| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Almonertinib (mesylate) perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Almonertinib (mesylate)_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | 0.15468 |
| AREG | amphiregulin | 0.124175 |
| VIM | vimentin | 0.10519 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0851316 |
| RPL23 | ribosomal protein L23 | 0.0763039 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0758533 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0706073 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0632231 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0623663 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0604006 |
| ECT2 | epithelial cell transforming 2 | 0.0585997 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0545261 |
| KRR1 | KRR1, small subunit (SSU) processome component, homolog (yeast) | 0.0510056 |
| VMP1 | vacuole membrane protein 1 | 0.0509461 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0461565 |
| MED13L | mediator complex subunit 13-like | 0.0457795 |
| RPL35A | ribosomal protein L35a | 0.0450577 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0440362 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0432638 |
| PCNP | PEST proteolytic signal containing nuclear protein | 0.0429359 |
| OLR1 | oxidized low density lipoprotein (lectin-like) receptor 1 | 0.0422263 |
| HLA-A | major histocompatibility complex, class I, A | 0.0421816 |
| PTMS | parathymosin | 0.0405897 |
| RAD51B | RAD51 paralog B | 0.0400582 |
| ANXA1 | annexin A1 | 0.0400158 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0398822 |
| LDHA | lactate dehydrogenase A | 0.0388805 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0385663 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.036682 |
| MYL12B | myosin, light chain 12B, regulatory | 0.0364382 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0360803 |
| RPL37A | ribosomal protein L37a | 0.0349808 |
| RPL37 | ribosomal protein L37 | 0.0346066 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0344884 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0344315 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0337109 |
| NHSL1 | NHS-like 1 | 0.0321579 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0317197 |
| ENO1 | enolase 1, (alpha) | 0.0317028 |
| TMEM41B | transmembrane protein 41B | 0.0316678 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.031662 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0312149 |
| S100A10 | S100 calcium binding protein A10 | 0.0311486 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0305858 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0305489 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | 0.0303747 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0302517 |
| RPL34 | ribosomal protein L34 | 0.0300578 |
| PNN | pinin, desmosome associated protein | 0.0298139 |
| H1-0 | H1.0 linker histone | 0.0297442 |
| RPS7 | ribosomal protein S7 | 0.0296302 |
| LARP1 | La ribonucleoprotein domain family, member 1 | 0.029356 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0286689 |
| ARRDC3 | arrestin domain containing 3 | 0.0283852 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0282286 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0282107 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0279805 |
| YEATS2 | YEATS domain containing 2 | 0.0278886 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0273335 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0272198 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0272035 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0270677 |
| NSD2 | nuclear receptor binding SET domain protein 2 | 0.0269949 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0269625 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0268296 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | 0.0264688 |
| TENM3 | teneurin transmembrane protein 3 | 0.026402 |
| RPS8 | ribosomal protein S8 | 0.0263236 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0260368 |
| MSI2 | musashi RNA-binding protein 2 | 0.02594 |
| PARD3 | par-3 family cell polarity regulator | 0.0258039 |
| RPLP2 | ribosomal protein, large, P2 | 0.0254342 |
| CLDND1 | claudin domain containing 1 | 0.0254299 |
| VPS8 | vacuolar protein sorting 8 homolog (S. cerevisiae) | 0.0254127 |
| CMIP | c-Maf inducing protein | 0.0247478 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0247316 |
| TRIM33 | tripartite motif containing 33 | 0.0244832 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0244739 |
| TMSB10 | thymosin beta 10 | 0.0244446 |
| PRELID2 | PRELI domain containing 2 | 0.0242406 |
| KDM1A | lysine (K)-specific demethylase 1A | 0.0237593 |
| DST | dystonin | 0.0237571 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0237447 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0235623 |
| RPS24 | ribosomal protein S24 | 0.0235546 |
| MEMO1 | mediator of cell motility 1 | 0.023462 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0233875 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0232703 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.023153 |
| ARHGAP12 | Rho GTPase activating protein 12 | 0.0230146 |
| PDE8A | phosphodiesterase 8A | 0.0229377 |
| RPS17 | ribosomal protein S17 | 0.0225953 |
| RAI1 | retinoic acid induced 1 | 0.0225881 |
| PER1 | period circadian clock 1 | 0.022542 |
| LDHB | lactate dehydrogenase B | 0.0224191 |
| SMYD3 | SET and MYND domain containing 3 | 0.022291 |
| ILF3 | interleukin enhancer binding factor 3, 90kDa | 0.0222288 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.022192 |
| PTK2 | protein tyrosine kinase 2 | 0.0221571 |
