Almonertinib (hydrochloride)_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Almonertinib (hydrochloride) perturbation in HS-578T cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Almonertinib (hydrochloride)_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 0.218054
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.175318
MT2A metallothionein 2A 0.148816
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.117182
VIM vimentin 0.115209
TMSB10 thymosin beta 10 0.0934878
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0926593
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0861528
FTL ferritin, light polypeptide 0.0660935
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0634417
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0627369
RPS8 ribosomal protein S8 0.0563894
CADM1 cell adhesion molecule 1 0.051852
RPS6 ribosomal protein S6 0.0517848
CALR calreticulin 0.0506815
B2M beta-2-microglobulin 0.0504245
RPL35A ribosomal protein L35a 0.0487076
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0468694
PTMA prothymosin, alpha 0.0442072
S100A9 S100 calcium binding protein A9 0.0404341
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0396396
LDHA lactate dehydrogenase A 0.0391505
RPS19 ribosomal protein S19 0.0380938
VEGFA vascular endothelial growth factor A 0.0369309
COL1A2 collagen, type I, alpha 2 0.0354056
CYB5R3 cytochrome b5 reductase 3 0.0340439
HLA-A major histocompatibility complex, class I, A 0.0334917
RPS12 ribosomal protein S12 0.0330418
HILPDA hypoxia inducible lipid droplet-associated 0.0326448
FTH1 ferritin, heavy polypeptide 1 0.0317522
RPL11 ribosomal protein L11 0.0316578
MTDH metadherin 0.0314578
LGALS1 lectin, galactoside-binding, soluble, 1 0.0313732
PFN1 profilin 1 0.030817
PDIA6 protein disulfide isomerase family A, member 6 0.0307068
RPS3 ribosomal protein S3 0.0300915
COL6A1 collagen, type VI, alpha 1 0.0300435
ENO1 enolase 1, (alpha) 0.0300378
RPL12 ribosomal protein L12 0.0297492
RPL37A ribosomal protein L37a 0.0278291
RPL5 ribosomal protein L5 0.0277443
SLC39A14 solute carrier family 39 (zinc transporter), member 14 0.0277224
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0273218
RACK1 receptor for activated C kinase 1 0.0271393
RPS14 ribosomal protein S14 0.0268861
RPL23 ribosomal protein L23 0.0268354
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0265283
MT1X metallothionein 1X 0.0265231
RPLP2 ribosomal protein, large, P2 0.0260353
TIMP1 TIMP metallopeptidase inhibitor 1 0.0255114
RPL18 ribosomal protein L18 0.0254643
RPL28 ribosomal protein L28 0.0254042
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0249389
PKM pyruvate kinase, muscle 0.0248942
RPL7 ribosomal protein L7 0.0247668
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.0245636
IFI6 interferon, alpha-inducible protein 6 0.0245068
DSTN destrin (actin depolymerizing factor) 0.0242805
ADM adrenomedullin 0.0240247
EEF2 eukaryotic translation elongation factor 2 0.0236588
RPL36 ribosomal protein L36 0.0234617
RPLP1 ribosomal protein, large, P1 0.0232135
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0231471
UBC ubiquitin C 0.0230414
RPL19 ribosomal protein L19 0.0228175
TGFBI transforming growth factor, beta-induced, 68kDa 0.0223215
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0220112
RPL8 ribosomal protein L8 0.0218961
EIF1 eukaryotic translation initiation factor 1 0.0218886
LOX lysyl oxidase 0.0217591
NAP1L1 nucleosome assembly protein 1-like 1 0.0211744
TPM2 tropomyosin 2 (beta) 0.0207563
SOD2 superoxide dismutase 2, mitochondrial 0.0204439
SEC61G Sec61 gamma subunit 0.0203901
TRAM1 translocation associated membrane protein 1 0.0203224
ATF4 activating transcription factor 4 0.0199709
RPLP0 ribosomal protein, large, P0 0.0198774
NUCB2 nucleobindin 2 0.0197989
GOLGA4 golgin A4 0.0197499
HYOU1 hypoxia up-regulated 1 0.0196668
RPS13 ribosomal protein S13 0.0196168
TMEM158 transmembrane protein 158 (gene/pseudogene) 0.0195789
RPL34 ribosomal protein L34 0.0194972
RPL9 ribosomal protein L9 0.0194331
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0194076
GARS1 glycyl-tRNA synthetase 1 0.0193017
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 0.0192645
TTC3 tetratricopeptide repeat domain 3 0.0192325
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.0191495
TPT1 tumor protein, translationally-controlled 1 0.0188876
RPL30 ribosomal protein L30 0.0188831
PCBP2 poly(rC) binding protein 2 0.0187734
WSB1 WD repeat and SOCS box containing 1 0.0187718
UGCG UDP-glucose ceramide glucosyltransferase 0.0185574
RPS11 ribosomal protein S11 0.0184416
TFG TRK-fused gene 0.0183539
RIOK3 RIO kinase 3 0.0182609
LIMS1 LIM and senescent cell antigen-like domains 1 0.0181426
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 0.0179784
YBX1 Y box binding protein 1 0.0179545

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.158281
