Almonertinib (hydrochloride)_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Almonertinib (hydrochloride) perturbation in SW 900 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Almonertinib (hydrochloride)_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0882185
FN1 fibronectin 1 0.0838235
PTMA prothymosin, alpha 0.0651439
FTL ferritin, light polypeptide 0.0640448
ASPH aspartate beta-hydroxylase 0.0619758
MT2A metallothionein 2A 0.0614595
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0598552
TMSB10 thymosin beta 10 0.0533471
SQSTM1 sequestosome 1 0.0515072
B2M beta-2-microglobulin 0.0480813
VIM vimentin 0.0464806
HLA-B major histocompatibility complex, class I, B 0.0462343
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0448371
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0447613
NDRG1 N-myc downstream regulated 1 0.0435532
NRG1 neuregulin 1 0.0433775
IFI27 interferon, alpha-inducible protein 27 0.0400395
TPT1 tumor protein, translationally-controlled 1 0.0400154
STC2 stanniocalcin 2 0.0388299
ENO1 enolase 1, (alpha) 0.0364837
CANX calnexin 0.035818
SFTPA2 surfactant protein A2 0.034042
S100A6 S100 calcium binding protein A6 0.0336881
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0331878
RPS6 ribosomal protein S6 0.0297151
NAMPT nicotinamide phosphoribosyltransferase 0.0287534
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0271135
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0270109
ITGA1 integrin, alpha 1 0.0267412
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0267028
RPL37A ribosomal protein L37a 0.0264071
HMGA2 high mobility group AT-hook 2 0.0256832
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.025521
TMSB4X thymosin beta 4, X-linked 0.0254881
RPL35A ribosomal protein L35a 0.0254262
LMNA lamin A/C 0.0252319
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0247072
TXNIP thioredoxin interacting protein 0.0242245
RACK1 receptor for activated C kinase 1 0.0240234
TPI1 triosephosphate isomerase 1 0.0239915
RPL31 ribosomal protein L31 0.0239824
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0239236
TRIO trio Rho guanine nucleotide exchange factor 0.0238819
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.023594
AKAP12 A kinase (PRKA) anchor protein 12 0.0234582
RPS12 ribosomal protein S12 0.0231212
LIMCH1 LIM and calponin homology domains 1 0.0230416
SOX4 SRY (sex determining region Y)-box 4 0.0221795
HLA-A major histocompatibility complex, class I, A 0.0219617
RPS27 ribosomal protein S27 0.0219109
RPL26 ribosomal protein L26 0.0212537
RPLP1 ribosomal protein, large, P1 0.0210447
FTH1 ferritin, heavy polypeptide 1 0.0209672
RPS19 ribosomal protein S19 0.0205463
DUSP6 dual specificity phosphatase 6 0.0204556
RPS3 ribosomal protein S3 0.02043
S100A10 S100 calcium binding protein A10 0.020229
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.019836
PGK1 phosphoglycerate kinase 1 0.0197177
MRPS6 mitochondrial ribosomal protein S6 0.0197152
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0194292
ERRFI1 ERBB receptor feedback inhibitor 1 0.0193617
PLIN2 perilipin 2 0.0193315
RPS8 ribosomal protein S8 0.0192113
EIF1 eukaryotic translation initiation factor 1 0.0186493
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0186275
PRRC2C proline-rich coiled-coil 2C 0.0185498
IFI6 interferon, alpha-inducible protein 6 0.0182516
RPS27A ribosomal protein S27a 0.0182443
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0180779
CALR calreticulin 0.0180349
ZFP36L1 ZFP36 ring finger protein-like 1 0.0179494
RAI14 retinoic acid induced 14 0.0178854
LOC102724023 ES1 protein homolog, mitochondrial 0.0178457
PDE4D phosphodiesterase 4D, cAMP-specific 0.0175795
PKM pyruvate kinase, muscle 0.0175756
S100A9 S100 calcium binding protein A9 0.0174444
RPL23 ribosomal protein L23 0.0173954
CD63 CD63 molecule 0.0173784
RPL36 ribosomal protein L36 0.0172197
HILPDA hypoxia inducible lipid droplet-associated 0.0170779
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0165843
RPL34 ribosomal protein L34 0.0164947
RPL37 ribosomal protein L37 0.016413
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0161646
RPL12 ribosomal protein L12 0.0160441
RPS29 ribosomal protein S29 0.0160235
RPL9 ribosomal protein L9 0.0157831
ACTG1 actin gamma 1 0.0157419
RPS21 ribosomal protein S21 0.0151725
RPL11 ribosomal protein L11 0.0151295
GNAS GNAS complex locus 0.0150807
LOXL2 lysyl oxidase-like 2 0.0147562
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0147437
IER3 immediate early response 3 0.01449
ENO2 enolase 2 (gamma, neuronal) 0.0144759
BASP1 brain abundant, membrane attached signal protein 1 0.0143812
WSB1 WD repeat and SOCS box containing 1 0.0143282
TFPI2 tissue factor pathway inhibitor 2 0.0139173
IGFBP3 insulin-like growth factor binding protein 3 0.0138993

decreased expression

Symbol Name Standardized Value
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0119776
