| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Almonertinib (hydrochloride) perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Almonertinib (hydrochloride)_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.138529 |
| MT2A | metallothionein 2A | 0.135926 |
| NSUN6 | NOP2/Sun domain family, member 6 | 0.0902913 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0732636 |
| RPS12 | ribosomal protein S12 | 0.0698007 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0672941 |
| RPS3 | ribosomal protein S3 | 0.0661163 |
| NDRG1 | N-myc downstream regulated 1 | 0.061038 |
| SEC61G | Sec61 gamma subunit | 0.0588008 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0536314 |
| RPL35A | ribosomal protein L35a | 0.0467716 |
| FTL | ferritin, light polypeptide | 0.0433319 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0427926 |
| RPL37A | ribosomal protein L37a | 0.0377379 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.0370569 |
| S100P | S100 calcium binding protein P | 0.036048 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0359669 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0351696 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0343942 |
| EFNA5 | ephrin-A5 | 0.033896 |
| MKNK2 | MAP kinase interacting serine/threonine kinase 2 | 0.0336291 |
| AREG | amphiregulin | 0.0333819 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0330438 |
| B2M | beta-2-microglobulin | 0.0327746 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0319995 |
| MCL1 | myeloid cell leukemia 1 | 0.0314428 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0306301 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0303648 |
| MT1X | metallothionein 1X | 0.0279244 |
| YBX3 | Y box binding protein 3 | 0.0276397 |
| SLTM | SAFB-like, transcription modulator | 0.0275227 |
| RPS19 | ribosomal protein S19 | 0.0274162 |
| RPL36 | ribosomal protein L36 | 0.0271394 |
| DCUN1D3 | DCN1, defective in cullin neddylation 1, domain containing 3 | 0.026762 |
| ST14 | suppression of tumorigenicity 14 (colon carcinoma) | 0.0265748 |
| CIB1 | calcium and integrin binding 1 (calmyrin) | 0.0259644 |
| CLDN4 | claudin 4 | 0.0256217 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0254068 |
| SIK3 | SIK family kinase 3 | 0.0253189 |
| RPS8 | ribosomal protein S8 | 0.0245308 |
| RPL31 | ribosomal protein L31 | 0.023957 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0237416 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.023737 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.0230938 |
| RPS27 | ribosomal protein S27 | 0.0229314 |
| RPS17 | ribosomal protein S17 | 0.0226413 |
| VIM | vimentin | 0.0225793 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0219755 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 0.021187 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0210816 |
| RHOV | ras homolog family member V | 0.0209016 |
| RPS27A | ribosomal protein S27a | 0.0206666 |
| MYO1E | myosin IE | 0.0206101 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0204991 |
| ANGPTL4 | angiopoietin-like 4 | 0.0204757 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0204594 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0202453 |
| VMP1 | vacuole membrane protein 1 | 0.0199151 |
| LIPH | lipase, member H | 0.0196616 |
| RPL28 | ribosomal protein L28 | 0.0194222 |
| ADGRF1 | adhesion G protein-coupled receptor F1 | 0.0192357 |
| SRSF5 | serine/arginine-rich splicing factor 5 | 0.019006 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | 0.0189728 |
| RPL23 | ribosomal protein L23 | 0.0189128 |
| DUSP5 | dual specificity phosphatase 5 | 0.0186815 |
| EGR1 | early growth response 1 | 0.0186473 |
| BMP6 | bone morphogenetic protein 6 | 0.0184256 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0183367 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0181515 |
| IFI44L | interferon-induced protein 44-like | 0.0181001 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | 0.0180827 |
| IRS2 | insulin receptor substrate 2 | 0.0179358 |
| RPS2 | ribosomal protein S2 | 0.017796 |
| JMJD1C | jumonji domain containing 1C | 0.0176284 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.017557 |
| RPLP1 | ribosomal protein, large, P1 | 0.0175494 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0174743 |
| FOSL1 | FOS-like antigen 1 | 0.0173354 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | 0.0172359 |
| RPL12 | ribosomal protein L12 | 0.0172069 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0171318 |
| RPLP2 | ribosomal protein, large, P2 | 0.016794 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0167253 |
| FZR1 | fizzy/cell division cycle 20 related 1 (Drosophila) | 0.0163961 |
| MSN | moesin | 0.0160032 |
| HLA-A | major histocompatibility complex, class I, A | 0.0155741 |
| ATF4 | activating transcription factor 4 | 0.0154377 |
| ARGLU1 | arginine and glutamate rich 1 | 0.0154185 |
| RPS7 | ribosomal protein S7 | 0.0151758 |
| BCL9L | B-cell CLL/lymphoma 9-like | 0.014978 |
| ATP11A | ATPase, class VI, type 11A | 0.0149422 |
| FRY | furry homolog (Drosophila) | 0.0147929 |
| ITGB5 | integrin, beta 5 | 0.0147887 |
| ATP5F1E | ATP synthase F1 subunit epsilon | 0.0147461 |
| RPS13 | ribosomal protein S13 | 0.014715 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0146765 |
| FAAH2 | fatty acid amide hydrolase 2 | 0.0143635 |
| KYNU | kynureninase | 0.0143328 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0141593 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0140916 |
