Almonertinib (hydrochloride)_SW480 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Almonertinib (hydrochloride) perturbation in SW480 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Almonertinib (hydrochloride)_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.13749
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.111056
AKAP12 A kinase (PRKA) anchor protein 12 0.0922965
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.07623
EGR1 early growth response 1 0.0760223
MT2A metallothionein 2A 0.0759868
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0724637
ZFP36L1 ZFP36 ring finger protein-like 1 0.069874
TMSB10 thymosin beta 10 0.0645315
IGFBP3 insulin-like growth factor binding protein 3 0.0632128
KRT18 keratin 18, type I 0.0625086
LOC102724023 ES1 protein homolog, mitochondrial 0.0587384
ITGA6 integrin, alpha 6 0.0568658
EZR ezrin 0.0558927
ITGB4 integrin, beta 4 0.055181
KRT8 keratin 8, type II 0.0490083
FLNB filamin B, beta 0.0468232
ANO1 anoctamin 1, calcium activated chloride channel 0.0456049
LAMA4 laminin, alpha 4 0.0453715
TPT1 tumor protein, translationally-controlled 1 0.044577
ANXA2 annexin A2 0.0435253
DUSP6 dual specificity phosphatase 6 0.0434572
NKD1 naked cuticle homolog 1 (Drosophila) 0.0424144
RPL35A ribosomal protein L35a 0.0404915
TPM4 tropomyosin 4 0.0400724
RPS19 ribosomal protein S19 0.0400612
TGM2 transglutaminase 2 0.0391845
S100A6 S100 calcium binding protein A6 0.0384228
FTL ferritin, light polypeptide 0.0382714
RPS12 ribosomal protein S12 0.0376762
BCL2L1 BCL2-like 1 0.0375703
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0375117
FTH1 ferritin, heavy polypeptide 1 0.0371684
VIM vimentin 0.0367145
RPS3 ribosomal protein S3 0.0365917
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0362099
MT1X metallothionein 1X 0.0354795
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0351129
CD9 CD9 molecule 0.0346259
JUN jun proto-oncogene 0.0345639
POTEF POTE ankyrin domain family, member F 0.0345195
MYOF myoferlin 0.0323906
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.032292
PFN1 profilin 1 0.0311812
HMGA1 high mobility group AT-hook 1 0.0306388
SOX9 SRY (sex determining region Y)-box 9 0.0296439
ARF4 ADP-ribosylation factor 4 0.0292841
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0289968
NDRG1 N-myc downstream regulated 1 0.0283374
YBX3 Y box binding protein 3 0.0283319
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0280754
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0279962
VMP1 vacuole membrane protein 1 0.0276568
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like 0.0274447
KLF6 Kruppel-like factor 6 0.0274306
NEBL nebulette 0.0270223
TNS4 tensin 4 0.0267464
LDHA lactate dehydrogenase A 0.0266086
ANXA3 annexin A3 0.0262358
LAMB3 laminin, beta 3 0.0248403
SPATA13 spermatogenesis associated 13 0.0248298
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0244215
LMCD1 LIM and cysteine-rich domains 1 0.0233816
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 0.0233366
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor 0.0231891
MRPS6 mitochondrial ribosomal protein S6 0.0229796
RBM25 RNA binding motif protein 25 0.0216879
EMP1 epithelial membrane protein 1 0.0216591
TNIK TRAF2 and NCK interacting kinase 0.0214633
LMNA lamin A/C 0.0213746
CDH13 cadherin 13 0.0210113
SKAP1 src kinase associated phosphoprotein 1 0.0210028
FOSL1 FOS-like antigen 1 0.0209917
TMEM41B transmembrane protein 41B 0.0207831
PLP2 proteolipid protein 2 (colonic epithelium-enriched) 0.0206684
RACK1 receptor for activated C kinase 1 0.0206303
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0204352
LIMS1 LIM and senescent cell antigen-like domains 1 0.020432
INHBB inhibin, beta B 0.0201733
RPL18 ribosomal protein L18 0.0199524
MACF1 microtubule-actin crosslinking factor 1 0.0197924
CLDN4 claudin 4 0.0197687
ITGB5 integrin, beta 5 0.0196836
GLI3 GLI family zinc finger 3 0.0195004
CCNL1 cyclin L1 0.019027
LAMA5 laminin, alpha 5 0.0190149
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0190112
KRT19 keratin 19, type I 0.018977
CBX3 chromobox homolog 3 0.0185508
MYL12B myosin, light chain 12B, regulatory 0.0184797
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0184461
MYADM myeloid-associated differentiation marker 0.0184247
S100A4 S100 calcium binding protein A4 0.017662
RPS14 ribosomal protein S14 0.0176502
TMEM87A transmembrane protein 87A 0.0175201
BACE2 beta-site APP-cleaving enzyme 2 0.0174219
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0173734
RPL12 ribosomal protein L12 0.0173663
MAML2 mastermind-like 2 (Drosophila) 0.0173333
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 0.0173047

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.150604
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.11027
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0903128
