| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Almonertinib (hydrochloride) perturbation in SK-MEL-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Almonertinib (hydrochloride)_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | 0.10892 |
| FN1 | fibronectin 1 | 0.0832955 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.077589 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0760098 |
| POTEF | POTE ankyrin domain family, member F | 0.0730987 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0673911 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0672857 |
| MSN | moesin | 0.0645097 |
| FRMD4A | FERM domain containing 4A | 0.0595016 |
| HDAC9 | histone deacetylase 9 | 0.0592235 |
| CD59 | CD59 molecule, complement regulatory protein | 0.0435468 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0433081 |
| MELTF | melanotransferrin | 0.0430266 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0421755 |
| ANGPTL4 | angiopoietin-like 4 | 0.040175 |
| RPS3 | ribosomal protein S3 | 0.0397852 |
| MT1X | metallothionein 1X | 0.038921 |
| GRID2 | glutamate receptor, ionotropic, delta 2 | 0.0384928 |
| RPS12 | ribosomal protein S12 | 0.0380482 |
| ASPH | aspartate beta-hydroxylase | 0.0371874 |
| RUNX1 | runt-related transcription factor 1 | 0.0355541 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0348886 |
| VMP1 | vacuole membrane protein 1 | 0.0322557 |
| FLNA | filamin A, alpha | 0.0310396 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0304831 |
| TPM3 | tropomyosin 3 | 0.0295662 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0295203 |
| FLNB | filamin B, beta | 0.028804 |
| FHIT | fragile histidine triad | 0.0282907 |
| YBX3 | Y box binding protein 3 | 0.0279017 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0276879 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | 0.0275855 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.0275291 |
| NOTCH2 | notch 2 | 0.0273463 |
| SFPQ | splicing factor proline/glutamine-rich | 0.027119 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0268134 |
| FRMD5 | FERM domain containing 5 | 0.0265822 |
| TAGLN2 | transgelin 2 | 0.0264227 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.025693 |
| DPY19L1 | dpy-19-like 1 (C. elegans) | 0.0252981 |
| IFI44L | interferon-induced protein 44-like | 0.0252408 |
| B2M | beta-2-microglobulin | 0.0251113 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0250283 |
| RAD51B | RAD51 paralog B | 0.0249853 |
| MACROD2 | MACRO domain containing 2 | 0.0245072 |
| RANGAP1 | Ran GTPase activating protein 1 | 0.0243641 |
| CENPF | centromere protein F, 350/400kDa | 0.024197 |
| MCL1 | myeloid cell leukemia 1 | 0.02419 |
| PTK2 | protein tyrosine kinase 2 | 0.023216 |
| BRD4 | bromodomain containing 4 | 0.0231231 |
| FMNL2 | formin-like 2 | 0.0229317 |
| RPL23 | ribosomal protein L23 | 0.0228343 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0227565 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0220989 |
| PCBP2 | poly(rC) binding protein 2 | 0.0216662 |
| CBX3 | chromobox homolog 3 | 0.021426 |
| RPL37A | ribosomal protein L37a | 0.0212045 |
| SON | SON DNA binding protein | 0.0211025 |
| AMOTL1 | angiomotin like 1 | 0.0208867 |
| NDRG1 | N-myc downstream regulated 1 | 0.0208865 |
| S100A9 | S100 calcium binding protein A9 | 0.0205061 |
| RPS21 | ribosomal protein S21 | 0.0204551 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0204024 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0202564 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0197178 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0196736 |
| RPL3 | ribosomal protein L3 | 0.0194107 |
| ATP5F1E | ATP synthase F1 subunit epsilon | 0.019403 |
| SET | SET nuclear proto-oncogene | 0.0191626 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0191064 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.019055 |
| ZNF114 | zinc finger protein 114 | 0.0190482 |
| CALD1 | caldesmon 1 | 0.0190152 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0189756 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0187005 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0186372 |
| ZFYVE16 | zinc finger, FYVE domain containing 16 | 0.0184546 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.018447 |
| SEC61G | Sec61 gamma subunit | 0.0184038 |
| TM9SF4 | transmembrane 9 superfamily protein member 4 | 0.0183717 |
| FAM219A | family with sequence similarity 219, member A | 0.0182894 |
| ACTN1 | actinin, alpha 1 | 0.0181895 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | 0.0178348 |
| NSUN6 | NOP2/Sun domain family, member 6 | 0.0177687 |
| RNF144A | ring finger protein 144A | 0.0175382 |
| SNX6 | sorting nexin 6 | 0.0174815 |
| RPL35A | ribosomal protein L35a | 0.0174555 |
| ZNRF1 | zinc and ring finger 1, E3 ubiquitin protein ligase | 0.0174186 |
| ZNF462 | zinc finger protein 462 | 0.0173104 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0172459 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.0169159 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0166873 |
| S100A13 | S100 calcium binding protein A13 | 0.0166641 |
| RPL36A | ribosomal protein L36a | 0.0166336 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | 0.0165756 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0165485 |
| RASAL2 | RAS protein activator like 2 | 0.016486 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0164781 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.016253 |
