Almonertinib (hydrochloride)_RKO Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Almonertinib (hydrochloride) perturbation in RKO cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Almonertinib (hydrochloride)_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPS12 ribosomal protein S12 0.0957395
RPL35A ribosomal protein L35a 0.082451
LAMB3 laminin, beta 3 0.0814787
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0804971
RPS3 ribosomal protein S3 0.0772422
RPL12 ribosomal protein L12 0.058352
EEF2 eukaryotic translation elongation factor 2 0.0575982
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0573532
RPL37A ribosomal protein L37a 0.0561568
RPS2 ribosomal protein S2 0.0525739
FTL ferritin, light polypeptide 0.0524657
PGK1 phosphoglycerate kinase 1 0.0511377
ACTG1 actin gamma 1 0.0495437
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0481365
RPS8 ribosomal protein S8 0.0481114
C2CD2 C2 calcium-dependent domain containing 2 0.0462821
RPL26 ribosomal protein L26 0.0446813
ZEB1 zinc finger E-box binding homeobox 1 0.044272
RPL36 ribosomal protein L36 0.043804
TXNRD1 thioredoxin reductase 1 0.0429837
SHANK1 SH3 and multiple ankyrin repeat domains 1 0.0423125
RACK1 receptor for activated C kinase 1 0.0422176
TPT1 tumor protein, translationally-controlled 1 0.0421644
ARHGAP22 Rho GTPase activating protein 22 0.0388491
STC1 stanniocalcin 1 0.0383913
RPS4X ribosomal protein S4, X-linked 0.0381065
ENO1 enolase 1, (alpha) 0.0378347
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0374946
RPL18 ribosomal protein L18 0.0372542
RPL34 ribosomal protein L34 0.036
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0345355
RPS17 ribosomal protein S17 0.0344211
RPS7 ribosomal protein S7 0.0340451
RPLP0 ribosomal protein, large, P0 0.0327148
RPS27A ribosomal protein S27a 0.0321578
RPL3 ribosomal protein L3 0.0315763
JUN jun proto-oncogene 0.0315747
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0305989
GLRX glutaredoxin (thioltransferase) 0.0302122
MCL1 myeloid cell leukemia 1 0.0290951
RPL23 ribosomal protein L23 0.0283611
ANGPTL4 angiopoietin-like 4 0.0280508
RPLP2 ribosomal protein, large, P2 0.0279024
LOC112694756 uncharaterized LOC112694756 0.0271287
GARS1 glycyl-tRNA synthetase 1 0.0270926
SPRY4 sprouty homolog 4 (Drosophila) 0.0267074
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 0.0266015
RPS19 ribosomal protein S19 0.0260712
SGMS2 sphingomyelin synthase 2 0.0260096
YBX1 Y box binding protein 1 0.0258275
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.0257188
CDCP1 CUB domain containing protein 1 0.0254903
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0254317
B2M beta-2-microglobulin 0.0252695
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0247367
SFTPA2 surfactant protein A2 0.0243829
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0241979
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 0.0240722
RPL36A ribosomal protein L36a 0.0239063
CD68 CD68 molecule 0.0237439
CD63 CD63 molecule 0.0235237
SPOCD1 SPOC domain containing 1 0.0234351
AKAP12 A kinase (PRKA) anchor protein 12 0.0232168
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.0231694
PFDN2 prefoldin subunit 2 0.0228845
MYH9 myosin, heavy chain 9, non-muscle 0.0228809
RPL13A ribosomal protein L13a 0.0225829
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0223477
RSL24D1 ribosomal L24 domain containing 1 0.0222388
RPL31 ribosomal protein L31 0.0221676
RIPK2 receptor-interacting serine-threonine kinase 2 0.022142
HSPA8 heat shock 70kDa protein 8 0.0219611
YBX3 Y box binding protein 3 0.0207395
EGR1 early growth response 1 0.0202566
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.020146
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.019538
CAPRIN2 caprin family member 2 0.0193733
STXBP1 syntaxin binding protein 1 0.0193484
RPS27 ribosomal protein S27 0.0193463
ZNF146 zinc finger protein 146 0.0193165
ZFP36L1 ZFP36 ring finger protein-like 1 0.0189366
CAVIN1 caveolae associated protein 1 0.0188364
MYO10 myosin X 0.0188221
ARL15 ADP-ribosylation factor-like 15 0.0186744
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0185741
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0185336
TMF1 TATA element modulatory factor 1 0.0182673
RPL5 ribosomal protein L5 0.0182079
DUSP6 dual specificity phosphatase 6 0.0180845
ZNF106 zinc finger protein 106 0.01808
TRAPPC9 trafficking protein particle complex 9 0.0180629
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0180329
PDE4D phosphodiesterase 4D, cAMP-specific 0.0180253
CTTNBP2NL CTTNBP2 N-terminal like 0.0178188
REL v-rel avian reticuloendotheliosis viral oncogene homolog 0.0175451
ZNF841 zinc finger protein 841 0.0173897
HSPA4 heat shock 70kDa protein 4 0.0172451
ADTRP androgen-dependent TFPI-regulating protein 0.0171228
ANXA5 annexin A5 0.0170826
TRIM25 tripartite motif containing 25 0.0169783

decreased expression

Symbol Name Standardized Value
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.230286
