Almonertinib (hydrochloride)_HT-29 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Almonertinib (hydrochloride) perturbation in HT-29 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Almonertinib (hydrochloride)_HT-29 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide 0.127702
RPL35A ribosomal protein L35a 0.0959512
RPS12 ribosomal protein S12 0.0899393
RPS19 ribosomal protein S19 0.0848145
RPS3 ribosomal protein S3 0.0786263
B2M beta-2-microglobulin 0.0740895
NDRG1 N-myc downstream regulated 1 0.0645579
POTEF POTE ankyrin domain family, member F 0.0532256
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0519927
RPS8 ribosomal protein S8 0.0504448
RPL23 ribosomal protein L23 0.0487793
RPL18 ribosomal protein L18 0.0427698
RPL26 ribosomal protein L26 0.0409106
ERRFI1 ERBB receptor feedback inhibitor 1 0.0402098
AREG amphiregulin 0.0398695
VMP1 vacuole membrane protein 1 0.0379752
RPS17 ribosomal protein S17 0.0378785
RPL21 ribosomal protein L21 0.03706
RPL37A ribosomal protein L37a 0.0363104
CLDN4 claudin 4 0.0348295
RPS21 ribosomal protein S21 0.0334346
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.033406
RPL36 ribosomal protein L36 0.0331683
VIM vimentin 0.0323097
AKAP12 A kinase (PRKA) anchor protein 12 0.0314541
RPL9 ribosomal protein L9 0.0313796
RPLP2 ribosomal protein, large, P2 0.0313706
NCEH1 neutral cholesterol ester hydrolase 1 0.0307949
RPL12 ribosomal protein L12 0.0305998
MT2A metallothionein 2A 0.0297208
RPL11 ribosomal protein L11 0.0294144
RPL31 ribosomal protein L31 0.0291502
TPT1 tumor protein, translationally-controlled 1 0.0290579
VCL vinculin 0.0287376
HLA-A major histocompatibility complex, class I, A 0.0283703
RPS2 ribosomal protein S2 0.0273492
RPL37 ribosomal protein L37 0.0268619
S100P S100 calcium binding protein P 0.0267328
IGF2 insulin-like growth factor 2 0.0262937
LMO7 LIM domain 7 0.0257982
PDE4D phosphodiesterase 4D, cAMP-specific 0.0255779
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0255193
RPL36A ribosomal protein L36a 0.0254058
RPS27 ribosomal protein S27 0.025355
ATP5F1E ATP synthase F1 subunit epsilon 0.0252229
KLF6 Kruppel-like factor 6 0.0246078
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0241545
WEE1 WEE1 G2 checkpoint kinase 0.0233879
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0230743
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 0.0230133
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0227739
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 0.0223289
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0223202
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.0222887
DSCAM Down syndrome cell adhesion molecule 0.0221734
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0220795
RPL13A ribosomal protein L13a 0.0220588
RPS14 ribosomal protein S14 0.0220367
SEC61G Sec61 gamma subunit 0.0218242
IGFBP3 insulin-like growth factor binding protein 3 0.0216858
GPX4 glutathione peroxidase 4 0.0216811
UGCG UDP-glucose ceramide glucosyltransferase 0.0215448
NAP1L1 nucleosome assembly protein 1-like 1 0.0214641
ZSWIM6 zinc finger, SWIM-type containing 6 0.020906
FN1 fibronectin 1 0.0207914
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0207608
RPS7 ribosomal protein S7 0.0205081
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0200175
SRRM1 serine/arginine repetitive matrix 1 0.0198165
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0194931
RPS10 ribosomal protein S10 0.0194743
RPL27A ribosomal protein L27a 0.0194067
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0193363
ADARB1 adenosine deaminase, RNA-specific, B1 0.0192766
RPS13 ribosomal protein S13 0.0192574
WSB1 WD repeat and SOCS box containing 1 0.0189947
SLC38A2 solute carrier family 38, member 2 0.0189889
LIMA1 LIM domain and actin binding 1 0.0188134
EIF1 eukaryotic translation initiation factor 1 0.0187968
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0187599
IRS2 insulin receptor substrate 2 0.0187346
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0182842
YTHDC1 YTH domain containing 1 0.0180326
RPS25 ribosomal protein S25 0.0178988
OCIAD2 OCIA domain containing 2 0.0177381
TRA2A transformer 2 alpha homolog (Drosophila) 0.0176709
RPL30 ribosomal protein L30 0.0175942
RPS4X ribosomal protein S4, X-linked 0.0175866
TUFT1 tuftelin 1 0.0173616
TRIB1 tribbles pseudokinase 1 0.0171869
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) 0.0170716
SON SON DNA binding protein 0.0167631
LAMB3 laminin, beta 3 0.0167385
NDUFB9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa 0.0166713
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0164543
PLK2 polo-like kinase 2 0.0164094
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0163983
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0161916
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0156893
PRRC2C proline-rich coiled-coil 2C 0.0156107

decreased expression

Symbol Name Standardized Value
