Almonertinib (hydrochloride)_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Almonertinib (hydrochloride) perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Almonertinib (hydrochloride)_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CD44 CD44 molecule (Indian blood group) 0.0918217
TPT1 tumor protein, translationally-controlled 1 0.0807939
RPS12 ribosomal protein S12 0.0779695
BIRC3 baculoviral IAP repeat containing 3 0.0746077
RTN4 reticulon 4 0.0671142
B2M beta-2-microglobulin 0.0602052
ZNF292 zinc finger protein 292 0.0565679
VIM vimentin 0.047201
ANKRD28 ankyrin repeat domain 28 0.047118
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0447747
NAP1L1 nucleosome assembly protein 1-like 1 0.0434215
CENPF centromere protein F, 350/400kDa 0.0425689
TMSB10 thymosin beta 10 0.0414015
IGFBP3 insulin-like growth factor binding protein 3 0.0404586
RPS6 ribosomal protein S6 0.0402654
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0395635
RPS17 ribosomal protein S17 0.0391153
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.038403
MT2A metallothionein 2A 0.0374586
HLA-A major histocompatibility complex, class I, A 0.0354474
FTL ferritin, light polypeptide 0.0345288
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0341005
YBX3 Y box binding protein 3 0.0339163
H3-3B H3.3 histone B 0.0336933
PRRC2C proline-rich coiled-coil 2C 0.0335513
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0332879
RPS3 ribosomal protein S3 0.0331809
S100A9 S100 calcium binding protein A9 0.0323564
EFNA5 ephrin-A5 0.0317167
CUL5 cullin 5 0.0315325
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.0309276
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0308689
DIAPH3 diaphanous-related formin 3 0.0307613
NKTR natural killer cell triggering receptor 0.0301966
RPL23 ribosomal protein L23 0.0299339
NT5E 5'-nucleotidase, ecto (CD73) 0.0297146
RPL31 ribosomal protein L31 0.0296127
SRRM2 serine/arginine repetitive matrix 2 0.0295832
NCEH1 neutral cholesterol ester hydrolase 1 0.0292184
RPS13 ribosomal protein S13 0.0292018
PCBP2 poly(rC) binding protein 2 0.0291554
SET SET nuclear proto-oncogene 0.0288689
MKI67 marker of proliferation Ki-67 0.0281608
PUM2 pumilio RNA-binding family member 2 0.0278423
RNF145 ring finger protein 145 0.027501
TPX2 TPX2, microtubule-associated 0.0270493
RPL26 ribosomal protein L26 0.0270349
EIF5B eukaryotic translation initiation factor 5B 0.0263358
RPS25 ribosomal protein S25 0.0263126
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0259819
UGCG UDP-glucose ceramide glucosyltransferase 0.025535
EGR1 early growth response 1 0.0250558
AOPEP aminopeptidase O (putative) 0.0250185
PCNX4 pecanex 4 0.0248754
PDE4D phosphodiesterase 4D, cAMP-specific 0.0247803
MCL1 myeloid cell leukemia 1 0.0247401
SEC62 SEC62 homolog (S. cerevisiae) 0.0247045
LIMA1 LIM domain and actin binding 1 0.0246993
HLA-B major histocompatibility complex, class I, B 0.0246829
AKAP9 A kinase (PRKA) anchor protein 9 0.0246784
SCAPER S-phase cyclin A-associated protein in the ER 0.0246423
PCM1 pericentriolar material 1 0.0245743
SCAF11 SR-related CTD-associated factor 11 0.0245374
GOLGA2 golgin A2 0.0245108
CELF1 CUGBP, Elav-like family member 1 0.0244856
RPS2 ribosomal protein S2 0.0244669
MRE11 MRE11 homolog, double strand break repair nuclease 0.0244043
BABAM2 BRISC and BRCA1 A complex member 2 0.0243329
SENP6 SUMO1/sentrin specific peptidase 6 0.0242947
PLIN3 perilipin 3 0.0242277
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0239879
RACK1 receptor for activated C kinase 1 0.0237322
NUCB2 nucleobindin 2 0.0237088
THOC2 THO complex 2 0.0236044
KMT2E lysine (K)-specific methyltransferase 2E 0.0234796
KIF20B kinesin family member 20B 0.0233187
CCDC88A coiled-coil domain containing 88A 0.023307
CKAP2 cytoskeleton associated protein 2 0.0232798
CEP112 centrosomal protein 112kDa 0.0231384
NAV2 neuron navigator 2 0.0229835
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0229315
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0226799
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0226302
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0225606
CSNK1G3 casein kinase 1, gamma 3 0.0225383
BTBD10 BTB (POZ) domain containing 10 0.022383
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0223322
COX4I1 cytochrome c oxidase subunit IV isoform 1 0.0222394
PACS1 phosphofurin acidic cluster sorting protein 1 0.0222111
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0222092
ENO1 enolase 1, (alpha) 0.0221692
BCAS3 breast carcinoma amplified sequence 3 0.0220047
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0219761
ARPP19 cAMP-regulated phosphoprotein, 19kDa 0.0219579
TMEM245 transmembrane protein 245 0.0217477
FAM3C family with sequence similarity 3, member C 0.0216803
ACTG1 actin gamma 1 0.0215692
SRSF5 serine/arginine-rich splicing factor 5 0.0213705
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0213006
SRSF11 serine/arginine-rich splicing factor 11 0.021274

decreased expression

Symbol Name Standardized Value
AHNAK AHNAK nucleoprotein -0.0843221
