| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Almonertinib (hydrochloride) perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Almonertinib (hydrochloride)_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| COL11A1 | collagen, type XI, alpha 1 | 0.118664 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.110356 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0822474 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0658361 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0586301 |
| PFN1 | profilin 1 | 0.0566829 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0558017 |
| HDAC9 | histone deacetylase 9 | 0.0557394 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0493904 |
| SNX6 | sorting nexin 6 | 0.0480642 |
| POTEF | POTE ankyrin domain family, member F | 0.0467481 |
| SRP54 | signal recognition particle 54kDa | 0.0434196 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0419639 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | 0.0418403 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0415169 |
| RPS2 | ribosomal protein S2 | 0.0396458 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0395372 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0393637 |
| CALR | calreticulin | 0.0391404 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0388289 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0384034 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.038299 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0382659 |
| TRPS1 | trichorhinophalangeal syndrome I | 0.0376724 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | 0.0364865 |
| PCBP2 | poly(rC) binding protein 2 | 0.0360838 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.0358164 |
| STAG2 | stromal antigen 2 | 0.0352319 |
| ZC3H13 | zinc finger CCCH-type containing 13 | 0.0349987 |
| SSB | Sjogren syndrome antigen B (autoantigen La) | 0.0348606 |
| YBX1 | Y box binding protein 1 | 0.0345913 |
| DDX56 | DEAD (Asp-Glu-Ala-Asp) box helicase 56 | 0.0344737 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0339568 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0339355 |
| RPS4X | ribosomal protein S4, X-linked | 0.0334559 |
| RPS12 | ribosomal protein S12 | 0.0329882 |
| RDX | radixin | 0.0328369 |
| ZNF292 | zinc finger protein 292 | 0.03238 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.0323231 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.031951 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0312885 |
| ANXA1 | annexin A1 | 0.0312003 |
| SERINC1 | serine incorporator 1 | 0.0311465 |
| CBX3 | chromobox homolog 3 | 0.0310642 |
| KIF1B | kinesin family member 1B | 0.0310299 |
| RPS3 | ribosomal protein S3 | 0.0295673 |
| NDUFA4 | NDUFA4, mitochondrial complex associated | 0.0294578 |
| OLA1 | Obg-like ATPase 1 | 0.0293629 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0293523 |
| TPM3 | tropomyosin 3 | 0.0288564 |
| NOP58 | NOP58 ribonucleoprotein | 0.0286731 |
| GPC4 | glypican 4 | 0.0281915 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | 0.0276661 |
| LSM14A | LSM14A, SCD6 homolog A (S. cerevisiae) | 0.0275782 |
| TPR | translocated promoter region, nuclear basket protein | 0.0275742 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0275259 |
| APP | amyloid beta (A4) precursor protein | 0.0274814 |
| ANK2 | ankyrin 2, neuronal | 0.02745 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0272755 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0271986 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | 0.0264905 |
| SET | SET nuclear proto-oncogene | 0.0254975 |
| SOX2 | SRY (sex determining region Y)-box 2 | 0.0254157 |
| ANP32A | acidic (leucine-rich) nuclear phosphoprotein 32 family, member A | 0.0249976 |
| TMSB10 | thymosin beta 10 | 0.0248424 |
| RPL36 | ribosomal protein L36 | 0.0247408 |
| SAMD4B | sterile alpha motif domain containing 4B | 0.0246075 |
| PRPF4B | pre-mRNA processing factor 4B | 0.0243202 |
| CENPF | centromere protein F, 350/400kDa | 0.023948 |
| SON | SON DNA binding protein | 0.0238187 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.023684 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0236643 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0235881 |
| MATR3 | matrin 3 | 0.0235823 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0233466 |
| TRIP11 | thyroid hormone receptor interactor 11 | 0.0231153 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | 0.0231085 |
| CCDC88A | coiled-coil domain containing 88A | 0.0230652 |
| MRPS30 | mitochondrial ribosomal protein S30 | 0.0230486 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0230151 |
| SNAPC1 | small nuclear RNA activating complex, polypeptide 1, 43kDa | 0.0229925 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0229479 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0227625 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0225899 |
| ANLN | anillin, actin binding protein | 0.0223887 |
| OSBPL6 | oxysterol binding protein-like 6 | 0.0220602 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0216899 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0216488 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0215394 |
| CCPG1 | cell cycle progression 1 | 0.0214457 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0212156 |
| RANBP9 | RAN binding protein 9 | 0.0210715 |
| TPX2 | TPX2, microtubule-associated | 0.021058 |
| LYPLA1 | lysophospholipase I | 0.0208294 |
| EP400 | E1A binding protein p400 | 0.020752 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | 0.0205886 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0205403 |
