Almonertinib (hydrochloride)_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Almonertinib (hydrochloride) perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Almonertinib (hydrochloride)_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.188407
TMSB10 thymosin beta 10 0.0900755
RPL35A ribosomal protein L35a 0.0863427
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0848405
RPS19 ribosomal protein S19 0.0766159
RPS12 ribosomal protein S12 0.0699627
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0684176
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0672814
TPT1 tumor protein, translationally-controlled 1 0.0541249
TP63 tumor protein p63 0.0527624
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.052255
RPL12 ribosomal protein L12 0.0520631
TSC22D1 TSC22 domain family, member 1 0.0519626
RAD51B RAD51 paralog B 0.0497791
RPL36 ribosomal protein L36 0.0487334
CADM2 cell adhesion molecule 2 0.0487035
RPL23 ribosomal protein L23 0.0479871
CD44 CD44 molecule (Indian blood group) 0.0475427
HLA-A major histocompatibility complex, class I, A 0.0437457
IFI6 interferon, alpha-inducible protein 6 0.0437007
ZDHHC14 zinc finger, DHHC-type containing 14 0.0404408
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0370968
MT1X metallothionein 1X 0.0345532
RPL26 ribosomal protein L26 0.0337892
DPH6 diphthamine biosynthesis 6 0.0336151
POTEF POTE ankyrin domain family, member F 0.0332677
CFAP299 cilia and flagella associated protein 299 0.0328408
DPYD dihydropyrimidine dehydrogenase 0.0328205
EFNA5 ephrin-A5 0.0320464
B2M beta-2-microglobulin 0.0315387
MT1E metallothionein 1E 0.0311755
HLA-B major histocompatibility complex, class I, B 0.0310209
PMP22 peripheral myelin protein 22 0.0308344
RUNX1 runt-related transcription factor 1 0.030067
S100A9 S100 calcium binding protein A9 0.0295067
VIM vimentin 0.0288577
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0288438
PFN1 profilin 1 0.0286217
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.0274
RPLP2 ribosomal protein, large, P2 0.0269761
EGR1 early growth response 1 0.0260505
RPS21 ribosomal protein S21 0.0257425
RPL37A ribosomal protein L37a 0.0253662
LPP LIM domain containing preferred translocation partner in lipoma 0.0251633
RPL31 ribosomal protein L31 0.0250079
FTL ferritin, light polypeptide 0.024858
ANKRD12 ankyrin repeat domain 12 0.0246423
PDE10A phosphodiesterase 10A 0.0240607
RPS8 ribosomal protein S8 0.023211
VEGFC vascular endothelial growth factor C 0.0228381
UBE2E3 ubiquitin-conjugating enzyme E2E 3 0.0226989
IFITM1 interferon induced transmembrane protein 1 0.022696
RPS3 ribosomal protein S3 0.0221813
RPS4X ribosomal protein S4, X-linked 0.0219905
RPS17 ribosomal protein S17 0.0218356
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0217227
CTSC cathepsin C 0.0216988
RPL9 ribosomal protein L9 0.0213365
RPL34 ribosomal protein L34 0.0211456
RPS24 ribosomal protein S24 0.0208262
NPAS2 neuronal PAS domain protein 2 0.0206356
SMYD3 SET and MYND domain containing 3 0.020591
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0198741
RPLP1 ribosomal protein, large, P1 0.0195467
THSD4 thrombospondin, type I, domain containing 4 0.019039
RPL27 ribosomal protein L27 0.0189287
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0188673
PTK2 protein tyrosine kinase 2 0.0184538
EXOC4 exocyst complex component 4 0.0181933
TPI1 triosephosphate isomerase 1 0.0181063
RPL36A ribosomal protein L36a 0.0180719
RPL28 ribosomal protein L28 0.0178958
CUBN cubilin (intrinsic factor-cobalamin receptor) 0.0178017
RPL18 ribosomal protein L18 0.017644
PABPN1 poly(A) binding protein, nuclear 1 0.0174915
WDR27 WD repeat domain 27 0.0174442
NCEH1 neutral cholesterol ester hydrolase 1 0.0174037
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0172529
CCDC190 coiled-coil domain containing 190 0.0171725
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 0.0168846
AREG amphiregulin 0.0168325
RABGAP1L RAB GTPase activating protein 1-like 0.0166936
RPS13 ribosomal protein S13 0.0164524
CSMD3 CUB and Sushi multiple domains 3 0.016444
ANTXR2 anthrax toxin receptor 2 0.0162014
PRELID2 PRELI domain containing 2 0.0161794
IER2 immediate early response 2 0.0160505
DNER delta/notch-like EGF repeat containing 0.016048
SP100 SP100 nuclear antigen 0.0160309
IFITM3 interferon induced transmembrane protein 3 0.0159899
INTS6 integrator complex subunit 6 0.0158146
S100A6 S100 calcium binding protein A6 0.0157038
RACK1 receptor for activated C kinase 1 0.0156319
HELZ2 helicase with zinc finger 2, transcriptional coactivator 0.0156108
SDCCAG8 serologically defined colon cancer antigen 8 0.0154295
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0154167
TPRG1 tumor protein p63 regulated 1 0.0153304
ENO2 enolase 2 (gamma, neuronal) 0.015126
CEP128 centrosomal protein 128kDa 0.0149079
PRKN parkin RBR E3 ubiquitin protein ligase 0.0149009

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.216518
ERRFI1 ERBB receptor feedback inhibitor 1 -0.185159
