| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Almonertinib (hydrochloride) perturbation in RPMI-7951 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Almonertinib (hydrochloride)_RPMI-7951 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | 0.127957 |
| FTL | ferritin, light polypeptide | 0.0859606 |
| MT2A | metallothionein 2A | 0.0769704 |
| RPL35A | ribosomal protein L35a | 0.0571427 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.055943 |
| FAM162A | family with sequence similarity 162, member A | 0.0504167 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0497652 |
| RPS8 | ribosomal protein S8 | 0.0487334 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0475759 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0463049 |
| STC1 | stanniocalcin 1 | 0.0453087 |
| RPLP1 | ribosomal protein, large, P1 | 0.0452313 |
| PTMA | prothymosin, alpha | 0.0446153 |
| RPS12 | ribosomal protein S12 | 0.0413853 |
| ANGPTL4 | angiopoietin-like 4 | 0.0412815 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0411043 |
| RPL23 | ribosomal protein L23 | 0.037851 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0373594 |
| RPS19 | ribosomal protein S19 | 0.0364686 |
| YBX1 | Y box binding protein 1 | 0.0344661 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0335154 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0327742 |
| RPL36 | ribosomal protein L36 | 0.030814 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0306637 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0292911 |
| CD109 | CD109 molecule | 0.0290583 |
| RPL12 | ribosomal protein L12 | 0.0270014 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0269003 |
| RPS6 | ribosomal protein S6 | 0.0254998 |
| LDHA | lactate dehydrogenase A | 0.0251694 |
| RPLP0 | ribosomal protein, large, P0 | 0.0250659 |
| RPL26 | ribosomal protein L26 | 0.0246156 |
| EGR1 | early growth response 1 | 0.0245361 |
| CAVIN1 | caveolae associated protein 1 | 0.0245007 |
| RPLP2 | ribosomal protein, large, P2 | 0.0244731 |
| PGK1 | phosphoglycerate kinase 1 | 0.0243992 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0243521 |
| ADM | adrenomedullin | 0.0239801 |
| RPS3 | ribosomal protein S3 | 0.0236709 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0234784 |
| RPL34 | ribosomal protein L34 | 0.0232869 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | 0.0225241 |
| SEC61G | Sec61 gamma subunit | 0.0223129 |
| JUN | jun proto-oncogene | 0.0222398 |
| RLF | rearranged L-myc fusion | 0.0222096 |
| KDM5B | lysine (K)-specific demethylase 5B | 0.0221812 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0213879 |
| RYBP | RING1 and YY1 binding protein | 0.0212196 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0210341 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | 0.0209972 |
| RACK1 | receptor for activated C kinase 1 | 0.0203252 |
| RPS4X | ribosomal protein S4, X-linked | 0.019939 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0198949 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0197832 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.019267 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.0190567 |
| ATP5F1E | ATP synthase F1 subunit epsilon | 0.0189135 |
| RPS17 | ribosomal protein S17 | 0.0186667 |
| RPL37A | ribosomal protein L37a | 0.0185911 |
| S100A9 | S100 calcium binding protein A9 | 0.0182403 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0181228 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | 0.017888 |
| RPS27A | ribosomal protein S27a | 0.0178873 |
| TMSB10 | thymosin beta 10 | 0.0178103 |
| RPS21 | ribosomal protein S21 | 0.0175727 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0171819 |
| ARHGAP35 | Rho GTPase activating protein 35 | 0.0171601 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0171053 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0170849 |
| RBBP6 | retinoblastoma binding protein 6 | 0.0170532 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0168309 |
| VDAC1 | voltage-dependent anion channel 1 | 0.0167922 |
| OGA | O-GlcNAcase | 0.0167767 |
| FAM13A | family with sequence similarity 13, member A | 0.016648 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0166366 |
| RPL32 | ribosomal protein L32 | 0.0161609 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | 0.0160524 |
| ANXA2 | annexin A2 | 0.0160467 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0159512 |
| RPL30 | ribosomal protein L30 | 0.0159074 |
| RPL27A | ribosomal protein L27a | 0.0158644 |
| RAB13 | RAB13, member RAS oncogene family | 0.0157844 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0154084 |
| ARF1 | ADP-ribosylation factor 1 | 0.0153725 |
| PER1 | period circadian clock 1 | 0.0152821 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0151506 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | 0.0150438 |
| MORF4L1 | mortality factor 4 like 1 | 0.0149359 |
| RHEB | Ras homolog enriched in brain | 0.0149268 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.014912 |
| USP3 | ubiquitin specific peptidase 3 | 0.0149068 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0148804 |
| RPS24 | ribosomal protein S24 | 0.0148783 |
| WASF2 | WAS protein family, member 2 | 0.0148693 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0145864 |
| CALR | calreticulin | 0.0144082 |
| RPS20 | ribosomal protein S20 | 0.0143984 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0143319 |
| MT1X | metallothionein 1X | 0.0142643 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | 0.0142578 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.201721 |
