| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Almonertinib (hydrochloride) perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Almonertinib (hydrochloride)_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | 0.124094 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.116548 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0832244 |
| ASPH | aspartate beta-hydroxylase | 0.0690683 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.060099 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0562814 |
| LDHA | lactate dehydrogenase A | 0.0540922 |
| MCL1 | myeloid cell leukemia 1 | 0.0540171 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.0499873 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.049094 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0475889 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0474341 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0429827 |
| NDRG1 | N-myc downstream regulated 1 | 0.0407895 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0401301 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0399882 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.039306 |
| FGB | fibrinogen beta chain | 0.0390712 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0387401 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.0384065 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0381325 |
| RPS12 | ribosomal protein S12 | 0.037069 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0369401 |
| RPL35A | ribosomal protein L35a | 0.0358532 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0345078 |
| IGF2 | insulin-like growth factor 2 | 0.0340746 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.033499 |
| INTS6 | integrator complex subunit 6 | 0.0331119 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0328274 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0326156 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0325832 |
| CAVIN1 | caveolae associated protein 1 | 0.0321788 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0319598 |
| B2M | beta-2-microglobulin | 0.0313301 |
| YBX1 | Y box binding protein 1 | 0.0308392 |
| IFRD1 | interferon-related developmental regulator 1 | 0.0303856 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0298636 |
| FMNL2 | formin-like 2 | 0.0297572 |
| BRD2 | bromodomain containing 2 | 0.0290078 |
| CALR | calreticulin | 0.0288648 |
| TPI1 | triosephosphate isomerase 1 | 0.0286943 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0286887 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0286332 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0286243 |
| HLA-A | major histocompatibility complex, class I, A | 0.0282849 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.027909 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0278826 |
| ANXA1 | annexin A1 | 0.0272723 |
| PAPOLA | poly(A) polymerase alpha | 0.0272667 |
| LMNA | lamin A/C | 0.027018 |
| RPS8 | ribosomal protein S8 | 0.0266885 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0265816 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0259373 |
| PGK1 | phosphoglycerate kinase 1 | 0.0249337 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0245973 |
| TAGLN2 | transgelin 2 | 0.024224 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0241854 |
| ATF4 | activating transcription factor 4 | 0.0239915 |
| RPL37A | ribosomal protein L37a | 0.023947 |
| FGA | fibrinogen alpha chain | 0.0239092 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0235628 |
| ASXL1 | additional sex combs like transcriptional regulator 1 | 0.0233049 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0232348 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0231425 |
| RPL26 | ribosomal protein L26 | 0.0229971 |
| TARS1 | threonyl-tRNA synthetase 1 | 0.0225499 |
| RPS2 | ribosomal protein S2 | 0.0224487 |
| MRTFA | myocardin related transcription factor A | 0.0223107 |
| RPL23 | ribosomal protein L23 | 0.0221982 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0221974 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0220771 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0219981 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0212801 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.0211902 |
| EZR | ezrin | 0.0211348 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0210857 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | 0.0210646 |
| CCL5 | chemokine (C-C motif) ligand 5 | 0.0209675 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.020877 |
| ENO1 | enolase 1, (alpha) | 0.020827 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | 0.0207841 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0207299 |
| ANXA2 | annexin A2 | 0.0203725 |
| GNAS | GNAS complex locus | 0.0203538 |
| PRELID2 | PRELI domain containing 2 | 0.0203215 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | 0.0202934 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | 0.0202197 |
| RBM39 | RNA binding motif protein 39 | 0.0201424 |
| RPS7 | ribosomal protein S7 | 0.0200017 |
| MT1X | metallothionein 1X | 0.0199449 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0199438 |
| USP3 | ubiquitin specific peptidase 3 | 0.0199148 |
| CLU | clusterin | 0.0198872 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0197941 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0195982 |
| TPR | translocated promoter region, nuclear basket protein | 0.0193227 |
| CTBP2 | C-terminal binding protein 2 | 0.0192881 |
| FTL | ferritin, light polypeptide | 0.0192501 |