| EIF3E | eukaryotic translation initiation factor 3, subunit E | 0.0205103 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0205099 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0204668 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | -0.149481 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.130084 |
| PTMA | prothymosin, alpha | -0.105034 |
| GPC3 | glypican 3 | -0.101537 |
| CADM2 | cell adhesion molecule 2 | -0.0986976 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | -0.0832652 |
| PCDH9 | protocadherin 9 | -0.0806265 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0799611 |
| GALNTL6 | polypeptide N-acetylgalactosaminyltransferase-like 6 | -0.0709251 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | -0.0668861 |
| PHIP | pleckstrin homology domain interacting protein | -0.0633475 |
| PCDH7 | protocadherin 7 | -0.0596657 |
| MED13L | mediator complex subunit 13-like | -0.0573596 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0550387 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | -0.0532883 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0516325 |
| H1-0 | H1.0 linker histone | -0.0505517 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | -0.0478269 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0472241 |
| CAVIN1 | caveolae associated protein 1 | -0.0461978 |
| RPS16 | ribosomal protein S16 | -0.0459144 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.0446568 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.0433922 |
| ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | -0.0430204 |
| RPL31 | ribosomal protein L31 | -0.0427891 |
| PGAP1 | post-GPI attachment to proteins 1 | -0.0426719 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0408612 |
| PARD3B | par-3 family cell polarity regulator beta | -0.0405233 |
| S100A10 | S100 calcium binding protein A10 | -0.0400351 |
| AHNAK | AHNAK nucleoprotein | -0.0395897 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0390758 |
| ADNP | activity-dependent neuroprotector homeobox | -0.0378031 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0371694 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.037027 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0367096 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0366843 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0356012 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0353309 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0342397 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0335601 |
| RPL37 | ribosomal protein L37 | -0.0331512 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0330456 |
| MEIS2 | Meis homeobox 2 | -0.0330082 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0326211 |
| PRR16 | proline rich 16 | -0.0321712 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0314749 |
| TENM3 | teneurin transmembrane protein 3 | -0.0311474 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0311413 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0308801 |
| SQSTM1 | sequestosome 1 | -0.0306765 |
| HMCN1 | hemicentin 1 | -0.0303676 |
| MAP4 | microtubule-associated protein 4 | -0.0302533 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0297253 |
| LRRC4C | leucine rich repeat containing 4C | -0.0296819 |
| PKM | pyruvate kinase, muscle | -0.0295824 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0293444 |
| URI1 | URI1, prefoldin-like chaperone | -0.0290657 |
| OGA | O-GlcNAcase | -0.0286782 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.028551 |
| SLC30A8 | solute carrier family 30 (zinc transporter), member 8 | -0.0284584 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.0284037 |
| VPS13D | vacuolar protein sorting 13 homolog D (S. cerevisiae) | -0.0275277 |
| FOXO3 | forkhead box O3 | -0.0275179 |
| SHROOM3 | shroom family member 3 | -0.0274045 |
| FST | follistatin | -0.027031 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0268 |
| PARD3 | par-3 family cell polarity regulator | -0.0267613 |
| MTCL1 | microtubule crosslinking factor 1 | -0.0266429 |
| NAP1L4 | nucleosome assembly protein 1-like 4 | -0.0263311 |
| PCDH17 | protocadherin 17 | -0.0261111 |
| ASPH | aspartate beta-hydroxylase | -0.0257565 |
| FNBP1 | formin binding protein 1 | -0.0256577 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0256353 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0255121 |
| MED12L | mediator complex subunit 12-like | -0.0254384 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.025398 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | -0.0252917 |
| JMJD1C | jumonji domain containing 1C | -0.0251978 |
| USP9X | ubiquitin specific peptidase 9, X-linked | -0.0251489 |
| FMNL2 | formin-like 2 | -0.0248253 |
| ATXN1 | ataxin 1 | -0.0247394 |
| GAB2 | GRB2-associated binding protein 2 | -0.0246588 |
| NF1 | neurofibromin 1 | -0.0246535 |
| ZNF217 | zinc finger protein 217 | -0.0246156 |
| NSD3 | nuclear receptor binding SET domain protein 3 | -0.0241015 |
| WDR33 | WD repeat domain 33 | -0.0240035 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0239768 |
| RPL38 | ribosomal protein L38 | -0.0239694 |
| ATP11A | ATPase, class VI, type 11A | -0.0237682 |
| RPS10 | ribosomal protein S10 | -0.0237644 |
| RPL34 | ribosomal protein L34 | -0.0236042 |
| NPAS3 | neuronal PAS domain protein 3 | -0.0233006 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0232413 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.0231936 |
| SMIM44 | small integral membrane protein 44 | -0.0230671 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0230454 |
| LMO7 | LIM domain 7 | -0.0230157 |
| GNAS | GNAS complex locus | -0.023012 |
| APOE | apolipoprotein E | -0.0229836 |
| PDS5A | PDS5 cohesin associated factor A | -0.0229407 |
