| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Almonertinib (hydrochloride) perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Almonertinib (hydrochloride)_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.176878 |
| YBX3 | Y box binding protein 3 | 0.15378 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.074218 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0710753 |
| PFN1 | profilin 1 | 0.0640747 |
| POTEF | POTE ankyrin domain family, member F | 0.0636557 |
| TMSB10 | thymosin beta 10 | 0.0629596 |
| MT2A | metallothionein 2A | 0.0586312 |
| TPI1 | triosephosphate isomerase 1 | 0.0578463 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0556374 |
| EGR1 | early growth response 1 | 0.049563 |
| GRAMD1B | GRAM domain containing 1B | 0.0396501 |
| KLF6 | Kruppel-like factor 6 | 0.033804 |
| RPS19 | ribosomal protein S19 | 0.0315772 |
| CDK17 | cyclin-dependent kinase 17 | 0.0310391 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0304658 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | 0.0304068 |
| RPLP0 | ribosomal protein, large, P0 | 0.0288497 |
| ATP11A | ATPase, class VI, type 11A | 0.0287307 |
| KRT18 | keratin 18, type I | 0.027483 |
| VMP1 | vacuole membrane protein 1 | 0.0271433 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0266808 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0257223 |
| HMGA2 | high mobility group AT-hook 2 | 0.025451 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0254183 |
| RPS7 | ribosomal protein S7 | 0.0252771 |
| ATP5F1E | ATP synthase F1 subunit epsilon | 0.0251441 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0251403 |
| RPS17 | ribosomal protein S17 | 0.0240191 |
| RPL18 | ribosomal protein L18 | 0.0235493 |
| WWOX | WW domain containing oxidoreductase | 0.0235274 |
| RPS3 | ribosomal protein S3 | 0.0231478 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0229147 |
| GPX4 | glutathione peroxidase 4 | 0.0228721 |
| RPS21 | ribosomal protein S21 | 0.0227617 |
| RPS2 | ribosomal protein S2 | 0.0226907 |
| STC1 | stanniocalcin 1 | 0.0225895 |
| RPS12 | ribosomal protein S12 | 0.0224134 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0222911 |
| RPS4X | ribosomal protein S4, X-linked | 0.0222691 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0220038 |
| TPM2 | tropomyosin 2 (beta) | 0.0218889 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0218338 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0214087 |
| PRELID2 | PRELI domain containing 2 | 0.0213381 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0207247 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | 0.0200827 |
| RPS26 | ribosomal protein S26 | 0.020074 |
| IGF2 | insulin-like growth factor 2 | 0.0200484 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | 0.0199548 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0197274 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0196207 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0196075 |
| MT1X | metallothionein 1X | 0.0194558 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | 0.0193914 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | 0.0191556 |
| YBX1 | Y box binding protein 1 | 0.0186382 |
| SUPT16H | suppressor of Ty 16 homolog (S. cerevisiae) | 0.0181804 |
| HOMER1 | homer scaffolding protein 1 | 0.0178611 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0176416 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0174768 |
| RPL27 | ribosomal protein L27 | 0.0172426 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0172034 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0171578 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0170909 |
| RPL36 | ribosomal protein L36 | 0.0169935 |
| CHD4 | chromodomain helicase DNA binding protein 4 | 0.0169027 |
| PHC2 | polyhomeotic homolog 2 (Drosophila) | 0.0167813 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.01672 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0165782 |
| RPS14 | ribosomal protein S14 | 0.0165315 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | 0.0164889 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0164772 |
| PA2G4 | proliferation-associated 2G4, 38kDa | 0.0164332 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0163636 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0163502 |
| BRD4 | bromodomain containing 4 | 0.0161771 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0161031 |
| PTMS | parathymosin | 0.0159154 |
| CRY1 | cryptochrome circadian clock 1 | 0.0158546 |
| TCIM | transcriptional and immune response regulator | 0.0158518 |
| RPL35 | ribosomal protein L35 | 0.0156347 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0156252 |
| RPL35A | ribosomal protein L35a | 0.0156032 |
| CCT3 | chaperonin containing TCP1, subunit 3 (gamma) | 0.0155809 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.015497 |
| NSUN6 | NOP2/Sun domain family, member 6 | 0.0153962 |
| ID3 | inhibitor of DNA binding 3, dominant negative helix-loop-helix protein | 0.0153363 |
| SF3B6 | splicing factor 3b, subunit 6, 14kDa | 0.0151608 |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | 0.0151421 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.0150723 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0149832 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0149755 |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.0149496 |
| SVIL | supervillin | 0.0148941 |
| WDR43 | WD repeat domain 43 | 0.0147912 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.0145681 |
| MYL12B | myosin, light chain 12B, regulatory | 0.0140944 |
