Almonertinib (hydrochloride)_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Almonertinib (hydrochloride) perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Almonertinib (hydrochloride)_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.163414
IGFBP3 insulin-like growth factor binding protein 3 0.0904885
FN1 fibronectin 1 0.0885736
RPS12 ribosomal protein S12 0.0858388
FTL ferritin, light polypeptide 0.0769293
TPT1 tumor protein, translationally-controlled 1 0.0711721
RPS3 ribosomal protein S3 0.0622626
MT2A metallothionein 2A 0.0606754
MCL1 myeloid cell leukemia 1 0.0564927
FTH1 ferritin, heavy polypeptide 1 0.0503149
RPL37A ribosomal protein L37a 0.0491404
RPL35A ribosomal protein L35a 0.04787
PM20D1 peptidase M20 domain containing 1 0.0448108
RACK1 receptor for activated C kinase 1 0.0431219
RPS8 ribosomal protein S8 0.0420454
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0415082
SMOC1 SPARC related modular calcium binding 1 0.0407808
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0404104
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0396934
RPL31 ribosomal protein L31 0.0389018
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0386329
RPL26 ribosomal protein L26 0.0386113
LDHA lactate dehydrogenase A 0.0379585
RPS2 ribosomal protein S2 0.0377333
EEF2 eukaryotic translation elongation factor 2 0.0366749
PSD3 pleckstrin and Sec7 domain containing 3 0.0362564
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0361425
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0345378
HLA-A major histocompatibility complex, class I, A 0.0345354
ZMIZ1 zinc finger, MIZ-type containing 1 0.0318129
B2M beta-2-microglobulin 0.0313303
RPL12 ribosomal protein L12 0.0306286
NDRG1 N-myc downstream regulated 1 0.0305635
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0305372
POTEF POTE ankyrin domain family, member F 0.0285641
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.02801
RPS17 ribosomal protein S17 0.0279492
GLRX glutaredoxin (thioltransferase) 0.0278755
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.027815
KYNU kynureninase 0.0275563
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.027543
RPL3 ribosomal protein L3 0.0275027
ENO1 enolase 1, (alpha) 0.0268204
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.026628
SQSTM1 sequestosome 1 0.0266014
PLAUR plasminogen activator, urokinase receptor 0.0260495
PDLIM5 PDZ and LIM domain 5 0.025633
VCL vinculin 0.025498
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0248733
RPL9 ribosomal protein L9 0.0244814
ZSWIM6 zinc finger, SWIM-type containing 6 0.0241736
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0236387
SOX9 SRY (sex determining region Y)-box 9 0.0231836
NFE2L1 nuclear factor, erythroid 2-like 1 0.0223435
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0223246
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0222935
AUTS2 autism susceptibility candidate 2 0.0222932
RPL36 ribosomal protein L36 0.0222868
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.021902
RPS7 ribosomal protein S7 0.0217931
RPL23 ribosomal protein L23 0.0214136
RPLP0 ribosomal protein, large, P0 0.0212533
CTIF CBP80/20-dependent translation initiation factor 0.0210916
CTSL cathepsin L 0.0210573
RPS19 ribosomal protein S19 0.0202276
RPS4X ribosomal protein S4, X-linked 0.0201507
RPS13 ribosomal protein S13 0.0199803
PGK1 phosphoglycerate kinase 1 0.0199366
INTS6 integrator complex subunit 6 0.0197114
RPL13A ribosomal protein L13a 0.0196293
EGR1 early growth response 1 0.0193328
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0192944
PRELID2 PRELI domain containing 2 0.0191694
MSN moesin 0.0191316
FMNL2 formin-like 2 0.0190455
ERRFI1 ERBB receptor feedback inhibitor 1 0.0189568
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0188701
NQO1 NAD(P)H dehydrogenase, quinone 1 0.018748
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.0186769
RPL18 ribosomal protein L18 0.0178858
RPLP1 ribosomal protein, large, P1 0.0177594
NRXN3 neurexin 3 0.0176503
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0174525
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0174309
MAP7 microtubule-associated protein 7 0.0173781
BZW1 basic leucine zipper and W2 domains 1 0.0170418
EEF1G eukaryotic translation elongation factor 1 gamma 0.0168777
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0167499
HILPDA hypoxia inducible lipid droplet-associated 0.0166972
PKM pyruvate kinase, muscle 0.0166816
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0166589
KRT19 keratin 19, type I 0.0165111
HSPA8 heat shock 70kDa protein 8 0.0163132
RPL36A ribosomal protein L36a 0.0162964
RPL19 ribosomal protein L19 0.0162034
IRS2 insulin receptor substrate 2 0.0160364
XYLT1 xylosyltransferase I 0.0159858
DOCK5 dedicator of cytokinesis 5 0.0157837
ENO2 enolase 2 (gamma, neuronal) 0.0157158
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0156815

decreased expression

Symbol Name Standardized Value
EFNA5 ephrin-A5 -0.1521
NAMPT nicotinamide phosphoribosyltransferase -0.112479
