Almonertinib (hydrochloride)_HOP62 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Almonertinib (hydrochloride) perturbation in HOP62 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Almonertinib (hydrochloride)_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.300062
TMSB10 thymosin beta 10 0.12124
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.110459
TPT1 tumor protein, translationally-controlled 1 0.108833
PTMA prothymosin, alpha 0.107254
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0892829
RPS8 ribosomal protein S8 0.0717124
RPL35A ribosomal protein L35a 0.0713651
RPS6 ribosomal protein S6 0.0696946
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0634683
ACTG1 actin gamma 1 0.0622729
RPL9 ribosomal protein L9 0.0597433
INTS6 integrator complex subunit 6 0.0573079
RPL37A ribosomal protein L37a 0.055735
ANKRD12 ankyrin repeat domain 12 0.0545277
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0535003
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0522589
IGF2 insulin-like growth factor 2 0.0514023
MT2A metallothionein 2A 0.0495506
RPL23 ribosomal protein L23 0.0489626
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0482705
RPLP1 ribosomal protein, large, P1 0.046703
LMNA lamin A/C 0.0463378
TM4SF1 transmembrane 4 L six family member 1 0.0455459
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0448324
NDRG1 N-myc downstream regulated 1 0.044726
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0446231
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0432156
RPLP2 ribosomal protein, large, P2 0.0424039
SMC4 structural maintenance of chromosomes 4 0.0422797
RPS12 ribosomal protein S12 0.0421256
ADM adrenomedullin 0.0417567
COL6A1 collagen, type VI, alpha 1 0.0398317
LAMB3 laminin, beta 3 0.0387392
MCL1 myeloid cell leukemia 1 0.0385805
RPS3 ribosomal protein S3 0.0366336
CENPF centromere protein F, 350/400kDa 0.0363349
WSB1 WD repeat and SOCS box containing 1 0.0362171
RRM2 ribonucleotide reductase M2 0.0357756
CXCL8 chemokine (C-X-C motif) ligand 8 0.0355239
KTN1 kinectin 1 (kinesin receptor) 0.0351923
RPL12 ribosomal protein L12 0.0351833
RPLP0 ribosomal protein, large, P0 0.0347012
NAP1L1 nucleosome assembly protein 1-like 1 0.0339689
CLIC4 chloride intracellular channel 4 0.0332652
RCOR1 REST corepressor 1 0.0328322
RPL31 ribosomal protein L31 0.0317081
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0314633
SFPQ splicing factor proline/glutamine-rich 0.0312125
RPS19 ribosomal protein S19 0.0311585
CSNK1A1 casein kinase 1, alpha 1 0.0305537
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0300369
RPS16 ribosomal protein S16 0.029568
CALR calreticulin 0.0294824
RPS24 ribosomal protein S24 0.0291442
RBM39 RNA binding motif protein 39 0.029091
DIAPH2 diaphanous-related formin 2 0.0290822
RPS27A ribosomal protein S27a 0.0286043
RPS13 ribosomal protein S13 0.0284831
CALD1 caldesmon 1 0.0281527
SETD5 SET domain containing 5 0.0279881
MBNL1 muscleblind-like splicing regulator 1 0.0275745
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 0.0274137
RPS14 ribosomal protein S14 0.0269979
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0269853
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0269775
RPS17 ribosomal protein S17 0.0269567
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0268781
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0265701
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0263323
ZSWIM6 zinc finger, SWIM-type containing 6 0.026112
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0260849
TPI1 triosephosphate isomerase 1 0.0259852
RPL36A ribosomal protein L36a 0.0259467
CLIP2 CAP-GLY domain containing linker protein 2 0.025809
GOLGB1 golgin B1 0.0257504
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.0257243
PDIA6 protein disulfide isomerase family A, member 6 0.0253783
RPL11 ribosomal protein L11 0.0251827
RPS29 ribosomal protein S29 0.0250852
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0250703
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0250085
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0249026
CMIP c-Maf inducing protein 0.0245253
ACTN1 actinin, alpha 1 0.0244041
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0243122
PLAUR plasminogen activator, urokinase receptor 0.0240775
RAB2A RAB2A, member RAS oncogene family 0.0239817
PICALM phosphatidylinositol binding clathrin assembly protein 0.0239222
RPS10 ribosomal protein S10 0.0238297
RPL26 ribosomal protein L26 0.0238281
EGFR epidermal growth factor receptor 0.0237216
SQSTM1 sequestosome 1 0.023524
PTK2 protein tyrosine kinase 2 0.0235157
ZNF207 zinc finger protein 207 0.0235043
IER3 immediate early response 3 0.0234638
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 0.0234065
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0233165
TPM4 tropomyosin 4 0.0232555
INHBA inhibin, beta A 0.0231011

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.277261
FN1 fibronectin 1 -0.227182
