Almonertinib (hydrochloride)_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Almonertinib (hydrochloride) perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Almonertinib (hydrochloride)_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.102093
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0941289
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0717563
PTMA prothymosin, alpha 0.0685933
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.043595
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0416683
RBM39 RNA binding motif protein 39 0.0394569
ZNF292 zinc finger protein 292 0.0390987
PGK1 phosphoglycerate kinase 1 0.037764
NAMPT nicotinamide phosphoribosyltransferase 0.0375036
RPS6 ribosomal protein S6 0.0335805
B2M beta-2-microglobulin 0.0335719
PKM pyruvate kinase, muscle 0.0316749
RTN4 reticulon 4 0.0316097
GOLGA4 golgin A4 0.0306417
EIF1 eukaryotic translation initiation factor 1 0.0294739
TXNIP thioredoxin interacting protein 0.0284644
ZFAND3 zinc finger, AN1-type domain 3 0.0282914
S100A6 S100 calcium binding protein A6 0.0277467
KDM3A lysine (K)-specific demethylase 3A 0.0269553
KMT2E lysine (K)-specific methyltransferase 2E 0.0267298
EIF4A2 eukaryotic translation initiation factor 4A2 0.0267044
WSB1 WD repeat and SOCS box containing 1 0.0263945
RPS19 ribosomal protein S19 0.0257341
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0256507
FTL ferritin, light polypeptide 0.0251355
DSCAM Down syndrome cell adhesion molecule 0.0242756
ADAM10 ADAM metallopeptidase domain 10 0.0241442
RPS3 ribosomal protein S3 0.0238618
RLF rearranged L-myc fusion 0.0222456
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0220506
VMP1 vacuole membrane protein 1 0.0219915
GARS1 glycyl-tRNA synthetase 1 0.0218743
XPO1 exportin 1 0.0218348
ANK2 ankyrin 2, neuronal 0.0217464
SQSTM1 sequestosome 1 0.0214109
CAMTA1 calmodulin binding transcription activator 1 0.0212605
OGA O-GlcNAcase 0.0209545
QKI QKI, KH domain containing, RNA binding 0.0209118
TFG TRK-fused gene 0.0207645
COG5 component of oligomeric golgi complex 5 0.0198841
UBA6 ubiquitin-like modifier activating enzyme 6 0.01975
EEF2 eukaryotic translation elongation factor 2 0.0193985
EML4 echinoderm microtubule associated protein like 4 0.0193573
RPL3 ribosomal protein L3 0.0187674
TXNRD1 thioredoxin reductase 1 0.0184636
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0184083
RPL35A ribosomal protein L35a 0.0181218
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0180988
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0179727
ARID4B AT rich interactive domain 4B (RBP1-like) 0.017969
RPL13A ribosomal protein L13a 0.0179632
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.017775
NBAS neuroblastoma amplified sequence 0.0177249
PYGB phosphorylase, glycogen; brain 0.0177217
FXR1 fragile X mental retardation, autosomal homolog 1 0.0176412
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0174761
RPL31 ribosomal protein L31 0.0171201
EXT1 exostosin glycosyltransferase 1 0.0168715
RPL37A ribosomal protein L37a 0.0168327
ADAM17 ADAM metallopeptidase domain 17 0.0167049
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0165165
RPL19 ribosomal protein L19 0.0163839
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0162788
FAM13A family with sequence similarity 13, member A 0.016261
RAB1A RAB1A, member RAS oncogene family 0.0162456
FNDC3B fibronectin type III domain containing 3B 0.0160909
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0158181
RPS29 ribosomal protein S29 0.015783
ELOVL5 ELOVL fatty acid elongase 5 0.0156604
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0155249
RNF145 ring finger protein 145 0.015443
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0153741
RPS12 ribosomal protein S12 0.0153443
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0152472
LDHA lactate dehydrogenase A 0.0151817
CDC73 cell division cycle 73 0.0151685
NCKAP1 NCK-associated protein 1 0.0151057
ADAM9 ADAM metallopeptidase domain 9 0.0151001
RPS2 ribosomal protein S2 0.0150232
FBXO11 F-box protein 11 0.01498
RPS25 ribosomal protein S25 0.0148944
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0148377
RPL23 ribosomal protein L23 0.0148276
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0147284
PTBP2 polypyrimidine tract binding protein 2 0.0147099
RSRC2 arginine/serine-rich coiled-coil 2 0.0146884
PHIP pleckstrin homology domain interacting protein 0.0146594
RPS27A ribosomal protein S27a 0.0146073
NCOA3 nuclear receptor coactivator 3 0.0144312
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0143817
RPLP1 ribosomal protein, large, P1 0.0142851
CCNL1 cyclin L1 0.0141784
USP9X ubiquitin specific peptidase 9, X-linked 0.0141472
PRRC2C proline-rich coiled-coil 2C 0.014098
CHD1 chromodomain helicase DNA binding protein 1 0.0140906
TPD52 tumor protein D52 0.0140888
DENND4A DENN/MADD domain containing 4A 0.0140709
STAG2 stromal antigen 2 0.0140231
KMT2C lysine (K)-specific methyltransferase 2C 0.0139481

decreased expression

Symbol Name Standardized Value
