Almonertinib (hydrochloride)_HEC-1-A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Almonertinib (hydrochloride) perturbation in HEC-1-A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Almonertinib (hydrochloride)_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.127085
TPT1 tumor protein, translationally-controlled 1 0.0854253
LAMB3 laminin, beta 3 0.078961
RPS12 ribosomal protein S12 0.076767
ENO1 enolase 1, (alpha) 0.0757197
RPL35A ribosomal protein L35a 0.0714555
MKI67 marker of proliferation Ki-67 0.0708584
B2M beta-2-microglobulin 0.0703469
FTL ferritin, light polypeptide 0.0691953
ASPH aspartate beta-hydroxylase 0.0687087
APP amyloid beta (A4) precursor protein 0.0664821
RPS3 ribosomal protein S3 0.0647178
MT2A metallothionein 2A 0.0628024
MYH9 myosin, heavy chain 9, non-muscle 0.0601797
RPL12 ribosomal protein L12 0.0598741
RPS8 ribosomal protein S8 0.0585773
PGK1 phosphoglycerate kinase 1 0.056347
RPS2 ribosomal protein S2 0.0548554
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0546792
RACK1 receptor for activated C kinase 1 0.050573
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0496373
DSG2 desmoglein 2 0.0489455
RPL26 ribosomal protein L26 0.0470856
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0468969
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0454393
IGFBP3 insulin-like growth factor binding protein 3 0.0431881
LDHA lactate dehydrogenase A 0.0431426
RPL18 ribosomal protein L18 0.0419898
YBX1 Y box binding protein 1 0.0401347
RPS19 ribosomal protein S19 0.0396197
EEF2 eukaryotic translation elongation factor 2 0.037415
RPL13A ribosomal protein L13a 0.0371764
RPS27A ribosomal protein S27a 0.0357318
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0353735
CSDE1 cold shock domain containing E1, RNA-binding 0.034439
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0333162
HSPA8 heat shock 70kDa protein 8 0.0332797
RPL37A ribosomal protein L37a 0.0311938
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.030601
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0304958
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0304202
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.029419
RPL23 ribosomal protein L23 0.0289024
RPS7 ribosomal protein S7 0.0287655
EPCAM epithelial cell adhesion molecule 0.0282008
KLF6 Kruppel-like factor 6 0.0281929
RPLP0 ribosomal protein, large, P0 0.0279686
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0277075
TPR translocated promoter region, nuclear basket protein 0.0274407
RPLP2 ribosomal protein, large, P2 0.0270876
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0263265
APOL1 apolipoprotein L, 1 0.0259156
NDRG1 N-myc downstream regulated 1 0.0255811
TMSB4X thymosin beta 4, X-linked 0.0250145
SERINC1 serine incorporator 1 0.0245949
SET SET nuclear proto-oncogene 0.0244686
ARHGAP35 Rho GTPase activating protein 35 0.0243745
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0242466
MACF1 microtubule-actin crosslinking factor 1 0.0241117
TPI1 triosephosphate isomerase 1 0.0239516
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0237558
OGA O-GlcNAcase 0.0234309
KDM3A lysine (K)-specific demethylase 3A 0.0232686
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0231554
ANLN anillin, actin binding protein 0.0230476
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0229547
ZNF292 zinc finger protein 292 0.0229376
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.022903
AHNAK2 AHNAK nucleoprotein 2 0.022545
BRCA1 breast cancer 1, early onset 0.0224587
EIF1 eukaryotic translation initiation factor 1 0.0222508
NAP1L1 nucleosome assembly protein 1-like 1 0.022009
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0218992
EREG epiregulin 0.0216103
WSB1 WD repeat and SOCS box containing 1 0.021515
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0214305
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0214287
DDIT4 DNA-damage-inducible transcript 4 0.0213742
RPL3 ribosomal protein L3 0.0211674
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0203963
RPL31 ribosomal protein L31 0.0202747
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0200886
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0199995
RPL30 ribosomal protein L30 0.0199895
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0199889
RPL4 ribosomal protein L4 0.0199778
MACC1 metastasis associated in colon cancer 1 0.0199642
ANKRD10 ankyrin repeat domain 10 0.0198567
RPL36 ribosomal protein L36 0.0198465
BHLHE40 basic helix-loop-helix family, member e40 0.0194727
RPL37 ribosomal protein L37 0.019437
MT1X metallothionein 1X 0.0190182
RPS4X ribosomal protein S4, X-linked 0.0190068
RBBP6 retinoblastoma binding protein 6 0.018855
POU5F1 POU class 5 homeobox 1 0.0185828
BZW1 basic leucine zipper and W2 domains 1 0.0185697
ANKLE2 ankyrin repeat and LEM domain containing 2 0.0185012
STAG2 stromal antigen 2 0.0183086
RPS27 ribosomal protein S27 0.0182734
SINHCAF SIN3-HDAC complex associated factor 0.0180426

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.18232
TMSB10 thymosin beta 10 -0.14856
