| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Almonertinib (hydrochloride) perturbation in SW48 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Almonertinib (hydrochloride)_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LMO7 | LIM domain 7 | 0.124518 |
| LAMA4 | laminin, alpha 4 | 0.102852 |
| PLAUR | plasminogen activator, urokinase receptor | 0.10196 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0863047 |
| LAMC2 | laminin, gamma 2 | 0.0856904 |
| EGFR | epidermal growth factor receptor | 0.0761555 |
| ITPKC | inositol-trisphosphate 3-kinase C | 0.0731653 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0718857 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0659144 |
| ATXN1 | ataxin 1 | 0.0611812 |
| FAT1 | FAT atypical cadherin 1 | 0.0607573 |
| RCOR1 | REST corepressor 1 | 0.0604639 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0590063 |
| LAMB3 | laminin, beta 3 | 0.0492309 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | 0.0476309 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0448225 |
| BCL2L1 | BCL2-like 1 | 0.043988 |
| RPS3 | ribosomal protein S3 | 0.0418602 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.0382469 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0381143 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0372007 |
| FHL2 | four and a half LIM domains 2 | 0.0364753 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0351742 |
| CD9 | CD9 molecule | 0.0344128 |
| ST14 | suppression of tumorigenicity 14 (colon carcinoma) | 0.0339518 |
| BMP4 | bone morphogenetic protein 4 | 0.0336154 |
| NTSR1 | neurotensin receptor 1 (high affinity) | 0.0334389 |
| FAM3C | family with sequence similarity 3, member C | 0.0331765 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.0330932 |
| OXR1 | oxidation resistance 1 | 0.0322642 |
| ANXA11 | annexin A11 | 0.0321367 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0319602 |
| SH3RF2 | SH3 domain containing ring finger 2 | 0.0305073 |
| VCL | vinculin | 0.0304364 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0302717 |
| AREG | amphiregulin | 0.0302496 |
| MTUS1 | microtubule associated tumor suppressor 1 | 0.0298314 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0282437 |
| RPS12 | ribosomal protein S12 | 0.027936 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0273983 |
| VMP1 | vacuole membrane protein 1 | 0.0271588 |
| EMP1 | epithelial membrane protein 1 | 0.0271039 |
| TNS3 | tensin 3 | 0.0269345 |
| DSC3 | desmocollin 3 | 0.026469 |
| DUSP4 | dual specificity phosphatase 4 | 0.0258808 |
| RPS19 | ribosomal protein S19 | 0.0251007 |
| TJP1 | tight junction protein 1 | 0.0250446 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0247456 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.024268 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0239841 |
| KLK10 | kallikrein-related peptidase 10 | 0.0238669 |
| EGR1 | early growth response 1 | 0.0238027 |
| RPS2 | ribosomal protein S2 | 0.0237157 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.0234614 |
| PPP1R9A | protein phosphatase 1, regulatory subunit 9A | 0.0227503 |
| FAR1 | fatty acyl CoA reductase 1 | 0.0224778 |
| STAG2 | stromal antigen 2 | 0.0221799 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 0.0220288 |
| S100A6 | S100 calcium binding protein A6 | 0.0217838 |
| ZFP36 | ZFP36 ring finger protein | 0.0208458 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0208263 |
| TOMM7 | translocase of outer mitochondrial membrane 7 homolog (yeast) | 0.0206612 |
| KLF6 | Kruppel-like factor 6 | 0.0205376 |
| PARD3B | par-3 family cell polarity regulator beta | 0.0202239 |
| FERMT1 | fermitin family member 1 | 0.0202181 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.0194326 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.0193397 |
| SEPTIN9 | septin 9 | 0.0191012 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0190675 |
| KDM6B | lysine (K)-specific demethylase 6B | 0.0189325 |
| KDM1B | lysine (K)-specific demethylase 1B | 0.0188988 |
| ATL2 | atlastin GTPase 2 | 0.0188412 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.0185965 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | 0.0184567 |
| EPHA2 | EPH receptor A2 | 0.0183732 |
| MT2A | metallothionein 2A | 0.0181277 |
| DCLK1 | doublecortin-like kinase 1 | 0.0181038 |
| RPL28 | ribosomal protein L28 | 0.017987 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.0178101 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0176822 |
| RACK1 | receptor for activated C kinase 1 | 0.0175612 |
| KIF16B | kinesin family member 16B | 0.0175407 |
| LIPH | lipase, member H | 0.0174511 |
| MPP2 | membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) | 0.0173351 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.0173251 |
| LRP8 | low density lipoprotein receptor-related protein 8, apolipoprotein e receptor | 0.0172009 |
| SGMS2 | sphingomyelin synthase 2 | 0.0170774 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0170245 |
| IDS | iduronate 2-sulfatase | 0.0169201 |
| RAB10 | RAB10, member RAS oncogene family | 0.0167311 |
| UBR1 | ubiquitin protein ligase E3 component n-recognin 1 | 0.016695 |
| FZR1 | fizzy/cell division cycle 20 related 1 (Drosophila) | 0.0166757 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | 0.0166687 |
| DSG2 | desmoglein 2 | 0.0166452 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0165621 |
| YBX3 | Y box binding protein 3 | 0.0162405 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0160341 |
| RPS7 | ribosomal protein S7 | 0.0160175 |
| ARHGEF1 | Rho guanine nucleotide exchange factor (GEF) 1 | 0.015881 |
