Almonertinib (hydrochloride)_hTERT-HPNE Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Almonertinib (hydrochloride) perturbation in hTERT-HPNE cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Almonertinib (hydrochloride)_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 0.144663
HLA-B major histocompatibility complex, class I, B 0.111345
MYO10 myosin X 0.107133
FN1 fibronectin 1 0.102875
MT2A metallothionein 2A 0.093495
STC1 stanniocalcin 1 0.092566
B2M beta-2-microglobulin 0.0895271
CD44 CD44 molecule (Indian blood group) 0.0892721
COL6A1 collagen, type VI, alpha 1 0.0864019
TPT1 tumor protein, translationally-controlled 1 0.0854852
RPS12 ribosomal protein S12 0.0827197
HMGA2 high mobility group AT-hook 2 0.080318
TMSB10 thymosin beta 10 0.076983
RPL35A ribosomal protein L35a 0.0719758
HLA-A major histocompatibility complex, class I, A 0.0697908
JARID2 jumonji, AT rich interactive domain 2 0.0665823
RPS3 ribosomal protein S3 0.0640228
RPL37A ribosomal protein L37a 0.0604879
EIF1 eukaryotic translation initiation factor 1 0.0585823
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0563307
RPL9 ribosomal protein L9 0.0550328
EEF2 eukaryotic translation elongation factor 2 0.0546751
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0496994
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0467038
IGFBP7 insulin-like growth factor binding protein 7 0.0453713
ARHGAP21 Rho GTPase activating protein 21 0.0431636
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 0.0431543
ZFP36L1 ZFP36 ring finger protein-like 1 0.0428997
TFPI2 tissue factor pathway inhibitor 2 0.0425913
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0425001
RPS8 ribosomal protein S8 0.0416218
HIPK2 homeodomain interacting protein kinase 2 0.0402021
TM4SF1 transmembrane 4 L six family member 1 0.0395929
ADM adrenomedullin 0.0395568
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0395113
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0383513
RPS27 ribosomal protein S27 0.0377556
HILPDA hypoxia inducible lipid droplet-associated 0.0376999
RPS19 ribosomal protein S19 0.0376002
CEMIP cell migration inducing protein, hyaluronan binding 0.037465
ZSWIM6 zinc finger, SWIM-type containing 6 0.0373671
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0372861
PTMA prothymosin, alpha 0.0367703
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0366952
POTEF POTE ankyrin domain family, member F 0.0364171
DNER delta/notch-like EGF repeat containing 0.0363404
RPL36 ribosomal protein L36 0.0362669
P4HB prolyl 4-hydroxylase, beta polypeptide 0.036058
EGFR epidermal growth factor receptor 0.0355388
RPS17 ribosomal protein S17 0.0354404
VEGFA vascular endothelial growth factor A 0.035054
RACK1 receptor for activated C kinase 1 0.0348807
PLAUR plasminogen activator, urokinase receptor 0.0347008
MCL1 myeloid cell leukemia 1 0.0339158
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0338898
COL4A1 collagen, type IV, alpha 1 0.033712
CD59 CD59 molecule, complement regulatory protein 0.033386
FMNL2 formin-like 2 0.0331776
NPTX1 neuronal pentraxin I 0.033085
FTL ferritin, light polypeptide 0.0326541
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0325565
NOTCH2 notch 2 0.0325185
AKAP12 A kinase (PRKA) anchor protein 12 0.0325078
NT5E 5'-nucleotidase, ecto (CD73) 0.032023
RPS2 ribosomal protein S2 0.0319872
CD63 CD63 molecule 0.0318917
SOD2 superoxide dismutase 2, mitochondrial 0.0317291
MYH9 myosin, heavy chain 9, non-muscle 0.0313027
PSD3 pleckstrin and Sec7 domain containing 3 0.0306767
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0304942
WSB1 WD repeat and SOCS box containing 1 0.030464
AKAP13 A kinase (PRKA) anchor protein 13 0.030185
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 0.0300788
MEIS1 Meis homeobox 1 0.0296419
LDHA lactate dehydrogenase A 0.0292392
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0291955
IL6 interleukin 6 0.0291401
RAB8B RAB8B, member RAS oncogene family 0.0290247
MAP1B microtubule-associated protein 1B 0.028925
RPL12 ribosomal protein L12 0.0287983
RPLP0 ribosomal protein, large, P0 0.0283734
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0282987
WWTR1 WW domain containing transcription regulator 1 0.0275304
RNF213 ring finger protein 213 0.0274547
ANGPTL4 angiopoietin-like 4 0.0273186
NFE2L1 nuclear factor, erythroid 2-like 1 0.0272561
FTH1 ferritin, heavy polypeptide 1 0.0272243
RPLP2 ribosomal protein, large, P2 0.0266583
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0263622
ATP13A3 ATPase type 13A3 0.0262655
RPL18 ribosomal protein L18 0.0261758
RPL31 ribosomal protein L31 0.0261503
SMYD3 SET and MYND domain containing 3 0.0259395
YBX1 Y box binding protein 1 0.0256361
PDE10A phosphodiesterase 10A 0.0253674
STC2 stanniocalcin 2 0.0253232
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0251821
JUN jun proto-oncogene 0.0250135
KLF6 Kruppel-like factor 6 0.0246925
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.02454

decreased expression

Symbol Name Standardized Value