| COL1A1 | collagen, type I, alpha 1 | -0.118592 |
| FRMD4A | FERM domain containing 4A | -0.117486 |
| FNDC3B | fibronectin type III domain containing 3B | -0.113962 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0915733 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0904602 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0842106 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0838449 |
| CDH13 | cadherin 13 | -0.0796921 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0749237 |
| NRP1 | neuropilin 1 | -0.0742635 |
| NAV1 | neuron navigator 1 | -0.0669131 |
| TPM1 | tropomyosin 1 (alpha) | -0.0649421 |
| APCDD1L | adenomatosis polyposis coli down-regulated 1-like | -0.0592853 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0591271 |
| EML5 | echinoderm microtubule associated protein like 5 | -0.0579911 |
| CD44 | CD44 molecule (Indian blood group) | -0.0550984 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0543475 |
| GLIS3 | GLIS family zinc finger 3 | -0.053697 |
| PTK2 | protein tyrosine kinase 2 | -0.0535866 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0532832 |
| HLA-B | major histocompatibility complex, class I, B | -0.0519575 |
| TNS3 | tensin 3 | -0.0514143 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0504324 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0502947 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0502037 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0493148 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0487266 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0482999 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0481674 |
| AFAP1 | actin filament associated protein 1 | -0.0480645 |
| DST | dystonin | -0.0476243 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0470301 |
| COL5A1 | collagen, type V, alpha 1 | -0.0457076 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0449617 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0449215 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0438466 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0436171 |
| SP100 | SP100 nuclear antigen | -0.0436123 |
| ASPH | aspartate beta-hydroxylase | -0.0434663 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0422695 |
| USP34 | ubiquitin specific peptidase 34 | -0.0420919 |
| FAM20C | family with sequence similarity 20, member C | -0.0414458 |
| RAD51B | RAD51 paralog B | -0.0412484 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0411641 |
| FHIT | fragile histidine triad | -0.0409957 |
| RFX8 | RFX family member 8, lacking RFX DNA binding domain | -0.0403017 |
| MSN | moesin | -0.0399276 |
| IL1B | interleukin 1, beta | -0.0388978 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0388601 |
| NAV2 | neuron navigator 2 | -0.0388209 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0383149 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.037792 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0376329 |
| NBAS | neuroblastoma amplified sequence | -0.0370332 |
| VEGFA | vascular endothelial growth factor A | -0.0363394 |
| MMP12 | matrix metallopeptidase 12 | -0.0359058 |
| ADAM12 | ADAM metallopeptidase domain 12 | -0.0357744 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0357503 |
| ATXN1 | ataxin 1 | -0.035258 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0350939 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0347095 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0346411 |
| ITGA11 | integrin, alpha 11 | -0.0346082 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0345379 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0338337 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0337667 |
| SH3RF3 | SH3 domain containing ring finger 3 | -0.0333031 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0331728 |
| LOXL2 | lysyl oxidase-like 2 | -0.0328805 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.032401 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.031132 |
| CDCP1 | CUB domain containing protein 1 | -0.0308563 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0307187 |
| YEATS2 | YEATS domain containing 2 | -0.0306656 |
| EXOC4 | exocyst complex component 4 | -0.0304763 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.030171 |
| PLSCR1 | phospholipid scramblase 1 | -0.0299782 |
| MSR1 | macrophage scavenger receptor 1 | -0.0298602 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | -0.0297498 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.0291758 |
| INHBA | inhibin, beta A | -0.0289478 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0284261 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0281567 |
| TMEM178B | transmembrane protein 178B | -0.0276525 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0275918 |
| FLNB | filamin B, beta | -0.0273298 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | -0.0270297 |
| CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | -0.0263558 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0263127 |
| SVIL | supervillin | -0.0261923 |
| RUNX1 | runt-related transcription factor 1 | -0.0261744 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.0260714 |
| MED13L | mediator complex subunit 13-like | -0.0257024 |
| LPAR1 | lysophosphatidic acid receptor 1 | -0.0256403 |
| TCF12 | transcription factor 12 | -0.0255659 |
| BBX | bobby sox homolog (Drosophila) | -0.0255086 |
| SBF2 | SET binding factor 2 | -0.0252195 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0249785 |
| CLTC | clathrin, heavy chain (Hc) | -0.0249774 |