| Symbol | Name | Standardized Value |
|---|---|---|
| EGFR | epidermal growth factor receptor | -0.214744 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.173405 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.149283 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.115023 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.108869 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.107215 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.103538 |
| TXNRD1 | thioredoxin reductase 1 | -0.0987986 |
| S100A10 | S100 calcium binding protein A10 | -0.0837548 |
| ACTG1 | actin gamma 1 | -0.082579 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0776375 |
| ANXA2 | annexin A2 | -0.0730634 |
| PKM | pyruvate kinase, muscle | -0.0718138 |
| AHNAK | AHNAK nucleoprotein | -0.0715198 |
| HDLBP | high density lipoprotein binding protein | -0.0674098 |
| CANX | calnexin | -0.0656707 |
| CCND1 | cyclin D1 | -0.0638644 |
| KRT7 | keratin 7, type II | -0.0634686 |
| H1-0 | H1.0 linker histone | -0.0615354 |
| ASPH | aspartate beta-hydroxylase | -0.05515 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0547962 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0532343 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0523621 |
| DSPP | dentin sialophosphoprotein | -0.0523186 |
| SCEL | sciellin | -0.0521006 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0520319 |
| KRT18 | keratin 18, type I | -0.0510662 |
| TES | testin LIM domain protein | -0.0508079 |
| TMSB10 | thymosin beta 10 | -0.0491597 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0479701 |
| LAMC2 | laminin, gamma 2 | -0.0465562 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0462251 |
| USP34 | ubiquitin specific peptidase 34 | -0.0457923 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0447936 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.043219 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0430247 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | -0.0421737 |
| ENO1 | enolase 1, (alpha) | -0.0417344 |
| LDHA | lactate dehydrogenase A | -0.0415215 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.041407 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0411953 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0403689 |
| ZC3H11A | zinc finger CCCH-type containing 11A | -0.0399897 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0382615 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0377636 |
| KRT8 | keratin 8, type II | -0.0356383 |
| INTS6 | integrator complex subunit 6 | -0.0352721 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0346979 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0340578 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0330578 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0327694 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0326727 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0323172 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0317519 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0314128 |
| AGR2 | anterior gradient 2 | -0.0303762 |
| ANKRD17 | ankyrin repeat domain 17 | -0.030362 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0301409 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | -0.0300783 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0297211 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0294616 |
| FAM13A | family with sequence similarity 13, member A | -0.0289676 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0288984 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0288661 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0288263 |
| MYOF | myoferlin | -0.0287417 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0284691 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0284634 |
| PGK1 | phosphoglycerate kinase 1 | -0.0284006 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0282174 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0281449 |
| TPD52 | tumor protein D52 | -0.0276622 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0274066 |
| GNAS | GNAS complex locus | -0.0271522 |
| GOLGB1 | golgin B1 | -0.0269897 |
| PTMA | prothymosin, alpha | -0.0268704 |
| MYO1D | myosin ID | -0.0268008 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0266558 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.026491 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0264831 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0262478 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0259388 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0257374 |
| ABLIM1 | actin binding LIM protein 1 | -0.0256101 |
| SPIRE1 | spire-type actin nucleation factor 1 | -0.0254577 |
| SUCO | SUN domain containing ossification factor | -0.0251439 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0250356 |
| TAOK1 | TAO kinase 1 | -0.0250306 |
| FNIP1 | folliculin interacting protein 1 | -0.0248816 |
| N4BP2 | NEDD4 binding protein 2 | -0.0247261 |
| PDE8A | phosphodiesterase 8A | -0.0246883 |
| GRAMD1B | GRAM domain containing 1B | -0.0246873 |
| MORF4L2 | mortality factor 4 like 2 | -0.0246361 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0246043 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0245307 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0244885 |
| FUS | FUS RNA binding protein | -0.0244472 |
| ARF1 | ADP-ribosylation factor 1 | -0.024291 |
| UBC | ubiquitin C | -0.0242904 |
| EMP1 | epithelial membrane protein 1 | -0.0242249 |
