Almonertinib (mesylate)_A498 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Almonertinib (mesylate) perturbation in A498 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Almonertinib (mesylate)_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYH9 myosin, heavy chain 9, non-muscle 0.128459
IGFBP3 insulin-like growth factor binding protein 3 0.120157
FRMD4A FERM domain containing 4A 0.0857445
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0819478
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0734581
NAV2 neuron navigator 2 0.0729547
SPTBN1 spectrin, beta, non-erythrocytic 1 0.070392
RPL26 ribosomal protein L26 0.0699672
MSN moesin 0.06482
MT2A metallothionein 2A 0.0632675
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0631605
RPS8 ribosomal protein S8 0.0605133
RPL23 ribosomal protein L23 0.0562342
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0555677
CALR calreticulin 0.0547687
ANKRD11 ankyrin repeat domain 11 0.0520595
RPL37A ribosomal protein L37a 0.0494305
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.049345
TPM3 tropomyosin 3 0.048451
DDIT4 DNA-damage-inducible transcript 4 0.0461341
SEPTIN9 septin 9 0.0455373
RPS13 ribosomal protein S13 0.0450947
G0S2 G0/G1 switch 2 0.0446456
RND3 Rho family GTPase 3 0.0444543
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0442615
RPL13A ribosomal protein L13a 0.041938
NDRG1 N-myc downstream regulated 1 0.0412293
IRS2 insulin receptor substrate 2 0.0409375
FMNL2 formin-like 2 0.0400165
TRIO trio Rho guanine nucleotide exchange factor 0.0399531
RPLP2 ribosomal protein, large, P2 0.0392038
NAP1L1 nucleosome assembly protein 1-like 1 0.0366876
HDGF hepatoma-derived growth factor 0.0363822
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0362735
RPL3 ribosomal protein L3 0.0361054
RPL7A ribosomal protein L7a 0.0352885
RPL5 ribosomal protein L5 0.0350143
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0347848
TPT1 tumor protein, translationally-controlled 1 0.0345095
RPL37 ribosomal protein L37 0.0337737
CADM1 cell adhesion molecule 1 0.033714
FLNA filamin A, alpha 0.0335294
VEGFA vascular endothelial growth factor A 0.0333552
ZMIZ1 zinc finger, MIZ-type containing 1 0.032771
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0327543
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.0326998
CALU calumenin 0.0325925
PTMA prothymosin, alpha 0.0325736
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0316372
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0314342
PLEC plectin 0.0313917
RPL7 ribosomal protein L7 0.0311484
KMT2C lysine (K)-specific methyltransferase 2C 0.0311121
SET SET nuclear proto-oncogene 0.0310267
MKNK2 MAP kinase interacting serine/threonine kinase 2 0.0307293
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0304942
RPS3 ribosomal protein S3 0.0304667
PAX8 paired box 8 0.0304466
LRRC59 leucine rich repeat containing 59 0.0302936
TNIP1 TNFAIP3 interacting protein 1 0.0302083
EEF1G eukaryotic translation elongation factor 1 gamma 0.0300417
ZFAND3 zinc finger, AN1-type domain 3 0.0296842
RPS19 ribosomal protein S19 0.0295719
RPS2 ribosomal protein S2 0.0292744
CAMTA1 calmodulin binding transcription activator 1 0.0288258
RPS27 ribosomal protein S27 0.0287659
LMNA lamin A/C 0.0286251
ARRDC3 arrestin domain containing 3 0.0285116
RPS21 ribosomal protein S21 0.0284582
HMGA1 high mobility group AT-hook 1 0.0283394
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0280745
COL5A1 collagen, type V, alpha 1 0.0280729
TM9SF2 transmembrane 9 superfamily member 2 0.028057
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0279582
XPO6 exportin 6 0.0277947
SND1 staphylococcal nuclease and tudor domain containing 1 0.0277284
RPL18 ribosomal protein L18 0.0272001
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0265728
CELF1 CUGBP, Elav-like family member 1 0.0263254
ADGRG1 adhesion G protein-coupled receptor G1 0.0261056
GOLGA4 golgin A4 0.0259896
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0255541
RPS12 ribosomal protein S12 0.0254983
HLA-B major histocompatibility complex, class I, B 0.0253158
NACA nascent polypeptide-associated complex alpha subunit 0.025272
KDM6A lysine (K)-specific demethylase 6A 0.0251511
RPL36A ribosomal protein L36a 0.0245609
VASP vasodilator-stimulated phosphoprotein 0.0242725
RPL9 ribosomal protein L9 0.0241849
ITCH itchy E3 ubiquitin protein ligase 0.024103
RB1CC1 RB1-inducible coiled-coil 1 0.0240529
RPS17 ribosomal protein S17 0.0240154
RPL35 ribosomal protein L35 0.0239372
CHMP4B charged multivesicular body protein 4B 0.0237397
RPS7 ribosomal protein S7 0.0236836
WDR43 WD repeat domain 43 0.0236141
ATP13A3 ATPase type 13A3 0.0235698
GIGYF2 GRB10 interacting GYF protein 2 0.0232784
LIMS1 LIM and senescent cell antigen-like domains 1 0.0227899
RPS15A ribosomal protein S15a 0.022739

decreased expression

Symbol Name Standardized Value
CXCL8 chemokine (C-X-C motif) ligand 8 -0.200015
