Almonertinib (hydrochloride)_LoVo Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Almonertinib (hydrochloride) perturbation in LoVo cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Almonertinib (hydrochloride)_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPS12 ribosomal protein S12 0.150869
TPT1 tumor protein, translationally-controlled 1 0.101037
TXNRD1 thioredoxin reductase 1 0.0809927
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0757496
RPS3 ribosomal protein S3 0.0622503
FAT1 FAT atypical cadherin 1 0.0621193
RPL26 ribosomal protein L26 0.060055
PKP2 plakophilin 2 0.0591689
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.053312
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0475322
RPS2 ribosomal protein S2 0.0462438
RPLP0 ribosomal protein, large, P0 0.0452857
RPL35A ribosomal protein L35a 0.0452718
RACK1 receptor for activated C kinase 1 0.0441906
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0428392
EEF2 eukaryotic translation elongation factor 2 0.0423033
MUC13 mucin 13, cell surface associated 0.0421717
RPL12 ribosomal protein L12 0.0398982
EREG epiregulin 0.0397969
PLAUR plasminogen activator, urokinase receptor 0.0384557
RPS8 ribosomal protein S8 0.037944
FLNB filamin B, beta 0.0367337
RPL37A ribosomal protein L37a 0.0364585
GARS1 glycyl-tRNA synthetase 1 0.0352793
PRSS3 protease, serine, 3 0.034839
PRELID2 PRELI domain containing 2 0.0346159
RPS17 ribosomal protein S17 0.0342034
KLF6 Kruppel-like factor 6 0.033936
S100P S100 calcium binding protein P 0.0337337
ABHD17C abhydrolase domain containing 17C 0.0330014
LAMB3 laminin, beta 3 0.0328999
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0317665
SHROOM3 shroom family member 3 0.0303475
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 0.0303266
RPL9 ribosomal protein L9 0.0302414
RPS27A ribosomal protein S27a 0.0292947
RPS19 ribosomal protein S19 0.029226
DSCAM Down syndrome cell adhesion molecule 0.028994
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0289098
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0285931
RPL13A ribosomal protein L13a 0.028245
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0282235
CCPG1 cell cycle progression 1 0.0282078
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0280377
YBX3 Y box binding protein 3 0.0270344
GOLGA4 golgin A4 0.02668
NAMPT nicotinamide phosphoribosyltransferase 0.0265629
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0265363
KRT8 keratin 8, type II 0.0264904
RPS7 ribosomal protein S7 0.0263421
GDF15 growth differentiation factor 15 0.0256888
RPL18 ribosomal protein L18 0.0255937
PCDHB16 protocadherin beta 16 0.0253374
CXADR coxsackie virus and adenovirus receptor 0.0248356
CLDN4 claudin 4 0.0248146
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0242254
WWC1 WW and C2 domain containing 1 0.0239658
TRIM2 tripartite motif containing 2 0.0238951
CHD1 chromodomain helicase DNA binding protein 1 0.0238354
EIF1 eukaryotic translation initiation factor 1 0.0230612
PGK1 phosphoglycerate kinase 1 0.0224237
TMEM45B transmembrane protein 45B 0.0224212
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0223524
PTEN phosphatase and tensin homolog 0.022219
MT2A metallothionein 2A 0.0222126
EPCAM epithelial cell adhesion molecule 0.0218802
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.0217621
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.021633
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0215315
CSDE1 cold shock domain containing E1, RNA-binding 0.021527
RTN4 reticulon 4 0.021049
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0210311
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0208152
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0206904
VCL vinculin 0.0206442
DUSP5 dual specificity phosphatase 5 0.0204807
NAP1L1 nucleosome assembly protein 1-like 1 0.020444
ASNS asparagine synthetase (glutamine-hydrolyzing) 0.0203873
DUSP4 dual specificity phosphatase 4 0.0202711
RPS4X ribosomal protein S4, X-linked 0.0201315
FHL2 four and a half LIM domains 2 0.0198938
RPL30 ribosomal protein L30 0.0197079
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0196567
ARHGAP29 Rho GTPase activating protein 29 0.0196024
BCL2L1 BCL2-like 1 0.019453
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0190077
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0189868
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0188433
SQSTM1 sequestosome 1 0.0187188
TRIM31 tripartite motif containing 31 0.0185589
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 0.0185338
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0184839
AVL9 AVL9 homolog (S. cerevisiase) 0.018393
DDIT4 DNA-damage-inducible transcript 4 0.0183764
RPL3 ribosomal protein L3 0.0181982
CTNND1 catenin (cadherin-associated protein), delta 1 0.018068
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0180043
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.017943
KLF3 Kruppel-like factor 3 (basic) 0.0177925
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0177105

decreased expression

Symbol Name Standardized Value
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.106572
