| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Almonertinib (hydrochloride) perturbation in NCI-H596 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Almonertinib (hydrochloride)_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.173438 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.104316 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.088332 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0881737 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0880065 |
| VIM | vimentin | 0.073372 |
| PTMA | prothymosin, alpha | 0.0732878 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0691376 |
| RPS6 | ribosomal protein S6 | 0.0687236 |
| YAP1 | Yes-associated protein 1 | 0.0680981 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0676472 |
| MYO1E | myosin IE | 0.0672798 |
| ENO1 | enolase 1, (alpha) | 0.0655993 |
| SQSTM1 | sequestosome 1 | 0.0648314 |
| EGR1 | early growth response 1 | 0.0644132 |
| VMP1 | vacuole membrane protein 1 | 0.0632546 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0590452 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0569953 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0548254 |
| B2M | beta-2-microglobulin | 0.053696 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0533717 |
| DST | dystonin | 0.0532572 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0520825 |
| DIAPH2 | diaphanous-related formin 2 | 0.0512477 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0510305 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0497194 |
| RPL31 | ribosomal protein L31 | 0.0493508 |
| RPL37A | ribosomal protein L37a | 0.0486411 |
| SEPTIN9 | septin 9 | 0.0473294 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.046747 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0466222 |
| STK24 | serine/threonine kinase 24 | 0.04544 |
| ATXN1 | ataxin 1 | 0.0453276 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0450669 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0450506 |
| HMGA1 | high mobility group AT-hook 1 | 0.0446122 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0445204 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0443399 |
| RPLP0 | ribosomal protein, large, P0 | 0.0440042 |
| ACTG1 | actin gamma 1 | 0.0428271 |
| NCOR1 | nuclear receptor corepressor 1 | 0.042819 |
| BCL2L1 | BCL2-like 1 | 0.0425095 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.0413321 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0378191 |
| ANXA2 | annexin A2 | 0.0370702 |
| BBX | bobby sox homolog (Drosophila) | 0.0370178 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0366086 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.03635 |
| NF1 | neurofibromin 1 | 0.0355451 |
| SET | SET nuclear proto-oncogene | 0.0353348 |
| PRKCA | protein kinase C, alpha | 0.0348456 |
| MED13 | mediator complex subunit 13 | 0.0345701 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0343558 |
| SPATA13 | spermatogenesis associated 13 | 0.0337081 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0332011 |
| JUN | jun proto-oncogene | 0.0326381 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0324992 |
| RPS12 | ribosomal protein S12 | 0.0314917 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0314171 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0306652 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0306098 |
| ERBIN | erbb2 interacting protein | 0.0297623 |
| CTBP2 | C-terminal binding protein 2 | 0.0294035 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0289013 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0279293 |
| TMSB10 | thymosin beta 10 | 0.0266873 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.026504 |
| RUNX1 | runt-related transcription factor 1 | 0.0264601 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0256996 |
| CANX | calnexin | 0.0251039 |
| EHBP1 | EH domain binding protein 1 | 0.0238547 |
| RPLP1 | ribosomal protein, large, P1 | 0.0235769 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0234035 |
| PHF3 | PHD finger protein 3 | 0.0230389 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0224134 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0216117 |
| FN1 | fibronectin 1 | 0.0205162 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.020367 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0200409 |
| ASPH | aspartate beta-hydroxylase | 0.0197859 |
| HELZ | helicase with zinc finger | 0.0190933 |
| SETD5 | SET domain containing 5 | 0.0186349 |
| RPL10A | ribosomal protein L10a | 0.0184609 |
| MCL1 | myeloid cell leukemia 1 | 0.0173453 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0172968 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0166741 |
| GRIK5 | glutamate receptor, ionotropic, kainate 5 | 0.0159244 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0153476 |
| POTEF | POTE ankyrin domain family, member F | 0.0151566 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0148648 |
| PGK1 | phosphoglycerate kinase 1 | 0.014575 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0142092 |
| MEF2A | myocyte enhancer factor 2A | 0.0140392 |
| FZR1 | fizzy/cell division cycle 20 related 1 (Drosophila) | 0.0139269 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | 0.013632 |
| LAMA4 | laminin, alpha 4 | 0.0133 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0132159 |
| SMAD3 | SMAD family member 3 | 0.0127041 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | 0.0126972 |
