Almonertinib (hydrochloride)_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Almonertinib (hydrochloride) perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Almonertinib (hydrochloride)_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0832649
RPS12 ribosomal protein S12 0.0542703
S100A6 S100 calcium binding protein A6 0.0457995
ZFP36L1 ZFP36 ring finger protein-like 1 0.0435873
LAMB3 laminin, beta 3 0.0418344
RBM25 RNA binding motif protein 25 0.0404577
TMF1 TATA element modulatory factor 1 0.0386551
CSTB cystatin B (stefin B) 0.0380187
PTMA prothymosin, alpha 0.0378212
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0366491
SOX4 SRY (sex determining region Y)-box 4 0.0351748
FBXO32 F-box protein 32 0.03491
BZW1 basic leucine zipper and W2 domains 1 0.0312361
POTEF POTE ankyrin domain family, member F 0.0305098
JUP junction plakoglobin 0.0286392
IFI27 interferon, alpha-inducible protein 27 0.0283953
WSB1 WD repeat and SOCS box containing 1 0.0275324
ACBD3 acyl-CoA binding domain containing 3 0.0270934
TMSB4X thymosin beta 4, X-linked 0.0243894
LMNA lamin A/C 0.0241256
CTSS cathepsin S 0.0228247
SRP54 signal recognition particle 54kDa 0.021999
RPL35A ribosomal protein L35a 0.0207769
TPM4 tropomyosin 4 0.0204373
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0201672
MSN moesin 0.0196989
RPS3 ribosomal protein S3 0.0194565
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0193096
RPS2 ribosomal protein S2 0.0191924
MT2A metallothionein 2A 0.0191568
ITCH itchy E3 ubiquitin protein ligase 0.0190162
RAB11FIP1 RAB11 family interacting protein 1 (class I) 0.0189944
RAI14 retinoic acid induced 14 0.0189827
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 0.0186605
RPL26 ribosomal protein L26 0.0185367
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0184041
RPL9 ribosomal protein L9 0.0183761
SEC61G Sec61 gamma subunit 0.0177646
BASP1 brain abundant, membrane attached signal protein 1 0.0177376
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0170412
TPM3 tropomyosin 3 0.0169849
DUSP5 dual specificity phosphatase 5 0.0164741
CLDN4 claudin 4 0.0163883
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0161318
FBXL20 F-box and leucine-rich repeat protein 20 0.0156702
IGFBP3 insulin-like growth factor binding protein 3 0.0154759
UBE2C ubiquitin-conjugating enzyme E2C 0.0153615
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0151124
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0150764
ISG15 ISG15 ubiquitin-like modifier 0.0146265
RCOR1 REST corepressor 1 0.0142095
NPEPPS aminopeptidase puromycin sensitive 0.0141093
UBXN4 UBX domain protein 4 0.0135778
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.0134115
BBX bobby sox homolog (Drosophila) 0.0133692
MYO6 myosin VI 0.0133426
CD63 CD63 molecule 0.0132489
CBX3 chromobox homolog 3 0.0130617
IRF7 interferon regulatory factor 7 0.0130167
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0128747
VEGFA vascular endothelial growth factor A 0.012866
PLAUR plasminogen activator, urokinase receptor 0.0128375
FTL ferritin, light polypeptide 0.012816
SYAP1 synapse associated protein 1 0.0127284
TMPRSS2 transmembrane protease, serine 2 0.0126824
RPL18 ribosomal protein L18 0.0125024
SNX6 sorting nexin 6 0.0124025
KDM7A lysine (K)-specific demethylase 7A 0.012353
RPL12 ribosomal protein L12 0.0120098
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0120055
HLA-A major histocompatibility complex, class I, A 0.0119923
DHRS7 dehydrogenase/reductase (SDR family) member 7 0.0119906
F3 coagulation factor III (thromboplastin, tissue factor) 0.0119021
NCOA2 nuclear receptor coactivator 2 0.0118104
BLZF1 basic leucine zipper nuclear factor 1 0.011787
ESRP1 epithelial splicing regulatory protein 1 0.0117239
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.0116598
ZMYM2 zinc finger, MYM-type 2 0.0115829
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2 0.0115619
HDGF hepatoma-derived growth factor 0.0115158
GGNBP2 gametogenetin binding protein 2 0.011444
ESYT2 extended synaptotagmin-like protein 2 0.0114217
KTN1 kinectin 1 (kinesin receptor) 0.0113438
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0112513
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4 0.0112455
KMT2C lysine (K)-specific methyltransferase 2C 0.0112183
NDUFB9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa 0.0111326
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0111034
EXOC1 exocyst complex component 1 0.0110578
CAVIN1 caveolae associated protein 1 0.0110427
S100A13 S100 calcium binding protein A13 0.0110367
FOSL1 FOS-like antigen 1 0.0110082
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 0.0109383
RAB6A RAB6A, member RAS oncogene family 0.0108683
CDK7 cyclin-dependent kinase 7 0.0107929
HLA-B major histocompatibility complex, class I, B 0.0107846
CAMLG calcium modulating ligand 0.010673
UBE2D2 ubiquitin-conjugating enzyme E2D 2 0.0106517
SLU7 SLU7 splicing factor homolog (S. cerevisiae) 0.0106188
LGALS3 lectin, galactoside-binding, soluble, 3 0.0106092