| EIF4A3 | eukaryotic translation initiation factor 4A3 | 0.0191707 |
| AHR | aryl hydrocarbon receptor | 0.0189893 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.24242 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.110825 |
| TXNRD1 | thioredoxin reductase 1 | -0.0597387 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0572524 |
| GRAMD1B | GRAM domain containing 1B | -0.0536487 |
| OSMR | oncostatin M receptor | -0.0524712 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0524013 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0520296 |
| VIM | vimentin | -0.0505085 |
| EGFR | epidermal growth factor receptor | -0.0452404 |
| NRG1 | neuregulin 1 | -0.040119 |
| BICC1 | BicC family RNA binding protein 1 | -0.0397335 |
| RPLP1 | ribosomal protein, large, P1 | -0.0396384 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0386973 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0384444 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0383635 |
| SVIL | supervillin | -0.036287 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0359974 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0352267 |
| NAV3 | neuron navigator 3 | -0.0337425 |
| FGD6 | FYVE, RhoGEF and PH domain containing 6 | -0.0321661 |
| TPM4 | tropomyosin 4 | -0.0311061 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0310585 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0306129 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0294774 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0292313 |
| CMIP | c-Maf inducing protein | -0.0290352 |
| DST | dystonin | -0.0289671 |
| AREG | amphiregulin | -0.0279631 |
| PYGL | phosphorylase, glycogen, liver | -0.0272721 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0267076 |
| AK1 | adenylate kinase 1 | -0.0262346 |
| RPS29 | ribosomal protein S29 | -0.0260987 |
| ATXN3 | ataxin 3 | -0.0254657 |
| NEBL | nebulette | -0.0249435 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0243827 |
| CDCP1 | CUB domain containing protein 1 | -0.0237258 |
| PCNX1 | pecanex 1 | -0.0230045 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0229226 |
| RAD51B | RAD51 paralog B | -0.0223338 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | -0.0218408 |
| SRSF4 | serine/arginine-rich splicing factor 4 | -0.0211777 |
| CFDP1 | craniofacial development protein 1 | -0.02114 |
| SSH1 | slingshot protein phosphatase 1 | -0.0210819 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0210647 |
| RPS23 | ribosomal protein S23 | -0.0210519 |
| RFWD3 | ring finger and WD repeat domain 3 | -0.020694 |
| ITGB5 | integrin, beta 5 | -0.0203571 |
| ERBIN | erbb2 interacting protein | -0.0202013 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | -0.0200542 |
| EVA1C | eva-1 homolog C (C. elegans) | -0.0199817 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0199222 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | -0.0199062 |
| RPS15 | ribosomal protein S15 | -0.019858 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0198166 |
| ACTG1 | actin gamma 1 | -0.0194497 |
| SHTN1 | shootin 1 | -0.0193659 |
| SPIRE1 | spire-type actin nucleation factor 1 | -0.0191678 |
| DSE | dermatan sulfate epimerase | -0.0190553 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0190028 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0189712 |
| LANCL1 | LanC lantibiotic synthetase component C-like 1 (bacterial) | -0.0187798 |
| ATG7 | autophagy related 7 | -0.01801 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0179761 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0179463 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0178913 |
| PCED1B | PC-esterase domain containing 1B | -0.0175551 |
| RPL8 | ribosomal protein L8 | -0.0175008 |
| SOS2 | son of sevenless homolog 2 (Drosophila) | -0.0172799 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0172756 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0169439 |
| TRMT112 | tRNA methyltransferase 11-2 homolog (S. cerevisiae) | -0.0168661 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -0.0167583 |
| TMED10 | transmembrane emp24-like trafficking protein 10 (yeast) | -0.0167056 |
| PLS3 | plastin 3 | -0.0166523 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0164578 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0163477 |
| ATXN10 | ataxin 10 | -0.0163433 |
| ZNF609 | zinc finger protein 609 | -0.0163081 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.0163036 |
| GLIS3 | GLIS family zinc finger 3 | -0.016269 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | -0.0162666 |
| NTN4 | netrin 4 | -0.016239 |
| BMP5 | bone morphogenetic protein 5 | -0.0161238 |
| EIF2AK3 | eukaryotic translation initiation factor 2-alpha kinase 3 | -0.0160252 |
| SBF2 | SET binding factor 2 | -0.0159567 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -0.0158825 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.01581 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0157858 |
| EPC1 | enhancer of polycomb homolog 1 (Drosophila) | -0.0157241 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | -0.0156241 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0156099 |
| NF1 | neurofibromin 1 | -0.0155392 |
| RPL19 | ribosomal protein L19 | -0.0155094 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0155001 |
| SNU13 | small nuclear ribonucleoprotein 13 | -0.015476 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0153835 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0153714 |
| HIBADH | 3-hydroxyisobutyrate dehydrogenase | -0.0151156 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0150812 |
