Almonertinib (hydrochloride)_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Almonertinib (hydrochloride) perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Almonertinib (hydrochloride)_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 0.166504
TPT1 tumor protein, translationally-controlled 1 0.0849281
NDRG1 N-myc downstream regulated 1 0.0840695
MT2A metallothionein 2A 0.075974
FTL ferritin, light polypeptide 0.0715591
RPL35A ribosomal protein L35a 0.0714361
AKAP12 A kinase (PRKA) anchor protein 12 0.0680045
ENO1 enolase 1, (alpha) 0.0663233
B2M beta-2-microglobulin 0.0662651
PTMA prothymosin, alpha 0.0609294
RPS12 ribosomal protein S12 0.060304
SYT1 synaptotagmin I 0.0584043
RPS19 ribosomal protein S19 0.0551239
STC1 stanniocalcin 1 0.0544053
VIM vimentin 0.0512749
IGFBP3 insulin-like growth factor binding protein 3 0.05074
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0501578
RPS8 ribosomal protein S8 0.0457304
EIF1 eukaryotic translation initiation factor 1 0.0422116
WSB1 WD repeat and SOCS box containing 1 0.0420051
TIMP1 TIMP metallopeptidase inhibitor 1 0.0419341
S100A6 S100 calcium binding protein A6 0.0418781
PDE4D phosphodiesterase 4D, cAMP-specific 0.0415709
NAP1L1 nucleosome assembly protein 1-like 1 0.0410286
HMGA2 high mobility group AT-hook 2 0.0410079
ANGPTL4 angiopoietin-like 4 0.041
NTN4 netrin 4 0.0404662
ZFP36L1 ZFP36 ring finger protein-like 1 0.039311
RPL12 ribosomal protein L12 0.0391065
PGK1 phosphoglycerate kinase 1 0.0386113
IFI6 interferon, alpha-inducible protein 6 0.036891
RPL34 ribosomal protein L34 0.0366505
RPS3 ribosomal protein S3 0.0350168
RPL37A ribosomal protein L37a 0.034884
RPLP2 ribosomal protein, large, P2 0.0346725
HLA-B major histocompatibility complex, class I, B 0.0343265
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0340339
PTPRF protein tyrosine phosphatase, receptor type, F 0.0339088
RPL36 ribosomal protein L36 0.0335521
HLA-A major histocompatibility complex, class I, A 0.0335215
ALCAM activated leukocyte cell adhesion molecule 0.0333471
SEC61G Sec61 gamma subunit 0.0298208
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0297063
RPS21 ribosomal protein S21 0.0295354
GARS1 glycyl-tRNA synthetase 1 0.0293808
RPL18 ribosomal protein L18 0.0286371
DUSP6 dual specificity phosphatase 6 0.0285992
DDIT3 DNA-damage-inducible transcript 3 0.0285177
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.028332
TGFB1 transforming growth factor, beta 1 0.0280799
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.027392
PSD3 pleckstrin and Sec7 domain containing 3 0.0267792
RPL30 ribosomal protein L30 0.0265919
PRSS23 protease, serine, 23 0.0263093
ATF4 activating transcription factor 4 0.0259407
LRRC49 leucine rich repeat containing 49 0.0258297
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.025756
FN1 fibronectin 1 0.0256724
PTPRK protein tyrosine phosphatase, receptor type, K 0.0256063
CALR calreticulin 0.0255951
MAP1B microtubule-associated protein 1B 0.0251001
CSDE1 cold shock domain containing E1, RNA-binding 0.0249821
RPS29 ribosomal protein S29 0.0243689
RPS24 ribosomal protein S24 0.0242837
EIF3B eukaryotic translation initiation factor 3, subunit B 0.0242136
RPS13 ribosomal protein S13 0.0240645
MYO9A myosin IXA 0.0236866
ZBTB7A zinc finger and BTB domain containing 7A 0.0236532
SOX4 SRY (sex determining region Y)-box 4 0.0236384
MAML3 mastermind-like 3 (Drosophila) 0.0235294
RPL9 ribosomal protein L9 0.0232978
MACF1 microtubule-actin crosslinking factor 1 0.0231785
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0229665
TIMP3 TIMP metallopeptidase inhibitor 3 0.0229267
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0227977
RPS16 ribosomal protein S16 0.0227963
ASPH aspartate beta-hydroxylase 0.0225309
RPLP0 ribosomal protein, large, P0 0.0221699
KLF5 Kruppel-like factor 5 (intestinal) 0.0220667
PLAUR plasminogen activator, urokinase receptor 0.0220107
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0217651
RPS17 ribosomal protein S17 0.021607
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0214388
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.0213538
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0209515
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0209008
LIMCH1 LIM and calponin homology domains 1 0.0208436
COL7A1 collagen, type VII, alpha 1 0.020769
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 0.0206566
RASAL2 RAS protein activator like 2 0.0206298
IARS1 isoleucyl-tRNA synthetase 1 0.0205454
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0205105
CAVIN1 caveolae associated protein 1 0.0204837
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0204545
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0203345
SLC38A2 solute carrier family 38, member 2 0.0203207
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.020059
HPCAL1 hippocalcin-like 1 0.0200491
RPL5 ribosomal protein L5 0.0200165
RPL36AL ribosomal protein L36a-like 0.0200137

decreased expression

Symbol Name Standardized Value
FNDC3B fibronectin type III domain containing 3B -0.141716
