0184257
RPL11 ribosomal protein L11 0.0184216
TIMP1 TIMP metallopeptidase inhibitor 1 0.0182339
UBE2V2 ubiquitin-conjugating enzyme E2 variant 2 0.0176942
S100A14 S100 calcium binding protein A14 0.0175376
IER2 immediate early response 2 0.0175313
QSOX1 quiescin Q6 sulfhydryl oxidase 1 0.0175089
TPI1 triosephosphate isomerase 1 0.017349
RIGI RNA sensor RIG-I 0.0173445
RPL15 ribosomal protein L15 0.0171937
COX6C cytochrome c oxidase subunit VIc 0.0169767
RPL13A ribosomal protein L13a 0.016799
TXNIP thioredoxin interacting protein 0.0165394
RPL19 ribosomal protein L19 0.0161504
WARS1 tryptophanyl-tRNA synthetase 1 0.0160924
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0160372
SUMF1 sulfatase modifying factor 1 0.0159101
DDIT4 DNA-damage-inducible transcript 4 0.0157726
HLA-A major histocompatibility complex, class I, A 0.0157456
SERINC1 serine incorporator 1 0.0153998

decreased expression

Symbol Name Standardized Value
AHNAK AHNAK nucleoprotein -0.197356
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.131254
FAT1 FAT atypical cadherin 1 -0.118845
PTMA prothymosin, alpha -0.097627
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0795264
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0726268
MKI67 marker of proliferation Ki-67 -0.0673619
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.053115
UBC ubiquitin C -0.0506587
SEC31A SEC31 homolog A (S. cerevisiae) -0.049931
PDIA3 protein disulfide isomerase family A, member 3 -0.0472317
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0451051
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0446701
FHIT fragile histidine triad -0.0425093
BIRC6 baculoviral IAP repeat containing 6 -0.0415161
CANX calnexin -0.0405427
PATJ PATJ crumbs cell polarity complex component -0.0402215
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0397906
DLG1 discs, large homolog 1 (Drosophila) -0.0391125
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0348751
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0347084
LMAN1 lectin, mannose-binding, 1 -0.0332031
ENO1 enolase 1, (alpha) -0.0323091
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0315193
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0307635
GSPT1 G1 to S phase transition 1 -0.0303629
PRRC2B proline-rich coiled-coil 2B -0.030312
CCND1 cyclin D1 -0.0301844
NF1 neurofibromin 1 -0.0301592
HDLBP high density lipoprotein binding protein -0.0298226
TUBB tubulin, beta class I -0.0292236
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0290078
ANLN anillin, actin binding protein -0.0287976
LCORL ligand dependent nuclear receptor corepressor-like -0.0287792
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0286626
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 -0.0286081
KPNB1 karyopherin (importin) beta 1 -0.0276304
MED13L mediator complex subunit 13-like -0.0272835
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0271941
RSL1D1 ribosomal L1 domain containing 1 -0.0270386
LRPPRC leucine-rich pentatricopeptide repeat containing -0.027037
USP34 ubiquitin specific peptidase 34 -0.026835
CENPF centromere protein F, 350/400kDa -0.0262364
CD2AP CD2-associated protein -0.0256551
RAB1A RAB1A, member RAS oncogene family -0.0256159
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0252951
ZNF638 zinc finger protein 638 -0.0250504
YY1 YY1 transcription factor -0.0249374
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0241736
PFKP phosphofructokinase, platelet -0.0241002
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0240812
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 -0.0239951
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0239871
COPA coatomer protein complex, subunit alpha -0.0235444
CDK12 cyclin-dependent kinase 12 -0.0234105
LTN1 listerin E3 ubiquitin protein ligase 1 -0.0232229
TBC1D5 TBC1 domain family, member 5 -0.0231889
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0227589
HMGA2 high mobility group AT-hook 2 -0.0225999
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0222813
ARF4 ADP-ribosylation factor 4 -0.0222645
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0220368
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.0217119
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0215493
TTC3 tetratricopeptide repeat domain 3 -0.0215393
KDM4C lysine (K)-specific demethylase 4C -0.0214901
FUS FUS RNA binding protein -0.0213936
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0213839
EPRS1 glutamyl-prolyl-tRNA synthetase 1 -0.0211283
TENM3 teneurin transmembrane protein 3 -0.0208828
IARS1 isoleucyl-tRNA synthetase 1 -0.0207978
FRMD5 FERM domain containing 5 -0.0207053
SETX senataxin -0.0206566
RAD21 RAD21 homolog (S. pombe) -0.0205619
ZFC3H1 zinc finger, C3H1-type containing -0.0205307
NBAS neuroblastoma amplified sequence -0.020508
GDI2 GDP dissociation inhibitor 2 -0.0204766
CEP192 centrosomal protein 192kDa -0.0204357
MSI2 musashi RNA-binding protein 2 -0.0203258
DEK DEK proto-oncogene -0.0202825
HMGB2 high mobility group box 2 -0.0200969
SOS1 son of sevenless homolog 1 (Drosophila) -0.0199728
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0198844
GOLGB1 golgin B1 -0.0198146
BPTF bromodomain PHD finger transcription factor -0.019808
S100A10 S100 calcium binding protein A10 -0.019764
QSER1 glutamine and serine rich 1 -0.0197003
RBM26 RNA binding motif protein 26 -0.0195937
GOLGA4 golgin A4 -0.0195684
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0193923
SEC24D SEC24 family member D -0.0193802
TPM4 tropomyosin 4 -0.019274
ECT2 epithelial cell transforming 2 -0.0192559
CADPS Ca++-dependent secretion activator -0.0192226
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0191771
MEF2A myocyte enhancer factor 2A -0.0190251
MYOF myoferlin -0.0189557
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0189338
TAOK1 TAO kinase 1 -0.0189052
SERINC5 serine incorporator 5 -0.0188606