| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Almonertinib (hydrochloride) perturbation in SHP-77 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Almonertinib (hydrochloride)_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE10A | phosphodiesterase 10A | 0.149281 |
| PTMA | prothymosin, alpha | 0.111061 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0744251 |
| CENPF | centromere protein F, 350/400kDa | 0.0707569 |
| PEG10 | paternally expressed 10 | 0.0684396 |
| TENM1 | teneurin transmembrane protein 1 | 0.0638152 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 0.0565497 |
| CALCA | calcitonin-related polypeptide alpha | 0.0537848 |
| FTL | ferritin, light polypeptide | 0.049693 |
| PCSK1 | proprotein convertase subtilisin/kexin type 1 | 0.0463263 |
| MT2A | metallothionein 2A | 0.0462297 |
| ENO1 | enolase 1, (alpha) | 0.0435575 |
| SASH1 | SAM and SH3 domain containing 1 | 0.0410405 |
| VGF | VGF nerve growth factor inducible | 0.0407674 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.0401271 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0390905 |
| TXNRD1 | thioredoxin reductase 1 | 0.0385027 |
| SINHCAF | SIN3-HDAC complex associated factor | 0.0381471 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0380676 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0373546 |
| MKI67 | marker of proliferation Ki-67 | 0.0349311 |
| RPS3 | ribosomal protein S3 | 0.0346387 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0342578 |
| NIPSNAP2 | nipsnap homolog 2 | 0.0317906 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.031157 |
| PCM1 | pericentriolar material 1 | 0.0304915 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0301359 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0299212 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0296436 |
| AOPEP | aminopeptidase O (putative) | 0.0295674 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 0.0292 |
| SYT1 | synaptotagmin I | 0.0278275 |
| RPS6 | ribosomal protein S6 | 0.0275534 |
| SMC1A | structural maintenance of chromosomes 1A | 0.0273189 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0270492 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.0267762 |
| RTN4 | reticulon 4 | 0.0262926 |
| CCDC88A | coiled-coil domain containing 88A | 0.0262531 |
| MIS18BP1 | MIS18 binding protein 1 | 0.0258789 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0257233 |
| PITPNM2 | phosphatidylinositol transfer protein, membrane-associated 2 | 0.025512 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | 0.0254037 |
| MATR3 | matrin 3 | 0.0252996 |
| RIT2 | Ras-like without CAAX 2 | 0.0251139 |
| RPS21 | ribosomal protein S21 | 0.0251129 |
| STMN1 | stathmin 1 | 0.0246275 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0245971 |
| CPE | carboxypeptidase E | 0.0239196 |
| PEX5L | peroxisomal biogenesis factor 5-like | 0.023895 |
| ARB2A | ARB2 cotranscriptional regulator A | 0.023598 |
| CKAP5 | cytoskeleton associated protein 5 | 0.023408 |
| IRS2 | insulin receptor substrate 2 | 0.0232308 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0230818 |
| ZNF292 | zinc finger protein 292 | 0.0227497 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0225004 |
| FGF14 | fibroblast growth factor 14 | 0.0224702 |
| NCOR1 | nuclear receptor corepressor 1 | 0.0224444 |
| PGK1 | phosphoglycerate kinase 1 | 0.0223289 |
| XPO1 | exportin 1 | 0.021979 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0214126 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0212349 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0211669 |
| RPS8 | ribosomal protein S8 | 0.0210103 |
| RPLP1 | ribosomal protein, large, P1 | 0.0207705 |
| S100A9 | S100 calcium binding protein A9 | 0.0205106 |
| MTMR7 | myotubularin related protein 7 | 0.0204452 |
| ASCL1 | achaete-scute family bHLH transcription factor 1 | 0.0204362 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0200687 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0200375 |
| RPS19 | ribosomal protein S19 | 0.0198871 |
| SET | SET nuclear proto-oncogene | 0.0198258 |
| RPL8 | ribosomal protein L8 | 0.0197319 |
| RPS12 | ribosomal protein S12 | 0.019523 |
| NFIA | nuclear factor I/A | 0.019187 |
| SLC35F4 | solute carrier family 35, member F4 | 0.0191073 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0189277 |
| GRIK1 | glutamate receptor, ionotropic, kainate 1 | 0.0187943 |
| TUBB | tubulin, beta class I | 0.0185909 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0183493 |
| RPL26 | ribosomal protein L26 | 0.0182783 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0182181 |
| SLC36A4 | solute carrier family 36 (proton/amino acid symporter), member 4 | 0.017985 |
| CBX3 | chromobox homolog 3 | 0.0179335 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0177992 |
| NOVA1 | neuro-oncological ventral antigen 1 | 0.0177009 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | 0.017612 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0175807 |
| DGKB | diacylglycerol kinase, beta 90kDa | 0.0174592 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0173374 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.017308 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0171461 |
| KIF5B | kinesin family member 5B | 0.0171243 |
| FCHSD2 | FCH and double SH3 domains 2 | 0.0171222 |
| RPL7 | ribosomal protein L7 | 0.017054 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.0170404 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0170089 |
| KCND2 | potassium channel, voltage gated Shal related subfamily D, member 2 | 0.0168272 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0168193 |
| SPIDR | scaffolding protein involved in DNA repair | 0.0167957 |