EXT1 exostosin glycosyltransferase 1 -0.104695
PSD3 pleckstrin and Sec7 domain containing 3 -0.100303
IGFBP3 insulin-like growth factor binding protein 3 -0.0787202
CDH13 cadherin 13 -0.0621917
HMGA2 high mobility group AT-hook 2 -0.0573356
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0559085
COL6A3 collagen, type VI, alpha 3 -0.0490989
GLIS3 GLIS family zinc finger 3 -0.0455678
ATP13A3 ATPase type 13A3 -0.0455294
DPYD dihydropyrimidine dehydrogenase -0.0439157
TRIO trio Rho guanine nucleotide exchange factor -0.0431243
NKAIN3 Na+/K+ transporting ATPase interacting 3 -0.0421161
FBN1 fibrillin 1 -0.0419517
COL5A1 collagen, type V, alpha 1 -0.041939
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0414518
ASPH aspartate beta-hydroxylase -0.0397892
PRELID2 PRELI domain containing 2 -0.0394553
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0393062
NAV1 neuron navigator 1 -0.0385781
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0384636
TRPS1 trichorhinophalangeal syndrome I -0.0377446
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.036328
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0347511
LTBP1 latent transforming growth factor beta binding protein 1 -0.0342714
DST dystonin -0.0333777
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.0316814
ZBTB20 zinc finger and BTB domain containing 20 -0.0300774
RUNX1 runt-related transcription factor 1 -0.0295081
AHNAK AHNAK nucleoprotein -0.0293917
GRB10 growth factor receptor-bound protein 10 -0.0292223
COL1A1 collagen, type I, alpha 1 -0.0289451
DOCK5 dedicator of cytokinesis 5 -0.0276714
MTSS1 metastasis suppressor 1 -0.0272198
LOXL2 lysyl oxidase-like 2 -0.0268271
LPP LIM domain containing preferred translocation partner in lipoma -0.0266976
CD44 CD44 molecule (Indian blood group) -0.0264938
VCAN versican -0.0263042
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0257524
PDE4D phosphodiesterase 4D, cAMP-specific -0.0256252
WWTR1 WW domain containing transcription regulator 1 -0.0239413
SBF2 SET binding factor 2 -0.0239383
ZFPM2 zinc finger protein, FOG family member 2 -0.0239205
BNC2 basonuclin 2 -0.0235644
VCL vinculin -0.023273
PDLIM5 PDZ and LIM domain 5 -0.0230243
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0228545
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0228521
OSMR oncostatin M receptor -0.0226817
PDE10A phosphodiesterase 10A -0.0225759
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0225286
ZEB2 zinc finger E-box binding homeobox 2 -0.0222971
CALD1 caldesmon 1 -0.021844
MAML2 mastermind-like 2 (Drosophila) -0.0218266
ANTXR2 anthrax toxin receptor 2 -0.0216348
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0216077
DPYSL3 dihydropyrimidinase-like 3 -0.0214671
ADAM12 ADAM metallopeptidase domain 12 -0.0212008
SMAD3 SMAD family member 3 -0.0211378
TPM4 tropomyosin 4 -0.0200439
ATXN1 ataxin 1 -0.019405
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0193109
PTPRG protein tyrosine phosphatase, receptor type, G -0.019129
F3 coagulation factor III (thromboplastin, tissue factor) -0.0191006
IL6ST interleukin 6 signal transducer -0.0190377
NRP1 neuropilin 1 -0.0189436
CNTN5 contactin 5 -0.0188017
NREP neuronal regeneration related protein -0.0186256
APP amyloid beta (A4) precursor protein -0.018434
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -0.0183259
CLMP CXADR-like membrane protein -0.0179323
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0179319
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0178511
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0175165
PALLD palladin, cytoskeletal associated protein -0.0175135
PTK2 protein tyrosine kinase 2 -0.0170957
TENM3 teneurin transmembrane protein 3 -0.0170757
FAT1 FAT atypical cadherin 1 -0.0170209
FRMD4A FERM domain containing 4A -0.0168714
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0168054
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0167718
ELL2 elongation factor, RNA polymerase II, 2 -0.0166566
ATXN10 ataxin 10 -0.0164961
HAS2 hyaluronan synthase 2 -0.0164377
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.0163906
FBXL13 F-box and leucine-rich repeat protein 13 -0.0163647
VEGFC vascular endothelial growth factor C -0.016031
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0159941
SMYD3 SET and MYND domain containing 3 -0.0159789
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0157038
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0154567
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0151676
HMCN1 hemicentin 1 -0.0151077
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0148726
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0146888
KIRREL3 kin of IRRE like 3 (Drosophila) -0.014534
STC1 stanniocalcin 1 -0.0144966
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0144288
KDM7A lysine (K)-specific demethylase 7A -0.0144073
ADAM19 ADAM metallopeptidase domain 19 -0.0141818