NAMPT nicotinamide phosphoribosyltransferase -0.124703
CXCL8 chemokine (C-X-C motif) ligand 8 -0.117819
SDK1 sidekick cell adhesion molecule 1 -0.108408
SOD2 superoxide dismutase 2, mitochondrial -0.0975792
ELL2 elongation factor, RNA polymerase II, 2 -0.0921673
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0902733
KDM2A lysine (K)-specific demethylase 2A -0.0846413
RICTOR RPTOR independent companion of MTOR, complex 2 -0.081477
GRB10 growth factor receptor-bound protein 10 -0.0800033
OSMR oncostatin M receptor -0.0783868
USP34 ubiquitin specific peptidase 34 -0.0726201
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0690105
CD44 CD44 molecule (Indian blood group) -0.0673725
SMAD3 SMAD family member 3 -0.0619025
DOCK5 dedicator of cytokinesis 5 -0.0505247
SEC31A SEC31 homolog A (S. cerevisiae) -0.0494432
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0478211
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0473703
RAB1A RAB1A, member RAS oncogene family -0.0473386
NRG1 neuregulin 1 -0.0452223
EFNA5 ephrin-A5 -0.0449185
CDH13 cadherin 13 -0.0447708
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0446656
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0444629
FTH1 ferritin, heavy polypeptide 1 -0.04264
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0424567
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0412225
NAV2 neuron navigator 2 -0.0411129
TRIO trio Rho guanine nucleotide exchange factor -0.0390364
SNX9 sorting nexin 9 -0.0389553
RAP1B RAP1B, member of RAS oncogene family -0.0377417
KYNU kynureninase -0.0373094
TMEM165 transmembrane protein 165 -0.0368088
MYO1E myosin IE -0.0367409
RUNX1 runt-related transcription factor 1 -0.0363887
FRMD4A FERM domain containing 4A -0.0351113
GLCCI1 glucocorticoid induced 1 -0.0349786
SPAG9 sperm associated antigen 9 -0.0347261
IQGAP1 IQ motif containing GTPase activating protein 1 -0.034697
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0346408
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0343872
RBM39 RNA binding motif protein 39 -0.0335489
BMAL2 basic helix-loop-helix ARNT like 2 -0.0327135
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0326276
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0322882
RND3 Rho family GTPase 3 -0.0321257
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 -0.0312468
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0311606
RARB retinoic acid receptor, beta -0.0311386
PTK2 protein tyrosine kinase 2 -0.0311021
NCOA7 nuclear receptor coactivator 7 -0.0307082
PDIA3 protein disulfide isomerase family A, member 3 -0.0304965
NUMB numb homolog (Drosophila) -0.030281
VRK2 vaccinia related kinase 2 -0.0296876
SREBF2 sterol regulatory element binding transcription factor 2 -0.0289873
KMT2E lysine (K)-specific methyltransferase 2E -0.0289583
NPC1 Niemann-Pick disease, type C1 -0.0285733
TAS2R14 taste receptor, type 2, member 14 -0.0283406
CTNNBL1 catenin, beta like 1 -0.0277837
DAAM1 dishevelled associated activator of morphogenesis 1 -0.0277627
PDK3 pyruvate dehydrogenase kinase, isozyme 3 -0.0277512
HELZ helicase with zinc finger -0.0277022
ANKRD28 ankyrin repeat domain 28 -0.0276327
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0274191
DTNA dystrobrevin, alpha -0.0272469
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0271928
PCNX1 pecanex 1 -0.0270921
ADD3 adducin 3 (gamma) -0.0269674
ZNF638 zinc finger protein 638 -0.0266628
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0265212
NRP1 neuropilin 1 -0.0263177
TNNC1 troponin C type 1 (slow) -0.0261756
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0260672
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0259743
EGR1 early growth response 1 -0.0259449
SBF2 SET binding factor 2 -0.0259287
AOPEP aminopeptidase O (putative) -0.0259078
DPYSL3 dihydropyrimidinase-like 3 -0.0256388
ZC3H12C zinc finger CCCH-type containing 12C -0.0254816
NGLY1 N-glycanase 1 -0.0254568
ZBTB20 zinc finger and BTB domain containing 20 -0.0254227
PDE8A phosphodiesterase 8A -0.0253186
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0251367
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0247036
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0246272
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0243798
PELI1 pellino E3 ubiquitin protein ligase 1 -0.0242802
MAPK8 mitogen-activated protein kinase 8 -0.0231724
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 -0.0228133
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0227815
MARCHF3 membrane associated ring-CH-type finger 3 -0.0226155
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0225059
AHR aryl hydrocarbon receptor -0.0223698
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) -0.0223363
PIAS2 protein inhibitor of activated STAT, 2 -0.0223197
PHIP pleckstrin homology domain interacting protein -0.0222423
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0220327
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0219329
ADAM17 ADAM metallopeptidase domain 17 -0.0217185