PDE4B phosphodiesterase 4B, cAMP-specific -0.0982682
BMP10 bone morphogenetic protein 10 -0.0838135
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0779704
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0775313
VCL vinculin -0.0706852
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0656065
NBEA neurobeachin -0.0467097
DLG1 discs, large homolog 1 (Drosophila) -0.0389972
GLI3 GLI family zinc finger 3 -0.0362207
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0361208
SOX6 SRY (sex determining region Y)-box 6 -0.0354584
DIAPH3 diaphanous-related formin 3 -0.0342957
CCND1 cyclin D1 -0.0332085
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -0.0326621
AHNAK AHNAK nucleoprotein -0.0314062
NPAS2 neuronal PAS domain protein 2 -0.0306508
CAMKMT calmodulin-lysine N-methyltransferase -0.0297523
EGFR epidermal growth factor receptor -0.0295912
DPYD dihydropyrimidine dehydrogenase -0.0289557
GLI2 GLI family zinc finger 2 -0.0270234
FOXP1 forkhead box P1 -0.0258615
EBNA1BP2 EBNA1 binding protein 2 -0.0244724
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 -0.0236634
PDE4D phosphodiesterase 4D, cAMP-specific -0.0233827
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0232027
SMC4 structural maintenance of chromosomes 4 -0.0218753
CRPPA CDP-L-ribitol pyrophosphorylase A -0.0213921
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 -0.0210565
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0209936
LPP LIM domain containing preferred translocation partner in lipoma -0.0209602
CENPF centromere protein F, 350/400kDa -0.0202413
NAV2 neuron navigator 2 -0.0195956
RFC3 replication factor C (activator 1) 3, 38kDa -0.01927
MKI67 marker of proliferation Ki-67 -0.0190338
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 -0.0188353
ZNF438 zinc finger protein 438 -0.0187726
TTC28 tetratricopeptide repeat domain 28 -0.0185765
EVI5 ecotropic viral integration site 5 -0.0184899
MYO5C myosin VC -0.0183313
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 -0.0178408
ARL4C ADP-ribosylation factor-like 4C -0.017517
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.016948
FUS FUS RNA binding protein -0.016943
CUX1 cut-like homeobox 1 -0.0166062
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0160394
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.0160283
SDK1 sidekick cell adhesion molecule 1 -0.0157982
SPRY4 sprouty homolog 4 (Drosophila) -0.0156356
PRUNE2 prune homolog 2 (Drosophila) -0.0154456
S100A4 S100 calcium binding protein A4 -0.0151999
TPX2 TPX2, microtubule-associated -0.0151495
PDE7B phosphodiesterase 7B -0.0148521
CACNB4 calcium channel, voltage-dependent, beta 4 subunit -0.0142106
BMP2K BMP2 inducible kinase -0.0140527
ZZZ3 zinc finger, ZZ-type containing 3 -0.0139472
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.0139014
EPC2 enhancer of polycomb homolog 2 (Drosophila) -0.0138053
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0136894
COMMD10 COMM domain containing 10 -0.013614
FER1L6 fer-1-like family member 6 -0.013581
ANLN anillin, actin binding protein -0.0133684
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.013274
HJURP Holliday junction recognition protein -0.0131046
LOC102724023 ES1 protein homolog, mitochondrial -0.0128959
SLC38A2 solute carrier family 38, member 2 -0.0128016
CENPE centromere protein E, 312kDa -0.0127623
CTIF CBP80/20-dependent translation initiation factor -0.012591
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0125369
UNC13A unc-13 homolog A (C. elegans) -0.0125074
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0124629
TUBA1B tubulin, alpha 1b -0.0124023
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0123639
PKP4 plakophilin 4 -0.0123303
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0123078
CNTNAP3B contactin associated protein-like 3B -0.0122619
TAS2R14 taste receptor, type 2, member 14 -0.0120296
RPLP0 ribosomal protein, large, P0 -0.0120083
PRSS23 protease, serine, 23 -0.0118907
RBL1 retinoblastoma-like 1 -0.0118399
TSC22D1 TSC22 domain family, member 1 -0.0117927
ZBTB38 zinc finger and BTB domain containing 38 -0.0115896
RRM2 ribonucleotide reductase M2 -0.011248
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0112395
FAF1 Fas (TNFRSF6) associated factor 1 -0.0111674
SMIM44 small integral membrane protein 44 -0.0111531
TPT1 tumor protein, translationally-controlled 1 -0.0109709
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form) -0.0109104
ONECUT2 one cut homeobox 2 -0.0107476
HDAC9 histone deacetylase 9 -0.0106218
NEBL nebulette -0.0105835
RAN RAN, member RAS oncogene family -0.0105753
HSPB1 heat shock 27kDa protein 1 -0.0105655
MSRB3 methionine sulfoxide reductase B3 -0.0105034
SCLT1 sodium channel and clathrin linker 1 -0.0102069
PRH1 proline-rich protein HaeIII subfamily 1 -0.0101195
PARD3 par-3 family cell polarity regulator -0.0101041
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 -0.0100152
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.00999554
RYR2 ryanodine receptor 2 (cardiac) -0.00999296
TUBB tubulin, beta class I -0.00997122