| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Almonertinib (hydrochloride) perturbation in Hs 766T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Almonertinib (hydrochloride)_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.151319 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.135506 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.126084 |
| MT2A | metallothionein 2A | 0.0997772 |
| INTS6 | integrator complex subunit 6 | 0.0815058 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0801379 |
| SLC35F3 | solute carrier family 35, member F3 | 0.078992 |
| B2M | beta-2-microglobulin | 0.0786578 |
| PDLIM5 | PDZ and LIM domain 5 | 0.072579 |
| MTSS1 | metastasis suppressor 1 | 0.0720432 |
| RPS12 | ribosomal protein S12 | 0.0694582 |
| ANO1 | anoctamin 1, calcium activated chloride channel | 0.0651501 |
| RASAL2 | RAS protein activator like 2 | 0.0610535 |
| RPL35A | ribosomal protein L35a | 0.060314 |
| RPS8 | ribosomal protein S8 | 0.0602303 |
| EGR1 | early growth response 1 | 0.0588736 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0587485 |
| RIGI | RNA sensor RIG-I | 0.0581961 |
| RPL37 | ribosomal protein L37 | 0.0560139 |
| RPL37A | ribosomal protein L37a | 0.0556385 |
| RPS3 | ribosomal protein S3 | 0.0552818 |
| POTEF | POTE ankyrin domain family, member F | 0.0536529 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0533138 |
| PLS3 | plastin 3 | 0.0526393 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0523439 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0520696 |
| RPS21 | ribosomal protein S21 | 0.0512613 |
| MT1E | metallothionein 1E | 0.0512549 |
| HLA-B | major histocompatibility complex, class I, B | 0.0507747 |
| RPL11 | ribosomal protein L11 | 0.050469 |
| LMO7 | LIM domain 7 | 0.0504285 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0500198 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0498741 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0485828 |
| RPS13 | ribosomal protein S13 | 0.0477631 |
| RCOR1 | REST corepressor 1 | 0.0476693 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0473125 |
| RPLP2 | ribosomal protein, large, P2 | 0.0470694 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0469784 |
| HMGA2 | high mobility group AT-hook 2 | 0.0464921 |
| LUZP1 | leucine zipper protein 1 | 0.0456226 |
| LAMC2 | laminin, gamma 2 | 0.0452512 |
| RPL26 | ribosomal protein L26 | 0.0449719 |
| RPL12 | ribosomal protein L12 | 0.0447329 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0436251 |
| SIK3 | SIK family kinase 3 | 0.0432422 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | 0.0428256 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0428232 |
| RPL34 | ribosomal protein L34 | 0.0425268 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0415545 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | 0.0404737 |
| RPS25 | ribosomal protein S25 | 0.0401013 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0396992 |
| CLIC4 | chloride intracellular channel 4 | 0.0396103 |
| RPL9 | ribosomal protein L9 | 0.0393789 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.038805 |
| PODXL | podocalyxin-like | 0.0383849 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0380949 |
| IFI44L | interferon-induced protein 44-like | 0.0379332 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0377324 |
| ECE1 | endothelin converting enzyme 1 | 0.0373208 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0369298 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | 0.0354275 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0351997 |
| RPL36 | ribosomal protein L36 | 0.0347603 |
| RPS19 | ribosomal protein S19 | 0.0346329 |
| PRSS23 | protease, serine, 23 | 0.0344976 |
| VCL | vinculin | 0.0344759 |
| CTBP2 | C-terminal binding protein 2 | 0.0339316 |
| RPS24 | ribosomal protein S24 | 0.0339293 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0338435 |
| PITPNB | phosphatidylinositol transfer protein, beta | 0.0337808 |
| SULF2 | sulfatase 2 | 0.0335166 |
| IGF2 | insulin-like growth factor 2 | 0.0319935 |
| HIVEP1 | human immunodeficiency virus type I enhancer binding protein 1 | 0.0314637 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0313453 |
| RPL36A | ribosomal protein L36a | 0.0310638 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.031005 |
| PLXNA2 | plexin A2 | 0.0305636 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0304348 |
| SEPTIN9 | septin 9 | 0.0301725 |
| CDK6 | cyclin-dependent kinase 6 | 0.0301612 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0301297 |
| KIAA1671 | KIAA1671 | 0.0297415 |
| RPL31 | ribosomal protein L31 | 0.0296492 |
| RPS17 | ribosomal protein S17 | 0.0293161 |
| ACTN1 | actinin, alpha 1 | 0.0287749 |
| PCDH1 | protocadherin 1 | 0.0285888 |
| ST3GAL6 | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 | 0.0284879 |
| SP100 | SP100 nuclear antigen | 0.0283595 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0281742 |
| RPL23 | ribosomal protein L23 | 0.0280913 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0280246 |
| CSTB | cystatin B (stefin B) | 0.0279642 |
| CSMD2 | CUB and Sushi multiple domains 2 | 0.0278501 |
| MSN | moesin | 0.0276075 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0272319 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | 0.0268709 |
| CD9 | CD9 molecule | 0.0268113 |