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -0.00914113
VCL vinculin -0.00861072
ETNK1 ethanolamine kinase 1 -0.00783057
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.00727575
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.00719463
ZNF644 zinc finger protein 644 -0.0066567
KSR1 kinase suppressor of ras 1 -0.00659899
TFG TRK-fused gene -0.00625764
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.00619846
SEC31A SEC31 homolog A (S. cerevisiae) -0.00605797
COG5 component of oligomeric golgi complex 5 -0.00600086
TMEM39A transmembrane protein 39A -0.00587863
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.00567762
STRN3 striatin, calmodulin binding protein 3 -0.00558593
CCNL1 cyclin L1 -0.00536286
RNF145 ring finger protein 145 -0.00524714
MON2 MON2 homolog (S. cerevisiae) -0.00500811
GLCCI1 glucocorticoid induced 1 -0.00495479
SP3 Sp3 transcription factor -0.00490195
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.00489279
EPS8 epidermal growth factor receptor pathway substrate 8 -0.00488264
WDR26 WD repeat domain 26 -0.00487973
TM9SF3 transmembrane 9 superfamily member 3 -0.0048772
UBE2E3 ubiquitin-conjugating enzyme E2E 3 -0.00480782
SHB Src homology 2 domain containing adaptor protein B -0.00472293
PPP1R15B protein phosphatase 1, regulatory subunit 15B -0.0047206
SUCO SUN domain containing ossification factor -0.00469898
NUP58 nucleoporin 58 -0.00450063
SEC23A Sec23 homolog A (S. cerevisiae) -0.0044866
PDLIM5 PDZ and LIM domain 5 -0.00443366
PTBP3 polypyrimidine tract binding protein 3 -0.00427812
ZMYM2 zinc finger, MYM-type 2 -0.00413837
BIRC6 baculoviral IAP repeat containing 6 -0.00412228
SEC24D SEC24 family member D -0.00407432
COPA coatomer protein complex, subunit alpha -0.00400213
TBC1D23 TBC1 domain family, member 23 -0.0039579
RUNX2 runt-related transcription factor 2 -0.0039472
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) -0.00393261
ACTR3 ARP3 actin-related protein 3 homolog (yeast) -0.00393204
SPRED1 sprouty-related, EVH1 domain containing 1 -0.00392842
TSC22D2 TSC22 domain family, member 2 -0.00390065
TJP1 tight junction protein 1 -0.00384265
MAP2K4 mitogen-activated protein kinase kinase 4 -0.00381288
ADD3 adducin 3 (gamma) -0.00380331
DHFR dihydrofolate reductase -0.003783
MNAT1 MNAT CDK-activating kinase assembly factor 1 -0.00376883
GLS2 glutaminase 2 (liver, mitochondrial) -0.00372059
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.00367821
VMP1 vacuole membrane protein 1 -0.00366292
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.00365821
ZCCHC7 zinc finger, CCHC domain containing 7 -0.00365722
SMOX spermine oxidase -0.00362591
SS18 synovial sarcoma translocation, chromosome 18 -0.00359648
AGRN agrin -0.00359531
CEP192 centrosomal protein 192kDa -0.00358258
FBXO34 F-box protein 34 -0.00351038
TENT2 terminal nucleotidyltransferase 2 -0.00345906
MEF2D myocyte enhancer factor 2D -0.00345461
UBE2W ubiquitin-conjugating enzyme E2W (putative) -0.00344422
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.00341434
SEC16A SEC16 homolog A (S. cerevisiae) -0.00340985
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 -0.00339608
GORASP2 golgi reassembly stacking protein 2, 55kDa -0.00339395
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.00331872
CDC73 cell division cycle 73 -0.00331576
PDIA5 protein disulfide isomerase family A, member 5 -0.00329396
ITGB8 integrin, beta 8 -0.00328394
TUFT1 tuftelin 1 -0.00325918
FOSL2 FOS-like antigen 2 -0.00323302
SPRED2 sprouty-related, EVH1 domain containing 2 -0.00320955
YOD1 YOD1 deubiquitinase -0.00318397
WDR20 WD repeat domain 20 -0.00313271
FOXO3 forkhead box O3 -0.00310562
TMEM165 transmembrane protein 165 -0.00309846
AP1G1 adaptor-related protein complex 1, gamma 1 subunit -0.00309663
ZFC3H1 zinc finger, C3H1-type containing -0.0030936
EWSR1 EWS RNA-binding protein 1 -0.00307758
SCFD2 sec1 family domain containing 2 -0.00306001
KDM6A lysine (K)-specific demethylase 6A -0.00302524
AHCTF1 AT hook containing transcription factor 1 -0.00300352
SLAIN2 SLAIN motif family, member 2 -0.00299773
FMN1 formin 1 -0.00297973
FNDC3A fibronectin type III domain containing 3A -0.00297945
RCOR1 REST corepressor 1 -0.00297282
UIMC1 ubiquitin interaction motif containing 1 -0.00294834
ZNF410 zinc finger protein 410 -0.00294099
SYNJ1 synaptojanin 1 -0.00293863
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.00290924
FBXW11 F-box and WD repeat domain containing 11 -0.00288839
PCNX1 pecanex 1 -0.00288286
LCOR ligand dependent nuclear receptor corepressor -0.00285603
USP12 ubiquitin specific peptidase 12 -0.00283009
ZC3H15 zinc finger CCCH-type containing 15 -0.00282219
GDI2 GDP dissociation inhibitor 2 -0.0028102
NCK1 NCK adaptor protein 1 -0.00280068
UBP1 upstream binding protein 1 (LBP-1a) -0.00279948
STK38L serine/threonine kinase 38 like -0.00277295
R3HCC1L R3H domain and coiled-coil containing 1-like -0.00276156
UBTD2 ubiquitin domain containing 2 -0.00275979