PTMA prothymosin, alpha -0.0801502
WWOX WW domain containing oxidoreductase -0.0767322
SYT1 synaptotagmin I -0.0759819
INTS6 integrator complex subunit 6 -0.0708076
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0653536
TNS3 tensin 3 -0.0630296
MKI67 marker of proliferation Ki-67 -0.062324
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0622906
RPS6 ribosomal protein S6 -0.0558966
DSPP dentin sialophosphoprotein -0.0555468
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0548272
RPL38 ribosomal protein L38 -0.0547139
AHNAK AHNAK nucleoprotein -0.0529008
RBM39 RNA binding motif protein 39 -0.0504671
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0500282
HSPA8 heat shock 70kDa protein 8 -0.0497849
MAN1A1 mannosidase, alpha, class 1A, member 1 -0.0493767
NAV2 neuron navigator 2 -0.0493359
ATXN1 ataxin 1 -0.0460489
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0434783
MYH9 myosin, heavy chain 9, non-muscle -0.0434706
HDAC4 histone deacetylase 4 -0.0430941
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0412595
ANLN anillin, actin binding protein -0.0392354
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0383895
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0383707
OGA O-GlcNAcase -0.037645
FAF1 Fas (TNFRSF6) associated factor 1 -0.0372229
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0368227
FUS FUS RNA binding protein -0.0366958
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 -0.0360098
CBFB core-binding factor, beta subunit -0.0354212
LMO7 LIM domain 7 -0.0353728
JMJD1C jumonji domain containing 1C -0.0348133
VGLL4 vestigial-like family member 4 -0.0347214
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0346288
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0345299
RPS23 ribosomal protein S23 -0.0345271
PEAK1 pseudopodium-enriched atypical kinase 1 -0.0343358
KMT2C lysine (K)-specific methyltransferase 2C -0.0339381
WNK1 WNK lysine deficient protein kinase 1 -0.0338924
MARCHF6 membrane associated ring-CH-type finger 6 -0.0338723
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit -0.0338635
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0337014
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -0.0335031
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0332357
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.0326734
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0318782
RPL4 ribosomal protein L4 -0.0310871
RPLP1 ribosomal protein, large, P1 -0.0308534
ARL15 ADP-ribosylation factor-like 15 -0.0305967
H1-4 H1.4 linker histone, cluster member -0.0305421
CKAP5 cytoskeleton associated protein 5 -0.0303784
RPL14 ribosomal protein L14 -0.030364
TTC3 tetratricopeptide repeat domain 3 -0.0302559
MYH10 myosin, heavy chain 10, non-muscle -0.0299949
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa -0.0299269
DIAPH3 diaphanous-related formin 3 -0.0298937
SBF2 SET binding factor 2 -0.0296701
AOPEP aminopeptidase O (putative) -0.0295423
DEK DEK proto-oncogene -0.0295224
CEMIP2 cell migration inducing hyaluronidase 2 -0.0292573
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0290839
RBMX RNA binding motif protein, X-linked -0.0289072
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0285154
RBM33 RNA binding motif protein 33 -0.028465
RPS2 ribosomal protein S2 -0.0284029
USP34 ubiquitin specific peptidase 34 -0.0281608
CHD4 chromodomain helicase DNA binding protein 4 -0.0278578
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.027634
ZNF638 zinc finger protein 638 -0.0275803
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0274544
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0274468
GOLGB1 golgin B1 -0.0274327
XPO1 exportin 1 -0.0273461
HELZ helicase with zinc finger -0.0273418
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0273259
MATR3 matrin 3 -0.0272816
ATAD2 ATPase family, AAA domain containing 2 -0.0272039
BMP5 bone morphogenetic protein 5 -0.0271743
NIPBL Nipped-B homolog (Drosophila) -0.0270722
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0269397
PRKCA protein kinase C, alpha -0.0269062
GPHN gephyrin -0.0268443
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -0.0267387
SPTAN1 spectrin, alpha, non-erythrocytic 1 -0.0265134
PRELID2 PRELI domain containing 2 -0.0263994
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0263898
NONO non-POU domain containing, octamer-binding -0.0263181
SMYD3 SET and MYND domain containing 3 -0.0262833
STK38L serine/threonine kinase 38 like -0.0262817
ZFAND3 zinc finger, AN1-type domain 3 -0.0261469
TBC1D22A TBC1 domain family, member 22A -0.0261025
GLG1 golgi glycoprotein 1 -0.0260054
KAT6A K(lysine) acetyltransferase 6A -0.0259727
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0258644
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.025743