| RPL27A | ribosomal protein L27a | 0.0265703 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FLNB | filamin B, beta | -0.125197 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.111524 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0941688 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0918304 |
| CLU | clusterin | -0.0904138 |
| NDRG1 | N-myc downstream regulated 1 | -0.0846701 |
| MYOF | myoferlin | -0.0797911 |
| AHNAK | AHNAK nucleoprotein | -0.0731979 |
| SULF1 | sulfatase 1 | -0.072789 |
| MEF2A | myocyte enhancer factor 2A | -0.0696056 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0633842 |
| OGA | O-GlcNAcase | -0.0609994 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0601823 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0592601 |
| CUL4B | cullin 4B | -0.0586606 |
| GOLGA4 | golgin A4 | -0.0583776 |
| CANX | calnexin | -0.0527774 |
| PGK1 | phosphoglycerate kinase 1 | -0.0516225 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0504098 |
| EMP1 | epithelial membrane protein 1 | -0.0502103 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.0499867 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0487236 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0473823 |
| EZR | ezrin | -0.0468886 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0456729 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.044796 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0446798 |
| KRT17 | keratin 17, type I | -0.0438978 |
| KIAA1217 | KIAA1217 | -0.0434169 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0432597 |
| ADAMTS16 | ADAM metallopeptidase with thrombospondin type 1 motif, 16 | -0.0431014 |
| H1-0 | H1.0 linker histone | -0.0414762 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0413661 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0412337 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0412059 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.040974 |
| ITGA6 | integrin, alpha 6 | -0.0385668 |
| NRG1 | neuregulin 1 | -0.0384948 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.0384238 |
| CD99 | CD99 molecule | -0.0383382 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | -0.0380308 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0379127 |
| ENO1 | enolase 1, (alpha) | -0.0375984 |
| ANLN | anillin, actin binding protein | -0.0358863 |
| FOXO1 | forkhead box O1 | -0.0354686 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.035411 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0351337 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0350161 |
| GLG1 | golgi glycoprotein 1 | -0.0346555 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0344033 |
| HDLBP | high density lipoprotein binding protein | -0.0343804 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | -0.034245 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | -0.0337585 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0332317 |
| SBF2 | SET binding factor 2 | -0.0326569 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0324133 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0317538 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0312538 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | -0.0311794 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0311755 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0309878 |
| SUCO | SUN domain containing ossification factor | -0.0308092 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | -0.0302987 |
| RBM39 | RNA binding motif protein 39 | -0.0298567 |
| FN1 | fibronectin 1 | -0.0297642 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0294463 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0294185 |
| CALU | calumenin | -0.0293943 |
| TMSB4X | thymosin beta 4, X-linked | -0.0293753 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | -0.0291069 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | -0.0290934 |
| APP | amyloid beta (A4) precursor protein | -0.0289239 |
| METTL15 | methyltransferase like 15 | -0.0286711 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | -0.0283999 |
| SQLE | squalene epoxidase | -0.0282853 |
| SRP54 | signal recognition particle 54kDa | -0.0282789 |
| CALR | calreticulin | -0.0279393 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.0277521 |
| PLAC8 | placenta-specific 8 | -0.0277313 |
| COL17A1 | collagen, type XVII, alpha 1 | -0.0276758 |
| LOXL2 | lysyl oxidase-like 2 | -0.027522 |
| RLF | rearranged L-myc fusion | -0.0274002 |
| NEK7 | NIMA-related kinase 7 | -0.0273999 |
| ALDH3A1 | aldehyde dehydrogenase 3 family, member A1 | -0.0272963 |
| MORF4L2 | mortality factor 4 like 2 | -0.0269859 |
| HELZ | helicase with zinc finger | -0.0269357 |
| ANKH | ANKH inorganic pyrophosphate transport regulator | -0.0269174 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0267528 |
| COG5 | component of oligomeric golgi complex 5 | -0.0265892 |
| PRELID2 | PRELI domain containing 2 | -0.026491 |
| COG6 | component of oligomeric golgi complex 6 | -0.0261791 |
| YEATS2 | YEATS domain containing 2 | -0.026174 |
| GATA6 | GATA binding protein 6 | -0.0259756 |
| KRT6A | keratin 6A, type II | -0.0257495 |
| EFHD2 | EF-hand domain family, member D2 | -0.0255758 |
| KDM7A | lysine (K)-specific demethylase 7A | -0.0255236 |
| STC1 | stanniocalcin 1 | -0.0253113 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.025025 |
| AOPEP | aminopeptidase O (putative) | -0.0246498 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0246139 |
