Almonertinib (hydrochloride)_PANC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Almonertinib (hydrochloride) perturbation in PANC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Almonertinib (hydrochloride)_PANC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 0.095191
YBX1 Y box binding protein 1 0.0900776
ZFP36 ZFP36 ring finger protein 0.0893536
RPS16 ribosomal protein S16 0.0749188
ERRFI1 ERBB receptor feedback inhibitor 1 0.070891
RPS12 ribosomal protein S12 0.0701566
MT2A metallothionein 2A 0.0696071
RPLP0 ribosomal protein, large, P0 0.0648821
RPS3 ribosomal protein S3 0.0642955
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0640697
FTL ferritin, light polypeptide 0.0631083
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0606072
TMEM41B transmembrane protein 41B 0.0589523
GARS1 glycyl-tRNA synthetase 1 0.0586487
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0580257
RPS2 ribosomal protein S2 0.0504186
B2M beta-2-microglobulin 0.0500929
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0500246
S100A6 S100 calcium binding protein A6 0.0490371
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0454977
FTH1 ferritin, heavy polypeptide 1 0.0451536
RPL35A ribosomal protein L35a 0.0445162
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0435615
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0431092
ARRDC3 arrestin domain containing 3 0.0430469
RTN4 reticulon 4 0.0423358
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0416577
NAP1L1 nucleosome assembly protein 1-like 1 0.0400856
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) 0.0399327
FOSL1 FOS-like antigen 1 0.0397574
MYH9 myosin, heavy chain 9, non-muscle 0.0394805
SMAD3 SMAD family member 3 0.0392336
RPL12 ribosomal protein L12 0.0392262
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0381212
WWTR1 WW domain containing transcription regulator 1 0.0373438
SFTPA2 surfactant protein A2 0.0367355
KTN1 kinectin 1 (kinesin receptor) 0.0365172
EEF2 eukaryotic translation elongation factor 2 0.0357724
ENO1 enolase 1, (alpha) 0.035474
RPLP1 ribosomal protein, large, P1 0.0350195
KLF6 Kruppel-like factor 6 0.0348536
DGKD diacylglycerol kinase, delta 130kDa 0.0346623
DDIT4 DNA-damage-inducible transcript 4 0.0342315
RACK1 receptor for activated C kinase 1 0.0337517
NAMPT nicotinamide phosphoribosyltransferase 0.0334039
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0331477
PCBP2 poly(rC) binding protein 2 0.0327518
CENPF centromere protein F, 350/400kDa 0.0327423
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0327421
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0324849
PFN1 profilin 1 0.0321185
SQSTM1 sequestosome 1 0.0320635
IPO7 importin 7 0.0313507
FBL fibrillarin 0.0312975
ANXA2 annexin A2 0.0310976
NFE2L1 nuclear factor, erythroid 2-like 1 0.0305507
LOC112694756 uncharaterized LOC112694756 0.0298886
PABPC1 poly(A) binding protein, cytoplasmic 1 0.029685
RPS19 ribosomal protein S19 0.0296665
ZNF292 zinc finger protein 292 0.0295619
ASPH aspartate beta-hydroxylase 0.029388
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0290681
BIRC2 baculoviral IAP repeat containing 2 0.028013
OGA O-GlcNAcase 0.027938
APLP2 amyloid beta (A4) precursor-like protein 2 0.0278631
RPS8 ribosomal protein S8 0.0276896
ITGAV integrin, alpha V 0.02755
ACTN4 actinin, alpha 4 0.0275192
SPAG9 sperm associated antigen 9 0.0275049
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0269905
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0269522
MATR3 matrin 3 0.0267727
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.026755
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0267402
ADAM17 ADAM metallopeptidase domain 17 0.0264461
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0264088
VMP1 vacuole membrane protein 1 0.0263774
FXR1 fragile X mental retardation, autosomal homolog 1 0.0261937
XPO1 exportin 1 0.0255894
LOC102724023 ES1 protein homolog, mitochondrial 0.0255856
ATP13A3 ATPase type 13A3 0.0254298
YBX3 Y box binding protein 3 0.025378
RPL23 ribosomal protein L23 0.0252251
SET SET nuclear proto-oncogene 0.0252176
PGK1 phosphoglycerate kinase 1 0.0251547
MFGE8 milk fat globule-EGF factor 8 protein 0.0249025
RPS4X ribosomal protein S4, X-linked 0.0246704
RPL11 ribosomal protein L11 0.0246339
CHD1 chromodomain helicase DNA binding protein 1 0.0239892
CSDE1 cold shock domain containing E1, RNA-binding 0.0239102
RPL3 ribosomal protein L3 0.0227175
PRRC2C proline-rich coiled-coil 2C 0.022483
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0220892
RPL30 ribosomal protein L30 0.0218809
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0218479
GOLGA4 golgin A4 0.0215846
RPS17 ribosomal protein S17 0.0215315
SOX9 SRY (sex determining region Y)-box 9 0.0215048
NUP58 nucleoporin 58 0.0214873
JUN jun proto-oncogene 0.0214383

decreased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 -0.223563
