Almonertinib (hydrochloride)_J82 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Almonertinib (hydrochloride) perturbation in J82 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Almonertinib (hydrochloride)_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.258411
IGFBP3 insulin-like growth factor binding protein 3 0.20433
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.186829
FN1 fibronectin 1 0.160217
NALF1 NALCN channel auxiliary factor 1 0.13864
EXT1 exostosin glycosyltransferase 1 0.0959025
PHACTR1 phosphatase and actin regulator 1 0.0831429
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0789317
AKAP12 A kinase (PRKA) anchor protein 12 0.0742067
CD44 CD44 molecule (Indian blood group) 0.0680027
ABI3BP ABI family, member 3 (NESH) binding protein 0.0668097
RPL35A ribosomal protein L35a 0.0667312
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0594999
TPT1 tumor protein, translationally-controlled 1 0.0572687
ASPH aspartate beta-hydroxylase 0.0540001
ERBIN erbb2 interacting protein 0.0534398
VIM vimentin 0.0524626
NDRG1 N-myc downstream regulated 1 0.0517464
ENO1 enolase 1, (alpha) 0.0492449
HLA-B major histocompatibility complex, class I, B 0.0478399
TMSB10 thymosin beta 10 0.0460575
RAI14 retinoic acid induced 14 0.0427632
ANXA2 annexin A2 0.0419998
DTNA dystrobrevin, alpha 0.040929
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0403654
RPS6 ribosomal protein S6 0.0388069
CAVIN1 caveolae associated protein 1 0.0386605
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0368862
RPLP2 ribosomal protein, large, P2 0.0368549
POTEF POTE ankyrin domain family, member F 0.036715
RPS3 ribosomal protein S3 0.0363237
HLA-A major histocompatibility complex, class I, A 0.0360444
PTPRF protein tyrosine phosphatase, receptor type, F 0.0348074
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0346323
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0344787
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.033655
RPS8 ribosomal protein S8 0.0335199
CD59 CD59 molecule, complement regulatory protein 0.033462
LDHA lactate dehydrogenase A 0.0315107
PODXL podocalyxin-like 0.0313504
RPL37 ribosomal protein L37 0.0313118
ACTG1 actin gamma 1 0.0290177
PTK2 protein tyrosine kinase 2 0.0279547
FLNB filamin B, beta 0.027033
LPP LIM domain containing preferred translocation partner in lipoma 0.0269823
F3 coagulation factor III (thromboplastin, tissue factor) 0.0267808
BZW1 basic leucine zipper and W2 domains 1 0.026501
PTMA prothymosin, alpha 0.0264942
IGFBP5 insulin-like growth factor binding protein 5 0.0263014
PGK1 phosphoglycerate kinase 1 0.0261634
RPS12 ribosomal protein S12 0.0261009
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0258485
WNT5B wingless-type MMTV integration site family, member 5B 0.0256675
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0254465
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0246298
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0244131
MSN moesin 0.0232696
SMYD3 SET and MYND domain containing 3 0.02314
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0229939
RPL12 ribosomal protein L12 0.022746
RAD51B RAD51 paralog B 0.0227302
ZSWIM6 zinc finger, SWIM-type containing 6 0.0225484
MT1X metallothionein 1X 0.0223729
RPL11 ribosomal protein L11 0.0222258
RPLP1 ribosomal protein, large, P1 0.0221718
B2M beta-2-microglobulin 0.0220427
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0219484
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0217883
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0217256
RPL26 ribosomal protein L26 0.0215873
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0214511
NAV2 neuron navigator 2 0.0214384
NAV1 neuron navigator 1 0.0213072
GLIS3 GLIS family zinc finger 3 0.0212016
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0209225
DST dystonin 0.0208549
MAML2 mastermind-like 2 (Drosophila) 0.0205766
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0204861
MYO10 myosin X 0.0204086
RPL5 ribosomal protein L5 0.0203636
RACK1 receptor for activated C kinase 1 0.0199031
RPS13 ribosomal protein S13 0.0196577
RPL37A ribosomal protein L37a 0.0194799
RPL34 ribosomal protein L34 0.0193136
SET SET nuclear proto-oncogene 0.0191632
CCND1 cyclin D1 0.0191522
RPS17 ribosomal protein S17 0.0189125
RPS21 ribosomal protein S21 0.0189079
ZNF841 zinc finger protein 841 0.0188419
RPL30 ribosomal protein L30 0.0186999
RPL27A ribosomal protein L27a 0.0186825
ZNF804A zinc finger protein 804A 0.0186419
RPL9 ribosomal protein L9 0.0182653
RPL36A ribosomal protein L36a 0.0180335
CAST calpastatin 0.0179651
ACTN1 actinin, alpha 1 0.0179139
THSD4 thrombospondin, type I, domain containing 4 0.0178866
DLG1 discs, large homolog 1 (Drosophila) 0.0177168
VCL vinculin 0.0175969
S100A6 S100 calcium binding protein A6 0.0174367

decreased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 -0.046815
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.041557