| SASH1 | SAM and SH3 domain containing 1 | 0.0158659 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.208161 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.193755 |
| IER3 | immediate early response 3 | -0.151553 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.121892 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.099867 |
| ACTG1 | actin gamma 1 | -0.0887298 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0854576 |
| FRAS1 | Fraser extracellular matrix complex subunit 1 | -0.0777017 |
| RPS6 | ribosomal protein S6 | -0.071878 |
| CD36 | CD36 molecule (thrombospondin receptor) | -0.0593538 |
| SMYD3 | SET and MYND domain containing 3 | -0.0582191 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0540849 |
| RPS29 | ribosomal protein S29 | -0.0529986 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0517344 |
| SQSTM1 | sequestosome 1 | -0.0484996 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0452675 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0452195 |
| RPS23 | ribosomal protein S23 | -0.0439467 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0419869 |
| PARD3 | par-3 family cell polarity regulator | -0.0419446 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0412248 |
| RPLP1 | ribosomal protein, large, P1 | -0.0402927 |
| RPL5 | ribosomal protein L5 | -0.0402064 |
| HSPA8 | heat shock 70kDa protein 8 | -0.0399579 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0398965 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0395107 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0381051 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0377531 |
| SETD5 | SET domain containing 5 | -0.0373995 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0367601 |
| RPS11 | ribosomal protein S11 | -0.0365519 |
| CALU | calumenin | -0.0351185 |
| FNDC3B | fibronectin type III domain containing 3B | -0.034877 |
| FHIT | fragile histidine triad | -0.0347462 |
| HLA-B | major histocompatibility complex, class I, B | -0.0347398 |
| GDF15 | growth differentiation factor 15 | -0.0345001 |
| DEK | DEK proto-oncogene | -0.0344371 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0342192 |
| RREB1 | ras responsive element binding protein 1 | -0.0333142 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.0332798 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0332311 |
| RNF43 | ring finger protein 43 | -0.0332242 |
| RPS25 | ribosomal protein S25 | -0.0329637 |
| GPC5 | glypican 5 | -0.0328858 |
| FTL | ferritin, light polypeptide | -0.0323313 |
| AHNAK | AHNAK nucleoprotein | -0.0322668 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.032178 |
| UBC | ubiquitin C | -0.0318061 |
| FUS | FUS RNA binding protein | -0.0313191 |
| GOLGA4 | golgin A4 | -0.030428 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.030099 |
| RPL32 | ribosomal protein L32 | -0.0296961 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0285652 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0284898 |
| ARF1 | ADP-ribosylation factor 1 | -0.0283947 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0282023 |
| RPL4 | ribosomal protein L4 | -0.0281851 |
| TFRC | transferrin receptor | -0.028107 |
| SBF2 | SET binding factor 2 | -0.0276875 |
| MXI1 | MAX interactor 1, dimerization protein | -0.0274706 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0274506 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0272512 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0269415 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | -0.0266343 |
| ANXA2 | annexin A2 | -0.026325 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | -0.026285 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.0261156 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | -0.0259683 |
| TMEM123 | transmembrane protein 123 | -0.0259473 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0258079 |
| COG5 | component of oligomeric golgi complex 5 | -0.0257519 |
| RPS8 | ribosomal protein S8 | -0.0255484 |
| MAP4 | microtubule-associated protein 4 | -0.0254163 |
| MSI2 | musashi RNA-binding protein 2 | -0.0253536 |
| GPHN | gephyrin | -0.02533 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0248878 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -0.0247815 |
| TMSB10 | thymosin beta 10 | -0.0246621 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.024591 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0245405 |
| RPL38 | ribosomal protein L38 | -0.0244971 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0243961 |
| TGFB2 | transforming growth factor, beta 2 | -0.0243324 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0243114 |
| JMY | junction mediating and regulatory protein, p53 cofactor | -0.0243019 |
| FN1 | fibronectin 1 | -0.0242747 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0242258 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.0241952 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0241944 |
| HDLBP | high density lipoprotein binding protein | -0.0241801 |
| CTDSPL | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like | -0.0240616 |
| NCOR2 | nuclear receptor corepressor 2 | -0.0234527 |
| TXNIP | thioredoxin interacting protein | -0.0233727 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0232098 |
| ZC3H11A | zinc finger CCCH-type containing 11A | -0.023193 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0231596 |
| MYO1B | myosin IB | -0.0227975 |
| RPL37 | ribosomal protein L37 | -0.0227036 |
| RPL31 | ribosomal protein L31 | -0.0227011 |
| ZNF292 | zinc finger protein 292 | -0.0226381 |
