| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Almonertinib (mesylate) perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Almonertinib (mesylate)_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.244559 |
| COL5A2 | collagen, type V, alpha 2 | 0.107216 |
| FLNB | filamin B, beta | 0.103468 |
| COL3A1 | collagen, type III, alpha 1 | 0.0922396 |
| THBS2 | thrombospondin 2 | 0.0919425 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0888867 |
| SLC39A11 | solute carrier family 39, member 11 | 0.0859687 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0806268 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0796655 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0795558 |
| COL5A1 | collagen, type V, alpha 1 | 0.0789877 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0778218 |
| SQSTM1 | sequestosome 1 | 0.0776846 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0764688 |
| HLA-B | major histocompatibility complex, class I, B | 0.075934 |
| PLAT | plasminogen activator, tissue | 0.0748127 |
| SEPTIN9 | septin 9 | 0.0742813 |
| LMNA | lamin A/C | 0.0717934 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0705271 |
| KLF6 | Kruppel-like factor 6 | 0.0618576 |
| CDH13 | cadherin 13 | 0.0562083 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0558212 |
| GPC6 | glypican 6 | 0.0529128 |
| PRELID2 | PRELI domain containing 2 | 0.0517934 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0511592 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.0500133 |
| PFN1 | profilin 1 | 0.0498761 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | 0.0483666 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0479962 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0477818 |
| NAV2 | neuron navigator 2 | 0.0474995 |
| CALU | calumenin | 0.0474068 |
| FLNA | filamin A, alpha | 0.046693 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0465954 |
| CALR | calreticulin | 0.0463017 |
| MSI2 | musashi RNA-binding protein 2 | 0.0456974 |
| UBC | ubiquitin C | 0.045472 |
| FN1 | fibronectin 1 | 0.045115 |
| CD99 | CD99 molecule | 0.0451052 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0450935 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.0447737 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0443477 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0440767 |
| DST | dystonin | 0.0433307 |
| SUCNR1 | succinate receptor 1 | 0.0432814 |
| TPM3 | tropomyosin 3 | 0.0425677 |
| ACTN4 | actinin, alpha 4 | 0.0424441 |
| PLAUR | plasminogen activator, urokinase receptor | 0.042418 |
| LDHA | lactate dehydrogenase A | 0.042297 |
| AUTS2 | autism susceptibility candidate 2 | 0.0420529 |
| LOXL2 | lysyl oxidase-like 2 | 0.0415934 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.0414402 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0407797 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0406638 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0400355 |
| MRPS6 | mitochondrial ribosomal protein S6 | 0.0396308 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0395755 |
| ANXA6 | annexin A6 | 0.0395544 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0395532 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | 0.0391829 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | 0.0384894 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0380166 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0374931 |
| SP3 | Sp3 transcription factor | 0.0369094 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0363346 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | 0.0360731 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0353673 |
| PDXK | pyridoxal (pyridoxine, vitamin B6) kinase | 0.0348269 |
| MCL1 | myeloid cell leukemia 1 | 0.034624 |
| GANAB | glucosidase, alpha; neutral AB | 0.0342545 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.0342394 |
| SMYD3 | SET and MYND domain containing 3 | 0.0326282 |
| NCOR2 | nuclear receptor corepressor 2 | 0.032062 |
| HLA-C | major histocompatibility complex, class I, C | 0.0320036 |
| ATXN1 | ataxin 1 | 0.0315921 |
| STK10 | serine/threonine kinase 10 | 0.0313843 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0312122 |
| ATP13A3 | ATPase type 13A3 | 0.0306869 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 0.0305641 |
| CEP170 | centrosomal protein 170kDa | 0.030093 |
| LOX | lysyl oxidase | 0.0300776 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0300021 |
| MSN | moesin | 0.029716 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0295233 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0292586 |
| CTSB | cathepsin B | 0.0291975 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0291418 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0291142 |
| CD59 | CD59 molecule, complement regulatory protein | 0.0285389 |
| PFKP | phosphofructokinase, platelet | 0.0283887 |
| COL4A2 | collagen, type IV, alpha 2 | 0.0283881 |
| SFXN3 | sideroflexin 3 | 0.0278935 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0277687 |
| RPL13A | ribosomal protein L13a | 0.0273278 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0272688 |
| SBF2 | SET binding factor 2 | 0.0271674 |
| DGKG | diacylglycerol kinase, gamma 90kDa | 0.0269097 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0268881 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0268685 |
| PODXL | podocalyxin-like | 0.0267889 |
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.225497 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.115615 |