| RACK1 | receptor for activated C kinase 1 | 0.0111803 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.115729 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.109489 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.100405 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0900384 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0898601 |
| STC1 | stanniocalcin 1 | -0.0865686 |
| PKM | pyruvate kinase, muscle | -0.085469 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0776521 |
| PDE10A | phosphodiesterase 10A | -0.077568 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.072392 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0710203 |
| COL5A2 | collagen, type V, alpha 2 | -0.0676934 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0675906 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0666533 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.060177 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0588716 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0567098 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0559171 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0555168 |
| FOXP1 | forkhead box P1 | -0.0535748 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0532591 |
| SMYD3 | SET and MYND domain containing 3 | -0.0524756 |
| EFNA5 | ephrin-A5 | -0.0518301 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0515631 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0513957 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0510714 |
| USP34 | ubiquitin specific peptidase 34 | -0.0510175 |
| SPAG9 | sperm associated antigen 9 | -0.0504072 |
| OGA | O-GlcNAcase | -0.0466923 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.0457062 |
| LAMB3 | laminin, beta 3 | -0.0455976 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0445646 |
| GLIS3 | GLIS family zinc finger 3 | -0.0427912 |
| KIAA0232 | KIAA0232 | -0.0414722 |
| TPM4 | tropomyosin 4 | -0.0408062 |
| JAK1 | Janus kinase 1 | -0.0401205 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0391452 |
| MT2A | metallothionein 2A | -0.0385078 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0364839 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0364607 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0361457 |
| FMNL2 | formin-like 2 | -0.0345477 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0342094 |
| RPS16 | ribosomal protein S16 | -0.0340571 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0339029 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | -0.0337457 |
| FTL | ferritin, light polypeptide | -0.0329629 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0325979 |
| EGFR | epidermal growth factor receptor | -0.0314376 |
| GOLGA4 | golgin A4 | -0.0311256 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0306004 |
| FAM13A | family with sequence similarity 13, member A | -0.0302785 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | -0.0298123 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0290106 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | -0.028446 |
| TNS3 | tensin 3 | -0.0279868 |
| VCL | vinculin | -0.0277313 |
| ZNF292 | zinc finger protein 292 | -0.0266071 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0259865 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0252354 |
| EZR | ezrin | -0.0248986 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0239663 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0239454 |
| RPS19 | ribosomal protein S19 | -0.0233908 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.0230506 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0229924 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0229858 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.0229378 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0220611 |
| ZFHX3 | zinc finger homeobox 3 | -0.021959 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0213266 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0204876 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0203887 |
| GPC6 | glypican 6 | -0.0197513 |
| JMJD1C | jumonji domain containing 1C | -0.0185014 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0184356 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | -0.0184252 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0179715 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0179689 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0171575 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0162435 |
| ITGA6 | integrin, alpha 6 | -0.0161966 |
| PARD3 | par-3 family cell polarity regulator | -0.0158165 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0151665 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0147958 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0140102 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0140069 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0121285 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0109535 |
| RPS3 | ribosomal protein S3 | -0.0102501 |
| GPBP1 | GC-rich promoter binding protein 1 | -0.0101934 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.00932288 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.00912421 |
| TOP1 | topoisomerase (DNA) I | -0.0090835 |
| TXNRD1 | thioredoxin reductase 1 | -0.00905988 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | -0.0086816 |
| SYT1 | synaptotagmin I | -0.00711239 |
| HMGA2 | high mobility group AT-hook 2 | -0.00617939 |
| NEK7 | NIMA-related kinase 7 | -0.00471489 |
| PMM2 | phosphomannomutase 2 | -0.00430165 |