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0766022
FNDC3B fibronectin type III domain containing 3B -0.0726506
HMGA1 high mobility group AT-hook 1 -0.0713306
KRT7 keratin 7, type II -0.0593496
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0542393
S100A10 S100 calcium binding protein A10 -0.0539616
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0531754
DLC1 DLC1 Rho GTPase activating protein -0.0504269
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0482302
DEK DEK proto-oncogene -0.0447382
SETD5 SET domain containing 5 -0.0443195
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0431363
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0405973
SPINT2 serine peptidase inhibitor, Kunitz type, 2 -0.0396485
ITGA6 integrin, alpha 6 -0.0390711
HMGA2 high mobility group AT-hook 2 -0.0386786
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0380877
IARS1 isoleucyl-tRNA synthetase 1 -0.0365671
LPP LIM domain containing preferred translocation partner in lipoma -0.0358806
BIRC6 baculoviral IAP repeat containing 6 -0.0357114
ACTG1 actin gamma 1 -0.0350323
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0349118
TTC3 tetratricopeptide repeat domain 3 -0.0335399
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0332831
ANKRD11 ankyrin repeat domain 11 -0.0331168
ZNF609 zinc finger protein 609 -0.0328761
POTEF POTE ankyrin domain family, member F -0.032684
TBC1D5 TBC1 domain family, member 5 -0.0325325
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0323301
ATG7 autophagy related 7 -0.0319914
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0318663
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0314697
MON2 MON2 homolog (S. cerevisiae) -0.0313691
DIAPH3 diaphanous-related formin 3 -0.0310152
EGFR epidermal growth factor receptor -0.0308992
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0303318
PCED1B PC-esterase domain containing 1B -0.0303004
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0301661
ANKRD17 ankyrin repeat domain 17 -0.0301078
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0299245
RAB7A RAB7A, member RAS oncogene family -0.029242
WWOX WW domain containing oxidoreductase -0.0289165
PICALM phosphatidylinositol binding clathrin assembly protein -0.0288744
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.028827
PTK2 protein tyrosine kinase 2 -0.028689
PFN1 profilin 1 -0.0283386
FUS FUS RNA binding protein -0.0279488
INTS6 integrator complex subunit 6 -0.0277947
JMJD1C jumonji domain containing 1C -0.027533
RAD51B RAD51 paralog B -0.0274313
CCND1 cyclin D1 -0.0267878
SVIL supervillin -0.026646
ACTN4 actinin, alpha 4 -0.0256684
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0256253
PDIA3 protein disulfide isomerase family A, member 3 -0.0254939
RHOA ras homolog family member A -0.0254679
FHIT fragile histidine triad -0.0253128
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0251217
ZNF638 zinc finger protein 638 -0.0250661
SCFD1 sec1 family domain containing 1 -0.024963
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0248638
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0246044
ZNF148 zinc finger protein 148 -0.0245101
SEC31A SEC31 homolog A (S. cerevisiae) -0.0244872
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0240829
DLG1 discs, large homolog 1 (Drosophila) -0.0239784
KRT19 keratin 19, type I -0.0238426
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0238318
PDIA5 protein disulfide isomerase family A, member 5 -0.0237199
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0236265
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.023512
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0233639
DOCK4 dedicator of cytokinesis 4 -0.0231836
RUNX1 runt-related transcription factor 1 -0.0231103
TRIO trio Rho guanine nucleotide exchange factor -0.0230288
SH3KBP1 SH3-domain kinase binding protein 1 -0.0229689
TFG TRK-fused gene -0.0228187
RPS15 ribosomal protein S15 -0.0228048
PPP4R2 protein phosphatase 4, regulatory subunit 2 -0.0227008
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0226003
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 -0.0225666
BICD1 bicaudal D homolog 1 (Drosophila) -0.0222427
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0221571
RHEX regulator of hemoglobinization and erythroid cell expansion -0.0221231
TMCC1 transmembrane and coiled-coil domain family 1 -0.0219974
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0219834
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 -0.0218591
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0217139
CCDC138 coiled-coil domain containing 138 -0.0217056
RCOR1 REST corepressor 1 -0.0215929
DIAPH1 diaphanous-related formin 1 -0.0215675
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0215622
HELZ helicase with zinc finger -0.0214644
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0213841
ERBIN erbb2 interacting protein -0.0213705
SETX senataxin -0.0212289
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0211306
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0210474