| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Almonertinib (hydrochloride) perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Almonertinib (hydrochloride)_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.109828 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0901829 |
| VIM | vimentin | 0.0864875 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.0837075 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.079179 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.074894 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0705864 |
| OASL | 2'-5'-oligoadenylate synthetase-like | 0.070549 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0672746 |
| PDE10A | phosphodiesterase 10A | 0.0653961 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.0640877 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0618262 |
| MYO1E | myosin IE | 0.0603663 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0599415 |
| ZNF292 | zinc finger protein 292 | 0.0515975 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0512112 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0497149 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0488913 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0482904 |
| SRPK2 | SRSF protein kinase 2 | 0.0465899 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0457778 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.0456452 |
| AGO3 | argonaute RISC catalytic component 3 | 0.0452112 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0447666 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0442259 |
| MT2A | metallothionein 2A | 0.0435842 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.0422065 |
| RPLP1 | ribosomal protein, large, P1 | 0.0420163 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0410602 |
| PTK2 | protein tyrosine kinase 2 | 0.0394486 |
| STK17A | serine/threonine kinase 17a | 0.0381621 |
| B2M | beta-2-microglobulin | 0.0381216 |
| INSIG1 | insulin induced gene 1 | 0.0378826 |
| RTN4 | reticulon 4 | 0.0375938 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0375083 |
| RPS19 | ribosomal protein S19 | 0.0369209 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0364136 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0358306 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0350888 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0349455 |
| GOLGA4 | golgin A4 | 0.0348476 |
| CD44 | CD44 molecule (Indian blood group) | 0.0347468 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0346552 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0343019 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0341547 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0337545 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.0330253 |
| WAPL | WAPL cohesin release factor | 0.0328464 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0326219 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0324769 |
| LMAN1 | lectin, mannose-binding, 1 | 0.0324531 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0321923 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.032059 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.031879 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0313759 |
| PLK2 | polo-like kinase 2 | 0.0306309 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0305738 |
| STAU1 | staufen double-stranded RNA binding protein 1 | 0.0303292 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0299715 |
| GPC6 | glypican 6 | 0.0297064 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.029571 |
| RIGI | RNA sensor RIG-I | 0.0295632 |
| RPS6 | ribosomal protein S6 | 0.02948 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0294306 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0291432 |
| MXD1 | MAX dimerization protein 1 | 0.0286127 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0284505 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0282893 |
| RLF | rearranged L-myc fusion | 0.0280982 |
| KRT17 | keratin 17, type I | 0.027771 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0277014 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0276641 |
| KIF5B | kinesin family member 5B | 0.0274766 |
| USP33 | ubiquitin specific peptidase 33 | 0.0271951 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | 0.0269249 |
| TMSB10 | thymosin beta 10 | 0.0269166 |
| PGK1 | phosphoglycerate kinase 1 | 0.0267806 |
| CARD16 | caspase recruitment domain family, member 16 | 0.026724 |
| CALR | calreticulin | 0.0267163 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0264878 |
| MCL1 | myeloid cell leukemia 1 | 0.0264172 |
| RPS12 | ribosomal protein S12 | 0.0262158 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0260076 |
| H3-3B | H3.3 histone B | 0.0259409 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0259257 |
| NCOR1 | nuclear receptor corepressor 1 | 0.0258991 |
| AK1 | adenylate kinase 1 | 0.0257042 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0255842 |
| NCKAP1 | NCK-associated protein 1 | 0.0255822 |
| LSM14A | LSM14A, SCD6 homolog A (S. cerevisiae) | 0.0254125 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0251764 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0251504 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | 0.0249663 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0246145 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0245123 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 0.0244528 |
| COPB1 | coatomer protein complex, subunit beta 1 | 0.0244293 |
| PEAK1 | pseudopodium-enriched atypical kinase 1 | 0.0244199 |