| SON | SON DNA binding protein | 0.0140039 |
| CALD1 | caldesmon 1 | 0.0138037 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.108672 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0857813 |
| UBC | ubiquitin C | -0.0800755 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0782685 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0685185 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0607983 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0522504 |
| RPS27A | ribosomal protein S27a | -0.0508506 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0501856 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0484586 |
| OGA | O-GlcNAcase | -0.045783 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0442504 |
| AHNAK | AHNAK nucleoprotein | -0.0424584 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0424551 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0377047 |
| PTMA | prothymosin, alpha | -0.0373891 |
| PHIP | pleckstrin homology domain interacting protein | -0.034956 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.03431 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0335337 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0335085 |
| RTN4 | reticulon 4 | -0.0317848 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0312292 |
| KMT2A | lysine (K)-specific methyltransferase 2A | -0.0299246 |
| ZNF638 | zinc finger protein 638 | -0.0298972 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0298819 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0296922 |
| GATAD2B | GATA zinc finger domain containing 2B | -0.0290783 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0288434 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0287302 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0280032 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0279882 |
| TXNRD1 | thioredoxin reductase 1 | -0.0277419 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0277039 |
| STK4 | serine/threonine kinase 4 | -0.0257581 |
| MAP4 | microtubule-associated protein 4 | -0.0254743 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0254326 |
| RPL37 | ribosomal protein L37 | -0.0253485 |
| ZFR | zinc finger RNA binding protein | -0.0253135 |
| TAOK1 | TAO kinase 1 | -0.0251542 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0250519 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0250092 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0248461 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.0247387 |
| WDR45B | WD repeat domain 45B | -0.024625 |
| XPO1 | exportin 1 | -0.0244503 |
| RPS29 | ribosomal protein S29 | -0.0244368 |
| RPS15 | ribosomal protein S15 | -0.0238376 |
| PLCB4 | phospholipase C, beta 4 | -0.0235693 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0233381 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0227151 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | -0.022467 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.022466 |
| SRP72 | signal recognition particle 72kDa | -0.0224562 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0224433 |
| RPL38 | ribosomal protein L38 | -0.0223605 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0222899 |
| NF1 | neurofibromin 1 | -0.0220294 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0215386 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | -0.0215103 |
| RSF1 | remodeling and spacing factor 1 | -0.0213994 |
| RNF169 | ring finger protein 169 | -0.0213712 |
| CDK12 | cyclin-dependent kinase 12 | -0.0212713 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -0.021178 |
| PGK1 | phosphoglycerate kinase 1 | -0.0208282 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.020786 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0206798 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0206752 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | -0.0206103 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.0206044 |
| CANX | calnexin | -0.0203478 |
| FBXO11 | F-box protein 11 | -0.0202462 |
| EPN2 | epsin 2 | -0.0199147 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0198845 |
| CCND1 | cyclin D1 | -0.0198338 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0197203 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0196445 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0196224 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0196203 |
| TRPM7 | transient receptor potential cation channel, subfamily M, member 7 | -0.0194151 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0193303 |
| ANXA2 | annexin A2 | -0.0192352 |
| SQSTM1 | sequestosome 1 | -0.0191981 |
| NABP1 | nucleic acid binding protein 1 | -0.0191894 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.0191156 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0190892 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.018966 |
| ATXN2 | ataxin 2 | -0.0189634 |
| WASF2 | WAS protein family, member 2 | -0.0188661 |
| TLK1 | tousled-like kinase 1 | -0.0187333 |
| GOLGA4 | golgin A4 | -0.0187296 |
| S100A10 | S100 calcium binding protein A10 | -0.018685 |
| HLA-E | major histocompatibility complex, class I, E | -0.0186786 |
| RPS13 | ribosomal protein S13 | -0.0185269 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0185267 |
| APP | amyloid beta (A4) precursor protein | -0.0184351 |
| VIM | vimentin | -0.0184142 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0183769 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | -0.0183672 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0181583 |
| CAVIN1 | caveolae associated protein 1 | -0.017987 |