| TUBA1B | tubulin, alpha 1b | 0.0167508 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GPC6 | glypican 6 | -0.0924349 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | -0.0871186 |
| NRG1 | neuregulin 1 | -0.0821661 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0706991 |
| RORA | RAR-related orphan receptor A | -0.0676945 |
| MCL1 | myeloid cell leukemia 1 | -0.0620485 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | -0.0522171 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0511913 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0450482 |
| NDRG1 | N-myc downstream regulated 1 | -0.0447235 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0357567 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0343255 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0328127 |
| KLHL29 | kelch-like family member 29 | -0.0324764 |
| HOMER1 | homer scaffolding protein 1 | -0.0322628 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | -0.030496 |
| KIF26B | kinesin family member 26B | -0.0289401 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0276891 |
| SNTG1 | syntrophin, gamma 1 | -0.027439 |
| TSHZ2 | teashirt zinc finger homeobox 2 | -0.0270149 |
| EYA2 | EYA transcriptional coactivator and phosphatase 2 | -0.0266341 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0257998 |
| DTNA | dystrobrevin, alpha | -0.0249269 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0244812 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.024251 |
| ESRRG | estrogen-related receptor gamma | -0.0239821 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0238093 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.023716 |
| STC1 | stanniocalcin 1 | -0.0227418 |
| ANKRD36C | ankyrin repeat domain 36C | -0.0227304 |
| ST18 | suppression of tumorigenicity 18, zinc finger | -0.0224109 |
| KCNMB3 | potassium channel subfamily M regulatory beta subunit 3 | -0.0220505 |
| ASPH | aspartate beta-hydroxylase | -0.0219526 |
| APP | amyloid beta (A4) precursor protein | -0.0208022 |
| FAM13A | family with sequence similarity 13, member A | -0.0207871 |
| CACNA1A | calcium channel, voltage-dependent, P/Q type, alpha 1A subunit | -0.0206542 |
| SETX | senataxin | -0.0206169 |
| PTCHD4 | patched domain containing 4 | -0.0205941 |
| NELL1 | NEL-like 1 (chicken) | -0.0201757 |
| CDK13 | cyclin-dependent kinase 13 | -0.0200435 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0195714 |
| INTS6 | integrator complex subunit 6 | -0.0194958 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | -0.0193149 |
| DENND4A | DENN/MADD domain containing 4A | -0.019139 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | -0.0190935 |
| TOP1 | topoisomerase (DNA) I | -0.0189759 |
| EFNA5 | ephrin-A5 | -0.0187573 |
| HM13 | histocompatibility (minor) 13 | -0.0187465 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0180941 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | -0.0179512 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0177951 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0177478 |
| ZFHX3 | zinc finger homeobox 3 | -0.0177465 |
| SCFD1 | sec1 family domain containing 1 | -0.0173729 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0172947 |
| NANOS1 | nanos homolog 1 (Drosophila) | -0.0172256 |
| MYT1L | myelin transcription factor 1-like | -0.0169349 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0166815 |
| PAEP | progestagen-associated endometrial protein | -0.0166481 |
| ARFGEF3 | ARFGEF family member 3 | -0.0165855 |
| EPHA6 | EPH receptor A6 | -0.0160951 |
| DGKD | diacylglycerol kinase, delta 130kDa | -0.0158877 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0155127 |
| LSAMP | limbic system-associated membrane protein | -0.0154444 |
| SP100 | SP100 nuclear antigen | -0.0151182 |
| SKI | SKI proto-oncogene | -0.0147634 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.014563 |
| NBEA | neurobeachin | -0.0144357 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0143349 |
| SMYD3 | SET and MYND domain containing 3 | -0.0140744 |
| EGFR | epidermal growth factor receptor | -0.0140267 |
| KCNJ6 | potassium channel, inwardly rectifying subfamily J, member 6 | -0.0140233 |
| LRFN2 | leucine rich repeat and fibronectin type III domain containing 2 | -0.0138934 |
| GPATCH2L | G patch domain containing 2-like | -0.0138392 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | -0.0136688 |
| ACTG1 | actin gamma 1 | -0.013604 |
| NAV2 | neuron navigator 2 | -0.0134173 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0133577 |
| EGR1 | early growth response 1 | -0.0133129 |
| PALLD | palladin, cytoskeletal associated protein | -0.0132878 |
| TTC19 | tetratricopeptide repeat domain 19 | -0.0131344 |
| ERO1B | endoplasmic reticulum oxidoreductase 1 beta | -0.0130794 |
| RGS17 | regulator of G-protein signaling 17 | -0.0129388 |
| GOLGA3 | golgin A3 | -0.0128002 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0127423 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -0.0126696 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | -0.0126266 |
| IQSEC1 | IQ motif and Sec7 domain 1 | -0.0126169 |
| WLS | wntless Wnt ligand secretion mediator | -0.0124825 |
| ATF6 | activating transcription factor 6 | -0.0124526 |
| GOLGB1 | golgin B1 | -0.012439 |
| EIF2AK3 | eukaryotic translation initiation factor 2-alpha kinase 3 | -0.012298 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.0121858 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0121654 |
| FERMT2 | fermitin family member 2 | -0.0119666 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0118781 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0117946 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0117865 |
| AP3B2 | adaptor-related protein complex 3, beta 2 subunit | -0.0117296 |
| PTPRS | protein tyrosine phosphatase, receptor type, S | -0.011511 |