| PIBF1 | progesterone immunomodulatory binding factor 1 | 0.024376 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0243104 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ATOSA | atos homolog A | -0.106493 |
| LMO7 | LIM domain 7 | -0.0900548 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0811451 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0752124 |
| LAMB3 | laminin, beta 3 | -0.0701654 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0605494 |
| KATNBL1 | katanin p80 subunit B-like 1 | -0.0559852 |
| PARD3 | par-3 family cell polarity regulator | -0.055617 |
| EZR | ezrin | -0.051961 |
| SQSTM1 | sequestosome 1 | -0.0511454 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.050189 |
| HMGA2 | high mobility group AT-hook 2 | -0.050119 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.047424 |
| MACC1 | metastasis associated in colon cancer 1 | -0.0438957 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.043583 |
| OGA | O-GlcNAcase | -0.0434407 |
| TJP1 | tight junction protein 1 | -0.0427451 |
| PPP2R2C | protein phosphatase 2, regulatory subunit B, gamma | -0.0412128 |
| ARHGAP12 | Rho GTPase activating protein 12 | -0.0412095 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | -0.0403263 |
| ABHD17C | abhydrolase domain containing 17C | -0.040088 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0397833 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | -0.037811 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | -0.0377468 |
| ANXA2 | annexin A2 | -0.0370053 |
| BPTF | bromodomain PHD finger transcription factor | -0.0369762 |
| IGF2 | insulin-like growth factor 2 | -0.0366441 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0361703 |
| TXNRD1 | thioredoxin reductase 1 | -0.0361699 |
| SVIL | supervillin | -0.0352863 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0351116 |
| MED13L | mediator complex subunit 13-like | -0.0350319 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0347652 |
| IGF1R | insulin-like growth factor 1 receptor | -0.034555 |
| CLMP | CXADR-like membrane protein | -0.0340568 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | -0.0339054 |
| MAN2A1 | mannosidase, alpha, class 2A, member 1 | -0.0335966 |
| PRKCA | protein kinase C, alpha | -0.0335867 |
| TXNIP | thioredoxin interacting protein | -0.0334389 |
| CUX1 | cut-like homeobox 1 | -0.0330845 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | -0.0327247 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0326747 |
| FOXP1 | forkhead box P1 | -0.032472 |
| FAM13A | family with sequence similarity 13, member A | -0.0323221 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | -0.0319884 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | -0.0319041 |
| MTUS1 | microtubule associated tumor suppressor 1 | -0.0318059 |
| TBL1X | transducin (beta)-like 1X-linked | -0.031794 |
| TNRC18 | trinucleotide repeat containing 18 | -0.0316977 |
| MUC16 | mucin 16, cell surface associated | -0.0315303 |
| AHNAK | AHNAK nucleoprotein | -0.03153 |
| USP34 | ubiquitin specific peptidase 34 | -0.0315194 |
| ETV6 | ets variant 6 | -0.0312023 |
| CCNI | cyclin I | -0.030303 |
| NCOR2 | nuclear receptor corepressor 2 | -0.0301713 |
| USP3 | ubiquitin specific peptidase 3 | -0.0297777 |
| ATXN1 | ataxin 1 | -0.0291845 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0291791 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | -0.0291505 |
| KRT7 | keratin 7, type II | -0.0289812 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0289765 |
| MYO5C | myosin VC | -0.028743 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.028374 |
| TULP4 | tubby like protein 4 | -0.0281977 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0279984 |
| NCOA2 | nuclear receptor coactivator 2 | -0.0278749 |
| ITGB4 | integrin, beta 4 | -0.0278292 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0277145 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0275918 |
| TPD52 | tumor protein D52 | -0.0274631 |
| ZC3H11A | zinc finger CCCH-type containing 11A | -0.0274578 |
| TCERG1 | transcription elongation regulator 1 | -0.0273539 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0273097 |
| SLC12A6 | solute carrier family 12 (potassium/chloride transporter), member 6 | -0.0271254 |
| RAB1A | RAB1A, member RAS oncogene family | -0.026891 |
| MTMR3 | myotubularin related protein 3 | -0.0267664 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.026738 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.026592 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | -0.0263679 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0262845 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.026273 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0261608 |
| ZNF609 | zinc finger protein 609 | -0.0261592 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0261278 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0259578 |
| ACTG1 | actin gamma 1 | -0.0259165 |
| SIK3 | SIK family kinase 3 | -0.0257938 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | -0.0255639 |
| TRPM7 | transient receptor potential cation channel, subfamily M, member 7 | -0.0255275 |
| ZFAND6 | zinc finger, AN1-type domain 6 | -0.0255148 |
| KIAA1217 | KIAA1217 | -0.0254922 |
| DAAM1 | dishevelled associated activator of morphogenesis 1 | -0.0253945 |
| RBM47 | RNA binding motif protein 47 | -0.0253577 |
| MEIS2 | Meis homeobox 2 | -0.0251906 |
| TJP2 | tight junction protein 2 | -0.0250681 |
| ERBIN | erbb2 interacting protein | -0.0249229 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | -0.0249068 |
| ABHD3 | abhydrolase domain containing 3 | -0.0244968 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0243697 |
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | -0.0243227 |