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.112735
HDAC9 histone deacetylase 9 -0.108501
DLC1 DLC1 Rho GTPase activating protein -0.0949418
IARS1 isoleucyl-tRNA synthetase 1 -0.0932499
CALD1 caldesmon 1 -0.0816971
DIAPH3 diaphanous-related formin 3 -0.0779378
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0774083
MT2A metallothionein 2A -0.0708495
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0697899
LPP LIM domain containing preferred translocation partner in lipoma -0.0690937
RAB7A RAB7A, member RAS oncogene family -0.0685304
PBX3 pre-B-cell leukemia homeobox 3 -0.0678597
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0566775
TRIO trio Rho guanine nucleotide exchange factor -0.0557455
BIRC6 baculoviral IAP repeat containing 6 -0.0555289
PTK2 protein tyrosine kinase 2 -0.0554547
RPL8 ribosomal protein L8 -0.0552655
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0519286
DEK DEK proto-oncogene -0.0502112
PDIA3 protein disulfide isomerase family A, member 3 -0.0495421
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) -0.0493203
ANKRD17 ankyrin repeat domain 17 -0.0486357
SETD5 SET domain containing 5 -0.0483746
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0480821
ERBIN erbb2 interacting protein -0.0479438
RAP1B RAP1B, member of RAS oncogene family -0.0477977
PRRC2B proline-rich coiled-coil 2B -0.0471337
PCNX4 pecanex 4 -0.0470469
JMJD1C jumonji domain containing 1C -0.0469329
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0450623
ZNF438 zinc finger protein 438 -0.0449115
NF1 neurofibromin 1 -0.044623
MON2 MON2 homolog (S. cerevisiae) -0.0434666
NABP1 nucleic acid binding protein 1 -0.0425203
FRMD6 FERM domain containing 6 -0.0423053
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0414058
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0397201
ADNP activity-dependent neuroprotector homeobox -0.039521
RAB3IP RAB3A interacting protein -0.0395169
COL27A1 collagen, type XXVII, alpha 1 -0.0394809
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0393077
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0387678
ANTXR2 anthrax toxin receptor 2 -0.038564
ZBTB20 zinc finger and BTB domain containing 20 -0.0383244
RBM25 RNA binding motif protein 25 -0.0380783
RAD51B RAD51 paralog B -0.0379937
FAF1 Fas (TNFRSF6) associated factor 1 -0.0379388
SRRM2 serine/arginine repetitive matrix 2 -0.0378039
IFI16 interferon, gamma-inducible protein 16 -0.0375422
PFN1 profilin 1 -0.0374743
CUX1 cut-like homeobox 1 -0.037282
ATP5F1B ATP synthase F1 subunit beta -0.0365438
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0361991
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0358898
SLC38A2 solute carrier family 38, member 2 -0.035143
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0339722
SCMH1 sex comb on midleg homolog 1 (Drosophila) -0.0335424
WDR43 WD repeat domain 43 -0.0331717
NUDCD1 NudC domain containing 1 -0.0331006
DENND1A DENN/MADD domain containing 1A -0.0329794
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0325662
CCT2 chaperonin containing TCP1, subunit 2 (beta) -0.0325367
FNIP1 folliculin interacting protein 1 -0.0325362
PTBP2 polypyrimidine tract binding protein 2 -0.0325328
BTBD9 BTB (POZ) domain containing 9 -0.032381
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0322511
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0321587
STAU2 staufen double-stranded RNA binding protein 2 -0.0319488
TCERG1 transcription elongation regulator 1 -0.0319361
SAMD4A sterile alpha motif domain containing 4A -0.0317285
NSD2 nuclear receptor binding SET domain protein 2 -0.0317247
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0314204
LDHB lactate dehydrogenase B -0.0314076
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.031342
FNDC3B fibronectin type III domain containing 3B -0.0307542
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0306643
TMEM87A transmembrane protein 87A -0.0299131
BNC2 basonuclin 2 -0.0298161
FNBP4 formin binding protein 4 -0.0297513
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0297341
LCORL ligand dependent nuclear receptor corepressor-like -0.0291324
DGKI diacylglycerol kinase, iota -0.0290143
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0289352
ZNF207 zinc finger protein 207 -0.0288474
SETX senataxin -0.0288467
HMGA1 high mobility group AT-hook 1 -0.0288175
RFX7 regulatory factor X, 7 -0.0287867
ZNF644 zinc finger protein 644 -0.0286979
CHD7 chromodomain helicase DNA binding protein 7 -0.0286476
PCBP2 poly(rC) binding protein 2 -0.0283101
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0282635
RPS15 ribosomal protein S15 -0.0281974
RRBP1 ribosome binding protein 1 -0.0278989
MEF2A myocyte enhancer factor 2A -0.0275558
FHIT fragile histidine triad -0.0275453
TAS2R14 taste receptor, type 2, member 14 -0.0269666
SRPK2 SRSF protein kinase 2 -0.0268566
BLZF1 basic leucine zipper nuclear factor 1 -0.0267177
ADIPOR2 adiponectin receptor 2 -0.0266858