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0784691
INTS6 integrator complex subunit 6 -0.0730276
HMGA2 high mobility group AT-hook 2 -0.072673
FNDC3B fibronectin type III domain containing 3B -0.0704579
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0623604
ANXA2 annexin A2 -0.0566082
CANX calnexin -0.052035
ATM ATM serine/threonine kinase -0.0518687
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0493131
FUS FUS RNA binding protein -0.0485951
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0464896
ZNF638 zinc finger protein 638 -0.0463493
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0452562
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0442433
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0408545
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0405399
ELOF1 elongation factor 1 homolog (S. cerevisiae) -0.0398723
PRKCA protein kinase C, alpha -0.0395092
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0390434
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0376027
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0375692
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0366925
AHNAK2 AHNAK nucleoprotein 2 -0.0366672
ANKRD11 ankyrin repeat domain 11 -0.0352765
RAI14 retinoic acid induced 14 -0.033839
KIF5B kinesin family member 5B -0.033168
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.03302
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0328598
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0327899
LPP LIM domain containing preferred translocation partner in lipoma -0.0326624
FMN1 formin 1 -0.0321944
LDHA lactate dehydrogenase A -0.031649
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.03159
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 -0.0311825
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0310769
MACF1 microtubule-actin crosslinking factor 1 -0.0308416
TAS2R14 taste receptor, type 2, member 14 -0.0307922
TAOK1 TAO kinase 1 -0.0298891
ZSWIM6 zinc finger, SWIM-type containing 6 -0.029838
IL1RAP interleukin 1 receptor accessory protein -0.0297151
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0295991
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0293542
CAPRIN2 caprin family member 2 -0.0292609
KDM4B lysine (K)-specific demethylase 4B -0.0291433
FLNA filamin A, alpha -0.029118
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0288675
TVP23C-CDRT4 TVP23C-CDRT4 readthrough -0.0287132
ATG7 autophagy related 7 -0.0284983
CDK13 cyclin-dependent kinase 13 -0.0277806
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0273836
MBNL1 muscleblind-like splicing regulator 1 -0.0270867
USP53 ubiquitin specific peptidase 53 -0.0270347
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.026859
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0266499
GOLGB1 golgin B1 -0.0264915
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0262325
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.026212
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0261918
SH3KBP1 SH3-domain kinase binding protein 1 -0.0261617
UBC ubiquitin C -0.0261289
TTC19 tetratricopeptide repeat domain 19 -0.0260102
FAM177A1 family with sequence similarity 177, member A1 -0.0258804
CLTC clathrin, heavy chain (Hc) -0.02554
SPTAN1 spectrin, alpha, non-erythrocytic 1 -0.0254212
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0253319
AHI1 Abelson helper integration site 1 -0.0252434
CAVIN1 caveolae associated protein 1 -0.0252224
TTC3 tetratricopeptide repeat domain 3 -0.0251324
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0250216
NPAS2 neuronal PAS domain protein 2 -0.0249862
GNA12 guanine nucleotide binding protein (G protein) alpha 12 -0.0248199
ZFAND3 zinc finger, AN1-type domain 3 -0.0242412
AEBP2 AE binding protein 2 -0.0241659
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0239878
ARHGAP12 Rho GTPase activating protein 12 -0.0236729
GPATCH2L G patch domain containing 2-like -0.0234626
HSPA8 heat shock 70kDa protein 8 -0.0233845
KIAA1671 KIAA1671 -0.023164
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0229207
PODXL podocalyxin-like -0.0228938
PRRC1 proline-rich coiled-coil 1 -0.0227571
TMEM14B transmembrane protein 14B -0.0227569
RNF213 ring finger protein 213 -0.0226708
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0226299
FMNL2 formin-like 2 -0.0226054
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0225464
ARL17B ADP-ribosylation factor-like 17B -0.0225076
GPR75-ASB3 GPR75-ASB3 readthrough -0.0221603
PRELID2 PRELI domain containing 2 -0.0220579
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0219884
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0219563
ZFYVE28 zinc finger, FYVE domain containing 28 -0.0218952
TLE4 transducin-like enhancer of split 4 -0.0218946
BZW1 basic leucine zipper and W2 domains 1 -0.0218172
DENND1A DENN/MADD domain containing 1A -0.021664
CTBP2 C-terminal binding protein 2 -0.0216093
CCND1 cyclin D1 -0.0216084
HMGB1 high mobility group box 1 -0.0216011
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0215287