THSD4 thrombospondin, type I, domain containing 4 -0.0943262
GMDS GDP-mannose 4,6-dehydratase -0.0928069
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0876249
RPS6 ribosomal protein S6 -0.0680614
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0648758
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.0599754
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0559449
LMO7 LIM domain 7 -0.0553221
PTPRB protein tyrosine phosphatase, receptor type, B -0.0532347
CUX1 cut-like homeobox 1 -0.0511664
INTS6 integrator complex subunit 6 -0.0510497
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0502759
RPS23 ribosomal protein S23 -0.0489207
NPSR1 neuropeptide S receptor 1 -0.0467337
FRMD5 FERM domain containing 5 -0.0439376
PDE4D phosphodiesterase 4D, cAMP-specific -0.0435461
MPRIP myosin phosphatase Rho interacting protein -0.0427445
MSI2 musashi RNA-binding protein 2 -0.0411196
CATSPERB catsper channel auxiliary subunit beta -0.0409493
RBM25 RNA binding motif protein 25 -0.040516
EZR ezrin -0.0404267
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0403525
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0400685
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.039182
SVIL supervillin -0.0391635
AOPEP aminopeptidase O (putative) -0.0385425
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 -0.0383702
PTPRR protein tyrosine phosphatase, receptor type, R -0.0363465
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0362698
MCU mitochondrial calcium uniporter -0.0362559
DENND1A DENN/MADD domain containing 1A -0.0362504
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0360192
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0355576
F3 coagulation factor III (thromboplastin, tissue factor) -0.0352816
SPINK13 serine peptidase inhibitor, Kazal type 13 (putative) -0.0344671
EGFR epidermal growth factor receptor -0.0343086
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0335463
FUS FUS RNA binding protein -0.0333359
TMSB10 thymosin beta 10 -0.0324832
ACTG1 actin gamma 1 -0.0321539
RPL8 ribosomal protein L8 -0.0321213
FOXO3 forkhead box O3 -0.0316967
FNDC3B fibronectin type III domain containing 3B -0.0316686
FBXO11 F-box protein 11 -0.0315125
PDIA3 protein disulfide isomerase family A, member 3 -0.0314998
LPP LIM domain containing preferred translocation partner in lipoma -0.0310888
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0308966
DIAPH1 diaphanous-related formin 1 -0.0306784
UBAP2 ubiquitin associated protein 2 -0.0301571
IFI27 interferon, alpha-inducible protein 27 -0.029734
PATJ PATJ crumbs cell polarity complex component -0.02967
MYH14 myosin, heavy chain 14, non-muscle -0.0293577
RABGAP1L RAB GTPase activating protein 1-like -0.0292029
SP100 SP100 nuclear antigen -0.0291507
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.029065
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0289102
RPS11 ribosomal protein S11 -0.028668
PDLIM5 PDZ and LIM domain 5 -0.0284404
PSD3 pleckstrin and Sec7 domain containing 3 -0.0283912
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0277897
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0269693
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0269208
CALB1 calbindin 1, 28kDa -0.0269169
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0268006
STK39 serine threonine kinase 39 -0.0266747
COBL cordon-bleu WH2 repeat protein -0.0264917
BACE2 beta-site APP-cleaving enzyme 2 -0.0263963
RREB1 ras responsive element binding protein 1 -0.0262236
ATP5F1B ATP synthase F1 subunit beta -0.0261518
LARP1B La ribonucleoprotein domain family, member 1B -0.0261183
ESYT2 extended synaptotagmin-like protein 2 -0.0251072
DSPP dentin sialophosphoprotein -0.0247624
PERP PERP, TP53 apoptosis effector -0.0247474
TTC3 tetratricopeptide repeat domain 3 -0.0247264
RNF213 ring finger protein 213 -0.0246179
PARD3 par-3 family cell polarity regulator -0.0246063
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0245307
BIRC6 baculoviral IAP repeat containing 6 -0.0245045
RPS29 ribosomal protein S29 -0.024406
DEK DEK proto-oncogene -0.0243493
ANKRD17 ankyrin repeat domain 17 -0.024081
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0237188
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0236624
LRPPRC leucine-rich pentatricopeptide repeat containing -0.02363
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0235392
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0234988
RCOR1 REST corepressor 1 -0.0234938
AHNAK AHNAK nucleoprotein -0.0233396
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) -0.0228471
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0228146
CCND1 cyclin D1 -0.0227413
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0227031
NABP1 nucleic acid binding protein 1 -0.0226069
CCSER1 coiled-coil serine-rich protein 1 -0.0225607
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) -0.022544
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0224647
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0224265
BZW2 basic leucine zipper and W2 domains 2 -0.0223693
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0223567