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.152234
VIM vimentin -0.137642
AHNAK AHNAK nucleoprotein -0.13093
THSD4 thrombospondin, type I, domain containing 4 -0.0928963
SLC35F3 solute carrier family 35, member F3 -0.0918334
VCL vinculin -0.0752711
TRIO trio Rho guanine nucleotide exchange factor -0.0716697
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0690594
PTMA prothymosin, alpha -0.0678348
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0650183
EGFR epidermal growth factor receptor -0.0620708
HMGA2 high mobility group AT-hook 2 -0.0593172
SDK1 sidekick cell adhesion molecule 1 -0.0571111
DST dystonin -0.0565682
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.055573
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0534378
TNS3 tensin 3 -0.05229
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0520517
INTS6 integrator complex subunit 6 -0.0499403
ATG7 autophagy related 7 -0.0498674
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0471912
RNF220 ring finger protein 220 -0.0461137
PTK2 protein tyrosine kinase 2 -0.0459605
EHBP1 EH domain binding protein 1 -0.04237
NAV2 neuron navigator 2 -0.0400485
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0400134
DIAPH2 diaphanous-related formin 2 -0.039214
MACF1 microtubule-actin crosslinking factor 1 -0.0391075
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.038164
ACTG1 actin gamma 1 -0.0373843
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0360687
SBF2 SET binding factor 2 -0.0354386
ATM ATM serine/threonine kinase -0.035252
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.034857
HSPG2 heparan sulfate proteoglycan 2 -0.0343435
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0340924
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0337387
SEPTIN9 septin 9 -0.0330707
EXT1 exostosin glycosyltransferase 1 -0.0327629
MYO1E myosin IE -0.0325664
PATJ PATJ crumbs cell polarity complex component -0.0325416
NHSL1 NHS-like 1 -0.0322699
NUP98 nucleoporin 98kDa -0.0322062
EXOC4 exocyst complex component 4 -0.0318243
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0313034
ZNF780B zinc finger protein 780B -0.0310936
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.030105
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0299782
MSRB3 methionine sulfoxide reductase B3 -0.0290572
CUX1 cut-like homeobox 1 -0.0289804
LPP LIM domain containing preferred translocation partner in lipoma -0.0288536
CDK13 cyclin-dependent kinase 13 -0.0287483
RAD51B RAD51 paralog B -0.0282925
NPAS2 neuronal PAS domain protein 2 -0.0280253
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0260983
CTBP2 C-terminal binding protein 2 -0.0253086
SAMD4A sterile alpha motif domain containing 4A -0.0253046
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.0251711
RABGAP1L RAB GTPase activating protein 1-like -0.0250527
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0250128
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 -0.0249573
ZNF407 zinc finger protein 407 -0.0248619
BICD1 bicaudal D homolog 1 (Drosophila) -0.0246197
FUS FUS RNA binding protein -0.0245495
MAML3 mastermind-like 3 (Drosophila) -0.0240971
TPM1 tropomyosin 1 (alpha) -0.0238526
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 -0.023496
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0234056
AGO3 argonaute RISC catalytic component 3 -0.0232932
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0232812
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0232414
TIAM2 T-cell lymphoma invasion and metastasis 2 -0.0231187
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0230997
CMIP c-Maf inducing protein -0.0230766
ZBTB20 zinc finger and BTB domain containing 20 -0.0229977
PRKCA protein kinase C, alpha -0.0228826
ST3GAL3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 -0.0228803
USP34 ubiquitin specific peptidase 34 -0.0227926
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0226951
CTSD cathepsin D -0.0226948
RASAL2 RAS protein activator like 2 -0.0225232
IGF1R insulin-like growth factor 1 receptor -0.0224321
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.022385
LARP1B La ribonucleoprotein domain family, member 1B -0.0223092
R3HDM2 R3H domain containing 2 -0.0223016
ZNF546 zinc finger protein 546 -0.0221574
EFNA5 ephrin-A5 -0.0219913
MAP4 microtubule-associated protein 4 -0.0219899
HM13 histocompatibility (minor) 13 -0.0218896
ZDHHC14 zinc finger, DHHC-type containing 14 -0.0216936
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0215484
TCF12 transcription factor 12 -0.0211591
ZMYND8 zinc finger, MYND-type containing 8 -0.0211081
RBMX RNA binding motif protein, X-linked -0.0206216
TTC28 tetratricopeptide repeat domain 28 -0.0205461
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.0203843
ATP9B ATPase, class II, type 9B -0.0203126
UBASH3B ubiquitin associated and SH3 domain containing B -0.0202646
DOCK1 dedicator of cytokinesis 1 -0.0202445