| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Almonertinib (hydrochloride) perturbation in SW 1088 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Almonertinib (hydrochloride)_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | 0.277826 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.114334 |
| POTEF | POTE ankyrin domain family, member F | 0.107764 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.100461 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.09141 |
| IL6 | interleukin 6 | 0.0774452 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0711626 |
| B2M | beta-2-microglobulin | 0.0710818 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0678208 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0614443 |
| HMGA2 | high mobility group AT-hook 2 | 0.0609764 |
| MT1X | metallothionein 1X | 0.0594492 |
| NDRG1 | N-myc downstream regulated 1 | 0.0542994 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0542705 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.053681 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0483995 |
| CDK6 | cyclin-dependent kinase 6 | 0.0466139 |
| RPL37A | ribosomal protein L37a | 0.0456669 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0442846 |
| MSN | moesin | 0.0439037 |
| EFNA5 | ephrin-A5 | 0.0436545 |
| RNF24 | ring finger protein 24 | 0.0435785 |
| VEGFA | vascular endothelial growth factor A | 0.0405336 |
| RPS12 | ribosomal protein S12 | 0.0401541 |
| HLA-A | major histocompatibility complex, class I, A | 0.039432 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0390441 |
| PKM | pyruvate kinase, muscle | 0.0386859 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | 0.0382795 |
| RPS6 | ribosomal protein S6 | 0.0377404 |
| FOSL1 | FOS-like antigen 1 | 0.0376232 |
| FAM13A | family with sequence similarity 13, member A | 0.0371735 |
| LDHA | lactate dehydrogenase A | 0.0363424 |
| HLA-B | major histocompatibility complex, class I, B | 0.036046 |
| ZNF395 | zinc finger protein 395 | 0.0356888 |
| RPS25 | ribosomal protein S25 | 0.0356798 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0356287 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0355556 |
| RPS8 | ribosomal protein S8 | 0.0353934 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0347757 |
| RPS21 | ribosomal protein S21 | 0.0346457 |
| PLOD1 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 | 0.0344572 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0339193 |
| CLEC1B | C-type lectin domain family 1, member B | 0.0331635 |
| RPL28 | ribosomal protein L28 | 0.0326606 |
| VIM | vimentin | 0.0324639 |
| YBX1 | Y box binding protein 1 | 0.0322632 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0314211 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0308229 |
| H3-3B | H3.3 histone B | 0.0304208 |
| RPL36 | ribosomal protein L36 | 0.0299029 |
| FTL | ferritin, light polypeptide | 0.0298893 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0295831 |
| RPL23 | ribosomal protein L23 | 0.0292427 |
| EGR1 | early growth response 1 | 0.029221 |
| RPLP2 | ribosomal protein, large, P2 | 0.0290573 |
| RPS3 | ribosomal protein S3 | 0.0290428 |
| VEGFC | vascular endothelial growth factor C | 0.0289066 |
| RUNX1 | runt-related transcription factor 1 | 0.0286769 |
| RPS27 | ribosomal protein S27 | 0.0286282 |
| RACK1 | receptor for activated C kinase 1 | 0.028399 |
| ANO6 | anoctamin 6 | 0.0283195 |
| S100A9 | S100 calcium binding protein A9 | 0.0279956 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0278063 |
| SNX13 | sorting nexin 13 | 0.027519 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0275063 |
| SEPTIN9 | septin 9 | 0.0271979 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0269514 |
| S100A6 | S100 calcium binding protein A6 | 0.0266407 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0266133 |
| PTN | pleiotrophin | 0.0265897 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0262516 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.026127 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0261197 |
| REST | RE1-silencing transcription factor | 0.0260948 |
| TAGLN2 | transgelin 2 | 0.0260222 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | 0.0259561 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | 0.0254706 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | 0.0254706 |
| NF1 | neurofibromin 1 | 0.0252681 |
| STC1 | stanniocalcin 1 | 0.0251309 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0250643 |
| ATP5F1E | ATP synthase F1 subunit epsilon | 0.0248082 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0247922 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0243661 |
| CCDC14 | coiled-coil domain containing 14 | 0.0242166 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | 0.0241647 |
| TMEM165 | transmembrane protein 165 | 0.024061 |
| CYB5R3 | cytochrome b5 reductase 3 | 0.0239748 |
| COL6A1 | collagen, type VI, alpha 1 | 0.0238834 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.023707 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0237029 |
| ENO1 | enolase 1, (alpha) | 0.0236605 |
| RPS19 | ribosomal protein S19 | 0.0234039 |
| ZFHX3 | zinc finger homeobox 3 | 0.0233717 |
| HYOU1 | hypoxia up-regulated 1 | 0.0232295 |
| ZNF148 | zinc finger protein 148 | 0.0232002 |
| PCM1 | pericentriolar material 1 | 0.0231926 |
| RPL19 | ribosomal protein L19 | 0.0231528 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0231412 |