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0992606
NALF1 NALCN channel auxiliary factor 1 -0.0972308
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.079017
SMYD3 SET and MYND domain containing 3 -0.0751734
TRIO trio Rho guanine nucleotide exchange factor -0.0743105
GDA guanine deaminase -0.0698372
PDE4D phosphodiesterase 4D, cAMP-specific -0.0679521
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0611292
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0610512
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0590736
TXNRD1 thioredoxin reductase 1 -0.0583071
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0569116
LIMCH1 LIM and calponin homology domains 1 -0.0503885
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0469672
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0443597
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.042361
NRCAM neuronal cell adhesion molecule -0.041522
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0412516
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0406673
PBX1 pre-B-cell leukemia homeobox 1 -0.0405607
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0397672
BCAS3 breast carcinoma amplified sequence 3 -0.0392282
NF1 neurofibromin 1 -0.0389928
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0388329
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0387479
PALLD palladin, cytoskeletal associated protein -0.0381001
CDH13 cadherin 13 -0.0366734
NEK7 NIMA-related kinase 7 -0.0366258
TGFBI transforming growth factor, beta-induced, 68kDa -0.03635
PDE10A phosphodiesterase 10A -0.0361718
TNPO1 transportin 1 -0.0354931
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0344481
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -0.033606
TTC28 tetratricopeptide repeat domain 28 -0.0329147
AOPEP aminopeptidase O (putative) -0.0327588
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0317464
SAMD4A sterile alpha motif domain containing 4A -0.0311404
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0308721
TM4SF1 transmembrane 4 L six family member 1 -0.0308357
SLC39A8 solute carrier family 39 (zinc transporter), member 8 -0.030601
JMJD1C jumonji domain containing 1C -0.0292233
RBM39 RNA binding motif protein 39 -0.0288805
EPB41L3 erythrocyte membrane protein band 4.1-like 3 -0.0287214
FNDC3B fibronectin type III domain containing 3B -0.0274621
ENAH enabled homolog (Drosophila) -0.0272581
COL4A5 collagen, type IV, alpha 5 -0.0271652
BIRC6 baculoviral IAP repeat containing 6 -0.0267276
RTN4 reticulon 4 -0.0263542
PTK2 protein tyrosine kinase 2 -0.0263175
SRPK2 SRSF protein kinase 2 -0.0263003
ZMYND8 zinc finger, MYND-type containing 8 -0.0261236
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.026009
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0259865
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0258856
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0257026
DIAPH3 diaphanous-related formin 3 -0.025691
SORBS2 sorbin and SH3 domain containing 2 -0.0254953
NFIA nuclear factor I/A -0.0252677
AGFG1 ArfGAP with FG repeats 1 -0.0250502
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0250007
IGF1R insulin-like growth factor 1 receptor -0.0249751
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0249206
KMT2C lysine (K)-specific methyltransferase 2C -0.024904
NPAS2 neuronal PAS domain protein 2 -0.0244725
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0243358
MFF mitochondrial fission factor -0.0239915
UBE2H ubiquitin-conjugating enzyme E2H -0.0238237
ANKRD28 ankyrin repeat domain 28 -0.0236594
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0236101
BMERB1 bMERB domain containing 1 -0.0235214
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0234927
PTEN phosphatase and tensin homolog -0.0234643
ZNF638 zinc finger protein 638 -0.023453
THOC2 THO complex 2 -0.0234018
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0233258
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0231595
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0225722
ATAD1 ATPase family, AAA domain containing 1 -0.0224647
OSMR oncostatin M receptor -0.0223904
CD109 CD109 molecule -0.0222282
PRKD3 protein kinase D3 -0.0222052
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.022197
R3HDM1 R3H domain containing 1 -0.0221293
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0220392
AHNAK AHNAK nucleoprotein -0.0218794
SCN3A sodium channel, voltage gated, type III alpha subunit -0.0215452
MARCHF7 membrane associated ring-CH-type finger 7 -0.021504
COG5 component of oligomeric golgi complex 5 -0.0214775
PUM2 pumilio RNA-binding family member 2 -0.0214419
RBM25 RNA binding motif protein 25 -0.021422
KIAA0825 KIAA0825 -0.0213679
MATR3 matrin 3 -0.0213252
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0213237
RPS23 ribosomal protein S23 -0.021294
DIAPH2 diaphanous-related formin 2 -0.0212535
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0210572
MYOF myoferlin -0.0208531
HLA-B major histocompatibility complex, class I, B -0.0207068