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0884882
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0875954
AHNAK AHNAK nucleoprotein -0.0738479
GLIS3 GLIS family zinc finger 3 -0.0658646
TENM2 teneurin transmembrane protein 2 -0.0568535
CDCP1 CUB domain containing protein 1 -0.0552153
LOC112694756 uncharaterized LOC112694756 -0.0514324
HMGA2 high mobility group AT-hook 2 -0.0504669
LOX lysyl oxidase -0.0481201
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0450646
COL5A1 collagen, type V, alpha 1 -0.04479
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0426495
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.03964
PDE10A phosphodiesterase 10A -0.0357761
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0331011
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0330688
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0318866
SMAD3 SMAD family member 3 -0.029816
HDLBP high density lipoprotein binding protein -0.0297739
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0297472
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0295235
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0285597
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0268889
COL6A3 collagen, type VI, alpha 3 -0.0266882
RAI14 retinoic acid induced 14 -0.0256287
SBF2 SET binding factor 2 -0.0239666
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0234232
THBS2 thrombospondin 2 -0.0228229
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0226414
DNMBP dynamin binding protein -0.0225979
TNNC1 troponin C type 1 (slow) -0.0225869
ETV6 ets variant 6 -0.0218654
ANTXR1 anthrax toxin receptor 1 -0.0217851
EXT1 exostosin glycosyltransferase 1 -0.0215057
IGFBP3 insulin-like growth factor binding protein 3 -0.01907
PDE4DIP phosphodiesterase 4D interacting protein -0.0190473
PHF3 PHD finger protein 3 -0.0184762
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 -0.0182792
CCND1 cyclin D1 -0.0180832
ENOSF1 enolase superfamily member 1 -0.0178269
PLEC plectin -0.0165409
ANTXR2 anthrax toxin receptor 2 -0.0162915
BHLHE40 basic helix-loop-helix family, member e40 -0.016182
ARF1 ADP-ribosylation factor 1 -0.0158427
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 -0.0156263
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.0155764
YES1 YES proto-oncogene 1, Src family tyrosine kinase -0.015431
ZBTB20 zinc finger and BTB domain containing 20 -0.0153802
EMP1 epithelial membrane protein 1 -0.0149182
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0146754
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0142903
BTBD9 BTB (POZ) domain containing 9 -0.014021
MT1X metallothionein 1X -0.0139217
ACTN4 actinin, alpha 4 -0.013567
F2RL1 coagulation factor II (thrombin) receptor-like 1 -0.013406
APCDD1L adenomatosis polyposis coli down-regulated 1-like -0.0133101
TWSG1 twisted gastrulation BMP signaling modulator 1 -0.013254
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0131823
HSPA8 heat shock 70kDa protein 8 -0.0131714
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.012923
ABI2 abl-interactor 2 -0.0128797
SPRY4 sprouty homolog 4 (Drosophila) -0.0128048
LONP2 lon peptidase 2, peroxisomal -0.0126901
RNF168 ring finger protein 168, E3 ubiquitin protein ligase -0.0126663
CUL4B cullin 4B -0.012635
NF1 neurofibromin 1 -0.0124989
ALDH18A1 aldehyde dehydrogenase 18 family, member A1 -0.0124684
DCBLD1 discoidin, CUB and LCCL domain containing 1 -0.0123567
TXLNG taxilin gamma -0.0121026
FAM20C family with sequence similarity 20, member C -0.0120368
BHLHE41 basic helix-loop-helix family, member e41 -0.0120043
TRAM2 translocation associated membrane protein 2 -0.0119756
SAMD3 sterile alpha motif domain containing 3 -0.011967
NT5E 5'-nucleotidase, ecto (CD73) -0.011899
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0117561
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0116225
CHSY1 chondroitin sulfate synthase 1 -0.0114727
COL4A2 collagen, type IV, alpha 2 -0.0114532
AFAP1 actin filament associated protein 1 -0.0114365
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.011409
ZNF175 zinc finger protein 175 -0.0113036
APP amyloid beta (A4) precursor protein -0.0112805
RIN2 Ras and Rab interactor 2 -0.0112546
XRN1 5'-3' exoribonuclease 1 -0.0112446
NGLY1 N-glycanase 1 -0.011224
GRB10 growth factor receptor-bound protein 10 -0.0111135
COL12A1 collagen, type XII, alpha 1 -0.0110425
WNT5A wingless-type MMTV integration site family, member 5A -0.0109846
SHB Src homology 2 domain containing adaptor protein B -0.0109394
SLC30A1 solute carrier family 30 (zinc transporter), member 1 -0.0107302
ADGRE2 adhesion G protein-coupled receptor E2 -0.0104668
FNDC3B fibronectin type III domain containing 3B -0.0103989
ZNF185 zinc finger protein 185 (LIM domain) -0.010392
PCYOX1 prenylcysteine oxidase 1 -0.0102678
FAM117B family with sequence similarity 117, member B -0.0101211
NAV1 neuron navigator 1 -0.0101145
CLTC clathrin, heavy chain (Hc) -0.0100715
POM121 POM121 transmembrane nucleoporin -0.0100642