Almonertinib (hydrochloride)_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Almonertinib (hydrochloride) perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Almonertinib (hydrochloride)_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.106272
TPT1 tumor protein, translationally-controlled 1 0.104366
RPS12 ribosomal protein S12 0.097757
PGK1 phosphoglycerate kinase 1 0.0829477
MT2A metallothionein 2A 0.0814544
RPS3 ribosomal protein S3 0.0804444
RPS8 ribosomal protein S8 0.0745355
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0722613
RPL37A ribosomal protein L37a 0.0669897
NAP1L1 nucleosome assembly protein 1-like 1 0.0652143
RPL26 ribosomal protein L26 0.064319
UGCG UDP-glucose ceramide glucosyltransferase 0.0612103
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0603716
RPS24 ribosomal protein S24 0.0555649
EEF2 eukaryotic translation elongation factor 2 0.0509124
FN1 fibronectin 1 0.0504981
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.050437
RPL23 ribosomal protein L23 0.0504108
RPLP2 ribosomal protein, large, P2 0.0502196
RPL35A ribosomal protein L35a 0.0499354
IGFBP3 insulin-like growth factor binding protein 3 0.0495046
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0493337
PTMA prothymosin, alpha 0.0476727
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0475133
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.047393
RPL12 ribosomal protein L12 0.0464279
RPL36A ribosomal protein L36a 0.0452309
FTL ferritin, light polypeptide 0.0447491
RPS2 ribosomal protein S2 0.043785
RPS27A ribosomal protein S27a 0.0431105
RACK1 receptor for activated C kinase 1 0.043084
RPLP1 ribosomal protein, large, P1 0.0415513
KDM3A lysine (K)-specific demethylase 3A 0.041194
WSB1 WD repeat and SOCS box containing 1 0.0408267
MXI1 MAX interactor 1, dimerization protein 0.0407371
RPS4X ribosomal protein S4, X-linked 0.0406001
OGA O-GlcNAcase 0.0399514
RPLP0 ribosomal protein, large, P0 0.0398145
B2M beta-2-microglobulin 0.0396652
FTH1 ferritin, heavy polypeptide 1 0.0394741
EIF1 eukaryotic translation initiation factor 1 0.0380915
RPS6 ribosomal protein S6 0.0379125
RPL27A ribosomal protein L27a 0.0362452
RPS13 ribosomal protein S13 0.0361548
ELL2 elongation factor, RNA polymerase II, 2 0.0357604
YBX1 Y box binding protein 1 0.0351306
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0346726
SFTPA2 surfactant protein A2 0.0346679
WTAP Wilms tumor 1 associated protein 0.0330995
RPL36 ribosomal protein L36 0.0329631
SDC4 syndecan 4 0.0325387
IER3 immediate early response 3 0.0316856
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0299873
EEF1G eukaryotic translation elongation factor 1 gamma 0.0298231
HLA-E major histocompatibility complex, class I, E 0.0297539
CALR calreticulin 0.0295793
RPL19 ribosomal protein L19 0.0294609
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0293079
TKT transketolase 0.0287184
CAVIN1 caveolae associated protein 1 0.0284738
SERINC1 serine incorporator 1 0.0280967
NAMPT nicotinamide phosphoribosyltransferase 0.0280326
RPL32 ribosomal protein L32 0.0275707
STC1 stanniocalcin 1 0.027567
TSC22D2 TSC22 domain family, member 2 0.027329
BHLHE40 basic helix-loop-helix family, member e40 0.0268743
RPL39 ribosomal protein L39 0.0261331
NPEPPS aminopeptidase puromycin sensitive 0.0259829
RPL11 ribosomal protein L11 0.0255667
RPS25 ribosomal protein S25 0.0254246
RPS17 ribosomal protein S17 0.025262
ZFAND3 zinc finger, AN1-type domain 3 0.0252395
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0249686
RPL37 ribosomal protein L37 0.0249623
RLF rearranged L-myc fusion 0.0248951
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0248733
HLA-A major histocompatibility complex, class I, A 0.0246984
RPL18 ribosomal protein L18 0.0243392
RPS20 ribosomal protein S20 0.0242672
SPAG9 sperm associated antigen 9 0.0240806
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 0.0240659
MYH9 myosin, heavy chain 9, non-muscle 0.0240498
RPL31 ribosomal protein L31 0.0239208
ANLN anillin, actin binding protein 0.0237749
MATR3 matrin 3 0.023706
RPL14 ribosomal protein L14 0.0236796
SRGN serglycin 0.023671
POTEF POTE ankyrin domain family, member F 0.023604
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0235479
RPL15 ribosomal protein L15 0.023484
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0231941
DDIT4 DNA-damage-inducible transcript 4 0.0231236
CD63 CD63 molecule 0.0230579
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0226335
RPS14 ribosomal protein S14 0.0226232
RPL5 ribosomal protein L5 0.022542
RPL13A ribosomal protein L13a 0.0224492
RPS10 ribosomal protein S10 0.0222992
RPS16 ribosomal protein S16 0.0222862
GARS1 glycyl-tRNA synthetase 1 0.0220525

decreased expression

Symbol Name Standardized Value
FRMD4A FERM domain containing 4A -0.151267
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0872667
VCL vinculin -0.0819408