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.305254
FN1 fibronectin 1 -0.254013
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.23207
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.141594
ASPH aspartate beta-hydroxylase -0.122419
ALCAM activated leukocyte cell adhesion molecule -0.121736
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.108974
FNDC3B fibronectin type III domain containing 3B -0.0778904
NAMPT nicotinamide phosphoribosyltransferase -0.0778634
ELL2 elongation factor, RNA polymerase II, 2 -0.0711655
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0660147
LMO7 LIM domain 7 -0.0652684
SAMD4A sterile alpha motif domain containing 4A -0.0645571
RPS23 ribosomal protein S23 -0.0605903
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0579597
ANXA2 annexin A2 -0.0576405
CAPN2 calpain 2, (m/II) large subunit -0.0558044
BHLHE40 basic helix-loop-helix family, member e40 -0.055139
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) -0.0536713
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0535778
MBNL1 muscleblind-like splicing regulator 1 -0.0528856
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0520282
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0519021
AHNAK AHNAK nucleoprotein -0.051868
S100A10 S100 calcium binding protein A10 -0.05175
KRT7 keratin 7, type II -0.0513607
UBC ubiquitin C -0.0500456
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0487336
TM4SF1 transmembrane 4 L six family member 1 -0.0482986
TRIO trio Rho guanine nucleotide exchange factor -0.0472114
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0466958
RUNX1 runt-related transcription factor 1 -0.0462179
LAMC2 laminin, gamma 2 -0.0451665
SLC38A1 solute carrier family 38, member 1 -0.0445205
PTK2 protein tyrosine kinase 2 -0.0444007
PGK1 phosphoglycerate kinase 1 -0.0443296
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0437675
ACTG1 actin gamma 1 -0.043222
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0422082
SMAD3 SMAD family member 3 -0.041075
NRIP1 nuclear receptor interacting protein 1 -0.0410041
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0408937
EFNA5 ephrin-A5 -0.0404984
PKM pyruvate kinase, muscle -0.0404793
MYH9 myosin, heavy chain 9, non-muscle -0.0401961
UPP1 uridine phosphorylase 1 -0.039955
ERBIN erbb2 interacting protein -0.0393611
PALLD palladin, cytoskeletal associated protein -0.0382719
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0377479
ARHGAP5 Rho GTPase activating protein 5 -0.037518
RPL8 ribosomal protein L8 -0.0367433
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.036359
TXNRD1 thioredoxin reductase 1 -0.0360781
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0359067
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0358961
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0353168
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0343327
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0337902
RPL11 ribosomal protein L11 -0.0336658
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0336193
EGFR epidermal growth factor receptor -0.0333328
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0333136
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.033082
RAD21 RAD21 homolog (S. pombe) -0.0326221
SGMS2 sphingomyelin synthase 2 -0.0325053
MARCHF6 membrane associated ring-CH-type finger 6 -0.0324349
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0319929
KIAA1217 KIAA1217 -0.0319061
SQSTM1 sequestosome 1 -0.0318285
MAP4 microtubule-associated protein 4 -0.0315429
ARF1 ADP-ribosylation factor 1 -0.0315341
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0312999
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0311322
UGDH UDP-glucose 6-dehydrogenase -0.0310144
HMGA1 high mobility group AT-hook 1 -0.0304751
EXT1 exostosin glycosyltransferase 1 -0.0303949
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0302332
RHEB Ras homolog enriched in brain -0.0300874
RHOBTB3 Rho-related BTB domain containing 3 -0.0300105
NDRG1 N-myc downstream regulated 1 -0.0300059
DLG1 discs, large homolog 1 (Drosophila) -0.0298313
SH3RF1 SH3 domain containing ring finger 1 -0.0296767
APP amyloid beta (A4) precursor protein -0.0294666
DST dystonin -0.0293976
RPS6 ribosomal protein S6 -0.028998
RHOA ras homolog family member A -0.0289944
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0287256
PLAU plasminogen activator, urokinase -0.0286324
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 -0.0285589
RASA2 RAS p21 protein activator 2 -0.0284951
SH3KBP1 SH3-domain kinase binding protein 1 -0.0284242
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0283487
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.0280727
USP15 ubiquitin specific peptidase 15 -0.027826
NAV2 neuron navigator 2 -0.0278235
ZFAND3 zinc finger, AN1-type domain 3 -0.0277957
CD46 CD46 molecule, complement regulatory protein -0.0276979
ATXN1 ataxin 1 -0.0276544
ZC3H11A zinc finger CCCH-type containing 11A -0.0276529
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0275869