Almonertinib (hydrochloride)_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Almonertinib (hydrochloride) perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Almonertinib (hydrochloride)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 0.292687
AKAP12 A kinase (PRKA) anchor protein 12 0.157186
ENO1 enolase 1, (alpha) 0.0777038
ASPH aspartate beta-hydroxylase 0.0605233
FN1 fibronectin 1 0.0565901
ERRFI1 ERBB receptor feedback inhibitor 1 0.0542777
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0528212
PLIN2 perilipin 2 0.0526932
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0524541
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0417706
TF transferrin 0.0381042
FAM107B family with sequence similarity 107, member B 0.0375381
PEG3 paternally expressed 3 0.0370031
DSPP dentin sialophosphoprotein 0.0364847
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.033515
MBNL2 muscleblind-like splicing regulator 2 0.0332022
PDLIM5 PDZ and LIM domain 5 0.032376
NDRG1 N-myc downstream regulated 1 0.0319533
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0310486
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0292953
LDHA lactate dehydrogenase A 0.0282009
RPS12 ribosomal protein S12 0.027547
AHSG alpha-2-HS-glycoprotein 0.0247647
STK17A serine/threonine kinase 17a 0.0241091
DUSP6 dual specificity phosphatase 6 0.0230654
RPS8 ribosomal protein S8 0.0229323
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0227083
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0226726
SAMD4A sterile alpha motif domain containing 4A 0.0217206
IGFBP1 insulin-like growth factor binding protein 1 0.0217065
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0216843
FTH1 ferritin, heavy polypeptide 1 0.0205261
RACK1 receptor for activated C kinase 1 0.0204687
MCL1 myeloid cell leukemia 1 0.0203607
GK glycerol kinase 0.0198019
NFE2L1 nuclear factor, erythroid 2-like 1 0.0196128
ERN1 endoplasmic reticulum to nucleus signaling 1 0.019336
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0189189
EEF2 eukaryotic translation elongation factor 2 0.0188029
TCIM transcriptional and immune response regulator 0.0186999
HMGA1 high mobility group AT-hook 1 0.0186196
SYNE1 spectrin repeat containing, nuclear envelope 1 0.0182595
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0182154
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0180979
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0179803
IGFBP3 insulin-like growth factor binding protein 3 0.0178945
IRF2BP2 interferon regulatory factor 2 binding protein 2 0.0177952
POTEF POTE ankyrin domain family, member F 0.0175409
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0175319
FTL ferritin, light polypeptide 0.0174635
ZFP36L2 ZFP36 ring finger protein-like 2 0.0173418
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.017248
TPM4 tropomyosin 4 0.0172091
ATXN1 ataxin 1 0.0170934
GCLC glutamate-cysteine ligase, catalytic subunit 0.0165994
MAP1B microtubule-associated protein 1B 0.0158903
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0154474
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0154254
ARFGEF3 ARFGEF family member 3 0.0153621
DST dystonin 0.0153152
RPL37A ribosomal protein L37a 0.0151839
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0151511
CANX calnexin 0.0149224
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0149182
UGDH UDP-glucose 6-dehydrogenase 0.0143821
SPDYA speedy/RINGO cell cycle regulator family member A 0.0141196
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0140819
RPLP0 ribosomal protein, large, P0 0.013983
SVIL supervillin 0.0139771
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0135473
CP ceruloplasmin (ferroxidase) 0.0135232
CRY1 cryptochrome circadian clock 1 0.0134546
ZHX2 zinc fingers and homeoboxes 2 0.0134449
PALLD palladin, cytoskeletal associated protein 0.0133206
STC2 stanniocalcin 2 0.0130638
GLRX glutaredoxin (thioltransferase) 0.0129942
INTS6 integrator complex subunit 6 0.0128954
RAD51B RAD51 paralog B 0.0128312
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0128222
RPS7 ribosomal protein S7 0.0127125
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0126364
LOC112694756 uncharaterized LOC112694756 0.0125071
EXT1 exostosin glycosyltransferase 1 0.0124994
FHL2 four and a half LIM domains 2 0.0121288
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0118392
ACTG1 actin gamma 1 0.0117639
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0117087
AHR aryl hydrocarbon receptor 0.0116134
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 0.0115993
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.011463
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 0.011447
DSG2 desmoglein 2 0.0113216
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0112233
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0111248
AKR1C1 aldo-keto reductase family 1, member C1 0.0111242
MPZL2 myelin protein zero-like 2 0.0107622
HM13 histocompatibility (minor) 13 0.0107579
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.0107019
PGK1 phosphoglycerate kinase 1 0.0106732
ARID5B AT rich interactive domain 5B (MRF1-like) 0.010589

decreased expression

