Almonertinib (hydrochloride)_KATO III Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Almonertinib (hydrochloride) perturbation in KATO III cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Almonertinib (hydrochloride)_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GMDS GDP-mannose 4,6-dehydratase 0.115706
MAML2 mastermind-like 2 (Drosophila) 0.102289
POTEF POTE ankyrin domain family, member F 0.0988336
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0904031
FGFR2 fibroblast growth factor receptor 2 0.0861971
NPSR1 neuropeptide S receptor 1 0.0813467
RPL35A ribosomal protein L35a 0.0713234
AREG amphiregulin 0.0570147
PTMA prothymosin, alpha 0.0526516
FLNB filamin B, beta 0.0525388
TPT1 tumor protein, translationally-controlled 1 0.0517004
LCN2 lipocalin 2 0.051275
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0480589
CEMIP cell migration inducing protein, hyaluronan binding 0.0473288
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 0.0471865
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.04398
RPS3 ribosomal protein S3 0.0439513
C6ORF132 chromosome 6 open reading frame 132 0.0406601
BCL2L1 BCL2-like 1 0.0404003
TNIK TRAF2 and NCK interacting kinase 0.0395087
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0388482
MCU mitochondrial calcium uniporter 0.0382374
FTL ferritin, light polypeptide 0.0382369
RPL37A ribosomal protein L37a 0.0379714
RPS12 ribosomal protein S12 0.0377732
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0370199
RPS6 ribosomal protein S6 0.0369764
ITGA6 integrin, alpha 6 0.0364815
LMO7 LIM domain 7 0.036439
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0359685
TJP1 tight junction protein 1 0.0353427
TMSB10 thymosin beta 10 0.0351407
RUNX1 runt-related transcription factor 1 0.0335204
MBNL1 muscleblind-like splicing regulator 1 0.0332869
RPS25 ribosomal protein S25 0.0330318
FNDC3B fibronectin type III domain containing 3B 0.0319598
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 0.0319002
VEGFA vascular endothelial growth factor A 0.0317978
KLHL29 kelch-like family member 29 0.031577
HLA-A major histocompatibility complex, class I, A 0.0292242
MYOF myoferlin 0.0291918
VMP1 vacuole membrane protein 1 0.0289876
ZSWIM6 zinc finger, SWIM-type containing 6 0.0288317
COBL cordon-bleu WH2 repeat protein 0.0288021
RPL9 ribosomal protein L9 0.0284003
INTS6 integrator complex subunit 6 0.0281882
B2M beta-2-microglobulin 0.028025
MYO1E myosin IE 0.0274645
RPS17 ribosomal protein S17 0.0273108
RPS8 ribosomal protein S8 0.0269792
DSTN destrin (actin depolymerizing factor) 0.0269248
EHBP1 EH domain binding protein 1 0.0268883
HMGA1 high mobility group AT-hook 1 0.0265108
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0264407
UBASH3B ubiquitin associated and SH3 domain containing B 0.0263701
DOCK5 dedicator of cytokinesis 5 0.0263231
PDLIM5 PDZ and LIM domain 5 0.026017
ANO1 anoctamin 1, calcium activated chloride channel 0.0259896
ARHGAP32 Rho GTPase activating protein 32 0.0253229
AUTS2 autism susceptibility candidate 2 0.0241793
NCOR2 nuclear receptor corepressor 2 0.0241691
SETD5 SET domain containing 5 0.0235828
MACC1 metastasis associated in colon cancer 1 0.0235235
CUX1 cut-like homeobox 1 0.0232007
RCOR1 REST corepressor 1 0.023141
S100A6 S100 calcium binding protein A6 0.0231172
SIK3 SIK family kinase 3 0.0230867
LOC102724023 ES1 protein homolog, mitochondrial 0.0226443
CTBP2 C-terminal binding protein 2 0.0223596
NCEH1 neutral cholesterol ester hydrolase 1 0.0221206
CATSPERB catsper channel auxiliary subunit beta 0.0220746
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0219675
EGR1 early growth response 1 0.0217686
KLK10 kallikrein-related peptidase 10 0.0217504
RPL31 ribosomal protein L31 0.0217121
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0217085
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0215978
HDAC9 histone deacetylase 9 0.0215513
SH3RF1 SH3 domain containing ring finger 1 0.0212951
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0211265
FBXO11 F-box protein 11 0.0210699
RPL23 ribosomal protein L23 0.0210308
ANXA1 annexin A1 0.0210063
RRM2 ribonucleotide reductase M2 0.0209827
CDK6 cyclin-dependent kinase 6 0.02098
RPS14 ribosomal protein S14 0.0209748
EPS8 epidermal growth factor receptor pathway substrate 8 0.0209729
PTPRK protein tyrosine phosphatase, receptor type, K 0.0208421
VCL vinculin 0.0207717
KRT7 keratin 7, type II 0.0205278
YAP1 Yes-associated protein 1 0.020449
RAB7A RAB7A, member RAS oncogene family 0.0202742
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough 0.0202101
ANXA3 annexin A3 0.0200819
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0200094
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0199956
ASPH aspartate beta-hydroxylase 0.019958
TRPS1 trichorhinophalangeal syndrome I 0.0199532
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.0199151
PCBP2 poly(rC) binding protein 2 0.0196655

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.191664
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.164909
PDIA4 protein disulfide isomerase family A, member 4 -0.0506245
