Almonertinib (hydrochloride)_SW1417 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Almonertinib (hydrochloride) perturbation in SW1417 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Almonertinib (hydrochloride)_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha 0.122717
FTL ferritin, light polypeptide 0.121496
TPT1 tumor protein, translationally-controlled 1 0.0588087
FTH1 ferritin, heavy polypeptide 1 0.0522797
EPCAM epithelial cell adhesion molecule 0.0511314
KRT18 keratin 18, type I 0.0459678
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0456902
RPL35A ribosomal protein L35a 0.043982
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0398332
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0377785
RPL12 ribosomal protein L12 0.0347379
RPS12 ribosomal protein S12 0.0343002
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0333622
DSPP dentin sialophosphoprotein 0.032676
RPS3 ribosomal protein S3 0.0326217
PGK1 phosphoglycerate kinase 1 0.0306363
RPS6 ribosomal protein S6 0.0291835
RPS21 ribosomal protein S21 0.028636
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0284689
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.028229
RPL37A ribosomal protein L37a 0.0275204
CTNND1 catenin (cadherin-associated protein), delta 1 0.0273253
KRT8 keratin 8, type II 0.0269652
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0260332
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0255365
RPS19 ribosomal protein S19 0.0253804
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0252249
CANX calnexin 0.0244838
RPL18 ribosomal protein L18 0.0240668
AHNAK AHNAK nucleoprotein 0.0240539
KDM3A lysine (K)-specific demethylase 3A 0.022929
SERINC5 serine incorporator 5 0.0213034
MACC1 metastasis associated in colon cancer 1 0.0212312
RPS13 ribosomal protein S13 0.0211188
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0208534
SLC38A1 solute carrier family 38, member 1 0.020793
IRF2BP2 interferon regulatory factor 2 binding protein 2 0.0205603
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0205336
GOLGA4 golgin A4 0.0202921
RPS25 ribosomal protein S25 0.0201362
RPS27A ribosomal protein S27a 0.0200307
FAT1 FAT atypical cadherin 1 0.0199619
CEMIP cell migration inducing protein, hyaluronan binding 0.0196037
RPS8 ribosomal protein S8 0.0194925
H1-0 H1.0 linker histone 0.0192767
RAD21 RAD21 homolog (S. pombe) 0.0190364
RPL31 ribosomal protein L31 0.0190276
RBM39 RNA binding motif protein 39 0.0190091
RPLP2 ribosomal protein, large, P2 0.0187497
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 0.0183806
B2M beta-2-microglobulin 0.0180601
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0178305
RPL23 ribosomal protein L23 0.0178185
RPL34 ribosomal protein L34 0.0177957
RPL36 ribosomal protein L36 0.0173069
NKD1 naked cuticle homolog 1 (Drosophila) 0.0172912
LDHA lactate dehydrogenase A 0.0172036
KDM7A lysine (K)-specific demethylase 7A 0.0171379
GSTP1 glutathione S-transferase pi 1 0.0171039
ZMYND8 zinc finger, MYND-type containing 8 0.0170201
PRELID2 PRELI domain containing 2 0.0170147
RPS24 ribosomal protein S24 0.0168365
TMSB10 thymosin beta 10 0.0166728
EIF1 eukaryotic translation initiation factor 1 0.0166068
RPL13A ribosomal protein L13a 0.0163214
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0162511
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0162273
EHBP1 EH domain binding protein 1 0.0161043
RPL36A ribosomal protein L36a 0.0160205
RPL19 ribosomal protein L19 0.0159645
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0159598
RPL32 ribosomal protein L32 0.0159278
STAU1 staufen double-stranded RNA binding protein 1 0.0158886
RPLP1 ribosomal protein, large, P1 0.015881
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0158238
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0157682
TPM4 tropomyosin 4 0.0157676
PRRC2C proline-rich coiled-coil 2C 0.0156868
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.01566
ZNF292 zinc finger protein 292 0.0156459
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.0156105
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0155239
GCC2 GRIP and coiled-coil domain containing 2 0.0153138
RACK1 receptor for activated C kinase 1 0.0152696
BCL2L1 BCL2-like 1 0.0152471
ARHGAP5 Rho GTPase activating protein 5 0.0151596
PLAUR plasminogen activator, urokinase receptor 0.0150514
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0150373
RPL28 ribosomal protein L28 0.0150262
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0149634
TMSB4X thymosin beta 4, X-linked 0.0149455
OGA O-GlcNAcase 0.0149263
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0148147
RPLP0 ribosomal protein, large, P0 0.0146623
PCLO piccolo presynaptic cytomatrix protein 0.0146551
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0144485
ETV6 ets variant 6 0.0144459
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0142485
RPL27A ribosomal protein L27a 0.0141187
S100A6 S100 calcium binding protein A6 0.0140994

decreased expression

Symbol Name Standardized Value
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0405189
EGR1 early growth response 1 -0.0153107
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0142571