TXNRD1 thioredoxin reductase 1 -0.0376765
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0370311
FTL ferritin, light polypeptide -0.0361466
SLC12A8 solute carrier family 12, member 8 -0.0354545
DEK DEK proto-oncogene -0.0344937
UGCG UDP-glucose ceramide glucosyltransferase -0.0318901
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) -0.0290022
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0275356
ARF4 ADP-ribosylation factor 4 -0.0265931
GOLGA4 golgin A4 -0.026067
NAMPT nicotinamide phosphoribosyltransferase -0.0260399
CCNL1 cyclin L1 -0.0254209
NUP58 nucleoporin 58 -0.024127
TSC22D2 TSC22 domain family, member 2 -0.0226285
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0223967
TGFB2 transforming growth factor, beta 2 -0.022335
PDIA3 protein disulfide isomerase family A, member 3 -0.0221756
SUCO SUN domain containing ossification factor -0.0209479
SOD2 superoxide dismutase 2, mitochondrial -0.0198944
SQSTM1 sequestosome 1 -0.0191905
PLIN2 perilipin 2 -0.0191384
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0189064
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0182783
COPB1 coatomer protein complex, subunit beta 1 -0.0181868
TFG TRK-fused gene -0.0179697
SRP54 signal recognition particle 54kDa -0.0170946
SULF1 sulfatase 1 -0.0165256
ADAM9 ADAM metallopeptidase domain 9 -0.0162172
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0160861
ATP13A3 ATPase type 13A3 -0.0160234
SPAG9 sperm associated antigen 9 -0.0158466
TPD52 tumor protein D52 -0.0157349
MBNL2 muscleblind-like splicing regulator 2 -0.0155265
UFM1 ubiquitin-fold modifier 1 -0.0154284
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0149637
PLK2 polo-like kinase 2 -0.0136324
PTBP3 polypyrimidine tract binding protein 3 -0.0132483
TBC1D23 TBC1 domain family, member 23 -0.0129999
CTSD cathepsin D -0.0129662
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0128323
POSTN periostin, osteoblast specific factor -0.0126865
COG6 component of oligomeric golgi complex 6 -0.0125379
WAC WW domain containing adaptor with coiled-coil -0.0125318
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0124888
GLS2 glutaminase 2 (liver, mitochondrial) -0.0124724
BHLHE40 basic helix-loop-helix family, member e40 -0.0124584
KMT2E lysine (K)-specific methyltransferase 2E -0.0123588
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0123562
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit -0.0122644
TRAM1 translocation associated membrane protein 1 -0.0121826
ANKRD10 ankyrin repeat domain 10 -0.0120874
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0117858
FNDC3B fibronectin type III domain containing 3B -0.0117747
NUP153 nucleoporin 153kDa -0.0117676
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0117043
RYBP RING1 and YY1 binding protein -0.0116738
ANKRD33B ankyrin repeat domain 33B -0.0116727
ARL5B ADP-ribosylation factor-like 5B -0.0115974
NOP58 NOP58 ribonucleoprotein -0.0115248
PDS5B PDS5 cohesin associated factor B -0.0115029
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0114781
USP3 ubiquitin specific peptidase 3 -0.0114586
FOSL1 FOS-like antigen 1 -0.0112789
MATR3 matrin 3 -0.0111597
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0111138
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0109825
TMEM178B transmembrane protein 178B -0.0108946
ZNF292 zinc finger protein 292 -0.0108788
YME1L1 YME1-like 1 ATPase -0.0107504
ADAM17 ADAM metallopeptidase domain 17 -0.0107475
GRAMD2B GRAM domain containing 2B -0.0106759
DNAJC25 DnaJ (Hsp40) homolog, subfamily C , member 25 -0.0106615
HELZ helicase with zinc finger -0.0106241
STAU1 staufen double-stranded RNA binding protein 1 -0.0106097
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0105818
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0105765
UBC ubiquitin C -0.010556
MORF4L2 mortality factor 4 like 2 -0.0105554
PPME1 protein phosphatase methylesterase 1 -0.0104926
RBM39 RNA binding motif protein 39 -0.0103864
RLF rearranged L-myc fusion -0.0103858
RAD23B RAD23 homolog B (S. cerevisiae) -0.0100753
BAZ2A bromodomain adjacent to zinc finger domain, 2A -0.0100724
SPTY2D1 SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae) -0.0100653
UBE2H ubiquitin-conjugating enzyme E2H -0.00999495
SEC31A SEC31 homolog A (S. cerevisiae) -0.00997567
GOLGB1 golgin B1 -0.00986913
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.00983432
PHC3 polyhomeotic homolog 3 (Drosophila) -0.00982171
ARID4B AT rich interactive domain 4B (RBP1-like) -0.00979001
OLA1 Obg-like ATPase 1 -0.00963408
TBK1 TANK-binding kinase 1 -0.00946967
TRPM7 transient receptor potential cation channel, subfamily M, member 7 -0.00937764
EPS8 epidermal growth factor receptor pathway substrate 8 -0.00936765
TKT transketolase -0.00908749
CPAP centrosome assembly and centriole elongation protein -0.00907608
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.00899785
ECT2 epithelial cell transforming 2 -0.00896712