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0490724
H1-0 H1.0 linker histone -0.0465336
AGR2 anterior gradient 2 -0.04375
RRBP1 ribosome binding protein 1 -0.0413774
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.040732
LOC112694756 uncharaterized LOC112694756 -0.0395529
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0371953
CANX calnexin -0.0371899
TMEM123 transmembrane protein 123 -0.0366807
EIF1 eukaryotic translation initiation factor 1 -0.0363208
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0325011
AHNAK AHNAK nucleoprotein -0.0315446
KDM3A lysine (K)-specific demethylase 3A -0.0313518
HLA-E major histocompatibility complex, class I, E -0.0310704
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0298674
HLA-C major histocompatibility complex, class I, C -0.0295761
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0291397
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0288902
RB1CC1 RB1-inducible coiled-coil 1 -0.028513
RAB1A RAB1A, member RAS oncogene family -0.0283123
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0269381
TXNRD1 thioredoxin reductase 1 -0.026889
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0268181
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -0.0257092
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0255705
TMSB4X thymosin beta 4, X-linked -0.0254373
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0252852
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0240004
EPCAM epithelial cell adhesion molecule -0.0236427
PDIA3 protein disulfide isomerase family A, member 3 -0.023617
INSIG1 insulin induced gene 1 -0.0233962
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0230568
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0230316
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 -0.0228966
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0210209
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0209908
S100A10 S100 calcium binding protein A10 -0.0205635
CD2AP CD2-associated protein -0.0203313
HDLBP high density lipoprotein binding protein -0.0199573
CLTC clathrin, heavy chain (Hc) -0.0199559
SEL1L sel-1 suppressor of lin-12-like (C. elegans) -0.0198479
STAU1 staufen double-stranded RNA binding protein 1 -0.0196204
HYOU1 hypoxia up-regulated 1 -0.0190088
AKAP9 A kinase (PRKA) anchor protein 9 -0.0186554
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.0186296
DSG2 desmoglein 2 -0.0184032
UBE4A ubiquitination factor E4A -0.0183604
RSL1D1 ribosomal L1 domain containing 1 -0.0182208
GARS1 glycyl-tRNA synthetase 1 -0.0182165
RAD21 RAD21 homolog (S. pombe) -0.0178825
ATF5 activating transcription factor 5 -0.0178318
SARAF store-operated calcium entry-associated regulatory factor -0.0178289
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0178195
ALDOC aldolase C, fructose-bisphosphate -0.0175721
SKAP2 src kinase associated phosphoprotein 2 -0.0174724
CDK12 cyclin-dependent kinase 12 -0.0173105
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0172409
ACSS2 acyl-CoA synthetase short-chain family member 2 -0.0169672
CD164 CD164 molecule, sialomucin -0.0168449
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0167244
LMAN1 lectin, mannose-binding, 1 -0.0166693
RPLP1 ribosomal protein, large, P1 -0.0166403
TES testin LIM domain protein -0.0164908
ZFR zinc finger RNA binding protein -0.0164428
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0163928
XPO1 exportin 1 -0.0161601
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0161124
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0160695
GSTP1 glutathione S-transferase pi 1 -0.0158107
AVL9 AVL9 homolog (S. cerevisiase) -0.0156399
RPL8 ribosomal protein L8 -0.0154298
JAK1 Janus kinase 1 -0.0154197
DEK DEK proto-oncogene -0.015369
CCDC146 coiled-coil domain containing 146 -0.0152249
SLC38A1 solute carrier family 38, member 1 -0.0151108
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta -0.0150365
CCDC47 coiled-coil domain containing 47 -0.0149792
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0148333
MUC17 mucin 17, cell surface associated -0.0145668
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0142554
PRRC2B proline-rich coiled-coil 2B -0.0141893
GPX2 glutathione peroxidase 2 -0.0141339
ACSL1 acyl-CoA synthetase long-chain family member 1 -0.0140262
PHF3 PHD finger protein 3 -0.0139945
EXPH5 exophilin 5 -0.0139433
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.0137914
MSMO1 methylsterol monooxygenase 1 -0.0137586
TMEM45B transmembrane protein 45B -0.0136935
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0136515
SLC31A1 solute carrier family 31 (copper transporter), member 1 -0.0136331
BHLHE40 basic helix-loop-helix family, member e40 -0.0135959
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase -0.0135779
CLMN calmin (calponin-like, transmembrane) -0.0134935
TKT transketolase -0.0133949
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0133134
DENND4C DENN/MADD domain containing 4C -0.0132863
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) -0.0132388