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.077619
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0736544
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0689725
PLIN2 perilipin 2 -0.0633558
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0618063
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0617154
SDK1 sidekick cell adhesion molecule 1 -0.0603825
ATXN1 ataxin 1 -0.0559785
EXT1 exostosin glycosyltransferase 1 -0.0528958
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0520736
HDAC9 histone deacetylase 9 -0.0517065
EGR1 early growth response 1 -0.051415
HMGA2 high mobility group AT-hook 2 -0.0500422
NAV2 neuron navigator 2 -0.0492217
NAV1 neuron navigator 1 -0.0479035
FNDC3B fibronectin type III domain containing 3B -0.0468514
CDH13 cadherin 13 -0.0467456
TRIO trio Rho guanine nucleotide exchange factor -0.0463698
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A -0.0439776
ZMYND8 zinc finger, MYND-type containing 8 -0.0439385
DST dystonin -0.0428744
EGFR epidermal growth factor receptor -0.0426048
FNIP1 folliculin interacting protein 1 -0.0425235
TNS3 tensin 3 -0.0421073
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.042033
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0391116
DIAPH2 diaphanous-related formin 2 -0.0387168
PDE10A phosphodiesterase 10A -0.0385137
RNF213 ring finger protein 213 -0.0383133
GLIS3 GLIS family zinc finger 3 -0.0373744
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0362983
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0350563
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0348622
NABP1 nucleic acid binding protein 1 -0.034585
JMJD1C jumonji domain containing 1C -0.0340083
ADAM12 ADAM metallopeptidase domain 12 -0.0339944
GOLGB1 golgin B1 -0.0337302
ANKRD12 ankyrin repeat domain 12 -0.0337188
PRELID2 PRELI domain containing 2 -0.0336538
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0327069
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0318565
C3 complement component 3 -0.0317395
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0311443
RAD51B RAD51 paralog B -0.0310139
IFI16 interferon, gamma-inducible protein 16 -0.0304393
ARFGEF3 ARFGEF family member 3 -0.0294629
INTS6 integrator complex subunit 6 -0.0289637
C6ORF62 chromosome 6 open reading frame 62 -0.0288545
NDRG1 N-myc downstream regulated 1 -0.0282016
CCNL1 cyclin L1 -0.0280069
MAML2 mastermind-like 2 (Drosophila) -0.0278028
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0274368
CLIC4 chloride intracellular channel 4 -0.0270139
RIGI RNA sensor RIG-I -0.0268079
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0265214
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0258084
EPAS1 endothelial PAS domain protein 1 -0.0257773
COL1A1 collagen, type I, alpha 1 -0.0253783
PALLD palladin, cytoskeletal associated protein -0.0253232
RAB7A RAB7A, member RAS oncogene family -0.0252143
SLC35F3 solute carrier family 35, member F3 -0.0251193
ZBTB38 zinc finger and BTB domain containing 38 -0.0250815
SEPTIN9 septin 9 -0.0245055
SMYD3 SET and MYND domain containing 3 -0.0244312
BPTF bromodomain PHD finger transcription factor -0.0242814
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0242269
ASPH aspartate beta-hydroxylase -0.0241768
BICC1 BicC family RNA binding protein 1 -0.0239601
PRR16 proline rich 16 -0.0235241
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0232241
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.02299
LPP LIM domain containing preferred translocation partner in lipoma -0.0223405
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0222759
ZNFX1 zinc finger, NFX1-type containing 1 -0.0220582
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0216967
ZBTB20 zinc finger and BTB domain containing 20 -0.0216664
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0214529
FBXL7 F-box and leucine-rich repeat protein 7 -0.0214286
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0212494
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0210471
SNX14 sorting nexin 14 -0.0209792
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0206682
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0206077
TMEM132D transmembrane protein 132D -0.0206003
PMP22 peripheral myelin protein 22 -0.0205945
EXOC4 exocyst complex component 4 -0.02037
ARL4C ADP-ribosylation factor-like 4C -0.0203256
DLG1 discs, large homolog 1 (Drosophila) -0.0201779
BTBD9 BTB (POZ) domain containing 9 -0.0199758
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.019953
FRMPD4 FERM and PDZ domain containing 4 -0.0199397
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0198941
PSD3 pleckstrin and Sec7 domain containing 3 -0.0198586
MYOF myoferlin -0.0194583
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.0193644
ENO2 enolase 2 (gamma, neuronal) -0.019357
PLSCR1 phospholipid scramblase 1 -0.0190165