ASPH aspartate beta-hydroxylase -0.163797
CD44 CD44 molecule (Indian blood group) -0.150282
FTL ferritin, light polypeptide -0.136102
TXNRD1 thioredoxin reductase 1 -0.133824
GLIS3 GLIS family zinc finger 3 -0.132245
CSF1 colony stimulating factor 1 (macrophage) -0.10783
FTH1 ferritin, heavy polypeptide 1 -0.0961713
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0919049
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0891355
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0800149
MX1 MX dynamin-like GTPase 1 -0.0734134
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0692975
EXT1 exostosin glycosyltransferase 1 -0.0677692
VCL vinculin -0.0673489
MAP1B microtubule-associated protein 1B -0.0670997
VIM vimentin -0.066842
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0643321
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0633944
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0575105
VCAM1 vascular cell adhesion molecule 1 -0.0569154
RIGI RNA sensor RIG-I -0.0568859
CA12 carbonic anhydrase XII -0.0558377
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0550616
OSMR oncostatin M receptor -0.0547847
TMSB10 thymosin beta 10 -0.0546783
PLIN2 perilipin 2 -0.0520552
CP ceruloplasmin (ferroxidase) -0.0483535
TSHZ2 teashirt zinc finger homeobox 2 -0.0483108
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0479549
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0470623
JUN jun proto-oncogene -0.0466916
KYNU kynureninase -0.0458801
RNF213 ring finger protein 213 -0.0453675
PALLD palladin, cytoskeletal associated protein -0.0453071
SP100 SP100 nuclear antigen -0.0443212
LOC112694756 uncharaterized LOC112694756 -0.0440303
ANXA2 annexin A2 -0.0440032
BIRC3 baculoviral IAP repeat containing 3 -0.0436037
PKM pyruvate kinase, muscle -0.0425774
PDIA3 protein disulfide isomerase family A, member 3 -0.0415453
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0407028
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0405652
UBC ubiquitin C -0.040466
RAB2A RAB2A, member RAS oncogene family -0.0394846
VDAC1 voltage-dependent anion channel 1 -0.0389289
PDLIM5 PDZ and LIM domain 5 -0.0384195
ZBTB20 zinc finger and BTB domain containing 20 -0.0373742
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0368601
FNDC3B fibronectin type III domain containing 3B -0.0366969
ITGAV integrin, alpha V -0.0365921
RTN4 reticulon 4 -0.0362201
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) -0.0361772
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0359516
UGCG UDP-glucose ceramide glucosyltransferase -0.0359312
STK17A serine/threonine kinase 17a -0.0358415
NRP2 neuropilin 2 -0.0353585
NAMPT nicotinamide phosphoribosyltransferase -0.0349915
RPLP0 ribosomal protein, large, P0 -0.0346162
IFI16 interferon, gamma-inducible protein 16 -0.0344326
PLK2 polo-like kinase 2 -0.0337148
PDE4D phosphodiesterase 4D, cAMP-specific -0.0336469
TUBA1B tubulin, alpha 1b -0.0330064
RRBP1 ribosome binding protein 1 -0.032944
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0329322
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0327194
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0322889
PLSCR1 phospholipid scramblase 1 -0.0320872
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0314512
PBX1 pre-B-cell leukemia homeobox 1 -0.0314245
SETX senataxin -0.0309229
LITAF lipopolysaccharide-induced TNF factor -0.0307343
COPB1 coatomer protein complex, subunit beta 1 -0.0306662
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0305871
GCLM glutamate-cysteine ligase, modifier subunit -0.0305665
CDK6 cyclin-dependent kinase 6 -0.0302844
PTBP3 polypyrimidine tract binding protein 3 -0.0301896
CBX3 chromobox homolog 3 -0.0301853
TKT transketolase -0.0301259
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0298537
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0298059
ITM2B integral membrane protein 2B -0.0296052
CREB5 cAMP responsive element binding protein 5 -0.0295343
SEC31A SEC31 homolog A (S. cerevisiae) -0.0291368
TRAM1 translocation associated membrane protein 1 -0.0290592
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0289428
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0288712
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0287267
ARF1 ADP-ribosylation factor 1 -0.0285326
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0283985
GNAS GNAS complex locus -0.0283649
ALCAM activated leukocyte cell adhesion molecule -0.0282886
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 -0.0282615
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa -0.0281365
XAF1 XIAP associated factor 1 -0.0281281
ATP5F1B ATP synthase F1 subunit beta -0.0280731
TMEM263 transmembrane protein 263 -0.0280391
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0277643
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa -0.0273051
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0270853