RBM25 RNA binding motif protein 25 -0.0134776
ARHGAP26 Rho GTPase activating protein 26 -0.0120518
HMGA1 high mobility group AT-hook 1 -0.0114668
FOSL1 FOS-like antigen 1 -0.0109772
CEMIP2 cell migration inducing hyaluronidase 2 -0.0109256
GLS2 glutaminase 2 (liver, mitochondrial) -0.0105854
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0103948
TSC22D2 TSC22 domain family, member 2 -0.0103892
TIMP2 TIMP metallopeptidase inhibitor 2 -0.010327
FUS FUS RNA binding protein -0.0102942
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0100864
ADNP activity-dependent neuroprotector homeobox -0.00916914
TJP1 tight junction protein 1 -0.00905252
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 -0.00904025
CCNL1 cyclin L1 -0.00899745
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.00894963
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.00885768
BTBD10 BTB (POZ) domain containing 10 -0.00883098
BIRC6 baculoviral IAP repeat containing 6 -0.00879603
VCL vinculin -0.00863523
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.00853085
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.00844924
CST3 cystatin C -0.008277
COG5 component of oligomeric golgi complex 5 -0.00811929
ZFP36 ZFP36 ring finger protein -0.00805532
SND1 staphylococcal nuclease and tudor domain containing 1 -0.00798651
TAF3 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa -0.007963
WWC1 WW and C2 domain containing 1 -0.00795438
SPRED2 sprouty-related, EVH1 domain containing 2 -0.007919
EIF3H eukaryotic translation initiation factor 3, subunit H -0.00780281
ANO10 anoctamin 10 -0.00779011
PCBP2 poly(rC) binding protein 2 -0.00759512
DIAPH1 diaphanous-related formin 1 -0.00756264
UBAP2 ubiquitin associated protein 2 -0.00752316
P4HB prolyl 4-hydroxylase, beta polypeptide -0.00747069
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 -0.00746572
HDAC9 histone deacetylase 9 -0.00741444
SPINT2 serine peptidase inhibitor, Kunitz type, 2 -0.00740286
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.00712694
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.00709905
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.00691092
APLP2 amyloid beta (A4) precursor-like protein 2 -0.00690876
EXT1 exostosin glycosyltransferase 1 -0.00689941
DIAPH3 diaphanous-related formin 3 -0.00677706
SEC31A SEC31 homolog A (S. cerevisiae) -0.00674156
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 -0.00669085
SIK3 SIK family kinase 3 -0.00663135
MBNL1 muscleblind-like splicing regulator 1 -0.00662044
MFSD14B major facilitator superfamily domain containing 14B -0.00658126
CDK6 cyclin-dependent kinase 6 -0.00652816
DOCK4 dedicator of cytokinesis 4 -0.00650445
TAPBP TAP binding protein (tapasin) -0.00648356
ERBIN erbb2 interacting protein -0.00647604
PDIA5 protein disulfide isomerase family A, member 5 -0.0063869
PTEN phosphatase and tensin homolog -0.00628176
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 -0.00626259
MAPK8 mitogen-activated protein kinase 8 -0.00624971
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.00623309
NKTR natural killer cell triggering receptor -0.00615901
FNDC3B fibronectin type III domain containing 3B -0.00615739
LENG8 leukocyte receptor cluster (LRC) member 8 -0.00613936
MON2 MON2 homolog (S. cerevisiae) -0.00613655
TASOR2 transcription activation suppressor family member 2 -0.00607845
GPATCH2L G patch domain containing 2-like -0.00601132
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.00600713
SETX senataxin -0.00594589
SETD1B SET domain containing 1B -0.00585601
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.00582337
MAP3K11 mitogen-activated protein kinase kinase kinase 11 -0.00578458
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4 -0.00578061
BZW2 basic leucine zipper and W2 domains 2 -0.0057518
TMEM165 transmembrane protein 165 -0.00574069
ATAD2 ATPase family, AAA domain containing 2 -0.00569519
TNPO3 transportin 3 -0.00566909
ATP5F1B ATP synthase F1 subunit beta -0.00558082
RAB7A RAB7A, member RAS oncogene family -0.00557889
TENT4A terminal nucleotidyltransferase 4A -0.00557397
LAMA4 laminin, alpha 4 -0.00553313
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.00550393
INTS6 integrator complex subunit 6 -0.00543297
TFG TRK-fused gene -0.00532599
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.00527745
PPP4R2 protein phosphatase 4, regulatory subunit 2 -0.00527637
CLDN4 claudin 4 -0.00527121
ACBD3 acyl-CoA binding domain containing 3 -0.00521196
UBE4A ubiquitination factor E4A -0.0052013
ATP11B ATPase, class VI, type 11B -0.00520045
MIDEAS mitotic deacetylase associated SANT domain protein -0.00511362
TIMM23B translocase of inner mitochondrial membrane 23 homolog B (yeast) -0.00508481
RCOR1 REST corepressor 1 -0.00499545
ANKRD17 ankyrin repeat domain 17 -0.00499401
LRP12 low density lipoprotein receptor-related protein 12 -0.00498915
HM13 histocompatibility (minor) 13 -0.00498286
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.00498272
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1 -0.00497192
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 -0.00495828
LEMD3 LEM domain containing 3 -0.00495192