| ZFP64 | ZFP64 zinc finger protein | 0.0220654 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.251266 |
| RPS2 | ribosomal protein S2 | -0.155336 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.128846 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.12472 |
| MMP12 | matrix metallopeptidase 12 | -0.123871 |
| PCDH7 | protocadherin 7 | -0.106691 |
| ZNF804A | zinc finger protein 804A | -0.0954833 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.093175 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0896893 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0886145 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.080989 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0794714 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0725843 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0724555 |
| NLGN1 | neuroligin 1 | -0.0685311 |
| TXNRD1 | thioredoxin reductase 1 | -0.0654636 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.063252 |
| CLTC | clathrin, heavy chain (Hc) | -0.0613841 |
| JMJD1C | jumonji domain containing 1C | -0.0607295 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0595662 |
| CCND1 | cyclin D1 | -0.0581547 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0577995 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0568882 |
| EXOC6B | exocyst complex component 6B | -0.0554493 |
| RAB10 | RAB10, member RAS oncogene family | -0.0528261 |
| NABP1 | nucleic acid binding protein 1 | -0.0503493 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0487675 |
| IL6ST | interleukin 6 signal transducer | -0.0485542 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0480452 |
| RTN4 | reticulon 4 | -0.0473951 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0472284 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | -0.0466959 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.046689 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0462257 |
| IPO7 | importin 7 | -0.0438746 |
| GOLGB1 | golgin B1 | -0.0425804 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0424581 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0409885 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0403355 |
| NEGR1 | neuronal growth regulator 1 | -0.0398629 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0395398 |
| WNK1 | WNK lysine deficient protein kinase 1 | -0.0393727 |
| EDN1 | endothelin 1 | -0.0389467 |
| FBXO11 | F-box protein 11 | -0.0376333 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | -0.0370418 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0366628 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0363672 |
| PCBP2 | poly(rC) binding protein 2 | -0.0358856 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0357931 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0356171 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0354029 |
| PRKCI | protein kinase C, iota | -0.0351859 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0341702 |
| SLC38A2 | solute carrier family 38, member 2 | -0.033768 |
| SPAG9 | sperm associated antigen 9 | -0.0334248 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.0332457 |
| CDK6 | cyclin-dependent kinase 6 | -0.0315954 |
| EPHA5 | EPH receptor A5 | -0.0310158 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.0304889 |
| RPL38 | ribosomal protein L38 | -0.0304506 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0304181 |
| G3BP2 | GTPase activating protein (SH3 domain) binding protein 2 | -0.0303935 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0302492 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.0299015 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0296764 |
| DSG2 | desmoglein 2 | -0.0293969 |
| CCN2 | cellular communication network factor 2 | -0.0290333 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -0.0288363 |
| WDR70 | WD repeat domain 70 | -0.0287838 |
| AHR | aryl hydrocarbon receptor | -0.0286732 |
| CDH12 | cadherin 12, type 2 (N-cadherin 2) | -0.0280684 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0278353 |
| SQSTM1 | sequestosome 1 | -0.0278341 |
| HDLBP | high density lipoprotein binding protein | -0.0277961 |
| PAPOLA | poly(A) polymerase alpha | -0.0277878 |
| NCOA1 | nuclear receptor coactivator 1 | -0.0276646 |
| PCM1 | pericentriolar material 1 | -0.0276596 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0274902 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0272939 |
| HMGA2 | high mobility group AT-hook 2 | -0.0272278 |
| IFT80 | intraflagellar transport 80 | -0.0265503 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0264129 |
| SPIRE1 | spire-type actin nucleation factor 1 | -0.0262642 |
| MPG | N-methylpurine-DNA glycosylase | -0.0259578 |
| POTEF | POTE ankyrin domain family, member F | -0.0259084 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0257739 |
| NBEA | neurobeachin | -0.0253382 |
| HACD2 | 3-hydroxyacyl-CoA dehydratase 2 | -0.0250582 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0250271 |
| ICE1 | interactor of little elongation complex ELL subunit 1 | -0.0248343 |
| BPTF | bromodomain PHD finger transcription factor | -0.0248192 |
| MAP3K14 | mitogen-activated protein kinase kinase kinase 14 | -0.0247752 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.0247725 |
| TJP1 | tight junction protein 1 | -0.0247011 |
| LCOR | ligand dependent nuclear receptor corepressor | -0.0245592 |
| ATP11A | ATPase, class VI, type 11A | -0.0245521 |
| AFF4 | AF4/FMR2 family, member 4 | -0.02447 |
| PHACTR4 | phosphatase and actin regulator 4 | -0.0244379 |
| CCDC88A | coiled-coil domain containing 88A | -0.0243524 |
| PDCD10 | programmed cell death 10 | -0.0242213 |