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.184466
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.131141
TXNRD1 thioredoxin reductase 1 -0.111426
SPAG9 sperm associated antigen 9 -0.0972327
EZR ezrin -0.0860536
CANX calnexin -0.080874
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0762935
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0733166
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0671706
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.064676
KMT2E lysine (K)-specific methyltransferase 2E -0.0616648
USP34 ubiquitin specific peptidase 34 -0.0604966
NAMPT nicotinamide phosphoribosyltransferase -0.0563237
MKI67 marker of proliferation Ki-67 -0.0547633
CENPF centromere protein F, 350/400kDa -0.053927
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0523204
MACF1 microtubule-actin crosslinking factor 1 -0.0522154
RAI1 retinoic acid induced 1 -0.0516268
ARHGAP5 Rho GTPase activating protein 5 -0.0486791
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0480577
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.047188
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0470321
GARS1 glycyl-tRNA synthetase 1 -0.0447735
AHNAK AHNAK nucleoprotein -0.0442569
EMP1 epithelial membrane protein 1 -0.0437073
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0425654
RTN4 reticulon 4 -0.0424402
RPS6 ribosomal protein S6 -0.0419302
TM4SF1 transmembrane 4 L six family member 1 -0.0406498
ANXA1 annexin A1 -0.0405001
SET SET nuclear proto-oncogene -0.0401112
ZNF217 zinc finger protein 217 -0.0396356
BIRC6 baculoviral IAP repeat containing 6 -0.0393771
KDM3A lysine (K)-specific demethylase 3A -0.0383115
CLTC clathrin, heavy chain (Hc) -0.0378513
HSPA8 heat shock 70kDa protein 8 -0.0378033
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0371855
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0371454
OGA O-GlcNAcase -0.0368695
MATR3 matrin 3 -0.0366094
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0366061
HOOK2 hook microtubule-tethering protein 2 -0.0363268
NUP58 nucleoporin 58 -0.0363216
UBC ubiquitin C -0.0361874
LOC112694756 uncharaterized LOC112694756 -0.0360845
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0354414
WNK1 WNK lysine deficient protein kinase 1 -0.0352565
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.035078
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0350338
APP amyloid beta (A4) precursor protein -0.0345257
WDR45B WD repeat domain 45B -0.0341706
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0340545
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0340534
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0337888
TMSB4X thymosin beta 4, X-linked -0.0334375
EIF1 eukaryotic translation initiation factor 1 -0.0332286
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0328042
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0327875
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0322715
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0322138
IPO7 importin 7 -0.0321124
EIF3A eukaryotic translation initiation factor 3, subunit A -0.031757
AFF4 AF4/FMR2 family, member 4 -0.031443
CKAP5 cytoskeleton associated protein 5 -0.0312297
JMJD1C jumonji domain containing 1C -0.0311552
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0310898
CEP170 centrosomal protein 170kDa -0.0308596
EEF2 eukaryotic translation elongation factor 2 -0.0300456
WDR26 WD repeat domain 26 -0.0300078
SPTAN1 spectrin, alpha, non-erythrocytic 1 -0.0292287
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0291259
PGK1 phosphoglycerate kinase 1 -0.0291099
ANLN anillin, actin binding protein -0.028853
KMT2C lysine (K)-specific methyltransferase 2C -0.0286186
MORF4L2 mortality factor 4 like 2 -0.0284919
ZEB1 zinc finger E-box binding homeobox 1 -0.0283898
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0283424
ADAR adenosine deaminase, RNA-specific -0.0282541
SRSF4 serine/arginine-rich splicing factor 4 -0.0276575
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.027608
MYH9 myosin, heavy chain 9, non-muscle -0.0275433
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0274373
SRRM2 serine/arginine repetitive matrix 2 -0.0273045
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0272994
NCOR1 nuclear receptor corepressor 1 -0.027287
RLF rearranged L-myc fusion -0.0272823
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0271276
SEPTIN7 septin 7 -0.0271191
PDIA6 protein disulfide isomerase family A, member 6 -0.0268013
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0266314
ADAM17 ADAM metallopeptidase domain 17 -0.0260439
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0260375
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0260077
MAP4 microtubule-associated protein 4 -0.0259221
DST dystonin -0.0259173
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0258723
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.025846
RBM39 RNA binding motif protein 39 -0.0256083