| RCOR1 | REST corepressor 1 | 0.0162111 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.205486 |
| LSAMP | limbic system-associated membrane protein | -0.178384 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.159451 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0927851 |
| VIM | vimentin | -0.0818338 |
| NRG3 | neuregulin 3 | -0.0782171 |
| ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | -0.0725367 |
| FMN1 | formin 1 | -0.0723421 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0627563 |
| PMEL | premelanosome protein | -0.0607462 |
| NLGN1 | neuroligin 1 | -0.0575378 |
| CCND1 | cyclin D1 | -0.0557447 |
| CANX | calnexin | -0.0531103 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0495464 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0494386 |
| FTL | ferritin, light polypeptide | -0.0488985 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0469247 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0451615 |
| SQSTM1 | sequestosome 1 | -0.0449511 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0448452 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0402195 |
| RPL38 | ribosomal protein L38 | -0.0385141 |
| PTMA | prothymosin, alpha | -0.0370131 |
| IER3 | immediate early response 3 | -0.0355987 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0349242 |
| CA8 | carbonic anhydrase VIII | -0.0341378 |
| MORF4L2 | mortality factor 4 like 2 | -0.0340256 |
| MXI1 | MAX interactor 1, dimerization protein | -0.0334075 |
| ANXA2 | annexin A2 | -0.0327982 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0326052 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0323241 |
| MAP4 | microtubule-associated protein 4 | -0.0321032 |
| GOLGA4 | golgin A4 | -0.031938 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0318698 |
| TPTEP2-CSNK1E | TPTEP2-CSNK1E readthrough | -0.0316934 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0315564 |
| UBC | ubiquitin C | -0.0314375 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0311594 |
| ACTG1 | actin gamma 1 | -0.0308822 |
| NAV2 | neuron navigator 2 | -0.0306322 |
| MARCHF1 | membrane associated ring-CH-type finger 1 | -0.0299686 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.029425 |
| GNB4 | guanine nucleotide binding protein (G protein), beta polypeptide 4 | -0.0293767 |
| MSI2 | musashi RNA-binding protein 2 | -0.0293737 |
| RPS23 | ribosomal protein S23 | -0.0293241 |
| CCDC47 | coiled-coil domain containing 47 | -0.0291189 |
| ARF1 | ADP-ribosylation factor 1 | -0.0290377 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0289565 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0289 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0286999 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0284074 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0282534 |
| CDH13 | cadherin 13 | -0.028055 |
| FBXL2 | F-box and leucine-rich repeat protein 2 | -0.0279396 |
| CDK13 | cyclin-dependent kinase 13 | -0.0277318 |
| DMXL1 | Dmx-like 1 | -0.0272852 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.027139 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0271016 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.027075 |
| DEK | DEK proto-oncogene | -0.0266735 |
| ANLN | anillin, actin binding protein | -0.0263805 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0263736 |
| EMP1 | epithelial membrane protein 1 | -0.0263687 |
| RRBP1 | ribosome binding protein 1 | -0.0261269 |
| RYBP | RING1 and YY1 binding protein | -0.0261219 |
| RPS24 | ribosomal protein S24 | -0.0260121 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0259665 |
| SFTPA2 | surfactant protein A2 | -0.0258582 |
| NAP1L4 | nucleosome assembly protein 1-like 4 | -0.0255643 |
| S100A10 | S100 calcium binding protein A10 | -0.025391 |
| PSMB7 | proteasome (prosome, macropain) subunit, beta type, 7 | -0.0253875 |
| WDFY1 | WD repeat and FYVE domain containing 1 | -0.0253131 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0250008 |
| RAB1A | RAB1A, member RAS oncogene family | -0.02492 |
| FYN | FYN proto-oncogene, Src family tyrosine kinase | -0.0246706 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0246389 |
| HELZ | helicase with zinc finger | -0.0245006 |
| FUS | FUS RNA binding protein | -0.0244657 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.024363 |
| ACBD6 | acyl-CoA binding domain containing 6 | -0.0243323 |
| WDR45B | WD repeat domain 45B | -0.024331 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | -0.0242828 |
| LITAF | lipopolysaccharide-induced TNF factor | -0.0242401 |
| HDAC8 | histone deacetylase 8 | -0.0241144 |
| HLA-B | major histocompatibility complex, class I, B | -0.0240441 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0239827 |
| UBE2O | ubiquitin-conjugating enzyme E2O | -0.0238931 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0237328 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.0235891 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0235804 |
| SPAG9 | sperm associated antigen 9 | -0.0234649 |
| THOC2 | THO complex 2 | -0.0234134 |
| GPHN | gephyrin | -0.0233338 |
| LRCH3 | leucine-rich repeats and calponin homology (CH) domain containing 3 | -0.0233109 |
| TBCA | tubulin folding cofactor A | -0.0231983 |
| NDFIP1 | Nedd4 family interacting protein 1 | -0.0230348 |
| CALU | calumenin | -0.0230136 |
| RPL11 | ribosomal protein L11 | -0.0229728 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0227417 |
| KAZN | kazrin, periplakin interacting protein | -0.0226535 |