COL1A1 collagen, type I, alpha 1 -0.292212
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.24129
MMP1 matrix metallopeptidase 1 -0.172434
EMP1 epithelial membrane protein 1 -0.154399
VIM vimentin -0.0995754
PRKG1 protein kinase, cGMP-dependent, type I -0.089523
ADGRB3 adhesion G protein-coupled receptor B3 -0.0626016
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0581617
COL1A2 collagen, type I, alpha 2 -0.0562195
NALF1 NALCN channel auxiliary factor 1 -0.0501797
CAV1 caveolin 1, caveolae protein, 22kDa -0.0486834
ACTG1 actin gamma 1 -0.0449164
CALU calumenin -0.0426651
ZEB1 zinc finger E-box binding homeobox 1 -0.0425367
VCAN versican -0.0408352
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0402347
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0401148
AHNAK AHNAK nucleoprotein -0.0400267
RRBP1 ribosome binding protein 1 -0.0386259
SEPTIN11 septin 11 -0.0380383
TMEM165 transmembrane protein 165 -0.0371013
FBN1 fibrillin 1 -0.0370322
SEC24D SEC24 family member D -0.0364171
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0361599
CCND1 cyclin D1 -0.0355639
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0348088
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0330588
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0328306
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0317033
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0316697
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0314554
SEC31A SEC31 homolog A (S. cerevisiae) -0.0313341
PTPRG protein tyrosine phosphatase, receptor type, G -0.0308757
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0305596
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) -0.0305411
GLG1 golgi glycoprotein 1 -0.0301046
KIAA1549L KIAA1549-like -0.0295463
CALD1 caldesmon 1 -0.0289513
CEP95 centrosomal protein 95kDa -0.0282863
ANKRD28 ankyrin repeat domain 28 -0.0273467
ABI3BP ABI family, member 3 (NESH) binding protein -0.0268761
FNDC3B fibronectin type III domain containing 3B -0.0266209
TMEM263 transmembrane protein 263 -0.0264845
ELL2 elongation factor, RNA polymerase II, 2 -0.026463
PRSS23 protease, serine, 23 -0.0259092
VEPH1 ventricular zone expressed PH domain-containing 1 -0.0257413
SSH1 slingshot protein phosphatase 1 -0.0255706
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 -0.0253898
CCDC102B coiled-coil domain containing 102B -0.0252983
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0245342
NBEAL1 neurobeachin-like 1 -0.0244711
IKBIP IKBKB interacting protein -0.0244105
SCLT1 sodium channel and clathrin linker 1 -0.023816
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0235717
KIF26B kinesin family member 26B -0.0233398
DIRAS3 DIRAS family, GTP-binding RAS-like 3 -0.0231445
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0231362
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0230925
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0229213
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0226962
PDE4B phosphodiesterase 4B, cAMP-specific -0.0222247
MED13L mediator complex subunit 13-like -0.022193
RAI14 retinoic acid induced 14 -0.0221314
DEK DEK proto-oncogene -0.0219658
ZBTB20 zinc finger and BTB domain containing 20 -0.0217585
ANXA2 annexin A2 -0.0216284
DDR2 discoidin domain receptor tyrosine kinase 2 -0.0214825
CHSY1 chondroitin sulfate synthase 1 -0.0212741
PRRX1 paired related homeobox 1 -0.0209731
RBMX RNA binding motif protein, X-linked -0.0207427
SRGN serglycin -0.0206162
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.0206063
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase -0.0202181
WDR26 WD repeat domain 26 -0.0200863
PXDN peroxidasin -0.0199901
PDIA3 protein disulfide isomerase family A, member 3 -0.0199267
ANO10 anoctamin 10 -0.0197969
CREB3L1 cAMP responsive element binding protein 3-like 1 -0.0195657
FUS FUS RNA binding protein -0.0194555
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0194474
CRADD CASP2 and RIPK1 domain containing adaptor with death domain -0.0192713
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0191503
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0191402
MMP12 matrix metallopeptidase 12 -0.0191273
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0191078
BAALC brain and acute leukemia, cytoplasmic -0.0190998
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0189582
CAVIN1 caveolae associated protein 1 -0.0187817
DIAPH2 diaphanous-related formin 2 -0.0186106
APOLD1 apolipoprotein L domain containing 1 -0.0186024
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0185914
CDH13 cadherin 13 -0.0185196
CRK v-crk avian sarcoma virus CT10 oncogene homolog -0.0184981
CLIC4 chloride intracellular channel 4 -0.0184029
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.018368
TNPO1 transportin 1 -0.0183532
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0182844
TRIP12 thyroid hormone receptor interactor 12 -0.0182365
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.018159
IQGAP1 IQ motif containing GTPase activating protein 1 -0.018055