| VIM | vimentin | -0.113022 |
| TMSB10 | thymosin beta 10 | -0.101671 |
| CD44 | CD44 molecule (Indian blood group) | -0.0819053 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.081764 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0806326 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.079313 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0671033 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0647901 |
| AHNAK | AHNAK nucleoprotein | -0.0604017 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0572553 |
| PTMA | prothymosin, alpha | -0.0568107 |
| VEGFA | vascular endothelial growth factor A | -0.0530932 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0520431 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0520246 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0513559 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0484344 |
| B2M | beta-2-microglobulin | -0.0474517 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0434697 |
| COPA | coatomer protein complex, subunit alpha | -0.0430641 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0411156 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0407676 |
| SEPTIN7 | septin 7 | -0.0395847 |
| CYLD | cylindromatosis (turban tumor syndrome) | -0.0390249 |
| NDRG1 | N-myc downstream regulated 1 | -0.0384309 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | -0.0383567 |
| PKM | pyruvate kinase, muscle | -0.037557 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0373334 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0369404 |
| CANX | calnexin | -0.0367317 |
| MYOF | myoferlin | -0.0354006 |
| UBAP1 | ubiquitin associated protein 1 | -0.0352972 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0346576 |
| S100A10 | S100 calcium binding protein A10 | -0.0342385 |
| ANXA2 | annexin A2 | -0.0339848 |
| SP100 | SP100 nuclear antigen | -0.0335136 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.033286 |
| RPLP1 | ribosomal protein, large, P1 | -0.0332537 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0325253 |
| GOLM2 | golgi membrane protein 2 | -0.0322521 |
| STC1 | stanniocalcin 1 | -0.0320095 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.0318588 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0318179 |
| TRAM2 | translocation associated membrane protein 2 | -0.0315649 |
| FTL | ferritin, light polypeptide | -0.0310634 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0303994 |
| FBXO11 | F-box protein 11 | -0.0303151 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0295843 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0295395 |
| RAI14 | retinoic acid induced 14 | -0.0289461 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0288428 |
| CDK6 | cyclin-dependent kinase 6 | -0.0288351 |
| DKK3 | dickkopf WNT signaling pathway inhibitor 3 | -0.0285137 |
| SAMD9L | sterile alpha motif domain containing 9-like | -0.0272768 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | -0.027099 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0267513 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0266355 |
| ZC3H11A | zinc finger CCCH-type containing 11A | -0.0264635 |
| RPS6 | ribosomal protein S6 | -0.026434 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0260652 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.025921 |
| FBN1 | fibrillin 1 | -0.0259045 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0255931 |
| MATR3 | matrin 3 | -0.0254281 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0250325 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0250052 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0249905 |
| TMCO3 | transmembrane and coiled-coil domains 3 | -0.0249262 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0246956 |
| GLIS3 | GLIS family zinc finger 3 | -0.0246878 |
| MAP1B | microtubule-associated protein 1B | -0.0242552 |
| IER3 | immediate early response 3 | -0.0239508 |
| ANXA5 | annexin A5 | -0.0237283 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.023135 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | -0.0230607 |
| GOLGB1 | golgin B1 | -0.0230441 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0222645 |
| RBM25 | RNA binding motif protein 25 | -0.0220562 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0218156 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0215497 |
| JUN | jun proto-oncogene | -0.0212689 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0212643 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0207458 |
| GNB4 | guanine nucleotide binding protein (G protein), beta polypeptide 4 | -0.0206666 |
| VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | -0.0204228 |
| PEA15 | phosphoprotein enriched in astrocytes 15 | -0.0203468 |
| MCFD2 | multiple coagulation factor deficiency 2 | -0.0202856 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.0202161 |
| PDXDC1 | pyridoxal-dependent decarboxylase domain containing 1 | -0.0199862 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0197415 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.0196894 |
| CSF1 | colony stimulating factor 1 (macrophage) | -0.0196473 |
| VCL | vinculin | -0.0196215 |
| BPTF | bromodomain PHD finger transcription factor | -0.0195532 |
| SEPTIN2 | septin 2 | -0.0195215 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0194926 |
| CEP350 | centrosomal protein 350kDa | -0.0192111 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0191622 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.019068 |