| SEC24A | SEC24 family member A | 0.0230066 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.235083 |
| FN1 | fibronectin 1 | -0.15357 |
| COL6A3 | collagen, type VI, alpha 3 | -0.140438 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0931743 |
| AHNAK | AHNAK nucleoprotein | -0.0888438 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0887047 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0823786 |
| VCL | vinculin | -0.0753768 |
| TPM4 | tropomyosin 4 | -0.0600283 |
| HOOK2 | hook microtubule-tethering protein 2 | -0.059163 |
| CDH13 | cadherin 13 | -0.0523891 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0519007 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0485047 |
| CANX | calnexin | -0.047915 |
| HDLBP | high density lipoprotein binding protein | -0.0464161 |
| COL3A1 | collagen, type III, alpha 1 | -0.0459573 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0423685 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0415576 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0412858 |
| LOX | lysyl oxidase | -0.0399372 |
| PGK1 | phosphoglycerate kinase 1 | -0.0398101 |
| PRSS23 | protease, serine, 23 | -0.0396614 |
| CALU | calumenin | -0.0390055 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0385978 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0367996 |
| KYNU | kynureninase | -0.0367279 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0365237 |
| KAZN | kazrin, periplakin interacting protein | -0.036286 |
| OXR1 | oxidation resistance 1 | -0.0340129 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0338095 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0336835 |
| PRKCA | protein kinase C, alpha | -0.0334812 |
| COL7A1 | collagen, type VII, alpha 1 | -0.0333613 |
| COL4A2 | collagen, type IV, alpha 2 | -0.0330878 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0325158 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0318276 |
| NAV1 | neuron navigator 1 | -0.0315859 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0303735 |
| PDE10A | phosphodiesterase 10A | -0.0299997 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0297743 |
| SPAG9 | sperm associated antigen 9 | -0.028919 |
| FHIT | fragile histidine triad | -0.0285689 |
| AUTS2 | autism susceptibility candidate 2 | -0.0283264 |
| CST3 | cystatin C | -0.0282297 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0282215 |
| COL1A2 | collagen, type I, alpha 2 | -0.0276417 |
| MORF4L2 | mortality factor 4 like 2 | -0.0273536 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | -0.0270523 |
| HLA-C | major histocompatibility complex, class I, C | -0.0269651 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0267087 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0260952 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0259192 |
| UTRN | utrophin | -0.0256805 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0254353 |
| MAP4 | microtubule-associated protein 4 | -0.0251989 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0250741 |
| SEL1L | sel-1 suppressor of lin-12-like (C. elegans) | -0.0250638 |
| OGA | O-GlcNAcase | -0.0244824 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0244163 |
| ACTG1 | actin gamma 1 | -0.0243945 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0242314 |
| ARF1 | ADP-ribosylation factor 1 | -0.0241518 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0240382 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | -0.0232875 |
| DMTF1 | cyclin D binding myb-like transcription factor 1 | -0.0227513 |
| ANXA2 | annexin A2 | -0.0227284 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0225538 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0221723 |
| ACVR1 | activin A receptor, type I | -0.0221393 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0220829 |
| CTBP2 | C-terminal binding protein 2 | -0.0220409 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0219188 |
| WDR45B | WD repeat domain 45B | -0.021905 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.0218557 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0218416 |
| PALLD | palladin, cytoskeletal associated protein | -0.0218102 |
| CXXC5 | CXXC finger protein 5 | -0.0217743 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0217719 |
| SYT1 | synaptotagmin I | -0.0216209 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0214873 |
| NABP1 | nucleic acid binding protein 1 | -0.0212552 |
| SIL1 | SIL1 nucleotide exchange factor | -0.0209235 |
| CLTC | clathrin, heavy chain (Hc) | -0.0208884 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | -0.0207469 |
| LOXL2 | lysyl oxidase-like 2 | -0.0205187 |
| PYGL | phosphorylase, glycogen, liver | -0.0204146 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0202707 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.0201784 |
| YARS1 | tyrosyl-tRNA synthetase 1 | -0.0201766 |
| TMEM45A | transmembrane protein 45A | -0.0200311 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0199568 |
| ZBTB35 | zinc finger and BTB domain containing 35 | -0.0199003 |
| SPTLC1 | serine palmitoyltransferase, long chain base subunit 1 | -0.0198403 |
| SEC24D | SEC24 family member D | -0.0197123 |
| COL1A1 | collagen, type I, alpha 1 | -0.0196766 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0196192 |
| BAZ2B | bromodomain adjacent to zinc finger domain, 2B | -0.0195115 |
| LAMB1 | laminin, beta 1 | -0.0194648 |
| PTK2 | protein tyrosine kinase 2 | -0.0194121 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | -0.0191958 |