Symbol Name Standardized Value
C3 complement component 3 -0.144366
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.138132
APOB apolipoprotein B -0.135487
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.130734
RBM39 RNA binding motif protein 39 -0.0663654
FNDC3B fibronectin type III domain containing 3B -0.0635977
LRMDA leucine rich melanocyte differentiation associated -0.0554206
APOA2 apolipoprotein A-II -0.0497454
EML4 echinoderm microtubule associated protein like 4 -0.0469191
RBM25 RNA binding motif protein 25 -0.0456473
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0430643
GPC3 glypican 3 -0.0411568
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0409116
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0405311
TRIM26 tripartite motif containing 26 -0.0391292
JMJD1C jumonji domain containing 1C -0.0344544
PTBP3 polypyrimidine tract binding protein 3 -0.0343852
RNF213 ring finger protein 213 -0.0335801
RRBP1 ribosome binding protein 1 -0.0330711
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0326663
MRTFA myocardin related transcription factor A -0.0318508
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0315739
GPC6 glypican 6 -0.0309206
NKD1 naked cuticle homolog 1 (Drosophila) -0.0305908
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0294121
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.0288736
ZFAND3 zinc finger, AN1-type domain 3 -0.0287131
PCBP2 poly(rC) binding protein 2 -0.0286408
TM9SF3 transmembrane 9 superfamily member 3 -0.0282215
RPL11 ribosomal protein L11 -0.0276401
AFDN afadin, adherens junction formation factor -0.0273391
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0271048
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0270778
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0267434
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 -0.026369
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0262528
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0259239
BIRC6 baculoviral IAP repeat containing 6 -0.0251688
TRIP12 thyroid hormone receptor interactor 12 -0.025091
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -0.0250468
ACTR3 ARP3 actin-related protein 3 homolog (yeast) -0.024676
SOS1 son of sevenless homolog 1 (Drosophila) -0.0246318
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -0.0245988
MATR3 matrin 3 -0.0242625
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18 -0.0241192
CCNL1 cyclin L1 -0.0240803
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0240004
PTK2 protein tyrosine kinase 2 -0.0237137
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 -0.0232067
CFB complement factor B -0.0230124
FCHSD2 FCH and double SH3 domains 2 -0.022872
WAC WW domain containing adaptor with coiled-coil -0.022869
UBXN4 UBX domain protein 4 -0.0227895
OLA1 Obg-like ATPase 1 -0.0225004
TOP1 topoisomerase (DNA) I -0.022431
MAML2 mastermind-like 2 (Drosophila) -0.0224133
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0223688
STAU1 staufen double-stranded RNA binding protein 1 -0.0222398
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0219491
PUM2 pumilio RNA-binding family member 2 -0.0218362
TRIO trio Rho guanine nucleotide exchange factor -0.021773
FRMD5 FERM domain containing 5 -0.0217133
FUS FUS RNA binding protein -0.021648
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.0216129
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0215307
ELL2 elongation factor, RNA polymerase II, 2 -0.0210097
TCF12 transcription factor 12 -0.0209217
YAP1 Yes-associated protein 1 -0.0207204
MT2A metallothionein 2A -0.0207071
PARD3 par-3 family cell polarity regulator -0.020568
MED13L mediator complex subunit 13-like -0.0204932
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0204862
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0204171
MSI2 musashi RNA-binding protein 2 -0.0204055
MX2 MX dynamin-like GTPase 2 -0.0204022
SETD5 SET domain containing 5 -0.0202683
DNAH17 dynein, axonemal, heavy chain 17 -0.0202174
COL27A1 collagen, type XXVII, alpha 1 -0.0202148
SNX9 sorting nexin 9 -0.0201753
A2M alpha-2-macroglobulin -0.0200038
RPS6 ribosomal protein S6 -0.0196731
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0195252
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0193976
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0192207
EIF5B eukaryotic translation initiation factor 5B -0.018897
EPS8 epidermal growth factor receptor pathway substrate 8 -0.018864
CNKSR3 CNKSR family member 3 -0.0187908
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0187546
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -0.0186541
KDM3A lysine (K)-specific demethylase 3A -0.0185794
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0185677
RTN4 reticulon 4 -0.0185238
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.0184384
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0183194
RAB1A RAB1A, member RAS oncogene family -0.0182473
SDC4 syndecan 4 -0.0180737
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0179633
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0179396
PTPRG protein tyrosine phosphatase, receptor type, G -0.0179386
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0178796