AHNAK AHNAK nucleoprotein -0.148054
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.136655
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.122103
PTMA prothymosin, alpha -0.113423
SAMD12 sterile alpha motif domain containing 12 -0.108405
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.105798
GMDS GDP-mannose 4,6-dehydratase -0.103083
KRT8 keratin 8, type II -0.09578
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0952177
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0868136
MYH14 myosin, heavy chain 14, non-muscle -0.0836488
KRT18 keratin 18, type I -0.0834028
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 -0.0833746
ANXA2 annexin A2 -0.0829993
FRY furry homolog (Drosophila) -0.0793471
CD2AP CD2-associated protein -0.0792413
LAMA4 laminin, alpha 4 -0.0778336
PTK2 protein tyrosine kinase 2 -0.0771244
S100A10 S100 calcium binding protein A10 -0.0757526
RAD21 RAD21 homolog (S. pombe) -0.0753849
EZR ezrin -0.0748668
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0714627
DIAPH2 diaphanous-related formin 2 -0.0698933
LYZ lysozyme -0.0691165
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0654075
KRT20 keratin 20, type I -0.0651303
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0634995
RRBP1 ribosome binding protein 1 -0.0620872
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0611417
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.060831
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.0606021
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0604813
ITPKC inositol-trisphosphate 3-kinase C -0.0603164
FNDC3B fibronectin type III domain containing 3B -0.0598715
TMEM123 transmembrane protein 123 -0.0596894
LOC102724023 ES1 protein homolog, mitochondrial -0.0587864
MMP7 matrix metallopeptidase 7 -0.056922
ACACA acetyl-CoA carboxylase alpha -0.0558497
PDIA3 protein disulfide isomerase family A, member 3 -0.0541635
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.054097
SLC45A4 solute carrier family 45, member 4 -0.0529392
DGKH diacylglycerol kinase, eta -0.0526155
ZMYND8 zinc finger, MYND-type containing 8 -0.0522271
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.0520078
CCSER1 coiled-coil serine-rich protein 1 -0.0518875
EIF3H eukaryotic translation initiation factor 3, subunit H -0.0512476
ACTG1 actin gamma 1 -0.0502873
TM4SF4 transmembrane 4 L six family member 4 -0.0497215
LDHA lactate dehydrogenase A -0.0496356
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.049486
HDLBP high density lipoprotein binding protein -0.0493242
ITGA6 integrin, alpha 6 -0.0492428
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0492359
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0491641
PGK1 phosphoglycerate kinase 1 -0.0491557
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0490503
KRT19 keratin 19, type I -0.0486732
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0477586
ABLIM1 actin binding LIM protein 1 -0.0473906
WASF2 WAS protein family, member 2 -0.0472782
KMT2C lysine (K)-specific methyltransferase 2C -0.0456526
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0455536
LMNA lamin A/C -0.0449763
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.04468
TRAPPC9 trafficking protein particle complex 9 -0.0442976
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0428118
PKP4 plakophilin 4 -0.0417344
ARHGAP32 Rho GTPase activating protein 32 -0.0411724
TM9SF3 transmembrane 9 superfamily member 3 -0.0409782
DEK DEK proto-oncogene -0.0409097
MAML3 mastermind-like 3 (Drosophila) -0.0402414
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.0400293
PATJ PATJ crumbs cell polarity complex component -0.0391495
EXT1 exostosin glycosyltransferase 1 -0.0390165
ACTN4 actinin, alpha 4 -0.0382927
NECTIN2 nectin cell adhesion molecule 2 -0.0379711
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0378139
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.0369476
BPTF bromodomain PHD finger transcription factor -0.0368005
NF1 neurofibromin 1 -0.0367977
STAU1 staufen double-stranded RNA binding protein 1 -0.0364923
SEC31A SEC31 homolog A (S. cerevisiae) -0.0364364
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.0363743
S100A6 S100 calcium binding protein A6 -0.0362176
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 -0.0359909
HMGB1 high mobility group box 1 -0.035701
BBX bobby sox homolog (Drosophila) -0.0351742
SULF2 sulfatase 2 -0.0351377
ST14 suppression of tumorigenicity 14 (colon carcinoma) -0.0350461
MTMR10 myotubularin related protein 10 -0.0342817
ETV6 ets variant 6 -0.0339778
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0336899
SDC4 syndecan 4 -0.0336241
DSPP dentin sialophosphoprotein -0.0335335
USP54 ubiquitin specific peptidase 54 -0.0335044
JUN jun proto-oncogene -0.0334697
SDCBP syndecan binding protein (syntenin) -0.0331629
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0330889
PKM pyruvate kinase, muscle -0.0328189
SMAD3 SMAD family member 3 -0.0326711